Gene info: ID 6117

Gene: RPA1

GENE ID: 6117

Synonyms: HSSB|MST075|REPA1|RF-A|RP-A|RPA70

Description: replication protein A1

Gene type: protein-coding

Location: 17p13.3

dbXrefs: Ensembl:ENSG00000132383 MIM:179835 Vega:OTTHUMG00000090579 UniprotKB:P27694

RefSeq: NC_000017.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.015e-1 (AD) 9.086e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4790825	chr17:1842556 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C6orf89	0.916
KPNB1	0.916
COX15	0.915
DCTN4	0.914
GDI2	0.912
SLC39A9	0.912
XRCC5	0.911
GANAB	0.911
RBBP4	0.91
LARS	0.909

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.73
OR4F29	-0.692
MTRNR2L6	-0.286
MTRNR2L9	-0.258
MTRNR2L10	-0.237
NANOGNB	-0.225
C8orf74	-0.22
TTLL10	-0.217
PPBP	-0.211
HMHB1	-0.209

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C020888	1,2-dielaidoylphosphatidylethanolamine	"1,2-dielaidoylphosphatidylethanolamine results in increased expression of RPA1 mRNA"	14668052
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of RPA1 mRNA	19933214
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of RPA1 mRNA"	20702594
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RPA1 mRNA"	19167446
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of RPA1 mRNA"	18648102
C006757	4-biphenylamine	4-biphenylamine results in decreased expression of RPA1 mRNA	24857880
D000082	Acetaminophen	Acetaminophen results in decreased expression of RPA1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen affects the expression of RPA1 mRNA	17562736
C103505	AM 251	AM 251 results in decreased expression of RPA1 mRNA	16500647
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of RPA1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of RPA1 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPA1 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPA1 protein	21467743
C006780	bisphenol A	bisphenol A affects the expression of RPA1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of RPA1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of RPA1 mRNA	22121209
C006780	bisphenol A	bisphenol A results in decreased expression of RPA1 mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of RPA1 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of RPA1 mRNA	12419474\|1533650
C018475	butyraldehyde	butyraldehyde results in decreased expression of RPA1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RPA1 mRNA	23741332
D000069287	Capecitabine	RPA1 protein results in decreased susceptibility to Capecitabine	16734730
D002220	Carbamazepine	Carbamazepine affects the expression of RPA1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of RPA1 mRNA	17484886
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RPA1 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RPA1 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of RPA1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of RPA1 mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of RPA1 mRNA	21878529
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of RPA1 mRNA	11906922
D016572	Cyclosporine	Cyclosporine results in decreased expression of RPA1 mRNA	25562108
C014347	decitabine	RPA1 protein affects the reaction [decitabine results in increased activity of ATR protein]	17977830
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RPA1 mRNA	17361019\|2126653
D004008	Diclofenac	Diclofenac affects the expression of RPA1 mRNA	24752500
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of RPA1 mRNA	26924002
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RPA1 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPA1 mRNA]	17854601
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of RPA1 mRNA	26924002
C025034	doxifluridine	RPA1 protein results in decreased susceptibility to doxifluridine	16734730
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPA1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA1 mRNA	17942748
C039281	furan	furan results in increased methylation of RPA1 gene	22079235
C419708	gefitinib	gefitinib results in increased expression of RPA1 mRNA	16685379
D005839	Gentamicins	Gentamicins results in increased expression of RPA1 mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of RPA1 mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of RPA1 mRNA	22634610
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of RPA1 mRNA	26941288
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of RPA1 mRNA	12419474
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RPA1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RPA1 mRNA	26941288
C410337	K 7174	K 7174 results in decreased expression of RPA1 mRNA	24086573
D007854	Lead	Lead affects the expression of RPA1 mRNA	28903495
C045463	leflunomide	leflunomide results in decreased expression of RPA1 mRNA	28988120
D064704	Levofloxacin	Levofloxacin results in decreased expression of RPA1 mRNA	24136188
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of RPA1 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of RPA1 mRNA	20020106
D008767	Methylmercury Compounds	[Polychlorinated Biphenyls co-treated with Methylmercury Compounds] results in increased expression of RPA1 mRNA	20020106
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of RPA1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of RPA1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of RPA1 mRNA"	25620056
C051752	nefazodone	nefazodone results in decreased expression of RPA1 mRNA	24136188
C012655	nimesulide	nimesulide results in decreased expression of RPA1 mRNA	24136188
C025589	ochratoxin A	ochratoxin A results in increased expression of RPA1 mRNA	22124623
C025589	ochratoxin A	ochratoxin A results in increased expression of RPA1 mRNA	22124623
C030110	oxaliplatin	oxaliplatin results in increased expression of RPA1 mRNA	17762391
C016030	pantogab	pantogab results in decreased expression of RPA1 mRNA	17379144
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RPA1 protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of RPA1 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RPA1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of RPA1 mRNA	19482888
C030090	phosphoramide mustard	phosphoramide mustard results in increased expression of RPA1 mRNA	26708502
C006253	pirinixic acid	pirinixic acid results in increased expression of RPA1 mRNA	18301758\|2381119
D011078	Polychlorinated Biphenyls	[Polychlorinated Biphenyls co-treated with Methylmercury Compounds] results in increased expression of RPA1 mRNA	20020106
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of RPA1 mRNA	20020106
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of RPA1 mRNA	19167446
C059514	resveratrol	resveratrol results in decreased expression of RPA1 mRNA	12569576
C547185	riccardin D	riccardin D results in decreased expression of RPA1 mRNA	24069304
C009277	sodium arsenate	sodium arsenate results in increased expression of RPA1 mRNA	23922661
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RPA1 mRNA	20702594\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPA1 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RPA1 mRNA	15310856\|1993321
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RPA1 mRNA	25613284
D019772	Topotecan	RPA1 protein affects the susceptibility to Topotecan	16217747
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of RPA1 gene	27618143
C012589	trichostatin A	trichostatin A results in decreased expression of RPA1 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of RPA1 mRNA	19140230
C080163	trovafloxacin	trovafloxacin results in decreased expression of RPA1 mRNA	24136188
D014501	Uranium	Uranium affects the expression of RPA1 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of RPA1 mRNA	15672453
C406224	valdecoxib	valdecoxib results in decreased expression of RPA1 mRNA	24136188
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RPA1 gene	25560391
D014800	Vitallium	Vitallium analog results in decreased expression of RPA1 mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of RPA1 mRNA	20044591
D015215	Zidovudine	Zidovudine results in increased expression of RPA1 mRNA	21192964

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003684	damaged DNA binding	-	IBA	21873635
GO:0003684	damaged DNA binding	-	IDA	7700386 27723717 27723720
GO:0003697	single-stranded DNA binding	-	IBA	21873635
GO:0003697	single-stranded DNA binding	-	IDA	8990123 19010961
GO:0005515	protein binding	-	IPI	1311258 2159011 7700386 8381428 10373438 10825162 11927569 12527904 14747526 15735006 15775963 15897895 15965237 17666013 17673209 19338310 20811460 24126761 25416956 26496610 27723717 27723720 29395061
GO:0043047	single-stranded telomeric DNA binding	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-
GO:0098505	G-rich strand telomeric DNA binding	-	IDA	16973897 24747047
GO:0098505	G-rich strand telomeric DNA binding	-	IMP	26041456

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	-
GO:0000723	telomere maintenance	-	IBA	21873635
GO:0000723	telomere maintenance	-	IC	16973897 24747047 26041456
GO:0000723	telomere maintenance	-	IMP	17959650
GO:0000724	double-strand break repair via homologous recombination	-	IBA	21873635
GO:0000724	double-strand break repair via homologous recombination	-	IMP	17765923
GO:0006260	DNA replication	-	IMP	9430682
GO:0006260	DNA replication	-	TAS	-
GO:0006261	DNA-dependent DNA replication	-	IBA	21873635
GO:0006261	DNA-dependent DNA replication	-	TAS	8756712
GO:0006268	DNA unwinding involved in DNA replication	-	IBA	21873635
GO:0006281	DNA repair	-	IBA	21873635
GO:0006281	DNA repair	-	IMP	18469000
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006284	base-excision repair	-	IDA	9765279
GO:0006289	nucleotide-excision repair	-	IBA	21873635
GO:0006289	nucleotide-excision repair	-	IMP	9430682
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	-
GO:0006298	mismatch repair	-	IMP	9430682
GO:0006310	DNA recombination	-	TAS	8756712
GO:0007004	telomere maintenance via telomerase	-	IBA	21873635
GO:0019985	translesion synthesis	-	TAS	-
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	-
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0034502	protein localization to chromosome	-	IDA	27723717 27723720
GO:0036297	interstrand cross-link repair	-	TAS	-
GO:0042276	error-prone translesion synthesis	-	TAS	-
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0051321	meiotic cell cycle	-	IBA	21873635
GO:0070987	error-free translesion synthesis	-	TAS	-
GO:1900034	regulation of cellular response to heat	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000784	nuclear chromosome, telomeric region	-	HDA	19135898
GO:0000784	nuclear chromosome, telomeric region	-	IBA	21873635
GO:0005634	nucleus	-	IDA	17959650
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005662	DNA replication factor A complex	-	IBA	21873635
GO:0005662	DNA replication factor A complex	-	IDA	11927569 27723717 27723720
GO:0005662	DNA replication factor A complex	-	IPI	16135809
GO:0016605	PML body	-	IDA	16135809
GO:0016605	PML body	colocalizes_with	IDA	17959650

KEGG ID	KEGG Term
hsa03030	DNA replication
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair
hsa03440	Homologous recombination

Reactome ID	Reactome Term	Evidence
R-HSA-110312	Translesion synthesis by REV1	TAS
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110320	Translesion Synthesis by POLH	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-1474165	Reproduction	IEA
R-HSA-1500620	Meiosis	IEA
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-174414	Processive synthesis on the C-strand of the telomere	TAS
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	TAS
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	TAS
R-HSA-176187	Activation of ATR in response to replication stress	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2990846	SUMOylation	TAS
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371511	HSF1 activation	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5358508	Mismatch Repair	TAS
R-HSA-5358508	Mismatch Repair	IEA
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	TAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	TAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	IEA
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-5655862	Translesion synthesis by POLK	TAS
R-HSA-5656121	Translesion synthesis by POLI	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	TAS
R-HSA-5693607	Processing of DNA double-strand break ends	TAS
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6783310	Fanconi Anemia Pathway	TAS
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68962	Activation of the pre-replicative complex	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69166	Removal of the Flap Intermediate	TAS
R-HSA-69183	Processive synthesis on the lagging strand	TAS
R-HSA-69186	Lagging Strand Synthesis	TAS
R-HSA-69190	DNA strand elongation	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69473	G2/M DNA damage checkpoint	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73894	DNA Repair	IEA
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-912446	Meiotic recombination	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal