Gene: RP1

6101
DCDC4A|ORP1
RP1, axonemal microtubule associated
protein-coding
8q11.23-q12.1
Ensembl:ENSG00000104237 MIM:603937 Vega:OTTHUMG00000164379 UniprotKB:P56715
NG_009840.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.092e-1 (AD)  4.436e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06704573chr8:55527950RP1Promoter1.190e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C11orf440.86
OR5H150.858
CDY2A0.854
OR5M10.854
OR11H10.854
OR5T20.854
KRTAP6-20.854
OR4C120.854
OR8J30.854
KRTAP27-10.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM43B-0.299
MMP15-0.295
HHATL-0.293
DBP-0.289
CHRNA4-0.287
TMEM221-0.277
MAGIX-0.277
TMEM81-0.275
PSPN-0.272
C16orf95-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of RP1 mRNA"25270620
D000082AcetaminophenAcetaminophen results in decreased expression of RP1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RP1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RP1 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of RP1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of RP1 mRNA19549813
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RP1 mRNA23550701
D014635Valproic AcidValproic Acid results in decreased methylation of RP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21148103  
GO:0008017microtubule binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IEA-  
GO:0007603phototransduction, visible light-TAS10391211  
GO:0035082axoneme assembly-IBA21873635  
GO:0035082axoneme assembly-ISS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0035845photoreceptor cell outer segment organization-ISS-  
GO:0042461photoreceptor cell development-IBA21873635  
GO:0042461photoreceptor cell development-ISS-  
GO:0045494photoreceptor cell maintenance-ISS-  
GO:0046548retinal rod cell development-ISS-  
GO:0046549retinal cone cell development-ISS-  
GO:0060041retina development in camera-type eye-IBA21873635  
GO:0071482cellular response to light stimulus-IEA-  
GO:1902857positive regulation of non-motile cilium assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001750photoreceptor outer segment-ISS-  
GO:0001917photoreceptor inner segment-IDA11773008  
GO:0005874microtubule-IEA-  
GO:0005875microtubule associated complex-ISS-  
GO:0005930axoneme-IBA21873635  
GO:0032391photoreceptor connecting cilium-IDA11767049  
GO:0097542ciliary tip-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27134767Genome-wide time-to-event analysis on smoking progression stages in a family-based study. (2016 May)He LBrain Behav
20378611Predictors of bleeding and user satisfaction during consecutive use of the levonorgestrel-releasing intrauterine system. (2010 Jun)Heikinheimo OHum Reprod
18295997In contrast to lung fibroblasts--no signs of senescence in skin fibroblasts of patients with emphysema. (2008 Jul)Muller KCExp Gerontol