Gene info: ID 6241

Gene: RRM2

GENE ID: 6241

Synonyms: R2|RR2|RR2M

Description: ribonucleotide reductase regulatory subunit M2

Gene type: protein-coding

Location: 2p25.1

dbXrefs: Ensembl:ENSG00000171848 MIM:180390 Vega:OTTHUMG00000090449 UniprotKB:P31350

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.411e-1 (AD) 8.710e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24419094	chr2:10266986	RRM2	Gene body	8.397e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MKI67	0.832
KIF20A	0.793
TROAP	0.761
TOP2A	0.754
CEP55	0.729
AURKB	0.719
MYBL2	0.716
DLGAP5	0.711
HJURP	0.7
CCNB2	0.645

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WIF1	-0.304
ARSF	-0.271
SLC13A5	-0.256
PRSS56	-0.252
MESP2	-0.245
ABCD2	-0.243
MOGAT3	-0.24
CHRDL2	-0.233
ENDOU	-0.223
GPT	-0.212

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00242	Cladribine	Small Molecule	4291-63-8	Approved\|Investigational	Target
DB05003	Imexon	Small Molecule	59643-91-3	Investigational	Target
DB05260	Gallium nitrate	Small Molecule	13494-90-1	Approved\|Investigational	Target
DB05428	motexafin gadolinium	Small Molecule	-	Investigational	Target
DB05801	GTI 2040	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of RRM2 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RRM2 mRNA"	28903501
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of RRM2 mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of RRM2 mRNA"	19095052
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM2 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of RRM2 mRNA"	20713471
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RRM2 mRNA"	20816883
C495818	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
C074761	3,4,5-trihydroxybenzamidoxime	"3,4,5-trihydroxybenzamidoxime results in decreased activity of RRM2 protein"	22403396
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of RRM2 mRNA"	18648102
C524814	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
C524814	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
C524814	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]	22403396
C524814	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one	[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased activity of MYC protein] inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
C054852	7-hydroxystaurosporine	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]	22403396
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]	22403396
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
C054852	7-hydroxystaurosporine	7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]	22403396
D000082	Acetaminophen	Acetaminophen affects the expression of RRM2 mRNA	25064622
D000082	Acetaminophen	Acetaminophen results in decreased expression of RRM2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in decreased expression of RRM2 mRNA	17942131
D000082	Acetaminophen	Acetaminophen results in increased expression of RRM2 mRNA	24126418
D020106	Acrylamide	Acrylamide results in increased expression of RRM2 mRNA	28959563
C006418	adrenocorticotropin zinc	adrenocorticotropin zinc results in increased expression of RRM2 mRNA	19920212
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of RRM2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of RRM2 mRNA	19770486
C412373	AG 1879	AG 1879 results in decreased expression of RRM2 mRNA	15073106
C412373	AG 1879	AG 1879 results in decreased expression of RRM2 protein	15073106
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of RRM2 mRNA	28522335
D000638	Amiodarone	Amiodarone affects the expression of RRM2 mRNA	25064622
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of RRM2 mRNA"	22863853
D000968	Antimycin A	Antimycin A results in decreased expression of RRM2 mRNA	19304788
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of RRM2 mRNA	26705709
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of RRM2 protein	25419056
D001374	Azacitidine	[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA	18720364
D001379	Azathioprine	Azathioprine results in decreased expression of RRM2 mRNA	22623647
C547126	AZM551248	AZM551248 results in increased expression of RRM2 mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of RRM2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RRM2 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RRM2 mRNA	17942131\|1977048
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RRM2 mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRM2 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of RRM2 mRNA	25566086
D004958	Estradiol	Estradiol results in decreased expression of RRM2 mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of RRM2 mRNA	16474171\|1831028
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA	17404688
D004958	Estradiol	Estradiol affects the expression of RRM2 mRNA	15598610
D001622	Betaine	Betaine results in decreased expression of RRM2 mRNA	26391144
C053541	bicalutamide	bicalutamide results in decreased expression of RRM2 mRNA	15638997
C006780	bisphenol A	bisphenol A results in decreased expression of RRM2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of RRM2 mRNA	16474171
C006780	bisphenol A	bisphenol A results in decreased expression of RRM2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of RRM2 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of RRM2 mRNA	17942131
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased phosphorylation of RRM2 protein	22174045
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RRM2 mRNA	22079614
D002065	Buspirone	Buspirone results in decreased expression of RRM2 mRNA	24136188
C584509	C646 compound	C646 compound results in decreased expression of RRM2 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of RRM2 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RRM2 mRNA	17961207
D019256	Cadmium Chloride	[nickel chloride co-treated with Cadmium Chloride] results in decreased expression of RRM2 mRNA	19187980
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RRM2 mRNA	26314618
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of RRM2 mRNA	25016106
D019256	Cadmium Chloride	[lead chloride co-treated with Cadmium Chloride] results in increased expression of RRM2 mRNA	25016106
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of RRM2 mRNA	25993096
D002110	Caffeine	Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]	22403396
D002110	Caffeine	Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002166	Camptothecin	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002166	Camptothecin	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]	22403396
D002166	Camptothecin	7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002166	Camptothecin	Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]	22403396
D002166	Camptothecin	Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002166	Camptothecin	Camptothecin results in increased expression of RRM2 mRNA	22403396
D002166	Camptothecin	Camptothecin results in increased expression of RRM2 protein	22403396
D002166	Camptothecin	E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]	22403396
D002220	Carbamazepine	Carbamazepine affects the expression of RRM2 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of RRM2 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of RRM2 mRNA	27339419
D002509	Cephaloridine	Cephaloridine results in decreased expression of RRM2 mRNA	18500788
D002746	Chlorpromazine	Chlorpromazine affects the expression of RRM2 mRNA	25064622
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of RRM2 mRNA	28472532
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA	27858113
C011585	ciclopirox	ciclopirox results in decreased activity of RRM2 protein	19589922
D002922	Ciguatoxins	Ciguatoxins affects the expression of RRM2 mRNA	18353800
D003033	Coal Tar	Coal Tar results in decreased expression of RRM2 mRNA	27858113
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA	23052192
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of RRM2 mRNA	19320972\|1937684
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA	20971185
D003300	Copper	Copper results in increased expression of RRM2 mRNA	22465980
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM2 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of RRM2 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of RRM2 mRNA	19167446
C030973	cupric oxide	cupric oxide results in decreased expression of RRM2 mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of RRM2 mRNA	26577399
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D003520	Cyclophosphamide	RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D016572	Cyclosporine	Cyclosporine affects the expression of RRM2 mRNA	25064622
D016572	Cyclosporine	Cyclosporine affects the expression of RRM2 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in decreased expression of RRM2 mRNA	19159671\|2010694
D016572	Cyclosporine	Cyclosporine results in decreased expression of RRM2 mRNA	17942131\|1977048
C093628	cyproconazole	cyproconazole affects the expression of RRM2 mRNA	21621602
D003561	Cytarabine	Cytarabine results in increased expression of RRM2 mRNA	19194470
D000069439	Dasatinib	Dasatinib results in decreased expression of RRM2 mRNA	20579391
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of RRM2 mRNA	23640034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of RRM2 mRNA	23914054
D013759	Dronabinol	Dronabinol results in decreased expression of RRM2 mRNA	18454173
D003703	Demecolcine	Demecolcine results in decreased expression of RRM2 mRNA	23649840
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RRM2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of RRM2 mRNA	22733784
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of RRM2 mRNA	10722888
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RRM2 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RRM2 mRNA	21266533
D002945	Cisplatin	BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]]	21875941
D002945	Cisplatin	BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]	21875941
D002945	Cisplatin	BRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]]	21875941
D002945	Cisplatin	Cisplatin results in increased expression of RRM2 mRNA	27594783
D002945	Cisplatin	ERCC1 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]	21875941
D002945	Cisplatin	ERCC1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]]	21875941
D002945	Cisplatin	ERCC5 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]	21875941
D002945	Cisplatin	RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of CHEK1 protein]]	21875941
D002945	Cisplatin	RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]	21875941
D002945	Cisplatin	RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]	21875941
D002945	Cisplatin	XPA mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]	21875941
D002945	Cisplatin	Cisplatin results in decreased expression of RRM2 mRNA	22023808
D004026	Dieldrin	Dieldrin results in increased expression of RRM2 mRNA	23041725
D004041	Dietary Fats	Dietary Fats results in increased expression of RRM2 mRNA	18042831
C014476	diethyl maleate	diethyl maleate results in increased expression of RRM2 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RRM2 mRNA	17854601
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of RRM2 mRNA	19638242
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA	22129741
D002117	Calcitriol	Calcitriol results in decreased expression of RRM2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA	21592394
D004317	Doxorubicin	Doxorubicin affects the expression of RRM2 mRNA	15205334
D004317	Doxorubicin	RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of RRM2 mRNA"	23262642
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of RRM2 mRNA	24412560
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of RRM2 mRNA	24412560
D004967	Estrogens	Estrogens inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D004967	Estrogens	Estrogens results in increased expression of RRM2 mRNA	22403396
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of RRM2 mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of RRM2 mRNA	17351261
C034096	ethoxyacetic acid	ethoxyacetic acid affects the expression of RRM2 mRNA	21621602
D018120	Finasteride	Finasteride results in increased expression of RRM2 mRNA	24136188
D005472	Fluorouracil	Fluorouracil affects the expression of RRM2 mRNA	15205334\|1658454
D005472	Fluorouracil	Fluorouracil results in decreased expression of RRM2 mRNA	16557594\|1703926
D005472	Fluorouracil	Fluorouracil results in increased expression of RRM2 mRNA	16709241
D005472	Fluorouracil	RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
D005472	Fluorouracil	RRM2 protein affects the susceptibility to Fluorouracil	15548681
C061365	flusilazole	flusilazole affects the expression of RRM2 mRNA	21621602
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA	24657277
C039281	furan	furan results in increased expression of RRM2 mRNA	25539665
C106014	gedunin	gedunin results in decreased expression of RRM2 mRNA	17010675
C056507	gemcitabine	[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein	25189999
C056507	gemcitabine	RRM2 protein affects the susceptibility to gemcitabine	26894857
C056507	gemcitabine	RRM2 protein results in decreased susceptibility to gemcitabine	14661056
D019833	Genistein	Genistein results in decreased expression of RRM2 mRNA	22228119
D019833	Genistein	Genistein results in increased expression of RRM2 mRNA	16474171\|2088496
D017313	Fenretinide	Fenretinide results in increased expression of RRM2 mRNA	28973697
D006835	Hydrazones	Hydrazones results in decreased expression of RRM2 protein	28716444
D006918	Hydroxyurea	Hydroxyurea results in decreased activity of RRM2 protein	22403396
C492448	ICG 001	ICG 001 results in decreased expression of RRM2 mRNA	26191083
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA	22129741
D007213	Indomethacin	Indomethacin results in increased expression of RRM2 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2 mRNA	25613284
D007501	Iron	[Iron co-treated with Oxygen] binds to RRM2 protein	16829694
C544151	jinfukang	jinfukang results in increased expression of RRM2 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of RRM2 mRNA	24086573
D007649	Ketamine	Ketamine results in decreased expression of RRM2 mRNA	20080153
D007840	Latex	Latex analog results in increased expression of RRM2 mRNA	24768652
C029891	lead chloride	[lead chloride co-treated with Cadmium Chloride] results in increased expression of RRM2 mRNA	25016106
C029891	lead chloride	lead chloride results in increased expression of RRM2 mRNA	25016106
C045463	leflunomide	leflunomide results in decreased expression of RRM2 mRNA	28988120
C045463	leflunomide	leflunomide results in decreased expression of RRM2 mRNA	24136188
D064704	Levofloxacin	Levofloxacin results in decreased expression of RRM2 mRNA	24136188
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of RRM2 mRNA	28070326
D008070	Lipopolysaccharides	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of RRM2 mRNA]	28070326
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of RRM2 mRNA	25613284
D008154	Lucanthone	Lucanthone results in decreased expression of RRM2 mRNA	21148553
C015329	lycopene	lycopene results in increased expression of RRM2 mRNA	16886892
D008694	Methamphetamine	Methamphetamine results in decreased expression of RRM2 mRNA	25290377
D008694	Methamphetamine	Methamphetamine results in decreased expression of RRM2 mRNA	28341135
D008694	Methamphetamine	Methamphetamine results in decreased expression of RRM2 protein	28341135
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA	24657277
D008727	Methotrexate	Methotrexate results in decreased expression of RRM2 mRNA	24657277
D008727	Methotrexate	Methotrexate affects the expression of RRM2 mRNA	18502557
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of RRM2 mRNA	21621602
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of RRM2 mRNA	20713471
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RRM2 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RRM2 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA	24810058
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA	17475336
C008493	methylselenic acid	methylselenic acid affects the expression of RRM2 mRNA	14617803
D015735	Mifepristone	7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]	22403396
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of RRM2 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of RRM2 mRNA	25102026
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of RRM2 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of RRM2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of RRM2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of RRM2 mRNA"	25620056
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of RRM2 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of RRM2 mRNA	24136188
D009532	Nickel	Nickel results in increased expression of RRM2 mRNA	25583101
C022838	nickel chloride	[nickel chloride co-treated with Cadmium Chloride] results in decreased expression of RRM2 mRNA	19187980
C012655	nimesulide	nimesulide results in decreased expression of RRM2 mRNA	24136188
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA	22561872
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA	20971185
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of RRM2 mRNA"	18204070
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of RRM2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of RRM2 mRNA	26516004
D010100	Oxygen	[Iron co-treated with Oxygen] binds to RRM2 protein	16829694
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RRM2 mRNA	25658374
D010126	Ozone	Ozone results in decreased expression of RRM2 mRNA	24336422
D010126	Ozone	Ozone results in increased expression of RRM2 mRNA	19555225
D017239	Paclitaxel	RRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]	16896004
C500026	palbociclib	palbociclib results in decreased expression of RRM2 mRNA	22869556
D000073878	Palm Oil	Palm Oil results in increased expression of RRM2 mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of RRM2 mRNA	25064622
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"	25510870
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of RRM2 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of RRM2 mRNA	17560707\|1916217
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of RRM2 mRNA	23978341
D010634	Phenobarbital	Phenobarbital affects the expression of RRM2 mRNA	19159669
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of RRM2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of RRM2 mRNA	19482888\|2040396
C415326	phenoxyacetic acid	phenoxyacetic acid affects the expression of RRM2 mRNA	21621602
D048789	Phytoestrogens	Phytoestrogens results in increased expression of RRM2 mRNA	18310284
C049032	pinosylvin	pinosylvin results in decreased expression of RRM2 mRNA	23333577
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of RRM2 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in increased expression of RRM2 mRNA	18301758\|1844570
D010894	Piroxicam	Piroxicam results in decreased expression of RRM2 mRNA	21858171
D010936	Plant Extracts	Plant Extracts affects the reaction [Lipopolysaccharides affects the expression of RRM2 mRNA]	28070326
D010936	Plant Extracts	Plant Extracts results in increased expression of RRM2 mRNA	23262642
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of RRM2 mRNA	16474171
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of RRM2 mRNA	22579512
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of RRM2 protein	23718831
D011374	Progesterone	Progesterone results in decreased expression of RRM2 mRNA	23012394\|2301818
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of RRM2 mRNA	21795739
D011374	Progesterone	Progesterone results in increased expression of RRM2 mRNA	18070364
D011374	Progesterone	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
D011374	Progesterone	5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]	22403396
D011374	Progesterone	[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased activity of MYC protein] inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
D011374	Progesterone	7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]	22403396
D011374	Progesterone	Cycloheximide inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	Estrogens inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]	22403396
D011374	Progesterone	MYC protein promotes the reaction [Progesterone results in increased expression of RRM2 mRNA]	22403396
D011374	Progesterone	Progesterone results in increased expression of RRM2 mRNA	22403396
D011374	Progesterone	Progesterone results in increased expression of RRM2 protein	22403396
C045950	propiconazole	propiconazole results in increased expression of RRM2 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in decreased expression of RRM2 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of RRM2 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of RRM2 mRNA	21632981
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of RRM2 mRNA	19167446
C059514	resveratrol	resveratrol results in decreased expression of RRM2 mRNA	15767336
D012402	Rotenone	Rotenone results in decreased expression of RRM2 mRNA	19304788
D012402	Rotenone	Rotenone results in increased expression of RRM2 mRNA	19013527
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RRM2 mRNA	21427059
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of RRM2 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of RRM2 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of RRM2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of RRM2 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of RRM2 mRNA	22431001
C017947	sodium arsenite	sodium arsenite results in decreased expression of RRM2 mRNA	20371982
C016104	sodium bichromate	sodium bichromate results in increased expression of RRM2 mRNA	24612858
C016104	sodium bichromate	sodium bichromate results in increased expression of RRM2 mRNA	22155349
C016104	sodium bichromate	sodium bichromate affects the expression of RRM2 mRNA	22110744
D012999	Soman	Soman results in increased expression of RRM2 mRNA	19281266
D053260	Soot	Soot results in increased expression of RRM2 mRNA	26551751
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of RRM2 mRNA	12734198
C061133	tamibarotene	tamibarotene affects the expression of RRM2 mRNA	15498508
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of RRM2 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA	16714409
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RRM2 mRNA	22574217
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA	21802500
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RRM2 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA	19770486\|2527062
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of RRM2 mRNA	15667827\|1946511
D013752	Tetracycline	Tetracycline affects the expression of RRM2 mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2 mRNA	25613284
D013792	Thalidomide	[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA	18720364
D019284	Thapsigargin	Thapsigargin results in decreased expression of RRM2 mRNA	22378314
D013853	Thioacetamide	Thioacetamide affects the expression of RRM2 mRNA	25064622
D013853	Thioacetamide	Thioacetamide results in increased expression of RRM2 mRNA	23411599
C009495	titanium dioxide	titanium dioxide affects the expression of RRM2 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in increased expression of RRM2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of RRM2 mRNA	20133372
D024505	Tocopherols	Tocopherols results in increased expression of RRM2 mRNA	17056531
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of RRM2 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of RRM2 mRNA"	19682533
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of RRM2 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in decreased expression of RRM2 mRNA	15498508
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of RRM2 mRNA	19042947
C050414	tripterine	tripterine results in decreased expression of RRM2 mRNA	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RRM2 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of RRM2 mRNA	19140230
C080163	trovafloxacin	trovafloxacin results in decreased expression of RRM2 mRNA	24136188
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA	23052192
D014415	Tunicamycin	Tunicamycin results in decreased expression of RRM2 mRNA	22378314
C406224	valdecoxib	valdecoxib results in decreased expression of RRM2 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of RRM2 mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of RRM2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of RRM2 mRNA	19101580
D014635	Valproic Acid	Valproic Acid results in increased methylation of RRM2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of RRM2 mRNA	21427059
D014747	Vinblastine	RRM2 protein affects the susceptibility to Vinblastine	16217747
D014750	Vincristine	Vincristine results in decreased expression of RRM2 mRNA	23649840
C029297	vinylidene chloride	vinylidene chloride results in increased expression of RRM2 mRNA	26682919
D015032	Zinc	Zinc results in decreased expression of RRM2 mRNA	20932299
C088658	zoledronic acid	zoledronic acid results in decreased expression of RRM2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	-	IBA	21873635
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	-	ISS	-
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	-	NAS	1627826
GO:0005515	protein binding	-	IPI	17726094 21336276 22632967
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	-
GO:0006260	DNA replication	-	IEA	-
GO:0009263	deoxyribonucleotide biosynthetic process	-	IBA	21873635
GO:0009263	deoxyribonucleotide biosynthetic process	-	ISS	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa00240	Pyrimidine metabolism
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways
hsa04115	p53 signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-15869	Metabolism of nucleotides	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-499943	Interconversion of nucleotide di- and triphosphates	TAS
R-HSA-539107	Activation of E2F1 target genes at G1/S	TAS
R-HSA-69205	G1/S-Specific Transcription	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953750	Transcriptional Regulation by E2F6	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26614807	Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)	Martin F	Hum Exp Toxicol
26001082	Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. (2015)	Mah V	PLoS One