Gene: RPS6

6194
S6
ribosomal protein S6
protein-coding
9p22.1
Ensembl:ENSG00000137154 MIM:180460 Vega:OTTHUMG00000019642 UniprotKB:P62753
NC_000009.12
PubMed
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.828e-1 (AD)  9.018e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01331992chr9:19379118RPS64.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPL110.981
RPS120.977
RPS80.976
RPS200.976
RPS130.976
RPL100.973
RPS270.969
RPL190.969
RPL320.969
RPS110.968

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.756
OR4F5-0.7
OPRD1-0.327
KCNH1-0.319
KCNH5-0.313
PCDHAC1-0.306
PLEKHD1-0.306
HTR3B-0.305
PCDHAC2-0.302
NXPH2-0.299

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]23001822
C5525301,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased phosphorylation of RPS6 protein"26035713
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA]"25940091
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one promotes the reaction [LARP1 protein binds to RPS6 mRNA]"25940091
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS6 protein"25940091
C5532941-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one"LARP1 protein promotes the reaction [1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one results in decreased expression of RPS6 protein]"25940091
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine affects the reaction [Oxygen deficiency results in increased phosphorylation of RPS6 protein]"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [sorafenib results in decreased phosphorylation of RPS6 protein]"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein"19411071|2010364
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[ERBB2 gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of RPS6 protein"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"GDC-0973 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]"22084396
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of RPS6 protein"22415236
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[Oxygen deficiency results in increased phosphorylation of RPS6 protein] which affects the susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"PD 0325901 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]"22415236
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of RPS6 protein"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PTEN gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased phosphorylation of RPS6 protein"20453058
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C5614542,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide"2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide results in decreased phosphorylation of RPS6 protein"21464613
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein results in increased phosphorylation of RPS6 protein]17606477
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]15778701
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein12939469|1714867
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]20361045
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein24898257
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]14502240
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]14502240
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]14502240
C00059917928-O-acetylbetulin-3-ylglucopyranoside28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein22343715
C00059917928-O-acetylbetulin-3-ylglucopyranosidealpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein]22343715
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of RPS6 mRNA"12097258
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of RPS6 mRNA"12097258
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS6 mRNA"15215175
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of RPS6 mRNA"20206263
C0163923,3'-diindolylmethane"3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]"11179685
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RPS6 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RPS6 mRNA"18648102
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]"14502240
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]"14502240
C1081234-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]"14502240
C0415944-nonylphenol4-nonylphenol affects the expression of RPS6 mRNA15792627
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of RPS6 protein"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"[5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased susceptibility to 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one] inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of RPS6 protein]"21266357
C4805415-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one"TGFA protein inhibits the reaction [5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one results in decreased phosphorylation of RPS6 protein]"21266357
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA1 protein results in decreased phosphorylation of RPS6 protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [PRKAA2 protein results in decreased phosphorylation of RPS6 protein]"19625624
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]"23211629
D000082AcetaminophenAcetaminophen affects the expression of RPS6 mRNA17562736
C031143AICA ribonucleotideAICA ribonucleotide results in decreased phosphorylation of RPS6 protein19625624
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in decreased phosphorylation of RPS6 protein]22343715
D000596Amino AcidsAmino Acids deficiency results in decreased expression of RPS6 protein25940091
D000596Amino AcidsAmino Acids results in increased phosphorylation of RPS6 protein28275691
D000596Amino AcidsLARP1 protein promotes the reaction [Amino Acids results in decreased expression of RPS6 protein]25940091
D000638AmiodaroneAmiodarone affects the expression of RPS6 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPS6 mRNA16483693
D000924Anticholesteremic AgentsAnticholesteremic Agents results in decreased phosphorylation of RPS6 protein28275691
D000970Antineoplastic AgentsAntineoplastic Agents results in decreased expression of RPS6 protein modified form23125191
C006632arsenic trioxidearsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein]21889928
C006632arsenic trioxidearsenic trioxide results in decreased expression of RPS6 protein25419056
C039726artesunateRPS6 mRNA results in decreased susceptibility to artesunate20144594
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of RPS6 protein modified form"27083413
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of RPS6 protein modified form"27083413
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of RPS6 protein"21135415
D001241AspirinAspirin results in decreased phosphorylation of RPS6 protein23363784
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNA15654877
D001374AzacitidineAzacitidine results in decreased phosphorylation of RPS6 protein21245298
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of RPS6 protein19931517
C528809BAG956BAG956 results in decreased phosphorylation of RPS6 protein22885370
D001553BenzbromaroneBenzbromarone affects the expression of RPS6 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPS6 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPS6 mRNA15034205|2222880
D001599BerberineBerberine results in decreased phosphorylation of RPS6 protein23363784
D004958Estradiol"3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]"11179685
D004958EstradiolEstradiol results in increased expression of RPS6 mRNA11179685
D004958EstradiolEstradiol results in increased phosphorylation of RPS6 protein16033851
D004958EstradiolEverolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]16033851
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]11179685
C053541bicalutamide[bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6 protein21036700
D001645BiguanidesBiguanides results in decreased phosphorylation of RPS6 protein22492524
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPS6 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RPS6 mRNA18214933
C006780bisphenol Abisphenol A results in decreased expression of RPS6 mRNA21890461
C006780bisphenol Abisphenol A results in increased expression of RPS6 protein21890461
C006780bisphenol Abisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein23222814
C006780bisphenol Abisphenol A results in increased phosphorylation of RPS6 protein21890461
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]23222814
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS6 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of RPS6 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS6 mRNA28628672
D0200011-Butanol1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6 protein]18621911
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of RPS6 mRNA15878706
D019256Cadmium Chloride[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein28342888
D019256Cadmium Chloride[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein28342888
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of RPS6 protein21544200
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]21544200
D019256Cadmium ChlorideSirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein]28342888
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RPS6 mRNA21297351
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of RPS6 protein21544200
D019256Cadmium ChlorideEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]21544200
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in increased expression of RPS6 mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in increased expression of RPS6 mRNA20596552
D002110CaffeineCaffeine results in decreased expression of RPS6 protein modified form21081844
D002110CaffeineCaffeine results in decreased expression of RPS6 protein modified form21081844
C059041calyculin Acalyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]18790744
D002235Carbofuran[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS6 mRNA21075942
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RPS6 mRNA15963342
C100187chloropicrinchloropicrin results in decreased expression of RPS6 mRNA26352163
D002784CholesterolCholesterol results in increased phosphorylation of RPS6 protein28275691
D002784CholesterolCYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein]28275691
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RPS6 mRNA28472532
D002994ClofibrateClofibrate affects the expression of RPS6 mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS6 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased phosphorylation of RPS6 protein24386346
C551994crizotinibcrizotinib results in decreased phosphorylation of RPS6 protein22034911
D003474Curcumincalyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]18790744
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]23222814
D003474CurcuminCurcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein23222814
D003474CurcuminCurcumin results in decreased phosphorylation of RPS6 protein18790744|2145033
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of RPS6 protein26506538
C057862cyanoginosin LRcyanoginosin LR results in increased expression of RPS6 mRNA26961614
D016572CyclosporineCyclosporine results in increased expression of RPS6 mRNA20106945
C531198dactolisibdactolisib results in decreased phosphorylation of RPS6 protein21372221|2146461
C531198dactolisibPD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein]22415236
D000069439DasatinibDasatinib results in decreased phosphorylation of RPS6 protein17962511|2062907
C107676deguelindeguelin metabolite results in decreased expression of RPS6 protein19139008
C107676deguelindeguelin metabolite results in decreased expression of RPS6 protein modified form19139008
C107676deguelindeguelin results in decreased expression of RPS6 protein19139008
C107676deguelindeguelin results in decreased expression of RPS6 protein modified form19139008
D003847DeoxyglucoseDeoxyglucose results in decreased phosphorylation of RPS6 protein23363784
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPS6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS6 mRNA28628672
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of RPS6 protein19931517
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RPS6 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]21358348
D002945CisplatinCisplatin results in decreased expression of RPS6 mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of RPS6 mRNA28302478
D004041Dietary Fats"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in decreased expression of RPS6 mRNA"12097258
D004041Dietary Fats"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of RPS6 mRNA"12097258
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of RPS6 mRNA24804967
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RPS6 mRNA17602206
C039060dihydroartemisinindihydroartemisinin analog binds to RPS6 protein26340163
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RPS6 mRNA"12097258
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of RPS6 mRNA"12097258
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNA15654877
D004281Docosahexaenoic AcidsDocosahexaenoic Acids analog results in decreased phosphorylation of RPS6 protein27041074
D004317DoxorubicinDoxorubicin results in decreased phosphorylation of RPS6 protein19801490
D004317DoxorubicinNRG1 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of RPS6 protein]19801490
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]21544200
D004533Egtazic AcidEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]21544200
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPS6 protein23301498
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased expression of RPS6 protein modified form23125191
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in decreased phosphorylation of RPS6 protein23440206
D000069347Erlotinib HydrochlorideMSMO1 protein inhibits the reaction [Erlotinib Hydrochloride results in decreased expression of RPS6 protein modified form]23125191
D000431EthanolEthanol results in decreased expression of RPS6 protein19609968
D005001EthionineEthionine affects the expression of RPS6 mRNA19483382
D000068338EverolimusEverolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]16033851
D000068338EverolimusEverolimus results in decreased phosphorylation of RPS6 protein16033851|2137222
D000068338Everolimus[letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein16033851
D005419FlavonoidsFlavonoids results in decreased expression of RPS6 mRNA18035473
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in decreased expression of RPS6 mRNA22406618
D005485FlutamideFlutamide results in increased expression of RPS6 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6 mRNA20938992
C574276GDC-0973"GDC-0973 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]"22084396
D005839GentamicinsGentamicins results in increased expression of RPS6 mRNA22061828
C035054ginsenoside Rg1ginsenoside Rg1 results in increased phosphorylation of RPS6 protein24386346
D005944GlucosamineGlucosamine results in decreased phosphorylation of RPS6 protein19254699
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased phosphorylation of RPS6 protein]20332614
D005978GlutathioneGlutathione deficiency results in increased expression of RPS6 mRNA15345336
C010974glyphosateglyphosate results in decreased expression of RPS6 mRNA16532367
D012701Serotonin1-Butanol inhibits the reaction [Serotonin results in increased phosphorylation of and results in increased activity of RPS6 protein]18621911
D012701SerotoninSerotonin results in increased phosphorylation of and results in increased activity of RPS6 protein18621911
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased phosphorylation of RPS6 protein12071973
D000068877Imatinib Mesylate[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein15604220
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPS6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RPS6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of RPS6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of RPS6 mRNA28628672
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of RPS6 protein]25597859
D007530IsofluraneIsoflurane results in decreased phosphorylation of RPS6 protein25597859
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in increased expression of RPS6 mRNA15654877
C541932Ku 0063794"[Ku 0063794 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of RPS6 protein"22415236
C541932Ku 0063794Ku 0063794 results in decreased phosphorylation of RPS6 protein22885370
D007854LeadLead affects the expression of RPS6 mRNA28903495
C067431letrozole[letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein16033851
C067431letrozoleletrozole results in decreased phosphorylation of RPS6 protein16033851
D001556Lindane[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS6 mRNA21075942
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of RPS6 protein19675143
C016371lonidaminearsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein]21889928
C016371lonidaminelonidamine results in increased phosphorylation of RPS6 protein21889928
D017336LoratadineLoratadine results in decreased expression of RPS6 protein modified form20570632
D008687MetforminMetformin results in decreased phosphorylation of RPS6 protein23363784
D008687MetforminMetformin analog results in decreased phosphorylation of RPS6 protein22492524
D008687MetforminMetformin results in decreased phosphorylation of RPS6 protein22492524
D008687MetforminTrientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]22492524
D008694MethamphetamineMethamphetamine results in decreased expression of RPS6 mRNA15644446
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of RPS6 mRNA24449571
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein]"28790194
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RPS6 mRNA29191790
C051786metolachlor[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS6 mRNA21075942
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to RPS6 protein]17220478
C548887MK 2206MK 2206 results in decreased phosphorylation of RPS6 protein22885370
C002373monobutyryl cyclic AMPmonobutyryl cyclic AMP results in increased expression of RPS6 protein modified form25381014
D016686MonocrotalineMonocrotaline results in increased phosphorylation of RPS6 protein25460361
D016686MonocrotalineQuercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of RPS6 protein]25460361
C523799MRK 003MRK 003 results in decreased phosphorylation of RPS6 protein19246562|2019746
D009151Mustard GasMustard Gas results in increased phosphorylation of RPS6 protein19845377
D009173Mycophenolic Acid[Mycophenolic Acid co-treated with Imatinib Mesylate] results in decreased phosphorylation of RPS6 protein15604220
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of RPS6 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RPS6 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of RPS6 mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in increased expression of RPS6 mRNA15878706
C562238N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide"N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-4-yl)-1H-pyrazol-3-yl)propanamide results in decreased phosphorylation of RPS6 protein"21823616
C025589ochratoxin Aochratoxin A results in increased phosphorylation of RPS6 protein25002221
D009853OmeprazoleOmeprazole affects the expression of RPS6 mRNA19483382
C507134ON 01910ON 01910 results in decreased phosphorylation of RPS6 protein23873848
C000594117ON123300ON123300 results in decreased phosphorylation of RPS6 protein24568969|2617462
C016340o,p'-DDT"o,p'-DDT affects the expression of RPS6 mRNA"17984292
D010100Oxygen"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine affects the reaction [Oxygen deficiency results in increased phosphorylation of RPS6 protein]"23036488
D010100OxygenOxygen deficiency results in increased phosphorylation of RPS6 protein23036488
D010100Oxygen"[Oxygen deficiency results in increased phosphorylation of RPS6 protein] which affects the susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"23036488
D052638Particulate MatterParticulate Matter results in increased expression of RPS6 mRNA24769257
D052638Particulate MatterParticulate Matter results in increased phosphorylation of RPS6 protein19675143
C000610380p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in decreased phosphorylation of RPS6 protein"26035713
C506614PD 0325901"PD 0325901 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of RPS6 protein]"22415236
C506614PD 0325901PD 0325901 promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein]22415236
D026023Permethrin[fluoranthene co-treated with Permethrin] results in decreased expression of RPS6 mRNA22406618
D026023PermethrinPermethrin results in decreased expression of RPS6 mRNA22406618
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]20335389
D015232Dinoprostone[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein20335389
D015232DinoprostonePertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]20335389
D015232Dinoprostonewortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]20335389
D010712Phosphatidic Acids[Phosphatidic Acids results in increased phosphorylation of MTOR protein] which results in increased phosphorylation of RPS6 protein18621911
C522973PI103PI103 results in decreased phosphorylation of and results in decreased expression of RPS6 protein23300809
C522973PI103PI103 results in decreased phosphorylation of and results in decreased expression of RPS6 protein23300809
C544306PI 540PI 540 results in decreased phosphorylation of RPS6 protein19584227
C544307PI 620PI 620 results in decreased phosphorylation of RPS6 protein19584227
D010862Pilocarpine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]"23211629
D010862PilocarpinePilocarpine results in increased phosphorylation of RPS6 protein23211629
D010862Pilocarpineresveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]23211629
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6 protein]26643070
C060836pioglitazonepioglitazone results in decreased phosphorylation of RPS6 protein26643070
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6 protein]]26643070
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RPS6 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of RPS6 mRNA19483382
D010936Plant ExtractsPlant Extracts inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6 protein]18245498
D011192Potassium DichromatePotassium Dichromate results in increased expression of RPS6 mRNA23608068
C045950propiconazolepropiconazole results in increased expression of RPS6 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of RPS6 mRNA19483382
C010423pyrithione zincpyrithione zinc affects the phosphorylation of RPS6 protein21557991
D011794QuercetinQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6 protein]18245498
D011794QuercetinQuercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of RPS6 protein]25460361
C059514resveratrol[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
C059514resveratrolresveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
C059514resveratrol[resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased phosphorylation of RPS6 protein21544240
C059514resveratrolresveratrol results in decreased activity of RPS6 protein26189302
C059514resveratrolresveratrol results in decreased expression of and results in decreased phosphorylation of RPS6 protein17554206
C059514resveratrolresveratrol results in decreased expression of RPS6 protein17534123
C059514resveratrolresveratrol results in decreased phosphorylation of RPS6 protein19471118|1982726
C059514resveratrol[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein20169165
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased phosphorylation of RPS6 protein20169165
C059514resveratrolTSC2 gene mutant form promotes the reaction [[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]24304514
C059514resveratrolTSC2 protein promotes the reaction [[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein]20169165
C059514resveratrol[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]22069489
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]]"23211629
C059514resveratrol[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased phosphorylation of RPS6 protein]20332614
C059514resveratrolresveratrol inhibits the reaction [Pilocarpine results in increased phosphorylation of RPS6 protein]23211629
C059514resveratrolresveratrol results in decreased phosphorylation of RPS6 protein20332614
C089730rosiglitazonerosiglitazone results in increased phosphorylation of RPS6 protein19397913
D012715Sesame OilSesame Oil results in increased expression of RPS6 mRNA29191790
D012834SilverSilver analog results in decreased expression of RPS6 mRNA22727896
D012835Silver NitrateSilver Nitrate results in increased expression of RPS6 mRNA22727896
D019821SimvastatinIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]27734117
D019821SimvastatinSimvastatin results in decreased phosphorylation of RPS6 protein27734117
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein17908691
D020123SirolimusLARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPS6 protein]25940091
D020123Sirolimus[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
D020123SirolimusSirolimus inhibits the reaction [CXCL8 protein results in increased phosphorylation of RPS6 protein]17606477
D020123SirolimusSirolimus inhibits the reaction [EIF4G1 protein binds to RPS6 mRNA]25940091
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]15297429
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]15778701
D020123SirolimusSirolimus inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein]28790194
D020123SirolimusSirolimus inhibits the reaction [Testosterone results in increased phosphorylation of RPS6 protein]21036700
D020123SirolimusSirolimus promotes the reaction [LARP1 protein binds to RPS6 mRNA]25940091
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein17908691|2016916
D020123SirolimusSirolimus results in decreased expression of RPS6 protein25940091
D020123SirolimusSirolimus results in decreased phosphorylation of RPS6 protein10373522|1293946
D020123SirolimusSirolimus results in increased phosphorylation of RPS6 protein24392034
D020123Sirolimus[Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]16832347
D020123SirolimusTSC2 gene mutant form promotes the reaction [[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein]24304514
D020123SirolimusTSC2 gene mutant form promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]24304514
D020123Sirolimus[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
D020123SirolimusSirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein]28342888
D020123SirolimusSirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]14502240
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]1614535
D020123SirolimusSirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]14502240|2206948
D020123SirolimusSirolimus inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]14502240
D020123SirolimusSirolimus results in decreased phosphorylation of RPS6 protein20038814|2006814
D020123SirolimusTacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]1614535
D020123Sirolimus[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of RPS6 protein24304514
D020123SirolimusSirolimus results in decreased phosphorylation of RPS6 protein24304514
D020123SirolimusSirolimus results in decreased phosphorylation of RPS6 protein19584227
D012969Sodium FluorideSodium Fluoride results in decreased expression of RPS6 protein28918527
D053260SootSoot affects the expression of RPS6 protein21135415
C471405sorafenib"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [sorafenib results in decreased phosphorylation of RPS6 protein]"23036488
C471405sorafenibsorafenib results in decreased phosphorylation of RPS6 protein23036488
D013012SorbitolSorbitol results in decreased phosphorylation of RPS6 protein12071973
C016766sulforafansulforafan inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein]28790194
C016767sulprostonesulprostone results in increased phosphorylation of RPS6 protein20335389
D016559TacrolimusTacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]1614535
C112765tanespimycintanespimycin results in decreased phosphorylation of RPS6 protein17121904
C401859temsirolimusCisplatin promotes the reaction [temsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]]21358348
C401859temsirolimustemsirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6 protein]21358348
C401859temsirolimustemsirolimus results in decreased phosphorylation of RPS6 protein16195324|2439203
D016593TerfenadineTerfenadine results in decreased expression of RPS6 protein modified form20570632
D013739TestosteroneAR mutant form inhibits the reaction [Testosterone results in increased phosphorylation of RPS6 protein]21036700
D013739Testosterone[bicalutamide co-treated with Testosterone] results in decreased phosphorylation of RPS6 protein21036700
D013739TestosteroneSirolimus inhibits the reaction [Testosterone results in increased phosphorylation of RPS6 protein]21036700
D013739TestosteroneTestosterone results in increased phosphorylation of RPS6 protein21036700
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]11179685
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPS6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS6 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPS6 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPS6 protein16548065
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of RPS6 protein23639626
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate results in increased activity of PRKCH protein] inhibits the reaction [Sirolimus results in decreased phosphorylation of RPS6 protein]16832347
D013755Tetradecanoylphorbol AcetatePlant Extracts inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6 protein]18245498
D013755Tetradecanoylphorbol AcetateQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6 protein]18245498
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of RPS6 protein18245498
C009438tetrandrinetetrandrine results in decreased expression of RPS6 protein modified form25266202
D013853ThioacetamideThioacetamide affects the expression of RPS6 mRNA19483382
C011559tributyltintributyltin results in increased expression of RPS6 mRNA29191790
D014266TrientineTrientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]22492524
D014266TrientineTrientine results in increased phosphorylation of RPS6 protein22492524
C000608764triphenyl(phenylethynyl)phosphoniumtriphenyl(phenylethynyl)phosphonium results in decreased expression of RPS6 protein26984758
C113580U 0126U 0126 results in decreased phosphorylation of RPS6 protein19478560
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RPS6 gene25560391
D009536Niacinamide[Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of RPS6 protein20169165
D002762CholecalciferolCholecalciferol results in decreased phosphorylation of RPS6 protein23363784
C111237vorinostatvorinostat results in decreased phosphorylation of RPS6 protein18850582
C009687wortmanninwortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]20335389
C009687wortmanninwortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]23001822
C510150ZSTK474ZSTK474 results in decreased phosphorylation of RPS6 protein23873848

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003735structural constituent of ribosome-IEA-  
GO:0005515protein binding-IPI16314389  18423201  19417104  21418524  24454821  
GO:0019901protein kinase binding-IPI21418524  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IEA-  
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-TAS-  
GO:0001890placenta development-IEA-  
GO:0002309T cell proliferation involved in immune response-IEA-  
GO:0006364rRNA processing-IMP18697920  
GO:0006364rRNA processing-TAS-  
GO:0006412translation-IC8706699  15883184  
GO:0006413translational initiation-TAS-  
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TAS-  
GO:0006924activation-induced cell death of T cells-IEA-  
GO:0007093mitotic cell cycle checkpoint-IEA-  
GO:0007369gastrulation-IEA-  
GO:0022605mammalian oogenesis stage-IEA-  
GO:0031929TOR signaling-IDA16428328  
GO:0033077T cell differentiation in thymus-IEA-  
GO:0042274ribosomal small subunit biogenesis-IMP18697920  
GO:0042593glucose homeostasis-ISS-  
GO:0043065positive regulation of apoptotic process-IDA18362888  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0048821erythrocyte development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA2334893  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA8590812  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005844polysome-IEA-  
GO:0015935small ribosomal subunit-IDA15590835  
GO:0016020membrane-HDA19946888  
GO:0022627cytosolic small ribosomal subunit-HDA15883184  
GO:0022627cytosolic small ribosomal subunit-IDA8706699  
GO:0022627cytosolic small ribosomal subunit-NAS1301164  
GO:0030425dendrite-IDA15121898  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
GO:0044297cell body-IDA15121898  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:1990904ribonucleoprotein complex-IDA18809582  
KEGG ID KEGG Term
hsa03010Ribosome
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismIEA
R-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842Eukaryotic Translation ElongationIEA
R-HSA-156902Peptide chain elongationIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-165159mTOR signallingTAS
R-HSA-166208mTORC1-mediated signallingTAS
R-HSA-168254Influenza InfectionTAS
R-HSA-168255Influenza Life CycleTAS
R-HSA-168273Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-192823Viral mRNA TranslationTAS
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-2408557Selenocysteine synthesisIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5663205Infectious diseaseTAS
R-HSA-6790901rRNA modification in the nucleus and cytosolIEA
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72312rRNA processingTAS
R-HSA-72312rRNA processingIEA
R-HSA-72613Eukaryotic Translation InitiationTAS
R-HSA-72649Translation initiation complex formationTAS
R-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43STAS
R-HSA-72689Formation of a pool of free 40S subunitsTAS
R-HSA-72695Formation of the ternary complex, and subsequently, the 43S complexTAS
R-HSA-72702Ribosomal scanning and start codon recognitionTAS
R-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737Cap-dependent Translation InitiationTAS
R-HSA-72764Eukaryotic Translation TerminationIEA
R-HSA-72766TranslationTAS
R-HSA-72766TranslationIEA
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolIEA
R-HSA-8953854Metabolism of RNATAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-927802Nonsense-Mediated Decay (NMD)TAS
R-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy