Gene: RRM2

6241
R2|RR2|RR2M
ribonucleotide reductase regulatory subunit M2
protein-coding
2p25.1
Ensembl:ENSG00000171848 MIM:180390 Vega:OTTHUMG00000090449 UniprotKB:P31350
NC_000002.12
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.411e-1 (AD)  8.710e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24419094chr2:10266986RRM2Gene body8.397e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MKI670.832
KIF20A0.793
TROAP0.761
TOP2A0.754
CEP550.729
AURKB0.719
MYBL20.716
DLGAP50.711
HJURP0.7
CCNB20.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WIF1-0.304
ARSF-0.271
SLC13A5-0.256
PRSS56-0.252
MESP2-0.245
ABCD2-0.243
MOGAT3-0.24
CHRDL2-0.233
ENDOU-0.223
GPT-0.212

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTarget
DB05003ImexonSmall Molecule59643-91-3InvestigationalTarget
DB05260Gallium nitrateSmall Molecule13494-90-1Approved|InvestigationalTarget
DB05428motexafin gadoliniumSmall Molecule-InvestigationalTarget
DB05801GTI 2040Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of RRM2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RRM2 mRNA"28903501
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of RRM2 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of RRM2 mRNA"19095052
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM2 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RRM2 mRNA"20713471
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RRM2 mRNA"20816883
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
C0747613,4,5-trihydroxybenzamidoxime"3,4,5-trihydroxybenzamidoxime results in decreased activity of RRM2 protein"22403396
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RRM2 mRNA"18648102
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]22403396
C5248145-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased activity of MYC protein] inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
C0548527-hydroxystaurosporine5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]22403396
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]22403396
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
C0548527-hydroxystaurosporine7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]22403396
D000082AcetaminophenAcetaminophen affects the expression of RRM2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of RRM2 mRNA29067470
D000082AcetaminophenAcetaminophen results in decreased expression of RRM2 mRNA17942131
D000082AcetaminophenAcetaminophen results in increased expression of RRM2 mRNA24126418
D020106AcrylamideAcrylamide results in increased expression of RRM2 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of RRM2 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RRM2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RRM2 mRNA19770486
C412373AG 1879AG 1879 results in decreased expression of RRM2 mRNA15073106
C412373AG 1879AG 1879 results in decreased expression of RRM2 protein15073106
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of RRM2 mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of RRM2 mRNA25064622
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RRM2 mRNA"22863853
D000968Antimycin AAntimycin A results in decreased expression of RRM2 mRNA19304788
C006632arsenic trioxidearsenic trioxide results in decreased expression of RRM2 mRNA26705709
C006632arsenic trioxidearsenic trioxide results in decreased expression of RRM2 protein25419056
D001374Azacitidine[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA18720364
D001379AzathioprineAzathioprine results in decreased expression of RRM2 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of RRM2 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of RRM2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RRM2 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RRM2 mRNA17942131|1977048
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRM2 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRM2 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of RRM2 mRNA25566086
D004958EstradiolEstradiol results in decreased expression of RRM2 mRNA20106945
D004958EstradiolEstradiol results in increased expression of RRM2 mRNA16474171|1831028
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA17404688
D004958EstradiolEstradiol affects the expression of RRM2 mRNA15598610
D001622BetaineBetaine results in decreased expression of RRM2 mRNA26391144
C053541bicalutamidebicalutamide results in decreased expression of RRM2 mRNA15638997
C006780bisphenol Abisphenol A results in decreased expression of RRM2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of RRM2 mRNA16474171
C006780bisphenol Abisphenol A results in decreased expression of RRM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RRM2 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of RRM2 mRNA17942131
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of RRM2 protein22174045
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RRM2 mRNA22079614
D002065BuspironeBuspirone results in decreased expression of RRM2 mRNA24136188
C584509C646 compoundC646 compound results in decreased expression of RRM2 mRNA26191083
D002104CadmiumCadmium results in decreased expression of RRM2 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RRM2 mRNA17961207
D019256Cadmium Chloride[nickel chloride co-treated with Cadmium Chloride] results in decreased expression of RRM2 mRNA19187980
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RRM2 mRNA26314618
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RRM2 mRNA25016106
D019256Cadmium Chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of RRM2 mRNA25016106
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RRM2 mRNA25993096
D002110CaffeineCaffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]22403396
D002110CaffeineCaffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
D002166Camptothecin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
D002166Camptothecin7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]22403396
D002166Camptothecin7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
D002166CamptothecinCaffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]22403396
D002166CamptothecinCaffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
D002166CamptothecinCamptothecin results in increased expression of RRM2 mRNA22403396
D002166CamptothecinCamptothecin results in increased expression of RRM2 protein22403396
D002166CamptothecinE2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]22403396
D002220CarbamazepineCarbamazepine affects the expression of RRM2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RRM2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RRM2 mRNA27339419
D002509CephaloridineCephaloridine results in decreased expression of RRM2 mRNA18500788
D002746ChlorpromazineChlorpromazine affects the expression of RRM2 mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RRM2 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of RRM2 mRNA27858113
C011585ciclopiroxciclopirox results in decreased activity of RRM2 protein19589922
D002922CiguatoxinsCiguatoxins affects the expression of RRM2 mRNA18353800
D003033Coal TarCoal Tar results in decreased expression of RRM2 mRNA27858113
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA23052192
C018021cobaltous chloridecobaltous chloride results in decreased expression of RRM2 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA20971185
D003300CopperCopper results in increased expression of RRM2 mRNA22465980
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RRM2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RRM2 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RRM2 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of RRM2 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of RRM2 mRNA26577399
D003513CycloheximideCycloheximide inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D003520CyclophosphamideRRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D016572CyclosporineCyclosporine affects the expression of RRM2 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of RRM2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of RRM2 mRNA19159671|2010694
D016572CyclosporineCyclosporine results in decreased expression of RRM2 mRNA17942131|1977048
C093628cyproconazolecyproconazole affects the expression of RRM2 mRNA21621602
D003561CytarabineCytarabine results in increased expression of RRM2 mRNA19194470
D000069439DasatinibDasatinib results in decreased expression of RRM2 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of RRM2 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RRM2 mRNA23914054
D013759DronabinolDronabinol results in decreased expression of RRM2 mRNA18454173
D003703DemecolcineDemecolcine results in decreased expression of RRM2 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RRM2 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of RRM2 mRNA22733784
C020735dibutyldichlorotindibutyldichlorotin results in increased expression of RRM2 mRNA10722888
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RRM2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RRM2 mRNA21266533
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased activity of and results in increased phosphorylation of CHEK1 protein]]]21875941
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]]21875941
D002945CisplatinCisplatin results in increased expression of RRM2 mRNA27594783
D002945CisplatinERCC1 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinERCC1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]]21875941
D002945CisplatinERCC5 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinRRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of CHEK1 protein]]21875941
D002945CisplatinRRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]21875941
D002945CisplatinRRM2 mutant form promotes the reaction [TP53 mutant form results in increased susceptibility to Cisplatin]21875941
D002945CisplatinXPA mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinCisplatin results in decreased expression of RRM2 mRNA22023808
D004026DieldrinDieldrin results in increased expression of RRM2 mRNA23041725
D004041Dietary FatsDietary Fats results in increased expression of RRM2 mRNA18042831
C014476diethyl maleatediethyl maleate results in increased expression of RRM2 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RRM2 mRNA17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RRM2 mRNA19638242
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of RRM2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA21592394
D004317DoxorubicinDoxorubicin affects the expression of RRM2 mRNA15205334
D004317DoxorubicinRRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of RRM2 mRNA"23262642
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of RRM2 mRNA24412560
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of RRM2 mRNA24412560
