Gene info: ID 6119

Gene: RPA3

GENE ID: 6119

Synonyms: REPA3|RP-A p14

Description: replication protein A3

Gene type: protein-coding

Location: 7p21.3

dbXrefs: Ensembl:ENSG00000106399 MIM:179837 Vega:OTTHUMG00000023748 UniprotKB:P35244

RefSeq: NC_000007.14

Retrived from: SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : 2.467e-2 (AD) 4.852e-1 (ND) (Frontal_Cortex)

Pascal p-value : 8.637e-2 (AD) 5.059e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10264890	chr7:7680356 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs1557997	chr7:7664329 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NFU1	0.9
C1D	0.889
DNAJC19	0.888
ZNHIT3	0.888
MRPS33	0.885
EEF1E1	0.882
MRPS23	0.876
ACP1	0.872
SNAPC5	0.871
SCOC	0.871

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.528
OR4F29	-0.487
MTRNR2L6	-0.41
P2RY14	-0.401
MTRNR2L10	-0.384
ANPEP	-0.381
MTRNR2L9	-0.374
MAGEA12	-0.372
CSAG1	-0.367
PPBP	-0.347

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of RPA3 mRNA"	19162173
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RPA3 mRNA"	19167446
C005975	3,4-dihydroxyphenylethanol	"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA"	16797527
D000082	Acetaminophen	Acetaminophen affects the expression of RPA3 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of RPA3 gene	27153756
D001151	Arsenic	Arsenic affects the methylation of RPA3 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of RPA3 mRNA	17530438
C547126	AZM551248	AZM551248 results in increased expression of RPA3 mRNA	22323515
D004958	Estradiol	Estradiol results in decreased expression of RPA3 mRNA	23019147
D004958	Estradiol	Estradiol results in increased expression of RPA3 mRNA	19167446
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of RPA3 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of RPA3 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of RPA3 mRNA	26496021
D000069286	Bortezomib	Bortezomib results in decreased expression of RPA3 mRNA	17659339
D002065	Buspirone	Buspirone results in decreased expression of RPA3 mRNA	24136188
C584509	C646 compound	C646 compound results in decreased expression of RPA3 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RPA3 mRNA	12760830
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of RPA3 mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of RPA3 mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of RPA3 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RPA3 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of RPA3 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of RPA3 mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in decreased expression of RPA3 mRNA	20106945\|2163298
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RPA3 mRNA]	27941970
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RPA3 mRNA	17361019
D002945	Cisplatin	Cisplatin results in increased expression of RPA3 mRNA	27594783
C000944	dicrotophos	dicrotophos results in decreased expression of RPA3 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of RPA3 mRNA	18042831
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of RPA3 mRNA	15766595
D004317	Doxorubicin	RPA3 protein affects the susceptibility to Doxorubicin	16217747
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of RPA3 mRNA	21040762
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPA3 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of RPA3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPA3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA3 mRNA	17942748
D005492	Folic Acid	Folic Acid affects the expression of RPA3 mRNA	16361273
D005665	Furosemide	Furosemide affects the expression of RPA3 mRNA	17497460
D005897	Glafenine	Glafenine results in increased expression of RPA3 mRNA	24136188
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of RPA3 mRNA	26941288
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPA3 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RPA3 mRNA	26941288
C006552	kaempferol	"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA"	16797527
C008261	lead acetate	lead acetate results in increased expression of RPA3 mRNA	22641619
C017557	nickel subsulfide	nickel subsulfide results in increased expression of RPA3 mRNA	12760830
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RPA3 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of RPA3 mRNA	25729387
D000073878	Palm Oil	Palm Oil results in increased expression of RPA3 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in decreased expression of RPA3 mRNA	24769257
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RPA3 protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of RPA3 mRNA	19159669
C006253	pirinixic acid	pirinixic acid results in decreased expression of RPA3 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of RPA3 mRNA	18301758\|2381119
C443641	poly(propyleneimine)	poly(propyleneimine) analog results in decreased expression of RPA3 mRNA	16308212
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of RPA3 protein	23718831
D011794	Quercetin	"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA"	16797527
C052785	rebamipide	rebamipide results in increased expression of RPA3 mRNA	18299717
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of RPA3 mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of RPA3 protein	25505154
C547185	riccardin D	riccardin D results in decreased expression of RPA3 mRNA	24069304
C017947	sodium arsenite	sodium arsenite results in increased expression of RPA3 mRNA	28595984
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of RPA3 mRNA	27862939
D010042	Ouabain	Ouabain affects the expression of RPA3 protein	17268060
D013629	Tamoxifen	Tamoxifen affects the expression of RPA3 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RPA3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPA3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RPA3 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPA3 mRNA	25613284
C066340	tolcapone	tolcapone results in decreased expression of RPA3 mRNA	24136188
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RPA3 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of RPA3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of RPA3 mRNA	21934132
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RPA3 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of RPA3 mRNA	19140230
D014520	Urethane	Urethane results in decreased expression of RPA3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of RPA3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of RPA3 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of RPA3 mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RPA3 gene	25560391
D014747	Vinblastine	RPA3 protein affects the susceptibility to Vinblastine	16217747
D014810	Vitamin E	"[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3,4-dihydroxyphenylethanol] results in increased expression of RPA3 mRNA"	16797527
C111237	vorinostat	vorinostat results in increased expression of RPA3 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003684	damaged DNA binding	-	IBA	21873635
GO:0003684	damaged DNA binding	-	IDA	7700386
GO:0003697	single-stranded DNA binding	-	IBA	21873635
GO:0003697	single-stranded DNA binding	-	IDA	19010961
GO:0005515	protein binding	-	IPI	2159011 10449415 10982866 11927569 12527904 15965237 19338310 20811460 24126761 26496610

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	-
GO:0000723	telomere maintenance	-	TAS	24747047
GO:0000724	double-strand break repair via homologous recombination	-	IBA	21873635
GO:0000724	double-strand break repair via homologous recombination	-	IMP	17765923
GO:0006260	DNA replication	-	IBA	21873635
GO:0006260	DNA replication	-	IMP	9430682
GO:0006260	DNA replication	-	TAS	-
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006284	base-excision repair	-	IBA	21873635
GO:0006284	base-excision repair	-	IDA	9765279
GO:0006289	nucleotide-excision repair	-	IBA	21873635
GO:0006289	nucleotide-excision repair	-	IMP	9430682
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	-
GO:0006298	mismatch repair	-	IBA	21873635
GO:0006298	mismatch repair	-	IMP	9430682
GO:0007346	regulation of mitotic cell cycle	-	IEA	-
GO:0019985	translesion synthesis	-	TAS	-
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	-
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0036297	interstrand cross-link repair	-	TAS	-
GO:0042127	regulation of cell proliferation	-	IEA	-
GO:0042276	error-prone translesion synthesis	-	TAS	-
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	-
GO:0070987	error-free translesion synthesis	-	TAS	-
GO:1900034	regulation of cellular response to heat	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-
GO:0005662	DNA replication factor A complex	-	IBA	21873635
GO:0005662	DNA replication factor A complex	-	IDA	11927569
GO:0035861	site of double-strand break	-	IBA	21873635

KEGG ID	KEGG Term
hsa03030	DNA replication
hsa03420	Nucleotide excision repair
hsa03430	Mismatch repair
hsa03440	Homologous recombination

Reactome ID	Reactome Term	Evidence
R-HSA-110312	Translesion synthesis by REV1	TAS
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	TAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	TAS
R-HSA-110320	Translesion Synthesis by POLH	TAS
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	TAS
R-HSA-1474165	Reproduction	IEA
R-HSA-1500620	Meiosis	IEA
R-HSA-157579	Telomere Maintenance	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1640170	Cell Cycle	IEA
R-HSA-174414	Processive synthesis on the C-strand of the telomere	TAS
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	TAS
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	TAS
R-HSA-176187	Activation of ATR in response to replication stress	TAS
R-HSA-180786	Extension of Telomeres	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371511	HSF1 activation	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5358508	Mismatch Repair	TAS
R-HSA-5358508	Mismatch Repair	IEA
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	TAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	TAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	IEA
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	TAS
R-HSA-5655862	Translesion synthesis by POLK	TAS
R-HSA-5656121	Translesion synthesis by POLI	TAS
R-HSA-5656169	Termination of translesion DNA synthesis	TAS
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	TAS
R-HSA-5685942	HDR through Homologous Recombination (HRR)	TAS
R-HSA-5693532	DNA Double-Strand Break Repair	TAS
R-HSA-5693538	Homology Directed Repair	TAS
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	TAS
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	TAS
R-HSA-5693607	Processing of DNA double-strand break ends	TAS
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	TAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6783310	Fanconi Anemia Pathway	TAS
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	TAS
R-HSA-68874	M/G1 Transition	TAS
R-HSA-68962	Activation of the pre-replicative complex	TAS
R-HSA-69002	DNA Replication Pre-Initiation	TAS
R-HSA-69166	Removal of the Flap Intermediate	TAS
R-HSA-69183	Processive synthesis on the lagging strand	TAS
R-HSA-69186	Lagging Strand Synthesis	TAS
R-HSA-69190	DNA strand elongation	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69239	Synthesis of DNA	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69306	DNA Replication	TAS
R-HSA-69473	G2/M DNA damage checkpoint	TAS
R-HSA-69481	G2/M Checkpoints	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73884	Base Excision Repair	TAS
R-HSA-73886	Chromosome Maintenance	TAS
R-HSA-73893	DNA Damage Bypass	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-73894	DNA Repair	IEA
R-HSA-73933	Resolution of Abasic Sites (AP sites)	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-912446	Meiotic recombination	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal