Gene: RRAD

6236
RAD|RAD1|REM3
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
protein-coding
16q22.1
Ensembl:ENSG00000166592 MIM:179503 Vega:OTTHUMG00000137511 UniprotKB:P55042
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.712e-1 (AD)  9.741e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA60.749
CLCF10.726
DNAJB10.718
ZC3H12A0.717
ATF30.711
SERPINH10.701
FOSL10.7
HSPA1A0.694
MAFA0.686
RELB0.685

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZC3H6-0.369
ZNF223-0.354
KBTBD7-0.338
CASC1-0.33
OMG-0.329
SCGB2B2-0.329
TBC1D32-0.323
YPEL1-0.321
PCDHA4-0.319
ZNF382-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of RRAD mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of RRAD mRNA"18711122
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of RRAD mRNA"18711122
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RRAD mRNA"25614096
D000082AcetaminophenAcetaminophen results in increased expression of RRAD mRNA22230336|2906747
D020106AcrylamideAcrylamide results in decreased expression of RRAD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RRAD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RRAD mRNA21632981|2164198
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RRAD mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RRAD mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RRAD mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRAD mRNA17879257|2006483
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RRAD gene25435355
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of RRAD mRNA"18711122
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of RRAD mRNA"18711122
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of RRAD mRNA18711122
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RRAD mRNA"20382639
D004958EstradiolEstradiol results in increased expression of RRAD mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of RRAD mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of RRAD mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RRAD mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of RRAD mRNA26079696
D002104CadmiumCadmium results in increased expression of RRAD mRNA23369406
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of RRAD mRNA11566570
D002737ChloropreneChloroprene results in decreased expression of RRAD mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of RRAD mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of RRAD mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of RRAD mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RRAD mRNA20938992
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of RRAD mRNA18078969
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of RRAD mRNA21356183
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of RRAD mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of RRAD mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of RRAD mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of RRAD mRNA17211630
D016572CyclosporineCyclosporine results in increased expression of RRAD mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of RRAD mRNA19770486
D016572CyclosporineCyclosporine results in decreased expression of RRAD mRNA18172885
C014347decitabinedecitabine affects the expression of RRAD mRNA17195088
D003703DemecolcineDemecolcine results in increased expression of RRAD mRNA23649840
C041517dibenzo(a,l)pyrene"[1,2,5,6-dibenzanthracene co-treated with dibenzo(a,l)pyrene] affects the expression of RRAD mRNA"18711122
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of RRAD mRNA"18711122
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RRAD mRNA24893172
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RRAD mRNA27392435
D002945CisplatinCisplatin results in increased expression of RRAD mRNA27392435
D002945CisplatinCisplatin results in increased expression of RRAD mRNA18172885
D002117CalcitriolCalcitriol results in decreased expression of RRAD mRNA16002434
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA24690739
D004237DiuronDiuron metabolite results in decreased expression of RRAD mRNA24172598
C118739entinostatentinostat results in increased expression of RRAD mRNA27188386
D000431EthanolEthanol results in decreased expression of RRAD mRNA11566570
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RRAD mRNA17351261
C007738fluoranthene"[1,2,5,6-dibenzanthracene co-treated with fluoranthene] affects the expression of RRAD mRNA"18711122
C007738fluoranthene[Benzo(a)pyrene co-treated with fluoranthene] affects the expression of RRAD mRNA18711122
C061365flusilazoleflusilazole results in decreased expression of RRAD mRNA22664269
C061365flusilazoleflusilazole results in decreased expression of RRAD mRNA22664269
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RRAD mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of RRAD mRNA17938736|2065599
C039281furanfuran results in increased expression of RRAD mRNA27387713
D019833GenisteinGenistein results in decreased expression of RRAD mRNA15257099
D006220HaloperidolHaloperidol results in increased expression of RRAD mRNA15860345
C010178heliotrineheliotrine results in increased expression of RRAD mRNA26100227
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of RRAD mRNA15046208
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRAD mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of RRAD mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RRAD mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RRAD mRNA25307878
C008261lead acetatelead acetate results in decreased expression of RRAD mRNA22609695
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of RRAD mRNA"24972896
D018021Lithium ChlorideLithium Chloride results in increased expression of RRAD mRNA15711924
D008558MelphalanMelphalan results in increased expression of RRAD mRNA22363485
D015122MercaptopurineMercaptopurine results in decreased expression of RRAD mRNA23358152
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RRAD mRNA20938992
D008731MethoxychlorMethoxychlor results in increased methylation of RRAD gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RRAD mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RRAD mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RRAD mRNA23649840
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RRAD mRNA22401849
D009151Mustard GasMustard Gas results in increased expression of RRAD mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RRAD mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RRAD mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of RRAD mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RRAD mRNA25729387
D010269ParaquatParaquat results in decreased expression of RRAD mRNA12595580
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of RRAD mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of RRAD mRNA19159669
D010656PhenylephrinePhenylephrine results in decreased expression of RRAD protein18056528
D010938Plant OilsPlant Oils results in increased expression of RRAD mRNA23370395
C531249Poly(amidoamine)Poly(amidoamine) analog results in decreased expression of RRAD mRNA23806026
C005556propionaldehydepropionaldehyde results in increased expression of RRAD mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of RRAD mRNA24780913
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in increased expression of RRAD mRNA26100227
D011794QuercetinQuercetin results in increased expression of RRAD mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA19059307
C009237senecioninesenecionine results in increased expression of RRAD mRNA26100227
C009238senkirkinesenkirkine results in increased expression of RRAD mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RRAD mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of RRAD mRNA25351596
D012834SilverSilver results in increased expression of RRAD mRNA26014281
D020123SirolimusSirolimus promotes the reaction [TP73 protein binds to RRAD promoter]21245298
C017947sodium arsenitesodium arsenite results in increased expression of RRAD mRNA10910055
C016104sodium bichromatesodium bichromate results in increased expression of RRAD mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of RRAD mRNA12325037
D013311StreptozocinStreptozocin results in increased expression of RRAD mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of RRAD mRNA]16684804
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of RRAD mRNA19059307
C004648testosterone enanthatetestosterone enanthate affects the expression of RRAD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RRAD mRNA16704738|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRAD mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RRAD mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRAD mRNA25613284
D013849ThimerosalThimerosal results in increased expression of RRAD mRNA16870260
C402769tipifarnibtipifarnib results in increased expression of RRAD mRNA16403772
C009495titanium dioxidetitanium dioxide results in decreased expression of RRAD mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RRAD mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RRAD mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RRAD mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RRAD mRNA25729387
D014212TretinoinTretinoin results in increased expression of RRAD mRNA16604517
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of RRAD mRNA18078969
D014520UrethaneUrethane results in increased expression of RRAD mRNA28818685
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of RRAD mRNA]16684804
D001335Vehicle EmissionsVehicle Emissions results in increased expression of RRAD mRNA19465080
D014812Vitamin KVitamin K affects the expression of RRAD mRNA16844298

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005246calcium channel regulator activity-IBA21873635  
GO:0005515protein binding-IPI10359610  20460530  
GO:0005516calmodulin binding-IEA-  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-TAS8248782  
GO:1901842negative regulation of high voltage-gated calcium channel activity-IEA-  
GO:1903169regulation of calcium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24451080Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients. (2013)Szymanowska-Narloch AAdv Med Sci
17195088Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers. (2007 Apr)Suzuki MAnn Surg Oncol