Gene info: ID 6196

Gene: RPS6KA2

GENE ID: 6196

Description: ribosomal protein S6 kinase A2

Gene type: protein-coding

Location: 6q27

dbXrefs: Ensembl:ENSG00000071242 MIM:601685 Vega:OTTHUMG00000016007 UniprotKB:Q15349

RefSeq: NC_000006.12

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.747e-2 (AD) 3.419e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6935679	chr6:166667229 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg16490823	chr6:167085508	RPS6KA2		5.700e-8	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EIF4B	0.845
DCAF7	0.845
NBR1	0.835
CSDE1	0.835
SPTBN1	0.833
ARHGAP21	0.831
ULK2	0.831
EIF3A	0.829
ZFR	0.824
NUCKS1	0.82

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.702
OR4F5	-0.674
MOGAT2	-0.173
LBP	-0.164
KCNK5	-0.164
BANF2	-0.16
C10orf113	-0.158
ALPI	-0.157
MTRNR2L6	-0.153
GRHL2	-0.152

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA	12419474
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of RPS6KA2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of RPS6KA2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of RPS6KA2 mRNA	22100608
D000447	Aldehydes	Aldehydes results in increased expression of RPS6KA2 mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RPS6KA2 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of RPS6KA2 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of RPS6KA2 mRNA	22378314
C547126	AZM551248	AZM551248 results in increased expression of RPS6KA2 mRNA	22323515
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RPS6KA2 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RPS6KA2 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of RPS6KA2 gene	25435355
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RPS6KA2 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to RPS6KA2 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPS6KA2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RPS6KA2 mRNA	22300585
D004958	Estradiol	Estradiol affects the expression of RPS6KA2 mRNA	14699072
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of RPS6KA2 mRNA	20404318
C516541	BI D1870	BI D1870 results in decreased activity of RPS6KA2 protein	21488662
C006780	bisphenol A	bisphenol A affects the expression of RPS6KA2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of RPS6KA2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of RPS6KA2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RPS6KA2 gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of RPS6KA2 mRNA	26079696
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]	17204746
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]	17204746
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of RPS6KA2 mRNA	17484886
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of RPS6KA2 mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of RPS6KA2 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of RPS6KA2 mRNA	20599845
D003471	Cuprizone	Cuprizone results in increased expression of RPS6KA2 mRNA	26577399
D003520	Cyclophosphamide	RPS6KA2 protein affects the susceptibility to Cyclophosphamide	16217747
D016572	Cyclosporine	Cyclosporine results in increased expression of RPS6KA2 mRNA	20106945\|2798913
C014347	decitabine	decitabine affects the expression of RPS6KA2 mRNA	23300844
C007262	deoxynivalenol	deoxynivalenol results in increased phosphorylation of RPS6KA2 protein	16424113
D002945	Cisplatin	Cisplatin affects the expression of RPS6KA2 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of RPS6KA2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of RPS6KA2 mRNA	27392435
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RPS6KA2 mRNA	18164116
D000431	Ethanol	Ethanol results in increased expression of RPS6KA2 mRNA	28986285
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of RPS6KA2 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPS6KA2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of RPS6KA2 mRNA	28196854
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RPS6KA2 mRNA	28196854
D006418	Heme	Heme metabolite results in increased expression of RPS6KA2 mRNA	19191707
D017313	Fenretinide	Fenretinide results in increased phosphorylation of RPS6KA2 protein	25246272
D017313	Fenretinide	U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of RPS6KA2 protein]	25246272
D017313	Fenretinide	Fenretinide results in increased expression of RPS6KA2 mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of RPS6KA2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of RPS6KA2 mRNA	23430699
D007854	Lead	Lead affects the splicing of RPS6KA2 mRNA	28903495
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RPS6KA2 mRNA	21641980
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA	18386188
D009150	Mustard Compounds	caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]	17204746
D009150	Mustard Compounds	Mustard Compounds results in increased phosphorylation of RPS6KA2 protein	17204746
D009151	Mustard Gas	Mustard Gas results in increased expression of RPS6KA2 mRNA	15674844
D009588	Nitrogen Mustard Compounds	caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein]	17204746
D009588	Nitrogen Mustard Compounds	Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein	17204746
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPS6KA2 mRNA"	19013360
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of RPS6KA2 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in increased expression of RPS6KA2 mRNA	27939613
D010126	Ozone	Ozone results in decreased expression of RPS6KA2 mRNA	12763052
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA	18386188
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of RPS6KA2 mRNA	26705709
C046012	pentanal	pentanal results in increased expression of RPS6KA2 mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPS6KA2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of RPS6KA2 mRNA	26272509
D010705	Phosgene	Phosgene affects the expression of RPS6KA2 mRNA	16300373
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of RPS6KA2 mRNA	22714537
C005556	propionaldehyde	propionaldehyde results in increased expression of RPS6KA2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RPS6KA2 mRNA	24780913
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA	19059307
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA2 mRNA	19244175
D012643	Selenium	Selenium results in increased expression of RPS6KA2 mRNA	19244175
D020123	Sirolimus	Sirolimus affects the localization of RPS6KA2 protein	19151764
D020123	Sirolimus	Sirolimus results in increased phosphorylation of RPS6KA2 protein	19151764
C017947	sodium arsenite	sodium arsenite affects the methylation of RPS6KA2 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of and affects the splicing of RPS6KA2 mRNA	25879800
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RPS6KA2 mRNA	21641980
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA	19059307
D013629	Tamoxifen	Tamoxifen affects the expression of RPS6KA2 mRNA	17555576
D013654	Taurine	Taurine results in increased expression of RPS6KA2 mRNA	16579726
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA2 mRNA	17942748
D013752	Tetracycline	Tetracycline results in increased expression of RPS6KA2 mRNA	16917069
D013792	Thalidomide	Thalidomide results in decreased expression of RPS6KA2 mRNA	26217789
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of RPS6KA2 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of RPS6KA2 mRNA	22363418
C113580	U 0126	U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of RPS6KA2 protein]	25246272
D014635	Valproic Acid	Valproic Acid affects the expression of RPS6KA2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of RPS6KA2 mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in increased expression of RPS6KA2 mRNA	22714537
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of RPS6KA2 mRNA	19244175
D014873	Water Pollutants	Water Pollutants results in increased expression of RPS6KA2 mRNA	23591932
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of RPS6KA2 mRNA	19013360

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004711	ribosomal protein S6 kinase activity	-	IBA	21873635
GO:0004712	protein serine/threonine/tyrosine kinase activity	-	IDA	22797923
GO:0005515	protein binding	-	IPI	16810323 23602568 25241761 25852190
GO:0005524	ATP binding	-	IEA	-
GO:0016301	kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006468	protein phosphorylation	-	IEA	-
GO:0007165	signal transduction	-	NAS	7623830
GO:0008285	negative regulation of cell proliferation	-	IDA	16878154
GO:0043065	positive regulation of apoptotic process	-	IDA	16878154
GO:0045786	negative regulation of cell cycle	-	IDA	16878154

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	16878154
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	16878154
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04150	mTOR signaling pathway
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation

Reactome ID	Reactome Term	Evidence
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	TAS
R-HSA-198753	ERK/MAPK targets	TAS
R-HSA-199920	CREB phosphorylation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2262752	Cellular responses to stress	IEA
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	TAS
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	IEA
R-HSA-2559583	Cellular Senescence	TAS
R-HSA-2559583	Cellular Senescence	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373760	L1CAM interactions	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-437239	Recycling pathway of L1	IEA
R-HSA-438064	Post NMDA receptor activation events	TAS
R-HSA-442742	CREB phosphorylation through the activation of Ras	TAS
R-HSA-442755	Activation of NMDA receptor and postsynaptic events	TAS
R-HSA-444257	RSK activation	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8953897	Cellular responses to external stimuli	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25424692	Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. (2014 Oct)	Tsaprouni LG	Epigenetics