Gene info: ID 6195

Gene: RPS6KA1

GENE ID: 6195

Synonyms: HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk

Description: ribosomal protein S6 kinase A1

Gene type: protein-coding

Location: 1p36.11

dbXrefs: Ensembl:ENSG00000117676 MIM:601684 Vega:OTTHUMG00000004003 UniprotKB:Q15418

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.653e-1 (AD) 7.792e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg13092108	chr1:26857284	RPS6KA1		5.500e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAN2B1	0.853
SPP1	0.851
TMC8	0.85
SYNGR2	0.846
LPCAT2	0.831
HCLS1	0.825
ARHGAP30	0.817
HAVCR2	0.81
ADORA3	0.81
ABI3	0.807

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.426
ARSF	-0.355
KIT	-0.343
POU3F1	-0.334
NOG	-0.331
WNT7A	-0.33
FAM163A	-0.318
VIP	-0.311
WIF1	-0.311
LYPD6	-0.309

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04751	Purvalanol A	Small Molecule	212844-53-6	Experimental	Target

ID	Drug Name	Action	PubMed
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein"	16611854
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of RPS6KA1 protein]"	15772366
C471843	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of RPS6KA1 protein	12534346
D000082	Acetaminophen	Acetaminophen affects the expression of RPS6KA1 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of RPS6KA1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of RPS6KA1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RPS6KA1 mRNA	22100608
C482289	Ageladine A	Ageladine A analog binds to RPS6KA1 protein	21413800
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of RPS6KA1 mRNA"	23195993
C103303	alitretinoin	"[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein"	16611854
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of RPS6KA1 mRNA	24449571
D001280	Atrazine	Atrazine results in increased expression of RPS6KA1 mRNA	25929836
C517975	AZD 6244	AZD 6244 results in decreased phosphorylation of RPS6KA1 protein	17876044
C517975	AZD 6244	Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of RPS6KA1 protein]	17876044
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPS6KA1 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPS6KA1 mRNA	22300585
C516541	BI D1870	BI D1870 results in decreased activity of RPS6KA1 protein	21488662
C006780	bisphenol A	bisphenol A affects the expression of RPS6KA1 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the methylation of RPS6KA1 promoter	27415467
C006780	bisphenol A	bisphenol A results in increased expression of RPS6KA1 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 protein	17003459
D020122	tert-Butylhydroperoxide	U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 protein]	17003459
C018475	butyraldehyde	butyraldehyde results in increased expression of RPS6KA1 mRNA	26079696
C584509	C646 compound	C646 compound results in increased expression of RPS6KA1 mRNA	26191083
C028031	cadmium acetate	cadmium acetate affects the expression of RPS6KA1 mRNA	16249259
D002220	Carbamazepine	Carbamazepine affects the expression of RPS6KA1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RPS6KA1 mRNA	17032414
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RPS6KA1 protein	17805973
C018021	cobaltous chloride	cobaltous chloride results in increased expression of RPS6KA1 mRNA	21139344
D003042	Cocaine	Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]	15470197
D003042	Cocaine	Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA1 protein	15470197
D016572	Cyclosporine	Cyclosporine results in decreased expression of RPS6KA1 mRNA	25562108\|2798913
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of RPS6KA1 mRNA	24317228
C007262	deoxynivalenol	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [deoxynivalenol results in increased phosphorylation of RPS6KA1 protein]"	15772366
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of and results in increased activity of RPS6KA1 protein	15976193
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of RPS6KA1 protein	15772366
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of RPS6KA1 mRNA	17361019
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of RPS6KA1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of RPS6KA1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased phosphorylation of RPS6KA1 protein	21742020
D002945	Cisplatin	U 0126 inhibits the reaction [Cisplatin results in increased phosphorylation of RPS6KA1 protein]	21742020
D004008	Diclofenac	Diclofenac affects the expression of RPS6KA1 mRNA	24752500
D004052	Diethylnitrosamine	Diethylnitrosamine affects the phosphorylation of RPS6KA1 protein	24535843
D002117	Calcitriol	Calcitriol results in increased expression of RPS6KA1 mRNA	21592394\|2648566
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of RPS6KA1 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of RPS6KA1 mRNA	17032414
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of RPS6KA1 protein	17032414
D004317	Doxorubicin	Doxorubicin promotes the reaction [AZD 6244 results in decreased phosphorylation of RPS6KA1 protein]	17876044
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPS6KA1 protein	23301498
D000431	Ethanol	Ethanol results in decreased expression of RPS6KA1 mRNA	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPS6KA1 mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of RPS6KA1 mRNA	23649840
C049347	fasudil	fasudil results in decreased activity of RPS6KA1 protein	10998351
D005557	Formaldehyde	Formaldehyde results in increased expression of RPS6KA1 mRNA	23649840
D005707	Gallic Acid	Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA1 protein]	21420233
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of RPS6KA1 mRNA	22634610
C492448	ICG 001	ICG 001 results in increased expression of RPS6KA1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RPS6KA1 mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of RPS6KA1 mRNA	27392435
C067431	letrozole	letrozole results in increased expression of and results in increased phosphorylation of RPS6KA1 protein	15967659
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of RPS6KA1 mRNA	12057914
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of RPS6KA1 protein	10998351
D008070	Lipopolysaccharides	U 0126 inhibits the reaction [Lipopolysaccharides results in increased activity of RPS6KA1 protein]	10998351
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of RPS6KA1 mRNA	25613284
C015329	lycopene	lycopene results in decreased expression of RPS6KA1 protein	17337101
C501277	Mangifera indica extract	Mangifera indica extract inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA1 protein]	21420233
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RPS6KA1 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RPS6KA1 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of RPS6KA1 protein	26558463
D009151	Mustard Gas	Mustard Gas results in increased phosphorylation of RPS6KA1 protein	19845377
C040015	myricetin	myricetin inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KA1 protein]	17693661
C040015	myricetin	myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein]	17693661
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of RPS6KA1 mRNA"	25554681\|2562005
D009532	Nickel	Nickel results in decreased expression of RPS6KA1 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of RPS6KA1 mRNA	24768652\|2558310
C063998	nodularin	nodularin results in increased phosphorylation of RPS6KA1 protein	25192816
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RPS6KA1 mRNA	19710929
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of RPS6KA1 mRNA	28903501
D011374	Progesterone	Progesterone results in decreased expression of RPS6KA1 mRNA	23018184
C045950	propiconazole	propiconazole results in decreased expression of RPS6KA1 mRNA	21278054
D011794	Quercetin	Quercetin results in decreased activity of RPS6KA1 protein	10998351
D011794	Quercetin	Quercetin results in increased expression of RPS6KA1 mRNA	21632981
C059514	resveratrol	resveratrol results in decreased phosphorylation of RPS6KA1 protein	16979140
D017975	Ruthenium Compounds	Ruthenium Compounds results in decreased activity of RPS6KA1 protein	16858717
C547874	SAR 020106	SAR 020106 results in decreased activity of RPS6KA1 protein	22111927
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA1 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of RPS6KA1 mRNA	19244175
D020123	Sirolimus	Sirolimus results in increased phosphorylation of RPS6KA1 protein	19151764
D020123	Sirolimus	Sirolimus results in increased phosphorylation of RPS6KA1 protein	19151764
D020123	Sirolimus	Sirolimus affects the localization of RPS6KA1 protein	19151764
D020123	Sirolimus	Sirolimus results in increased phosphorylation of and results in increased activity of RPS6KA1 protein	19151764
D020123	Sirolimus	Sirolimus results in increased phosphorylation of RPS6KA1 protein	19151764
C017947	sodium arsenite	sodium arsenite results in decreased expression of RPS6KA1 mRNA	12760830
C017947	sodium arsenite	sodium arsenite results in decreased expression of RPS6KA1 protein	12760830
C016104	sodium bichromate	sodium bichromate results in decreased expression of RPS6KA1 mRNA	12760830
D012999	Soman	Soman results in increased expression of RPS6KA1 mRNA	19281266
C416927	SU 6656	SU 6656 results in decreased activity of RPS6KA1 protein	12534346
C473478	sunitinib	sunitinib results in decreased activity of RPS6KA1 protein	21906609
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of RPS6KA1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of RPS6KA1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RPS6KA1 mRNA	21570461\|2637764
D013755	Tetradecanoylphorbol Acetate	myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein]	17693661
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased phosphorylation of RPS6KA1 protein	17693661
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RPS6KA1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of RPS6KA1 mRNA	23557971
D014118	Toxins, Biological	"Toxins, Biological affects the expression of RPS6KA1 mRNA"	19682533
D014212	Tretinoin	RPS6KA1 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]	16280361
C012589	trichostatin A	trichostatin A results in increased expression of RPS6KA1 mRNA	15901671
C113580	U 0126	U 0126 inhibits the reaction [Cisplatin results in increased phosphorylation of RPS6KA1 protein]	21742020
C113580	U 0126	U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of RPS6KA1 protein]	17003459
C113580	U 0126	U 0126 inhibits the reaction [EGF protein results in increased activity of RPS6KA1 protein]	10998351
C113580	U 0126	U 0126 inhibits the reaction [Lipopolysaccharides results in increased activity of RPS6KA1 protein]	10998351
D014635	Valproic Acid	Valproic Acid results in increased expression of RPS6KA1 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RPS6KA1 gene	25560391
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA1 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0004674	protein serine/threonine kinase activity	-	IDA	10679322 22357623
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004711	ribosomal protein S6 kinase activity	-	IBA	21873635
GO:0004712	protein serine/threonine/tyrosine kinase activity	-	IDA	22797923
GO:0005515	protein binding	-	IPI	19470470 21423205 22130794 22939624 23455922
GO:0005524	ATP binding	-	IEA	-
GO:0016301	kinase activity	-	TAS	-
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-	IDA	18402937

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006468	protein phosphorylation	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0007049	cell cycle	-	IEA	-
GO:0007165	signal transduction	-	TAS	8141249
GO:0030307	positive regulation of cell growth	-	TAS	18813292
GO:0043066	negative regulation of apoptotic process	-	IMP	11684016
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	18402937
GO:0043555	regulation of translation in response to stress	-	TAS	18813292
GO:0043620	regulation of DNA-templated transcription in response to stress	-	TAS	18813292
GO:0045597	positive regulation of cell differentiation	-	TAS	18813292
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	22065586
GO:0072574	hepatocyte proliferation	-	ISS	-
GO:2000491	positive regulation of hepatic stellate cell activation	-	IMP	10679322

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04150	mTOR signaling pathway
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	TAS
R-HSA-198753	ERK/MAPK targets	TAS
R-HSA-199920	CREB phosphorylation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2262752	Cellular responses to stress	IEA
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	TAS
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	IEA
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559583	Cellular Senescence	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373760	L1CAM interactions	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-437239	Recycling pathway of L1	IEA
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-444257	RSK activation	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8953897	Cellular responses to external stimuli	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28592245	In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)	El-Aarag SA	BMC Med Genomics