Gene info: ID 6128

Gene: RPL6

GENE ID: 6128

Synonyms: L6|SHUJUN-2|TAXREB107|TXREB1

Description: ribosomal protein L6

Gene type: protein-coding

Location: 12q24.13

dbXrefs: Ensembl:ENSG00000089009 MIM:603703 Vega:OTTHUMG00000169685 UniprotKB:Q02878

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.860e-2 (AD) 2.522e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RPL5	0.983
RPL4	0.981
RPL7	0.976
RPL3	0.974
RPL7A	0.973
RPL17	0.971
NACA	0.969
EEF1G	0.969
RPS3A	0.968
RPL10A	0.968

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.867
OR4F5	-0.836
P2RX2	-0.095
SEC14L3	-0.094
SSX5	-0.092
S100A11P1	-0.085
SDIM1	-0.083
OR52H1	-0.079
OR10K1	-0.078
FANCD2OS	-0.078

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C020888	1,2-dielaidoylphosphatidylethanolamine	"1,2-dielaidoylphosphatidylethanolamine results in decreased expression of RPL6 mRNA"	14668052
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of RPL6 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of RPL6 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPL6 mRNA"	12376462\|1521517
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of RPL6 mRNA	15890375
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RPL6 mRNA	12958071
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPL6 mRNA	15890375
C041594	4-nonylphenol	4-nonylphenol results in increased expression of RPL6 mRNA	17912697
C105260	4-tert-octylphenol	4-tert-octylphenol results in decreased expression of RPL6 mRNA	17011747
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of RPL6 mRNA	17011747
D000082	Acetaminophen	Acetaminophen results in decreased expression of RPL6 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of RPL6 mRNA	17562736
C016601	afimoxifene	afimoxifene results in decreased expression of RPL6 mRNA	16514628
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RPL6 mRNA	15890375
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RPL6 mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of RPL6 mRNA	11940349
C039726	artesunate	RPL6 mRNA results in decreased susceptibility to artesunate	20144594
D001280	Atrazine	Atrazine results in increased expression of RPL6 mRNA	22378314
D001280	Atrazine	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL6 mRNA	16532367
D004958	Estradiol	Estradiol results in increased expression of RPL6 mRNA	17912697
D004958	Estradiol	Estradiol results in increased expression of RPL6 mRNA	16514628
C006780	bisphenol A	bisphenol A results in increased expression of RPL6 mRNA	17912697
D001761	Bleomycin	Bleomycin affects the expression of RPL6 protein	25933445
C032036	bromobenzene	bromobenzene results in increased expression of RPL6 mRNA	12628495
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of RPL6 mRNA	15707499
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of RPL6 mRNA	18804290
D019256	Cadmium Chloride	[lead chloride co-treated with Cadmium Chloride] results in increased expression of RPL6 mRNA	25016106
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RPL6 mRNA	18804290
D002392	Catechin	Catechin results in increased expression of RPL6 mRNA	15465739
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of RPL6 mRNA	28472532
D002994	Clofibrate	Clofibrate results in decreased expression of RPL6 mRNA	17585979
D003042	Cocaine	Cocaine affects the expression of RPL6 mRNA	20187946
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RPL6 mRNA]	27941970
D002945	Cisplatin	RPL6 protein results in decreased susceptibility to Cisplatin	15846068
C000944	dicrotophos	dicrotophos results in decreased expression of RPL6 mRNA	28302478
D004026	Dieldrin	Dieldrin results in increased expression of RPL6 mRNA	23041725
D004041	Dietary Fats	[Dietary Fats co-treated with resveratrol] results in decreased expression of RPL6 mRNA	21852083
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of RPL6 mRNA	17011747
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of RPL6 mRNA	15890375\|1701174
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RPL6 mRNA"	12376462
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of RPL6 mRNA	15890375
D004147	Dioxins	Dioxins affects the expression of RPL6 mRNA	20463971
D004221	Disulfiram	Disulfiram results in decreased expression of RPL6 mRNA	20530235
D004237	Diuron	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL6 mRNA	16532367
D004317	Doxorubicin	Doxorubicin affects the expression of RPL6 protein	29385562
D004317	Doxorubicin	RPL6 protein results in decreased susceptibility to Doxorubicin	15846068
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPL6 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPL6 mRNA	17912697
D005047	Etoposide	RPL6 protein results in decreased susceptibility to Etoposide	15846068
D005419	Flavonoids	Flavonoids results in decreased expression of RPL6 mRNA	15465739
D005419	Flavonoids	Flavonoids results in decreased expression of RPL6 mRNA	18035473
D005472	Fluorouracil	RPL6 protein results in decreased susceptibility to Fluorouracil	15846068
D005485	Flutamide	Flutamide results in increased expression of RPL6 mRNA	21126777
D005485	Flutamide	Flutamide results in increased expression of RPL6 mRNA	24136188
C070081	fulvestrant	fulvestrant results in decreased expression of RPL6 mRNA	16514628
D005839	Gentamicins	Gentamicins results in increased expression of RPL6 mRNA	22061828
C010974	glyphosate	glyphosate results in increased expression of RPL6 mRNA	15654877
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of RPL6 mRNA	20044591
C492448	ICG 001	ICG 001 results in decreased expression of RPL6 mRNA	26191083
C028904	isoproturon	[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPL6 mRNA	16532367
D007854	Lead	Lead affects the expression of RPL6 mRNA	28903495
C029891	lead chloride	[lead chloride co-treated with Cadmium Chloride] results in increased expression of RPL6 mRNA	25016106
D008701	Methapyrilene	Methapyrilene results in increased expression of RPL6 mRNA	15890375
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of RPL6 mRNA	18804290
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of RPL6 mRNA	20039754
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of RPL6 mRNA	12102619
C025589	ochratoxin A	ochratoxin A results in increased expression of RPL6 mRNA	12700408
C016340	o,p'-DDT	"o,p'-DDT affects the expression of RPL6 mRNA"	17984292
D010433	Pentylenetetrazole	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of RPL6 mRNA	21503142
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of RPL6 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RPL6 mRNA	18804290
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of RPL6 mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in decreased expression of RPL6 mRNA	16940010
C006253	pirinixic acid	pirinixic acid results in increased expression of RPL6 mRNA	15890375
D010936	Plant Extracts	Plant Extracts results in decreased expression of RPL6 mRNA	15465739
D059808	Polyphenols	Polyphenols results in decreased expression of RPL6 mRNA	15465739
D011374	Progesterone	Progesterone results in increased expression of RPL6 mRNA	19693291
C015586	propiverine	propiverine binds to RPL6 protein	29273565
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of RPL6 mRNA	16514628
C059514	resveratrol	[Dietary Fats co-treated with resveratrol] results in decreased expression of RPL6 mRNA	21852083
C066198	SDZ 51641	SDZ 51641 results in increased expression of RPL6 mRNA	19234235
C094089	SDZ FOX 988	SDZ FOX 988 results in increased expression of RPL6 mRNA	19234235
C017947	sodium arsenite	sodium arsenite results in increased expression of RPL6 mRNA	12760830
C017947	sodium arsenite	sodium arsenite results in increased expression of RPL6 mRNA	19072884
D018038	Sodium Selenite	Sodium Selenite results in increased expression of RPL6 mRNA	18175754
D013739	Testosterone	Testosterone results in decreased expression of RPL6 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RPL6 mRNA	21570461\|2468072
D013893	Thiram	Thiram results in decreased expression of RPL6 mRNA	20530235
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of RPL6 mRNA	21346803
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid affects the expression of RPL6 mRNA	18422935
D014635	Valproic Acid	Valproic Acid affects the expression of RPL6 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of RPL6 gene	25560391
D020888	Vigabatrin	[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of RPL6 mRNA	21503142
D014750	Vincristine	RPL6 protein results in decreased susceptibility to Vincristine	15846068

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	TAS	8457378
GO:0003723	RNA binding	-	HDA	22658674
GO:0003735	structural constituent of ribosome	-	IBA	21873635
GO:0003735	structural constituent of ribosome	-	NAS	12962325
GO:0045296	cadherin binding	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000027	ribosomal large subunit assembly	-	IBA	21873635
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	-
GO:0002181	cytoplasmic translation	-	IBA	21873635
GO:0002181	cytoplasmic translation	-	IDA	25957688
GO:0006355	regulation of transcription, DNA-templated	-	TAS	8457378
GO:0006412	translation	-	NAS	12962325
GO:0006413	translational initiation	-	TAS	-
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IDA	25468996
GO:0005791	rough endoplasmic reticulum	-	IEA	-
GO:0005829	cytosol	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0016020	membrane	-	HDA	19946888
GO:0022625	cytosolic large ribosomal subunit	-	HDA	12962325
GO:0022625	cytosolic large ribosomal subunit	-	IBA	21873635
GO:0022625	cytosolic large ribosomal subunit	-	IDA	25957688
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	15121898
GO:0042788	polysomal ribosome	-	IDA	25957688

KEGG ID	KEGG Term
hsa03010	Ribosome

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1430728	Metabolism	IEA
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	TAS
R-HSA-156842	Eukaryotic Translation Elongation	IEA
R-HSA-156902	Peptide chain elongation	IEA
R-HSA-1643685	Disease	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168273	Influenza Viral RNA Transcription and Replication	TAS
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	IEA
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	TAS
R-HSA-192823	Viral mRNA Translation	TAS
R-HSA-2408522	Selenoamino acid metabolism	IEA
R-HSA-2408557	Selenocysteine synthesis	IEA
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	IEA
R-HSA-72312	rRNA processing	TAS
R-HSA-72613	Eukaryotic Translation Initiation	TAS
R-HSA-72689	Formation of a pool of free 40S subunits	TAS
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	TAS
R-HSA-72737	Cap-dependent Translation Initiation	TAS
R-HSA-72764	Eukaryotic Translation Termination	IEA
R-HSA-72766	Translation	TAS
R-HSA-72766	Translation	IEA
R-HSA-8868773	rRNA processing in the nucleus and cytosol	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-927802	Nonsense-Mediated Decay (NMD)	TAS
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	TAS
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23341933	Overexpression of ANXA1 in penile carcinomas positive for high-risk HPVs. (2013)	Calmon MF	PLoS One