Gene: RPS6KA3

6197
CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2
ribosomal protein S6 kinase A3
protein-coding
Xp22.12
Ensembl:ENSG00000177189 MIM:300075 Vega:OTTHUMG00000021231 UniprotKB:P51812
NG_007488.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASAP10.9
MEF2A0.9
KLHL80.893
UBXN2B0.884
EPC20.876
BMPR20.873
M6PR0.873
CPSF60.872
ARFGEF10.871
RNF1450.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.489
S100A1-0.453
OR4F29-0.451
NXNL1-0.373
TLCD1-0.353
FXYD3-0.348
TPPP2-0.344
HOGA1-0.338
TST-0.335
ACOT6-0.33

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTarget
ID Drug Name Action PubMed
C52473317-ethynyl-5-androstene-3, 7, 17-triol"17-ethynyl-5-androstene-3, 7, 17-triol binds to RPS6KA3 protein"22384159
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RPS6KA3 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [CXCL2 protein results in increased phosphorylation of RPS6KA3 protein]15608143
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of RPS6KA3 mRNA"20206263
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of RPS6KA3 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RPS6KA3 mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of RPS6KA3 mRNA20829426
C0548527-hydroxystaurosporine7-hydroxystaurosporine results in decreased activity of RPS6KA3 protein10998351
D000082AcetaminophenAcetaminophen results in decreased expression of RPS6KA3 mRNA11793227|2142099
D000082AcetaminophenAcetaminophen affects the expression of RPS6KA3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RPS6KA3 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RPS6KA3 mRNA19770486
D001104ArbutinArbutin results in increased expression of RPS6KA3 mRNA17103032
C006632arsenic trioxidearsenic trioxide results in decreased expression of RPS6KA3 mRNA24831965
D001280AtrazineAtrazine results in increased expression of RPS6KA3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RPS6KA3 mRNA20106945|2163298
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of RPS6KA3 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RPS6KA3 mRNA19619570
D004958EstradiolEstradiol results in increased expression of RPS6KA3 mRNA15757668|1826069
C516541BI D1870BI D1870 results in decreased activity of RPS6KA3 protein21488662
C006780bisphenol Abisphenol A results in increased expression of RPS6KA3 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of RPS6KA3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RPS6KA3 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of RPS6KA3 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of RPS6KA3 protein24057571
D002110CaffeineCaffeine results in decreased expression of RPS6KA3 mRNA11793227
D002211CapsaicinCapsaicin results in increased expression of RPS6KA3 protein18991268
D002220CarbamazepineCarbamazepine affects the expression of RPS6KA3 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6KA3 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of RPS6KA3 mRNA24386269
D003042CocaineRPS6KA3 affects the reaction [Cocaine results in increased phosphorylation of FOS protein]16339038
D003042CocaineRPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]16339038
D003042CocaineRPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]16339038
D019327Copper SulfateCopper Sulfate results in increased expression of RPS6KA3 mRNA20599845
D016572CyclosporineCyclosporine results in decreased expression of RPS6KA3 mRNA20106945|2556210
C004742daidzeindaidzein results in increased expression of RPS6KA3 mRNA15757668
D002945CisplatinCisplatin results in decreased expression of RPS6KA3 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of RPS6KA3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of RPS6KA3 mRNA21592394
C024629dimethyl phthalatedimethyl phthalate affects the expression of RPS6KA3 mRNA26924002
D004147DioxinsDioxins affects the expression of RPS6KA3 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPS6KA3 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KA3 mRNA22079256
D000431EthanolEthanol results in decreased expression of RPS6KA3 mRNA29018328
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA3 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6KA3 mRNA20938992
D019833GenisteinGenistein results in increased expression of RPS6KA3 mRNA15757668
C086566glyciteinglycitein results in increased expression of RPS6KA3 mRNA15757668
D017313FenretinideFenretinide results in decreased expression of RPS6KA3 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RPS6KA3 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of RPS6KA3 mRNA27392435
C015329lycopenelycopene results in decreased expression of RPS6KA3 protein17337101
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPS6KA3 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of RPS6KA3 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RPS6KA3 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RPS6KA3 mRNA26924002
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of RPS6KA3 protein10998351
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RPS6KA3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RPS6KA3 mRNA"25554681
D009532NickelNickel results in increased expression of RPS6KA3 mRNA25583101
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RPS6KA3 mRNA"25510870
C046012pentanalpentanal results in decreased expression of RPS6KA3 mRNA26079696
D010672PhenytoinPhenytoin results in increased expression of RPS6KA3 mRNA20345932
D010936Plant ExtractsPlant Extracts results in increased expression of RPS6KA3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KA3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RPS6KA3 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of RPS6KA3 mRNA20660070
D011374ProgesteroneProgesterone results in increased phosphorylation of RPS6KA3 protein17055699
D011794QuercetinQuercetin results in decreased expression of RPS6KA3 mRNA21632981
C064758Ro 31-8220Ro 31-8220 results in decreased activity of RPS6KA3 protein21488662
C547874SAR 020106SAR 020106 results in decreased activity of RPS6KA3 protein22111927
D020280SertralineSertraline results in decreased expression of RPS6KA3 mRNA24865413
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RPS6KA3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of RPS6KA3 mRNA23221170
D012834SilverSilver results in increased expression of RPS6KA3 mRNA26551752
D020123SirolimusSirolimus affects the localization of RPS6KA3 protein19151764
D020123SirolimusSirolimus results in increased phosphorylation of RPS6KA3 protein19151764
C497449SL0101SL0101 results in decreased activity of RPS6KA3 protein21488662
D013431SulfatesSulfates affects the methylation of RPS6KA3 promoter25395096
C473478sunitinibsunitinib results in decreased activity of RPS6KA3 protein21906609
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RPS6KA3 mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of RPS6KA3 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of RPS6KA3 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of RPS6KA3 mRNA21592394
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of RPS6KA3 mRNA20189893
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of RPS6KA3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPS6KA3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RPS6KA3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RPS6KA3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RPS6KA3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RPS6KA3 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RPS6KA3 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in increased expression of RPS6KA3 protein20109541
D013853ThioacetamideThioacetamide results in decreased expression of RPS6KA3 mRNA11793227
D013853ThioacetamideThioacetamide results in increased expression of RPS6KA3 mRNA23411599
D014212TretinoinRPS6KA3 protein promotes the reaction [Tretinoin results in increased phosphorylation of CREB1 protein]16280361
D014212TretinoinTretinoin results in decreased expression of RPS6KA3 mRNA15498508
D014212TretinoinTretinoin results in increased expression of RPS6KA3 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RPS6KA3 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of RPS6KA3 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of RPS6KA3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of RPS6KA3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of RPS6KA3 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of RPS6KA3 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of RPS6KA3 mRNA20044591
C108830Y 27632Y 27632 results in decreased activity of RPS6KA3 protein10998351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004672protein kinase activity-TAS10436156  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004711ribosomal protein S6 kinase activity-IBA21873635  
GO:0005515protein binding-IPI21988832  23602568  25241761  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-TAS-  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IDA18402937  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS8955270  
GO:0002224toll-like receptor signaling pathway-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007165signal transduction-TAS10436156  
GO:0007417central nervous system development-TAS10319851  
GO:0018105peptidyl-serine phosphorylation-TAS11404397  
GO:0030307positive regulation of cell growth-TAS18813292  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0043066negative regulation of apoptotic process-TAS18813292  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA18402937  
GO:0043555regulation of translation in response to stress-TAS18813292  
GO:0043620regulation of DNA-templated transcription in response to stress-TAS18813292  
GO:0045597positive regulation of cell differentiation-TAS18813292  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP22065586  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04114Oocyte meiosis
hsa04150mTOR signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-198753ERK/MAPK targetsTAS
R-HSA-199920CREB phosphorylationTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)IEA
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559583Cellular SenescenceIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1IEA
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-444257RSK activationTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPKTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24204162Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking. (2013)Tan QOnco Targets Ther