Gene info: ID 6223

Gene: RPS19

GENE ID: 6223

Synonyms: DBA|DBA1|S19|eS19

Description: ribosomal protein S19

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000105372 MIM:603474 Vega:OTTHUMG00000182676 UniprotKB:P39019

RefSeq: NG_007080.3

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.167e-1 (AD) 5.646e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RPL27A	0.965
RPL35	0.962
RPL18A	0.962
RPS16	0.958
RPLP1	0.955
RPS9	0.952
RPLP2	0.951
RPL28	0.949
RPS27	0.947
RPL18	0.947

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.651
OR4F5	-0.609
MCHR2	-0.416
PCDHAC1	-0.414
NCR3LG1	-0.412
OTOGL	-0.411
STARD4-AS1	-0.404
PCDHAC2	-0.404
PPM1E	-0.401
KCNH1	-0.401

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of RPS19 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of RPS19 mRNA"	15215175
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of RPS19 mRNA	14600272\|1589037
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RPS19 mRNA"	28973690
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of RPS19 mRNA"	20589742
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RPS19 mRNA	14600272\|1589037
D000082	Acetaminophen	Acetaminophen affects the expression of RPS19 mRNA	17562736
D000108	Acetylcarnitine	[Acetylcarnitine co-treated with NGF protein] results in increased expression of RPS19 mRNA	14654561
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RPS19 mRNA	14600272\|1589037
D000638	Amiodarone	Amiodarone affects the expression of RPS19 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of RPS19 mRNA	16483693
D001241	Aspirin	Aspirin results in increased expression of RPS19 mRNA	15456535
D001280	Atrazine	Atrazine results in decreased expression of RPS19 mRNA	25929836
D001280	Atrazine	[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNA	16532367
D001553	Benzbromarone	Benzbromarone affects the expression of RPS19 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the splicing of RPS19 exon	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RPS19 mRNA	20504355\|2222880
C006780	bisphenol A	bisphenol A results in decreased expression of RPS19 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of RPS19 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RPS19 gene	28505145
D000069286	Bortezomib	Bortezomib results in increased expression of RPS19 mRNA	15509775
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of RPS19 mRNA	12419474
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RPS19 mRNA	12760830
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RPS19 mRNA	20589742
D002235	Carbofuran	[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS19 mRNA	21075942
D002713	Chlorine	Chlorine results in increased expression of RPS19 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of RPS19 mRNA	18636392
C100187	chloropicrin	chloropicrin results in increased expression of RPS19 mRNA	26352163
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of RPS19 mRNA	28472532
D002994	Clofibrate	Clofibrate affects the expression of RPS19 mRNA	19483382
C018021	cobaltous chloride	cobaltous chloride results in increased expression of RPS19 mRNA	19376846
D003300	Copper	Copper affects the expression of RPS19 mRNA	23825565
D016572	Cyclosporine	Cyclosporine results in increased expression of RPS19 mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RPS19 mRNA	17379624
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of RPS19 mRNA	28412506
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of RPS19 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of RPS19 mRNA]	19850644
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of RPS19 mRNA	15766595
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of RPS19 mRNA	15890375
C039060	dihydroartemisinin	dihydroartemisinin analog binds to RPS19 protein	26340163
D002117	Calcitriol	Calcitriol results in decreased expression of RPS19 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of RPS19 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of RPS19 mRNA	14600272\|1589037
D004237	Diuron	[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNA	16532367
D004317	Doxorubicin	Doxorubicin affects the expression of RPS19 protein	29385562
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of RPS19 mRNA	12655031
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPS19 protein	23301498
D000431	Ethanol	Ethanol affects the expression of RPS19 mRNA	24355176
D000431	Ethanol	Ethanol affects the expression of RPS19 protein	22960358
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of RPS19 mRNA	17557909
D005001	Ethionine	Ethionine affects the expression of RPS19 mRNA	19483382
C504383	fenbuconazole	fenbuconazole results in increased expression of RPS19 mRNA	15942997
D005485	Flutamide	Flutamide results in increased expression of RPS19 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in decreased expression of RPS19 mRNA	12679049
C039281	furan	furan results in increased expression of RPS19 mRNA	26194646
D019833	Genistein	Genistein results in decreased expression of RPS19 mRNA	15256057
D019833	Genistein	[Genistein co-treated with Methoxychlor] results in increased expression of RPS19 mRNA	21782745
D005839	Gentamicins	Gentamicins results in increased expression of RPS19 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of RPS19 mRNA	24136188
C492448	ICG 001	ICG 001 results in increased expression of RPS19 mRNA	26191083
D007213	Indomethacin	Indomethacin results in increased expression of RPS19 mRNA	28201806
C028904	isoproturon	[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of RPS19 mRNA	16532367
D007657	Ketone Bodies	Ketone Bodies results in increased expression of RPS19 mRNA	15469884
C008261	lead acetate	lead acetate results in increased expression of RPS19 mRNA	22613225
D001556	Lindane	[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS19 mRNA	21075942
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of RPS19 mRNA	20353558
D008701	Methapyrilene	Methapyrilene results in increased expression of RPS19 mRNA	15890375
D008727	Methotrexate	Methotrexate affects the expression of RPS19 mRNA	18502557
D008731	Methoxychlor	[Genistein co-treated with Methoxychlor] results in increased expression of RPS19 mRNA	21782745
D008731	Methoxychlor	Methoxychlor results in increased expression of RPS19 mRNA	21782745
C051786	metolachlor	[Lindane co-treated with metolachlor co-treated with Carbofuran] results in increased expression of RPS19 mRNA	21075942
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of RPS19 protein"	22001959
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of RPS19 mRNA	20551477
C038541	N-benzyloxycarbonylprolylprolinal	N-benzyloxycarbonylprolylprolinal results in increased expression of RPS19 mRNA	21487212
C012655	nimesulide	nimesulide results in increased expression of RPS19 mRNA	24136188
D009853	Omeprazole	Omeprazole affects the expression of RPS19 mRNA	19483382
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of RPS19 mRNA	18636392
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RPS19 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of RPS19 mRNA	19162173
D010575	Pesticides	Pesticides results in decreased methylation of RPS19 gene	28396702
C031181	phenanthrene	phenanthrene results in increased expression of RPS19 mRNA	19457238
C031181	phenanthrene	phenanthrene results in decreased expression of RPS19 mRNA	20589742
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of RPS19 mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of RPS19 mRNA	23811191
C006253	pirinixic acid	pirinixic acid affects the expression of RPS19 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of RPS19 mRNA	15890375
D011441	Propylthiouracil	Propylthiouracil affects the expression of RPS19 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RPS19 mRNA	24780913
C059514	resveratrol	resveratrol results in decreased expression of RPS19 protein	25505154
C016104	sodium bichromate	sodium bichromate results in increased expression of RPS19 mRNA	22561333
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of RPS19 protein	28918527
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of RPS19 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of RPS19 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RPS19 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPS19 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RPS19 mRNA	18796159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RPS19 mRNA	27913140
D013853	Thioacetamide	Thioacetamide affects the expression of RPS19 mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in increased expression of RPS19 mRNA	27760801
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of RPS19 mRNA	21346803
D014520	Urethane	Urethane results in increased expression of RPS19 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of RPS19 mRNA	17963808
D014810	Vitamin E	Vitamin E results in decreased expression of RPS19 mRNA	19244175
D015032	Zinc	Zinc deficiency results in decreased expression of RPS19 mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22681889
GO:0003735	structural constituent of ribosome	-	HDA	15883184
GO:0003735	structural constituent of ribosome	-	IBA	21873635
GO:0005515	protein binding	-	IPI	16266891 24965446
GO:0017134	fibroblast growth factor binding	-	IPI	11716516
GO:0019901	protein kinase binding	-	IPI	16266891
GO:0042803	protein homodimerization activity	-	IDA	11226885

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000028	ribosomal small subunit assembly	-	IBA	21873635
GO:0000028	ribosomal small subunit assembly	-	IMP	17053056
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	-
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	-	IMP	16990592 17053056
GO:0002548	monocyte chemotaxis	-	IDA	11226885
GO:0006364	rRNA processing	-	IMP	18697920
GO:0006412	translation	-	IC	8706699
GO:0006413	translational initiation	-	TAS	-
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	-
GO:0007000	nucleolus organization	-	IMP	17053056
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0009991	response to extracellular stimulus	-	TAS	16289379
GO:0030218	erythrocyte differentiation	-	IMP	16289379
GO:0030490	maturation of SSU-rRNA	-	IMP	16990592 17053056
GO:0031640	killing of cells of other organism	-	IDA	15019208
GO:0042274	ribosomal small subunit biogenesis	-	IMP	18697920
GO:0050829	defense response to Gram-negative bacterium	-	IDA	15019208
GO:0051262	protein tetramerization	-	IDA	11226885
GO:0051272	positive regulation of cellular component movement	-	TAS	16289379
GO:0060265	positive regulation of respiratory burst involved in inflammatory response	-	IDA	15750715
GO:0060266	negative regulation of respiratory burst involved in inflammatory response	-	IDA	15750715
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	-	IDA	15019208

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IDA	12586610 16289379 17517689
GO:0005737	cytoplasm	-	IDA	17517689
GO:0005829	cytosol	-	IDA	11716516
GO:0005829	cytosol	-	TAS	-
GO:0005840	ribosome	-	IDA	17517689
GO:0005925	focal adhesion	-	HDA	21423176
GO:0016020	membrane	-	HDA	19946888
GO:0022627	cytosolic small ribosomal subunit	-	HDA	15883184
GO:0022627	cytosolic small ribosomal subunit	-	IBA	21873635
GO:0022627	cytosolic small ribosomal subunit	-	IDA	8706699
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa03010	Ribosome

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1430728	Metabolism	IEA
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	TAS
R-HSA-156842	Eukaryotic Translation Elongation	IEA
R-HSA-156902	Peptide chain elongation	IEA
R-HSA-1643685	Disease	TAS
R-HSA-168254	Influenza Infection	TAS
R-HSA-168255	Influenza Life Cycle	TAS
R-HSA-168273	Influenza Viral RNA Transcription and Replication	TAS
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	IEA
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	TAS
R-HSA-192823	Viral mRNA Translation	TAS
R-HSA-2408522	Selenoamino acid metabolism	IEA
R-HSA-2408557	Selenocysteine synthesis	IEA
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-5663205	Infectious disease	TAS
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	IEA
R-HSA-72312	rRNA processing	TAS
R-HSA-72613	Eukaryotic Translation Initiation	TAS
R-HSA-72649	Translation initiation complex formation	TAS
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	TAS
R-HSA-72689	Formation of a pool of free 40S subunits	TAS
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	TAS
R-HSA-72702	Ribosomal scanning and start codon recognition	TAS
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	TAS
R-HSA-72737	Cap-dependent Translation Initiation	TAS
R-HSA-72764	Eukaryotic Translation Termination	IEA
R-HSA-72766	Translation	TAS
R-HSA-72766	Translation	IEA
R-HSA-8868773	rRNA processing in the nucleus and cytosol	TAS
R-HSA-8953854	Metabolism of RNA	TAS
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	IEA
R-HSA-927802	Nonsense-Mediated Decay (NMD)	TAS
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	TAS
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23826176	RPS19 and TYMS SNPs and Prevalent High Risk Human Papilloma Virus Infection in Nigerian Women. (2013)	Famooto A	PLoS One