Gene: RORC

6097
IMD42|NR1F3|RORG|RZR-GAMMA|RZRG|TOR
RAR related orphan receptor C
protein-coding
1q21.3
Ensembl:ENSG00000143365 MIM:602943 Vega:OTTHUMG00000013053 UniprotKB:P51449
NG_029118.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.940e-1 (AD)  8.387e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09171692chr1:151798824RORC1.500e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC26A70.625
SCNN1A0.592
MYOM30.583
TP630.555
C10orf710.554
DSC30.551
XIRP20.546
IYD0.542
SLFN120.54
MYPN0.538

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF835-0.292
HNF1A-0.292
KCNG1-0.288
RHO-0.278
FRMPD2-0.273
HAS1-0.27
ASPDH-0.269
CALHM1-0.269
GJD4-0.268
WNT7A-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RORC mRNA"28903501
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of RORC mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of RORC mRNA"20453058
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of RORC mRNA"28433925
C00799725-hydroxycholesterol25-hydroxycholesterol binds to RORC protein22659100
C00799725-hydroxycholesterolbisphenol A analog inhibits the reaction [25-hydroxycholesterol binds to RORC protein]22659100
C00799725-hydroxycholesterolTO-901317 inhibits the reaction [25-hydroxycholesterol binds to RORC protein]22659100
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of RORC mRNA28522335
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of RORC mRNA16014739
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RORC mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of RORC mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of RORC mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of RORC mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RORC protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RORC mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RORC gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of RORC mRNA28522335
D001151ArsenicArsenic results in decreased expression of RORC mRNA22617429
C087670azoxystrobinazoxystrobin results in increased activity of RORC protein20143881
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RORC mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RORC mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RORC mRNA20106945
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RORC mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RORC mRNA21569818
D004958EstradiolEstradiol results in decreased expression of RORC mRNA20106945
D004958EstradiolEstradiol results in decreased expression of RORC mRNA19484750|2557526
C004541biochanin Abiochanin A promotes the reaction [RORC protein binds to NCOA1 protein]25583575
C004541biochanin Abiochanin A results in increased activity of RORC protein25583575
C004541biochanin A[biochanin A results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
C006780bisphenol Abisphenol A analog binds to and results in decreased activity of RORC protein22659100
C006780bisphenol Abisphenol A analog inhibits the reaction [25-hydroxycholesterol binds to RORC protein]22659100
C006780bisphenol Abisphenol A affects the methylation of RORC promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of RORC mRNA14967926
C006780bisphenol Abisphenol A results in increased expression of RORC mRNA27693988
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of RORC mRNA"28433925
C006780bisphenol Abisphenol A results in increased expression of RORC mRNA25181051
D002065BuspironeBuspirone results in decreased expression of RORC mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of RORC mRNA26177832
C018475butyraldehydebutyraldehyde results in decreased expression of RORC mRNA26079696
D002220CarbamazepineCarbamazepine results in increased expression of RORC mRNA22790970
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of RORC mRNA27339419
D002706ChlordanChlordan results in decreased expression of RORC mRNA23153324
D002737ChloropreneChloroprene results in increased expression of RORC mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RORC mRNA27858113
D002994Clofibrate[Clofibrate co-treated with PPARG] results in increased expression of RORC mRNA9543393
D016572CyclosporineCyclosporine results in decreased expression of RORC mRNA20106945
C004742daidzeindaidzein results in increased activity of RORC protein25583575
C004742daidzein[daidzein results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
D015230Prostaglandin D2Prostaglandin D2 results in increased expression of RORC mRNA9543393
D003907Dexamethasone[Dexamethasone co-treated with INS1 protein] results in increased expression of RORC mRNA9543393
D003907DexamethasoneTGFB1 inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORC mRNA]9543393
D003907DexamethasoneTNF inhibits the reaction [[Dexamethasone co-treated with INS1 protein] results in increased expression of RORC mRNA]9543393
D004008DiclofenacDiclofenac results in increased expression of RORC mRNA22285467
D004041Dietary FatsDietary Fats affects the expression of RORC mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of RORC mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of RORC mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of RORC mRNA]22010203
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of RORC mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of RORC mRNA"28433925
D004077DigoxinDigoxin results in decreased activity of RORC protein21441909
D002117CalcitriolCalcitriol results in increased expression of RORC mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RORC mRNA"22485181
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RORC mRNA26159488
D005485FlutamideFlutamide results in decreased expression of RORC mRNA24136188
C007768formononetinformononetin results in increased activity of RORC protein25583575
C007768formononetin[formononetin results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
D005620Freund's Adjuvant[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of RORC mRNA alternative form25481498
D005620Freund's Adjuvantnorisoboldine inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of RORC mRNA alternative form]25481498
C069837fullerene C60fullerene C60 results in decreased expression of RORC mRNA19167457
D019833GenisteinGenistein results in increased activity of RORC protein25583575
D019833Genistein[Genistein results in increased activity of RORC protein] which results in increased expression of IL17A mRNA25583575
D005897GlafenineGlafenine results in decreased expression of RORC mRNA24136188
C409722hexaconazolehexaconazole binds to and results in decreased activity of RORC protein22289359
D017313FenretinideFenretinide results in increased expression of RORC mRNA28973697
C056493imiquimodimiquimod results in increased expression of RORC mRNA26149470
C056493imiquimodimiquimod results in increased expression of RORC protein26149470
C056493imiquimod(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]26149470
