Gene: RRM1

6240
R1|RIR1|RR1
ribonucleotide reductase catalytic subunit M1
protein-coding
11p15.4
Ensembl:ENSG00000167325 MIM:180410 Vega:OTTHUMG00000133361 UniprotKB:P23921
NG_027992.2
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.237e-1 (AD)  1.890e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GGNBP20.902
DHX360.901
TTF10.898
TTC370.896
RRAGB0.895
UBA50.892
RAD170.891
IBTK0.891
NUP1330.891
PSIP10.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.543
MTRNR2L6-0.371
MTRNR2L9-0.357
MTRNR2L10-0.353
MTRNR2L2-0.319
FOXJ1-0.318
PLA2G5-0.308
MTRNR2L8-0.303
WDR38-0.297

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTarget
DB00441GemcitabineSmall Molecule95058-81-4ApprovedTarget
DB00631ClofarabineSmall Molecule123318-82-1Approved|InvestigationalTarget
DB01005HydroxyureaSmall Molecule127-07-1ApprovedTarget
DB01073FludarabineSmall Molecule21679-14-1ApprovedTarget
DB05003ImexonSmall Molecule59643-91-3InvestigationalTarget
DB05420gallium maltolateSmall MoleculeInvestigationalTarget
DB06433TezacitabineSmall Molecule171176-43-5InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RRM1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RRM1 mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RRM1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RRM1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RRM1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RRM1 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to RRM1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RRM1 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RRM1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RRM1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of RRM1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of RRM1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of RRM1 mRNA17942131
C016601afimoxifeneafimoxifene results in decreased expression of RRM1 mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RRM1 protein20106945
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RRM1 protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of RRM1 protein25174355|2533511
C006632arsenic trioxidearsenic trioxide results in increased expression of RRM1 protein25419056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of RRM1 mRNA"19446018
D001280AtrazineAtrazine results in increased expression of RRM1 mRNA22982499
D001379AzathioprineAzathioprine results in decreased expression of RRM1 mRNA22623647
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA27858113
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of RRM1 mRNA]15034205
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RRM1 mRNA15034205|1794213
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRM1 mRNA20504355|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRM1 mRNA"20382639
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA24657404
D004958EstradiolEstradiol results in increased expression of RRM1 mRNA16514628|1916744
D004958EstradiolEstradiol affects the expression of RRM1 mRNA15598610|1668458
C006780bisphenol Abisphenol A affects the expression of RRM1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RRM1 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of RRM1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of RRM1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of RRM1 mRNA17942131
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of RRM1 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RRM1 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RRM1 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of RRM1 mRNA23650126
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of RRM1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RRM1 mRNA20971185
D003345CorticosteroneCorticosterone results in decreased expression of RRM1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RRM1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RRM1 mRNA19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of RRM1 mRNA21041162
D016572CyclosporineCyclosporine affects the expression of RRM1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of RRM1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of RRM1 mRNA17942131
D000069439DasatinibDasatinib results in decreased expression of RRM1 mRNA20579391
D003907DexamethasoneDexamethasone results in decreased expression of RRM1 mRNA21041162
D003976DiazinonDiazinon results in decreased expression of RRM1 mRNA16539210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RRM1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of RRM1 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in decreased expression of RRM1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RRM1 mRNA17854601
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of RRM1 mRNA21041162
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of RRM1 mRNA27638505
D004147DioxinsDioxins affects the expression of RRM1 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RRM1 protein23301498
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of RRM1 mRNA17317680
D005472FluorouracilFluorouracil results in increased expression of RRM1 protein15331170
C070081fulvestrantfulvestrant results in decreased expression of RRM1 mRNA16514628
C039281furanfuran results in increased expression of RRM1 mRNA25539665
C419708gefitinibRRM1 gene polymorphism affects the susceptibility to gefitinib21264830
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 mRNA25189999
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 protein25189999
C056507gemcitabineRRM1 protein affects the susceptibility to gemcitabine26894857
C056507gemcitabineRRM1 results in increased metabolism of gemcitabine14977831
D006108GraphiteGraphite results in decreased expression of RRM1 protein22157353
D017313FenretinideFenretinide results in increased expression of RRM1 mRNA28973697
D006835HydrazonesHydrazones results in decreased expression of RRM1 protein28716444
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RRM1 mRNA20044591|2341063
C492448ICG 001ICG 001 results in decreased expression of RRM1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RRM1 mRNA25961927
C410337K 7174K 7174 results in decreased expression of RRM1 mRNA24086573
D007854LeadLead results in decreased expression of RRM1 mRNA19921347
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RRM1 mRNA"25926378
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RRM1 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RRM1 mRNA"20188158
C008493methylselenic acidmethylselenic acid affects the expression of RRM1 mRNA14617803
D009151Mustard GasMustard Gas results in decreased expression of RRM1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RRM1 protein"22157353
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RRM1 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RRM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RRM1 mRNA"25554681
C025256nonylphenolnonylphenol results in increased expression of RRM1 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RRM1 mRNA20971185
D008939MitotaneMitotane results in increased expression of RRM1 mRNA22547773
D008939MitotaneRRM1 protein results in decreased susceptibility to Mitotane22547773
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RRM1 mRNA25729387
D010126OzoneOzone results in increased expression of RRM1 mRNA12763052|1955522
C500026palbociclibpalbociclib results in decreased expression of RRM1 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in decreased expression of RRM1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RRM1 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RRM1 protein26879310
D010578PetroleumPetroleum affects the expression of RRM1 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of RRM1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of RRM1 mRNA19136022|2309116
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RRM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RRM1 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of RRM1 mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of RRM1 mRNA17950772|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of RRM1 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in increased expression of RRM1 mRNA23557933
D028321Plant PreparationsPlant Preparations affects the expression of RRM1 mRNA16046712
D011374ProgesteroneProgesterone results in decreased expression of RRM1 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of RRM1 mRNA23018184
D011374ProgesteroneProgesterone affects the expression of RRM1 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of RRM117510236
D011794QuercetinQuercetin results in increased expression of RRM1 mRNA21632981
C037219quinolinequinoline analog results in decreased expression of RRM1 protein18645022
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of RRM1 mRNA16514628
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RRM1 mRNA19167446
C017947sodium arsenitesodium arsenite results in decreased methylation of RRM1 gene25199682
C016104sodium bichromatesodium bichromate affects the expression of RRM1 mRNA22110744
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RRM1 mRNA"26680231
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of RRM1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRM1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RRM1 mRNA15034205
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of RRM1 mRNA22378314
D013893ThiramThiram results in decreased expression of RRM1 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of RRM1 mRNA23557971
D024505TocopherolsTocopherols results in increased expression of RRM1 mRNA17056531
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RRM1 mRNA19042947
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of RRM1 mRNA26898711
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RRM1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RRM1 mRNA19140230
D014520UrethaneUrethane results in decreased expression of RRM1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of RRM1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of RRM1 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of RRM1 mRNA10716750
D014640VancomycinVancomycin results in decreased expression of RRM1 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in increased expression of RRM1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of RRM1 mRNA20044591|2341063
C111237vorinostatvorinostat results in increased expression of RRM1 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of RRM1 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-IBA21873635  
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-ISS-  
GO:0005515protein binding-IPI17726094  21336276  22632967  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IPI17726094  21336276  25416956  
GO:0097718disordered domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-IEA-  
GO:0006206pyrimidine nucleobase metabolic process-IEA-  
GO:0006260DNA replication-IEA-  
GO:0008584male gonad development-IEA-  
GO:0009263deoxyribonucleotide biosynthetic process-IBA21873635  
GO:0009263deoxyribonucleotide biosynthetic process-ISS-  
GO:0010212response to ionizing radiation-IEA-  
GO:0021846cell proliferation in forebrain-IEA-  
GO:0051290protein heterotetramerization-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0060041retina development in camera-type eye-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005971ribonucleoside-diphosphate reductase complex-IBA21873635  
GO:0005971ribonucleoside-diphosphate reductase complex-IEA-  
GO:0042995cell projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26323924The genotype of ribonucleotidereductase M1 -269C > A is associated with the response to platinum-based chemotherapy and as a prognostic biomarker in advanced nonsmall cell lung cancer. (2015 Aug)Xu XLJ Cancer Res Ther
25327655[Relationship between the efficacy of gemcitabine/cisplatin adjuvant chemotherapy and RRM1 protein expression in postoperative NSCLC patients]. (2014 Jul)Ma KZhonghua Zhong Liu Za Zhi
25667646Association between epidermal growth factor receptor mutations and the expression of excision repair cross-complementing protein 1 and ribonucleotide reductase subunit M1 mRNA in patients with non-small cell lung cancer. (2015 Mar)Xu CWExp Ther Med
25366782Associations between clinical characteristics and oncogene expression in patients with non-small cell lung cancer. (2014 Oct 31)Han YGenet Mol Res
22044695Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer. (2012 Mar)de Andrade MCancer Prev Res (Phila)
26001082Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. (2015)Mah VPLoS One
24994038Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer. (2014 Dec)Deng LLJ Cancer Res Clin Oncol
21496433[Relations between RRM1 protein expression levels and effects of gemcitabine and cisplatin chemotherapy in advanced non-small cell lung cancer patients]. (2011 Apr)Gao ZZhongguo Fei Ai Za Zhi
23086647[Expression of RRM1 and ERCC1 genes in tumor tissues and peripheral blood lymphocytes of advanced non-small cell lung cancer]. (2012 Sep)Zhang GBZhejiang Da Xue Xue Bao Yi Xue Ban
24667263[Clinicopathological and prognostic significance of a panel of tumor biomarkers in lung adenocarcinoma: a tissue microarray study]. (2014 Mar)Yang XZhongguo Fei Ai Za Zhi
26542178Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer. (2016 Aug)Lafuente-Sanchis AClin Transl Oncol