Gene info: ID 6239

Gene: RREB1

GENE ID: 6239

Synonyms: FINB|HNT|LZ321|RREB-1|Zep-1

Description: ras responsive element binding protein 1

Gene type: protein-coding

Location: 6p24.3

dbXrefs: Ensembl:ENSG00000124782 MIM:602209 Vega:OTTHUMG00000014201 UniprotKB:Q92766

RefSeq: NG_016201.1

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.957e-2 (AD) 9.200e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs9392863	chr6:7194776 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg04418434	chr6:7110773	RREB1		2.250e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF217	0.897
MAML2	0.858
TEP1	0.858
MSN	0.851
CMTM6	0.849
PRKD3	0.845
ITGA6	0.837
CD302	0.835
IL6R	0.832
LRP10	0.832

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMIM18	-0.585
KCNB2	-0.578
HAS1	-0.574
CALHM1	-0.566
PTPRR	-0.565
PPEF1	-0.564
TMEFF2	-0.562
SLC7A4	-0.56
ABCC12	-0.559
BCL11A	-0.555

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of RREB1 mRNA	21420995
D001151	Arsenic	Arsenic affects the methylation of RREB1 gene	25304211
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of RREB1 mRNA"	17331233
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of RREB1 gene	25435355
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RREB1 mRNA"	19150397
D004958	Estradiol	Estradiol results in increased expression of RREB1 mRNA	23019147
C006780	bisphenol A	bisphenol A affects the expression of RREB1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RREB1 gene	28505145
D002104	Cadmium	Cadmium results in increased expression of RREB1 mRNA	24376830
D002994	Clofibrate	Clofibrate results in increased expression of RREB1 mRNA	23811191
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]	18200517
D003907	Dexamethasone	Dexamethasone results in increased expression of RREB1 mRNA	16144937
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RREB1 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of RREB1 mRNA	28962523
D002945	Cisplatin	Cisplatin results in decreased expression of RREB1 mRNA	27392435\|2759478
C000944	dicrotophos	dicrotophos results in increased expression of RREB1 mRNA	28302478
D005557	Formaldehyde	Formaldehyde results in decreased expression of RREB1 mRNA	20655997
D005978	Glutathione	Glutathione deficiency results in decreased expression of RREB1 mRNA	20621112
D017313	Fenretinide	Fenretinide results in increased expression of RREB1 mRNA	28973697
D006851	Hydrochloric Acid	Hydrochloric Acid results in decreased expression of RREB1 mRNA	15046208
C045463	leflunomide	leflunomide results in increased expression of RREB1 mRNA	28988120
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of RREB1 mRNA	28392392
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RREB1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RREB1 mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of RREB1 mRNA	24810058
C012655	nimesulide	nimesulide results in decreased expression of RREB1 mRNA	24136188
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RREB1 mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of RREB1 mRNA	26272509
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of RREB1 mRNA	23892564
D010634	Phenobarbital	Phenobarbital results in decreased expression of RREB1 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of RREB1 mRNA	18301758\|2381119
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of RREB1 mRNA	27029645
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of RREB1 mRNA	19073995
C009277	sodium arsenate	sodium arsenate results in increased expression of RREB1 mRNA	21795629
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RREB1 mRNA	21570461
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RREB1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of RREB1 mRNA	25729387
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of RREB1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in increased expression of RREB1 mRNA	26272509
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA	18200517
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RREB1 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of RREB1 mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of RREB1 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of RREB1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RREB1 gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RREB1 mRNA"	27188386
D015032	Zinc	Zinc affects the expression of RREB1 mRNA	21613827

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IDA	8816445
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IMP	20133935
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IDA	8816445
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	20133935
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0006355	regulation of transcription, DNA-templated	-	TAS	9305772
GO:0006366	transcription by RNA polymerase II	-	TAS	8816445
GO:0007265	Ras protein signal transduction	-	TAS	8816445
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007275	multicellular organism development	-	TAS	8816445
GO:0010634	positive regulation of epithelial cell migration	-	IMP	18394891
GO:0033601	positive regulation of mammary gland epithelial cell proliferation	-	IMP	18394891
GO:0045893	positive regulation of transcription, DNA-templated	-	TAS	9305772
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	8816445
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	-	IMP	18394891
GO:1903691	positive regulation of wound healing, spreading of epidermal cells	-	IMP	18394891
GO:2000394	positive regulation of lamellipodium morphogenesis	-	IMP	18394891

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001650	fibrillar center	-	IDA	-
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	TAS	9305772
GO:0005737	cytoplasm	-	TAS	9305772
GO:0016604	nuclear body	-	TAS	9305772
GO:0016607	nuclear speck	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal