Gene: RPE

6120
RPE2-1
ribulose-5-phosphate-3-epimerase
protein-coding
2q34
Ensembl:ENSG00000197713 MIM:180480 Vega:OTTHUMG00000154690 UniprotKB:Q96AT9
NC_000002.12
PubMed
CD|ND|AD
33   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.644e-1 (AD)  3.402e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAPC30.942
CAPRIN10.938
KRIT10.932
ATG120.931
COPS20.93
TAX1BP10.929
CGGBP10.929
LEPROTL10.927
EXOC20.926
USO10.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.587
OR4F29-0.548
MTRNR2L10-0.301
MTRNR2L6-0.284
PTGDR2-0.282
KLRB1-0.28
PLA2G5-0.257
MTRNR2L9-0.255
RSPO1-0.252
TTLL10-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RPE mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of RPE mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of RPE mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RPE mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of RPE mRNA"23195993
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPE mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPE mRNA22228805
D004958EstradiolEstradiol affects the expression of RPE mRNA23557687
C044887beta-methylcholinebeta-methylcholine affects the expression of RPE mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of RPE mRNA29275510
C006780bisphenol Abisphenol A affects the expression of RPE mRNA25181051
D002065BuspironeBuspirone results in decreased expression of RPE mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RPE protein24527689
C018021cobaltous chloridecobaltous chloride results in decreased expression of RPE mRNA19376846
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RPE mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of RPE mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of RPE mRNA18042831
D005485FlutamideFlutamide results in increased expression of RPE mRNA24136188
C039281furanfuran results in increased expression of RPE mRNA27387713
D017313FenretinideFenretinide results in decreased expression of RPE mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RPE mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of RPE mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPE mRNA25613284
D009532NickelNickel results in decreased expression of RPE mRNA23195993
C025589ochratoxin Aochratoxin A results in decreased expression of RPE mRNA22124623
D000073878Palm OilPalm Oil results in decreased expression of RPE mRNA18042831
D010672PhenytoinPhenytoin results in increased expression of RPE mRNA20345932
D010936Plant ExtractsPlant Extracts results in increased expression of RPE mRNA23557933
D011794QuercetinQuercetin results in decreased expression of RPE mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPE mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RPE mRNA25613284
D014212TretinoinTretinoin results in decreased expression of RPE mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of RPE mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RPE gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004750ribulose-phosphate 3-epimerase activity-EXP7396409  
GO:0004750ribulose-phosphate 3-epimerase activity-IBA21873635  
GO:0004750ribulose-phosphate 3-epimerase activity-IDA20923965  
GO:0005515protein binding-IPI27107014  
GO:0042802identical protein binding-IPI16189514  20923965  25416956  
GO:0042803protein homodimerization activity-IPI20923965  
GO:0046872metal ion binding-IBA21873635  
GO:0046872metal ion binding-IDA20923965  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IDA20923965  
GO:0006098pentose-phosphate shunt-IDA20923965  
GO:0006098pentose-phosphate shunt-TAS-  
GO:0009052pentose-phosphate shunt, non-oxidative branch-IBA21873635  
GO:0019323pentose catabolic process-IBA21873635  
GO:0044262cellular carbohydrate metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00030Pentose phosphate pathway
hsa00040Pentose and glucuronate interconversions
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-71336Pentose phosphate pathway (hexose monophosphate shunt)TAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29286114Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. (2018 Mar)Park GBMol Med Rep
28147216An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies. (2016 Dec)Mao XDiscov Med
21386905Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. (2011 Feb 28)Pons MPLoS One
27668132Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. (2016 Feb)Du HOpen J Ophthalmol
23825688Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury. (2013)Woodell APLoS One
19796758Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration. (2009 Dec)Andreoli MTAm J Ophthalmol
19959636Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke. (2010 May)Mansoor SInvest Ophthalmol Vis Sci
26218915Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. (2015 Jul)Keenan TDInvest Ophthalmol Vis Sci
25568320Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2. (2015 Feb 27)Huang CJ Biol Chem
19703486Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration. (2010 Mar 31)Cano MVision Res
20448088Nicotine alters morphology and function of retinal pigment epithelial cells in mice. (2010 Jun)Yang LToxicol Pathol
26604166A novel fluorescence-based assay for measuring A2E removal from human retinal pigment epithelial cells to screen for age-related macular degeneration inhibitors. (2016 Jan 5)Jin HLJ Pharm Biomed Anal
24711457Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. (2014 May 23)Kunchithapautham KJ Biol Chem
28600524Disruption of retinal pigment epithelial cell properties under the exposure of cotinine. (2017 Jun 9)Zhang XYSci Rep
27239555Oxidative stress, innate immunity, and age-related macular degeneration. (2016)Shaw PXAIMS Mol Sci
24440594Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells. (2014 May)Wang LFree Radic Biol Med
24084092VEGF rescues cigarette smoking-induced human RPE cell death by increasing autophagic flux: implications of the role of autophagy in advanced age-related macular degeneration. (2013 Nov 8)Chu YKInvest Ophthalmol Vis Sci
25205867Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. (2014 Sep 9)Nakayama MInvest Ophthalmol Vis Sci
21330654Nicotine increases the VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. (2011 Jun 1)Pons MInvest Ophthalmol Vis Sci
16823865An apolipoprotein E variant may protect against age-related macular degeneration through cytokine regulation. (2006 Oct)Bojanowski CMEnviron Mol Mutagen
25893111Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)Chavali VRJ Clin Med
26654980Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration. (2016 Apr)Marazita MCRedox Biol
24053669Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. (2014 May 10)Chen CAntioxid Redox Signal
18948096Prevention of cadmium accumulation in retinal pigment epithelium with manganese and zinc. (2008 Dec)Satarug SExp Eye Res
2101061Effects of caffeine on the rate of perceived exertion. (1990)Rodrigues LOBraz J Med Biol Res
22504022Complement dysregulation in AMD: RPE-Bruch's membrane-choroid. (2012 Aug)Sparrow JRMol Aspects Med
22293241Can a standard dose of eicosapentaenoic acid (EPA) supplementation reduce the symptoms of delayed onset of muscle soreness? (2012 Jan 31)Houghton DJ Int Soc Sports Nutr
28767736Cigarette smoke induced autophagy-impairment regulates AMD pathogenesis mechanisms in ARPE-19 cells. (2017)Govindaraju VKPLoS One
20153624alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. (2010 Dec)Feng ZJ Nutr Biochem
28336424The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. (2017 Sep)Datta SProg Retin Eye Res
19567368Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells. (2009 Oct)Alcazar OMol Cell Proteomics
19524565Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. (2009 Oct)Kalariya NMExp Eye Res
26067391Differential DNA methylation identified in the blood and retina of AMD patients. (2015)Oliver VFEpigenetics