Gene: ROS1

6098
MCF3|ROS|c-ros-1
ROS proto-oncogene 1, receptor tyrosine kinase
protein-coding
6q22.1
Ensembl:ENSG00000047936 MIM:165020 Vega:OTTHUMG00000016188 UniprotKB:P08922
NG_033929.1
PubMed
ND|AD
61   
5.182e-1 (AD)  1.007e-1 (ND)   (Frontal_Cortex)
4.565e-1 (AD)  3.005e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIAM20.786
LANCL30.778
RTKN20.754
FAM13A0.746
ADPRHL10.745
SYN30.745
CRHR20.741
KCNS10.738
PTH2R0.735
NIPAL20.734

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL7C-0.491
AQP5-0.454
RBP1-0.45
COPZ2-0.445
HEY2-0.439
PINLYP-0.435
KLRC3-0.423
MDFI-0.417
RARRES2-0.409
MYL3-0.404

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of ROS1 mRNA19643169
D000082AcetaminophenAcetaminophen results in decreased expression of ROS1 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ROS1 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of ROS1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ROS1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROS1 mRNA20106945|2231617
C006780bisphenol Abisphenol A affects the expression of ROS1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of ROS1 gene28505145
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ROS1 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ROS1 mRNA28472532
D016572CyclosporineCyclosporine results in decreased expression of ROS1 mRNA20106945
D003609DactinomycinDactinomycin results in increased expression of ROS1 mRNA16001973
C014347decitabinedecitabine results in decreased methylation of ROS1 promoter19276365
C014347decitabinedecitabine results in increased expression of ROS1 mRNA19276365
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ROS1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ROS1 mRNA27392435
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of ROS1 mRNA17187413
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of ROS1 gene28505145
D019833GenisteinGenistein results in decreased expression of ROS1 mRNA17341692
C004312glycidolglycidol results in decreased expression of ROS1 mRNA24915197
D007213IndomethacinIndomethacin results in increased expression of ROS1 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ROS1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ROS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ROS1 mRNA24796395
C005219methyl cellosolvemethyl cellosolve results in increased expression of ROS1 mRNA19643169
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ROS1 mRNA26011545
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of ROS1 mRNA15120970
C464660obeticholic acidobeticholic acid results in increased expression of ROS1 mRNA27939613
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ROS1 mRNA20106945
D013853ThioacetamideThioacetamide results in increased expression of ROS1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of ROS1 mRNA23409001
D014241TrichloroethyleneTrichloroethylene results in decreased expression of ROS1 mRNA26745549

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IDA16885344  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI11266449  17416557  
GO:0005524ATP binding-IEA-  
GO:0019903protein phosphatase binding-IPI16885344  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IDA16885344  
GO:0001934positive regulation of protein phosphorylation-IBA21873635  
GO:0002066columnar/cuboidal epithelial cell development-ISS-  
GO:0006468protein phosphorylation-IDA16885344  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0007283spermatogenesis-ISS-  
GO:0008283cell proliferation-ISS-  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010629negative regulation of gene expression-IEA-  
GO:0010966regulation of phosphate transport-IEA-  
GO:0023014signal transduction by protein phosphorylation-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-ISS-  
GO:0032006regulation of TOR signaling-IDA16885344  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0038083peptidyl-tyrosine autophosphorylation-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0070372regulation of ERK1 and ERK2 cascade-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0009986cell surface-IEA-  
GO:0016020membrane-TAS3785223  
GO:0016021integral component of membrane-IEA-  
GO:0043235receptor complex-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27262212Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma through Oncogene Overlap Analysis. (2016 Aug)Noonan SAJ Thorac Oncol
28065467Lung Adenocarcinoma With MUC4 Expression Is Associated With Smoking Status, HER2 Protein Expression, and Poor Prognosis: Clinicopathologic Analysis of 338 Cases. (2017 Jul)Rokutan-Kurata MClin Lung Cancer
27027665Gene aberrations for precision medicine against lung adenocarcinoma. (2016 Jun)Saito MCancer Sci
26689248Polymorphism of rs9387478 correlates with overall survival in female nonsmoking patients with lung cancer. (2016 May 28)Han JFInt J Biol Markers
28280984Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy. (2018 Jan)Saito MSurg Today
25855381Development of lung adenocarcinomas with exclusive dependence on oncogene fusions. (2015 Jun 1)Saito MCancer Res
26705279[Detection of ALK, ROS1 and RET fusion genes in non-small cell lung cancer patients and its clinicopathologic correlation]. (2015 Sep)Zhong SZhonghua Bing Li Xue Za Zhi
25267753How long is long enough? Extended anticoagulation for the treatment of cancer-associated deep vein thrombosis. (2014 Nov 10)Zwicker JIJ Clin Oncol
29277178[Clinical Significance and Mechanism of PI3K p110beta Overexpression in Non-small Cell Lung Cancer]. (2017 Dec 20)Xiong YZhongguo Fei Ai Za Zhi
25862146PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy. (2015 Jun)Chang YLLung Cancer
26273395Clinicopathological characteristics and outcomes of ROS1-rearranged patients with lung adenocarcinoma without EGFR, KRAS mutations and ALK rearrangements. (2015 Jul)Wu SThorac Cancer
26775573[News about targeted therapies in non-small-cell lung cancer in 2015 (except immuno-therapy)]. (2016 Jan)Hamard CAnn Pathol
27793199Epidemiological study of HER-2 mutations among EGFR wild-type lung adenocarcinoma patients in China. (2016 Oct 28)Li XBMC Cancer
27268911Smoking, hormonal factors and molecular markers in female lung cancer. (2016)Schveigert DNeoplasma
23514723ROS1 fusions in Chinese patients with non-small-cell lung cancer. (2013 Jul)Cai WAnn Oncol
24920890Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis. (2014)Primiani AInt J Chron Obstruct Pulmon Dis
24390215Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (2014 Aug)Mackinnon AC JrMod Pathol
23788756The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma. (2013 Sep)Kim HRAnn Oncol
22585869ROS1 gene rearrangement is identified in NSCLC. (2012 Feb)-Cancer Discov
26955281The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations. (2016)Zheng DOnco Targets Ther
29413057Tumor biomarker testing in non-small-cell lung cancer: A decade of change. (2018 Feb)VanderLaan PALung Cancer
25870798Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. (2015 Apr)Kohno TTransl Lung Cancer Res
28468034[To evaluate the clinicopathologic characteristics and outcome of tumor cells spreading through air spaces in patients with adenocarcinoma of lung]. (2017 May 8)Sun PLZhonghua Bing Li Xue Za Zhi
28468033[Clinicopathologic features and genetic profile of the redefined large cell lung carcinoma]. (2017 May 8)Hou LKZhonghua Bing Li Xue Za Zhi
28676214DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel. (2017 Aug)Takamochi KLung Cancer
26331813Differences in driver genes between smoking-related and non-smoking-related lung cancer in the Chinese population. (2015 Sep 1)Gou LYCancer
24300132Clinical characteristics associated with ALK rearrangements in never-smokers with pulmonary adenocarcinoma. (2014 Feb)Sun JMLung Cancer
29128428Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer. (2018 Jan)Ferrara RJ Thorac Oncol
28104537Correlation between Classic Driver Oncogene Mutations in EGFR, ALK, or ROS1 and 22C3-PD-L1 >/=50% Expression in Lung Adenocarcinoma. (2017 May)Rangachari DJ Thorac Oncol
26437441Molecular Process Producing Oncogene Fusion in Lung Cancer Cells by Illegitimate Repair of DNA Double-Strand Breaks. (2015 Sep 30)Seki YBiomolecules
27438512Driver Mutation Analysis and PD-L1 Expression in Synchronous Double Primary Lung Cancer. (2018 Apr)Jia XAppl Immunohistochem Mol Morphol
25567908Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches. (2015 Aug 15)Drilon AClin Cancer Res
28740441Detection of ROS1 rearrangement in non-small cell lung cancer: current and future perspectives. (2017)Rossi GLung Cancer (Auckl)
28881815Clinicopathological characteristics of ROS1- and RET-rearranged NSCLC in caucasian patients: Data from a cohort of 713 non-squamous NSCLC lacking KRAS/EGFR/HER2/BRAF/PIK3CA/ALK alterations. (2017 Aug 8)Dugay FOncotarget
27635639Clinicopathological characteristics and survival of ALK, ROS1 and RET rearrangements in non-adenocarcinoma non-small cell lung cancer patients. (2017 Nov 2)Song ZCancer Biol Ther
26207220Clinicopathologic characteristics of patients with ROS1 fusion gene in non-small cell lung cancer: a meta-analysis. (2015 Jun)Zhu QTransl Lung Cancer Res
28025329Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017 Jan 15)Seow WJHum Mol Genet
23887156ROS1 immunohistochemistry for detection of ROS1-rearranged lung adenocarcinomas. (2013 Sep)Sholl LMAm J Surg Pathol
26601054Experience with targeted next generation sequencing for the care of lung cancer: insights into promises and limitations of genomic oncology in day-to-day practice. (2015)Rangachari DCancer Treat Commun
29413048Distinct clinicopathologic features, genomic characteristics and survival of central and peripheral pulmonary large cell neuroendocrine carcinoma: From different origin cells? (2018 Feb)Zhou FLung Cancer
23877438CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013 Oct)Matsuura SOncol Rep
28103968[Gene Expression and Clinical Characteristics of Molecular Targeted Therapy in Non-small Cell Lung Cancer Patients in Shandong]. (2017 Jan 20)Qiao XZhongguo Fei Ai Za Zhi
29631966MET Expression in Advanced Non-Small-Cell Lung Cancer: Effect on Clinical Outcomes of Chemotherapy, Targeted Therapy, and Immunotherapy. (2018 Mar 17)Reis HClin Lung Cancer
26164066Spectrum of gene mutations detected by next generation exome sequencing in brain metastases of lung adenocarcinoma. (2015 Sep)Preusser MEur J Cancer
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
27298405Management of Brain Metastases in ALK-Positive Non-Small-Cell Lung Cancer. (2016 Aug 20)Rusthoven CGJ Clin Oncol
28210164Spotlight on crizotinib in the first-line treatment of ALK-positive advanced non-small-cell lung cancer: patients selection and perspectives. (2016)Leprieur EGLung Cancer (Auckl)
27033383[Correlation of clinicopathologic features and driver gene mutation in non-small cell lung cancer]. (2016 Apr 8)Chen LFZhonghua Bing Li Xue Za Zhi
28914263Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma. (2018 Feb)Tang ZMod Pathol
18097620Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. (2008 Jan)Yamada YInt J Mol Med
25007143Pulmonary adenocarcinoma with signet ring cell features: a comprehensive study from 3 distinct patient cohorts. (2014 Dec)Boland JMAm J Surg Pathol
25567305[Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. (2014 Oct)Cheng HZhonghua Zhong Liu Za Zhi
24087953[Genetic predictors of myocardial infarction in subjects of young age]. (2013)Shesternia PAKardiologiia
24850843FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. (2014 Aug 1)Wang RClin Cancer Res
26704833[Detection of ROS1 fusion gene in pulmonary adenocarcinoma and its clinicopathologic features]. (2015 Jun)Liu JZhonghua Bing Li Xue Za Zhi
24163741Molecular biology of lung cancer. (2013 Oct)Cooper WAJ Thorac Dis
27708233Advanced lung adenocarcinomas with ROS1-rearrangement frequently show hepatoid cell. (2016 Nov 8)Zhao JOncotarget
28952227Analysis of the status of EGFR, ROS1 and MET genes in non-small cell lung adenocarcinoma. (2017 Jul-Aug)Wang QJ BUON
27008586Clinicopathologic Characteristics of Patients with HER2 Insertions in Non-small Cell Lung Cancer. (2017 Jan)Bu SAnn Surg Oncol
29217530The Impact of Smoking and TP53 Mutations in Lung Adenocarcinoma Patients with Targetable Mutations-The Lung Cancer Mutation Consortium (LCMC2). (2018 Mar 1)Aisner DLClin Cancer Res
25180059Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples. (2014 Jun)Zhao CTransl Oncol