C056493imiquimod(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]26149470
D007200IndicanIndican results in increased expression of RORC mRNA23639249
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RORC mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC mRNA]26149470
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [imiquimod results in increased expression of RORC protein]26149470
D007840LatexLatex analog results in increased expression of RORC mRNA24768652
C045463leflunomideleflunomide inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]26640276
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RORC mRNA26011545
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RORC mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RORC mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RORC mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of RORC mRNA20594950
C051752nefazodonenefazodone results in decreased expression of RORC mRNA24136188
D009532NickelNickel results in decreased expression of RORC mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of RORC mRNA19167457
C012655nimesulidenimesulide results in decreased expression of RORC mRNA24136188
C464745norisoboldinenorisoboldine inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased expression of RORC mRNA alternative form]25481498
D010126OzoneOzone results in increased expression of RORC mRNA24336422
D052638Particulate MatterCARD9 protein affects the reaction [Particulate Matter results in increased expression of RORC mRNA]28315386
D052638Particulate MatterCARD9 protein affects the reaction [Particulate Matter results in increased phosphorylation of RORC protein]28315386
D052638Particulate MatterParticulate Matter results in increased expression of RORC mRNA28315386|2865563
D052638Particulate MatterParticulate Matter results in increased phosphorylation of RORC protein28315386
D010476PerfumePerfume results in decreased expression of RORC mRNA24768652
D015232DinoprostoneDinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]19273625
D015232DinoprostoneDinoprostone results in increased expression of RORC19273625
D010634PhenobarbitalPhenobarbital affects the expression of RORC mRNA23091169
C060836pioglitazonepioglitazone results in increased expression of RORC mRNA9543393
C006253pirinixic acidpirinixic acid results in decreased expression of RORC mRNA20813756|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of RORC mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of RORC mRNA23012394
C116926rofecoxibrofecoxib results in decreased expression of RORC mRNA17070997
C089730rosiglitazonerosiglitazone results in increased expression of RORC mRNA9543393
D019821SimvastatinIFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D019821SimvastatinIL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D019821SimvastatinIL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA]18453621
D019821SimvastatinSimvastatin results in decreased expression of RORC mRNA18453621
C017947sodium arsenitesodium arsenite results in decreased expression of RORC mRNA28843991
C013698tallowtallow affects the expression of RORC mRNA19680557
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of RORC mRNA]22010203
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RORC mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RORC mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RORC mRNA24058054
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of RORC mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RORC gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RORC mRNA25975270|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RORC mRNA21215274|2172422
C009438tetrandrinetetrandrine inhibits the reaction [COL2A1 protein results in increased expression of RORC mRNA]26640276
C009438tetrandrinetetrandrine results in decreased expression of RORC mRNA26640276
C423915TO-901317TO-901317 binds to and results in decreased activity of RORC protein22659100
C423915TO-901317TO-901317 inhibits the reaction [25-hydroxycholesterol binds to RORC protein]22659100
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RORC mRNA20133372
C479163tofacitinibtofacitinib inhibits the reaction [[IL6 protein co-treated with IL23A protein] results in increased expression of RORC mRNA]21383241
C479163tofacitinibtofacitinib inhibits the reaction [[IL6 protein co-treated with TGFB1 protein] results in increased expression of RORC mRNA]21383241
D014241TrichloroethyleneTrichloroethylene results in increased expression of RORC mRNA26745549
D014241TrichloroethyleneTrichloroethylene results in increased expression of RORC mRNA alternative form22490199
C053549triflumizoltriflumizol binds to and results in decreased activity of RORC protein22289359
C001899triptolidetriptolide results in increased expression of RORC mRNA24949944
D014520UrethaneUrethane results in decreased expression of RORC mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of RORC mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of RORC mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of RORC gene29154799
D014635Valproic AcidValproic Acid affects the expression of RORC mRNA17292431|1796380
D001335Vehicle EmissionsVehicle Emissions results in increased expression of RORC mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20427770  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA20427770  
GO:0001223transcription coactivator binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0004879nuclear receptor activity-IEA-  
GO:0005515protein binding-IPI18368049  20203100  22170608  23555304  
GO:0008142oxysterol binding-IBA21873635  
GO:0008142oxysterol binding-IDA19965867  
GO:0008270zinc ion binding-IEA-  
GO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding-IDA19965867  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA20427770  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006805xenobiotic metabolic process-ISS-  
GO:0010906regulation of glucose metabolic process-ISS-  
GO:0019218regulation of steroid metabolic process-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030522intracellular receptor signaling pathway-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0036315cellular response to sterol-IDA19965867  
GO:0042753positive regulation of circadian rhythm-ISS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045598regulation of fat cell differentiation-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0060612adipose tissue development-ISS-  
GO:0060850regulation of transcription involved in cell fate commitment-ISS-  
GO:0072539T-helper 17 cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19965867  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8949275RUNX3 Regulates Immune Response and Cell MigrationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28658564A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype. (2017 Nov)Hirai KClin Exp Allergy
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One