Gene: RPA2

6118
REPA2|RP-A p32|RP-A p34|RPA32
replication protein A2
protein-coding
1p35.3
Ensembl:ENSG00000117748 MIM:179836 Vega:OTTHUMG00000003915 UniprotKB:P15927
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
1.870e-1 (AD)  5.972e-1 (ND)   (Frontal_Cortex)
3.881e-1 (AD)  8.432e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSN0.9
COPZ10.896
PSMC20.893
ESD0.893
PSMD60.893
XRCC60.893
ILF20.891
EMC40.888
MRPS18B0.888
SUCLG10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.733
OR4F29-0.698
MTRNR2L6-0.282
MTRNR2L9-0.28
MTRNR2L10-0.248
KLRB1-0.235
TTLL10-0.232
C8orf74-0.229
RNF223-0.217
PPBP-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RPA2 mRNA"22698814
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RPA2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RPA2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RPA2 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid analog results in increased phosphorylation of RPA2 protein17512204
D000082AcetaminophenAcetaminophen results in increased expression of RPA2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RPA2 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of RPA2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RPA2 mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of RPA2 mRNA"23195993
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of RPA2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPA2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of RPA2 mRNA12420312
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RPA2 mRNA"22863853
D001280AtrazineAtrazine results in decreased expression of RPA2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPA2 protein20097212
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPA2 mRNA21715664|2222880
C006780bisphenol Abisphenol A results in increased expression of RPA2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPA2 mRNA28628672
D002087ButyratesButyrates results in decreased expression of RPA2 mRNA14674679
C584509C646 compoundC646 compound results in decreased expression of RPA2 mRNA23698071
D002104CadmiumCadmium results in increased expression of RPA2 mRNA23358151
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RPA2 mRNA23741332
D002110CaffeineCaffeine inhibits the reaction [Camptothecin promotes the reaction [PRKDC protein results in increased phosphorylation of RPA2 protein]]15060176
D002166CamptothecinCaffeine inhibits the reaction [Camptothecin promotes the reaction [PRKDC protein results in increased phosphorylation of RPA2 protein]]15060176
D002166CamptothecinCamptothecin promotes the reaction [PRKDC protein results in increased phosphorylation of RPA2 protein]15060176
D002220CarbamazepineCarbamazepine affects the expression of RPA2 mRNA24752500|2597931
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RPA2 mRNA17484886
D019327Copper SulfateCopper Sulfate results in decreased expression of RPA2 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of RPA2 mRNA15755911
D003520CyclophosphamideCyclophosphamide results in decreased expression of RPA2 mRNA11906922
D016572CyclosporineCyclosporine affects the expression of RPA2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of RPA2 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPA2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RPA2 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of RPA2 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of RPA2 mRNA24752500
D002117CalcitriolCalcitriol results in decreased expression of RPA2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RPA2 mRNA21592394
D000431EthanolEthanol affects the expression of RPA2 mRNA24355176
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA2 mRNA17942748
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of RPA2 mRNA22634610
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of RPA2 mRNA26941288
D017313FenretinideFenretinide results in increased expression of RPA2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPA2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RPA2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RPA2 mRNA26941288
C410337K 7174K 7174 results in decreased expression of RPA2 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of RPA2 mRNA28988120
D008748MethylcholanthreneMethylcholanthrene results in increased expression of RPA2 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RPA2 mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of RPA2 mRNA12517777
D008777MethyltestosteroneMethyltestosterone results in increased expression of RPA2 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RPA2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RPA2 mRNA"25554681
D009532NickelNickel results in decreased expression of RPA2 mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RPA2 mRNA25729387
D010126OzoneOzone results in increased expression of RPA2 mRNA16330353
D052638Particulate MatterParticulate Matter results in decreased expression of RPA2 mRNA24769257
D010433PentylenetetrazolePentylenetetrazole affects the expression of RPA2 mRNA21503142
D010634PhenobarbitalPhenobarbital results in increased expression of RPA2 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RPA2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RPA2 mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of RPA2 mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of RPA2 mRNA19162173
D010894PiroxicamPiroxicam results in decreased expression of RPA2 mRNA21858171
D011374ProgesteroneProgesterone results in increased expression of RPA2 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of RPA2 mRNA20726854
C059514resveratrolresveratrol results in increased expression of RPA2 protein25505154
D012176RetinoidsRetinoids analog results in increased phosphorylation of RPA2 protein17512204
C547185riccardin Driccardin D results in decreased expression of RPA2 mRNA24069304
D012715Sesame OilSesame Oil results in decreased expression of RPA2 mRNA29191790
C009277sodium arsenatesodium arsenate results in increased expression of RPA2 mRNA16882884
C016104sodium bichromatesodium bichromate results in increased expression of RPA2 mRNA12325037|2211074
D012999SomanSoman results in decreased expression of RPA2 mRNA19281266
D014284TriiodothyronineTriiodothyronine analog results in increased phosphorylation of RPA2 protein22383522
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RPA2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RPA2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPA2 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPA2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RPA2 promoter]19654925
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of RPA2 protein20109541
D013853ThioacetamideThioacetamide results in increased expression of RPA2 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RPA2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RPA2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RPA2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RPA2 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of RPA2 mRNA21427059
C521013veliparibveliparib inhibits the reaction [PARP1 protein mutant form results in increased expression of RPA2 protein modified form]27694308
D015032ZincZinc deficiency results in decreased expression of RPA2 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IBA21873635  
GO:0003684damaged DNA binding-IDA7700386  27723717  27723720  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IC2406247  
GO:0003697single-stranded DNA binding-IDA19010961  
GO:0003697single-stranded DNA binding-ISS-  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI2159011  7700386  8702565  10449415  10982866  11927569  
12509449  12527904  15793585  15897895  15965237  16169070  
17765923  19338310  20154705  20304803  20643958  20670893  
20811460  22684010  23910567  24126761  24910198  26496610  
27723717  27723720  28575657  28575658  
GO:0019899enzyme binding-IPI19793862  19793863  
GO:0019903protein phosphatase binding-IPI20154705  
GO:0031625ubiquitin protein ligase binding-IPI21504906  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0047485protein N-terminus binding-IEA-  
GO:0098505G-rich strand telomeric DNA binding-IBA21873635  
GO:0098505G-rich strand telomeric DNA binding-IDA24747047  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0000723telomere maintenance-IC24747047  
GO:0000723telomere maintenance-IMP17959650  
GO:0000724double-strand break repair via homologous recombination-IMP17765923  
GO:0006260DNA replication-IDA2406247  
GO:0006260DNA replication-IMP9430682  
GO:0006260DNA replication-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006284base-excision repair-IDA9765279  
GO:0006289nucleotide-excision repair-IMP9430682  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006297nucleotide-excision repair, DNA gap filling-TAS-  
GO:0006298mismatch repair-IMP9430682  
GO:0010569regulation of double-strand break repair via homologous recombination-IMP20154705  
GO:0019985translesion synthesis-TAS-  
GO:0031571mitotic G1 DNA damage checkpoint-IMP21731742  
GO:0032201telomere maintenance via semi-conservative replication-TAS-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0034502protein localization to chromosome-IDA27723717  27723720  
GO:0036297interstrand cross-link repair-TAS-  
GO:0042276error-prone translesion synthesis-TAS-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0070987error-free translesion synthesis-TAS-  
GO:1900034regulation of cellular response to heat-TAS-  
GO:2000001regulation of DNA damage checkpoint-IMP21504906  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric regioncolocalizes_withIDA17959650  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000785chromatin-IDA10336450  
GO:0005634nucleus-IDA10982866  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005662DNA replication factor A complex-IDA2406247  11927569  27723717  27723720  
GO:0005662DNA replication factor A complex-IPI16135809  
GO:0016604nuclear body-IDA-  
GO:0016605PML body-IDA12814551  
GO:0016605PML bodycolocalizes_withIDA17959650  
GO:0035861site of double-strand breakcolocalizes_withIDA21504906  
KEGG ID KEGG Term
hsa03030DNA replication
hsa03420Nucleotide excision repair
hsa03430Mismatch repair
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-110312Translesion synthesis by REV1TAS
R-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateTAS
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-110320Translesion Synthesis by POLHTAS
R-HSA-110373Resolution of AP sites via the multiple-nucleotide patch replacement pathwayTAS
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-174414Processive synthesis on the C-strand of the telomereTAS
R-HSA-174417Telomere C-strand (Lagging Strand) SynthesisTAS
R-HSA-174437Removal of the Flap Intermediate from the C-strandTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371511HSF1 activationTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5651801PCNA-Dependent Long Patch Base Excision RepairTAS
R-HSA-5655862Translesion synthesis by POLKTAS
R-HSA-5656121Translesion synthesis by POLITAS
R-HSA-5656169Termination of translesion DNA synthesisTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6783310Fanconi Anemia PathwayTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69166Removal of the Flap IntermediateTAS
R-HSA-69183Processive synthesis on the lagging strandTAS
R-HSA-69186Lagging Strand SynthesisTAS
R-HSA-69190DNA strand elongationTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-73894DNA RepairIEA
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17451265S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining. (2007 Jun)Lo WYJ Proteome Res