Gene: RPS6KA2

6196
HU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3
ribosomal protein S6 kinase A2
protein-coding
6q27
Ensembl:ENSG00000071242 MIM:601685 Vega:OTTHUMG00000016007 UniprotKB:Q15349
NC_000006.12
PubMed|SNP Mapped
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.747e-2 (AD)  3.419e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6935679chr6:166667229 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16490823chr6:167085508RPS6KA25.700e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF4B0.845
DCAF70.845
NBR10.835
CSDE10.835
SPTBN10.833
ARHGAP210.831
ULK20.831
EIF3A0.829
ZFR0.824
NUCKS10.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.702
OR4F5-0.674
MOGAT2-0.173
LBP-0.164
KCNK5-0.164
BANF2-0.16
C10orf113-0.158
ALPI-0.157
MTRNR2L6-0.153
GRHL2-0.152

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of RPS6KA2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of RPS6KA2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RPS6KA2 mRNA22100608
D000447AldehydesAldehydes results in increased expression of RPS6KA2 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RPS6KA2 mRNA16483693
D001151ArsenicArsenic affects the methylation of RPS6KA2 gene25304211
D001280AtrazineAtrazine results in decreased expression of RPS6KA2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of RPS6KA2 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RPS6KA2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPS6KA2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RPS6KA2 gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RPS6KA2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to RPS6KA2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPS6KA2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RPS6KA2 mRNA22300585
D004958EstradiolEstradiol affects the expression of RPS6KA2 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of RPS6KA2 mRNA20404318
C516541BI D1870BI D1870 results in decreased activity of RPS6KA2 protein21488662
C006780bisphenol Abisphenol A affects the expression of RPS6KA2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RPS6KA2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of RPS6KA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RPS6KA2 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of RPS6KA2 mRNA26079696
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]17204746
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]17204746
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RPS6KA2 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of RPS6KA2 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of RPS6KA2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of RPS6KA2 mRNA20599845
D003471CuprizoneCuprizone results in increased expression of RPS6KA2 mRNA26577399
D003520CyclophosphamideRPS6KA2 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in increased expression of RPS6KA2 mRNA20106945|2798913
C014347decitabinedecitabine affects the expression of RPS6KA2 mRNA23300844
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of RPS6KA2 protein16424113
D002945CisplatinCisplatin affects the expression of RPS6KA2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RPS6KA2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RPS6KA2 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RPS6KA2 mRNA18164116
D000431EthanolEthanol results in increased expression of RPS6KA2 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RPS6KA2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RPS6KA2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RPS6KA2 mRNA28196854
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RPS6KA2 mRNA28196854
D006418HemeHeme metabolite results in increased expression of RPS6KA2 mRNA19191707
D017313FenretinideFenretinide results in increased phosphorylation of RPS6KA2 protein25246272
D017313FenretinideU 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of RPS6KA2 protein]25246272
D017313FenretinideFenretinide results in increased expression of RPS6KA2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RPS6KA2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RPS6KA2 mRNA23430699
D007854LeadLead affects the splicing of RPS6KA2 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RPS6KA2 mRNA21641980
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA18386188
D009150Mustard Compoundscaffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]17204746
D009150Mustard CompoundsMustard Compounds results in increased phosphorylation of RPS6KA2 protein17204746
D009151Mustard GasMustard Gas results in increased expression of RPS6KA2 mRNA15674844
D009588Nitrogen Mustard Compoundscaffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]17204746
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein17204746
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPS6KA2 mRNA"19013360
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of RPS6KA2 mRNA20971185
C464660obeticholic acidobeticholic acid results in increased expression of RPS6KA2 mRNA27939613
D010126OzoneOzone results in decreased expression of RPS6KA2 mRNA12763052
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA18386188
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of RPS6KA2 mRNA26705709
C046012pentanalpentanal results in increased expression of RPS6KA2 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RPS6KA2 mRNA26272509
D010705PhosgenePhosgene affects the expression of RPS6KA2 mRNA16300373
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RPS6KA2 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of RPS6KA2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of RPS6KA2 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA19059307
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA2 mRNA19244175
D012643SeleniumSelenium results in increased expression of RPS6KA2 mRNA19244175
D020123SirolimusSirolimus affects the localization of RPS6KA2 protein19151764
D020123SirolimusSirolimus results in increased phosphorylation of RPS6KA2 protein19151764
C017947sodium arsenitesodium arsenite affects the methylation of RPS6KA2 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of RPS6KA2 mRNA25879800
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RPS6KA2 mRNA21641980
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of RPS6KA2 mRNA17555576
D013654TaurineTaurine results in increased expression of RPS6KA2 mRNA16579726
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA2 mRNA17942748
D013752TetracyclineTetracycline results in increased expression of RPS6KA2 mRNA16917069
D013792ThalidomideThalidomide results in decreased expression of RPS6KA2 mRNA26217789
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RPS6KA2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RPS6KA2 mRNA22363418
C113580U 0126U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of RPS6KA2 protein]25246272
D014635Valproic AcidValproic Acid affects the expression of RPS6KA2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RPS6KA2 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of RPS6KA2 mRNA22714537
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA2 mRNA19244175
D014873Water PollutantsWater Pollutants results in increased expression of RPS6KA2 mRNA23591932
D019287Zinc SulfateZinc Sulfate results in increased expression of RPS6KA2 mRNA19013360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004711ribosomal protein S6 kinase activity-IBA21873635  
GO:0004712protein serine/threonine/tyrosine kinase activity-IDA22797923  
GO:0005515protein binding-IPI16810323  23602568  25241761  25852190  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-NAS7623830  
GO:0008285negative regulation of cell proliferation-IDA16878154  
GO:0043065positive regulation of apoptotic process-IDA16878154  
GO:0045786negative regulation of cell cycle-IDA16878154  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16878154  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA16878154  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04114Oocyte meiosis
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-198753ERK/MAPK targetsTAS
R-HSA-199920CREB phosphorylationTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)IEA
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559583Cellular SenescenceIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1IEA
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-444257RSK activationTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPKTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25424692Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)Tsaprouni LGEpigenetics