D004967EstrogensEstrogens inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D004967EstrogensEstrogens results in increased expression of RRM2 mRNA22403396
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RRM2 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RRM2 mRNA17351261
C034096ethoxyacetic acidethoxyacetic acid affects the expression of RRM2 mRNA21621602
D018120FinasterideFinasteride results in increased expression of RRM2 mRNA24136188
D005472FluorouracilFluorouracil affects the expression of RRM2 mRNA15205334|1658454
D005472FluorouracilFluorouracil results in decreased expression of RRM2 mRNA16557594|1703926
D005472FluorouracilFluorouracil results in increased expression of RRM2 mRNA16709241
D005472FluorouracilRRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D005472FluorouracilRRM2 protein affects the susceptibility to Fluorouracil15548681
C061365flusilazoleflusilazole affects the expression of RRM2 mRNA21621602
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA24657277
C039281furanfuran results in increased expression of RRM2 mRNA25539665
C106014geduningedunin results in decreased expression of RRM2 mRNA17010675
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein25189999
C056507gemcitabineRRM2 protein affects the susceptibility to gemcitabine26894857
C056507gemcitabineRRM2 protein results in decreased susceptibility to gemcitabine14661056
D019833GenisteinGenistein results in decreased expression of RRM2 mRNA22228119
D019833GenisteinGenistein results in increased expression of RRM2 mRNA16474171|2088496
D017313FenretinideFenretinide results in increased expression of RRM2 mRNA28973697
D006835HydrazonesHydrazones results in decreased expression of RRM2 protein28716444
D006918HydroxyureaHydroxyurea results in decreased activity of RRM2 protein22403396
C492448ICG 001ICG 001 results in decreased expression of RRM2 mRNA26191083
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RRM2 mRNA22129741
D007213IndomethacinIndomethacin results in increased expression of RRM2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2 mRNA25613284
D007501Iron[Iron co-treated with Oxygen] binds to RRM2 protein16829694
C544151jinfukangjinfukang results in increased expression of RRM2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of RRM2 mRNA24086573
D007649KetamineKetamine results in decreased expression of RRM2 mRNA20080153
D007840LatexLatex analog results in increased expression of RRM2 mRNA24768652
C029891lead chloride[lead chloride co-treated with Cadmium Chloride] results in increased expression of RRM2 mRNA25016106
C029891lead chloridelead chloride results in increased expression of RRM2 mRNA25016106
C045463leflunomideleflunomide results in decreased expression of RRM2 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of RRM2 mRNA24136188
D064704LevofloxacinLevofloxacin results in decreased expression of RRM2 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides affects the expression of RRM2 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of RRM2 mRNA]28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RRM2 mRNA25613284
D008154LucanthoneLucanthone results in decreased expression of RRM2 mRNA21148553
C015329lycopenelycopene results in increased expression of RRM2 mRNA16886892
D008694MethamphetamineMethamphetamine results in decreased expression of RRM2 mRNA25290377
D008694MethamphetamineMethamphetamine results in decreased expression of RRM2 mRNA28341135
D008694MethamphetamineMethamphetamine results in decreased expression of RRM2 protein28341135
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of RRM2 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of RRM2 mRNA24657277
D008727MethotrexateMethotrexate affects the expression of RRM2 mRNA18502557
C013598methoxyacetic acidmethoxyacetic acid affects the expression of RRM2 mRNA21621602
D008748MethylcholanthreneMethylcholanthrene results in increased expression of RRM2 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RRM2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RRM2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of RRM2 mRNA17475336
C008493methylselenic acidmethylselenic acid affects the expression of RRM2 mRNA14617803
D015735Mifepristone7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]22403396
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
C517284monomethyl phthalatemonomethyl phthalate affects the expression of RRM2 mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of RRM2 mRNA25102026
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of RRM2 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of RRM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RRM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RRM2 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of RRM2 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of RRM2 mRNA24136188
D009532NickelNickel results in increased expression of RRM2 mRNA25583101
C022838nickel chloride[nickel chloride co-treated with Cadmium Chloride] results in decreased expression of RRM2 mRNA19187980
C012655nimesulidenimesulide results in decreased expression of RRM2 mRNA24136188
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA22561872
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RRM2 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in decreased expression of RRM2 mRNA"18204070
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RRM2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of RRM2 mRNA26516004
D010100Oxygen[Iron co-treated with Oxygen] binds to RRM2 protein16829694
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of RRM2 mRNA25658374
D010126OzoneOzone results in decreased expression of RRM2 mRNA24336422
D010126OzoneOzone results in increased expression of RRM2 mRNA19555225
D017239PaclitaxelRRM2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C500026palbociclibpalbociclib results in decreased expression of RRM2 mRNA22869556
D000073878Palm OilPalm Oil results in increased expression of RRM2 mRNA18042831
D010269ParaquatParaquat affects the expression of RRM2 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RRM2 mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of RRM2 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of RRM2 mRNA17560707|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RRM2 mRNA23978341
D010634PhenobarbitalPhenobarbital affects the expression of RRM2 mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of RRM2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of RRM2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of RRM2 mRNA19482888|2040396
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of RRM2 mRNA21621602
D048789PhytoestrogensPhytoestrogens results in increased expression of RRM2 mRNA18310284
C049032pinosylvinpinosylvin results in decreased expression of RRM2 mRNA23333577
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of RRM2 mRNA22484513
C006253pirinixic acidpirinixic acid results in increased expression of RRM2 mRNA18301758|1844570
D010894PiroxicamPiroxicam results in decreased expression of RRM2 mRNA21858171
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of RRM2 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of RRM2 mRNA23262642
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of RRM2 mRNA16474171
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of RRM2 mRNA22579512
D011192Potassium DichromatePotassium Dichromate results in increased expression of RRM2 protein23718831
D011374ProgesteroneProgesterone results in decreased expression of RRM2 mRNA23012394|2301818
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of RRM2 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of RRM2 mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of RRM2 mRNA18070364
D011374Progesterone2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374Progesterone5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374Progesterone5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
D011374Progesterone5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one promotes the reaction [7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]]22403396
D011374Progesterone[5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one results in decreased activity of MYC protein] inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374Progesterone7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374Progesterone7-hydroxystaurosporine inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
D011374Progesterone7-hydroxystaurosporine promotes the reaction [Mifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]]22403396
D011374ProgesteroneCycloheximide inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374ProgesteroneEstrogens inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of RRM2 protein]22403396
D011374ProgesteroneMYC protein promotes the reaction [Progesterone results in increased expression of RRM2 mRNA]22403396
D011374ProgesteroneProgesterone results in increased expression of RRM2 mRNA22403396
D011374ProgesteroneProgesterone results in increased expression of RRM2 protein22403396
C045950propiconazolepropiconazole results in increased expression of RRM2 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of RRM2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of RRM2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of RRM2 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RRM2 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of RRM2 mRNA15767336
D012402RotenoneRotenone results in decreased expression of RRM2 mRNA19304788
D012402RotenoneRotenone results in increased expression of RRM2 mRNA19013527
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RRM2 mRNA21427059
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of RRM2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RRM2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RRM2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RRM2 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of RRM2 mRNA22431001
C017947sodium arsenitesodium arsenite results in decreased expression of RRM2 mRNA20371982
C016104sodium bichromatesodium bichromate results in increased expression of RRM2 mRNA24612858
C016104sodium bichromatesodium bichromate results in increased expression of RRM2 mRNA22155349
C016104sodium bichromatesodium bichromate affects the expression of RRM2 mRNA22110744
D012999SomanSoman results in increased expression of RRM2 mRNA19281266
D053260SootSoot results in increased expression of RRM2 mRNA26551751
C025462sulindac sulfidesulindac sulfide results in decreased expression of RRM2 mRNA12734198
C061133tamibarotenetamibarotene affects the expression of RRM2 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RRM2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RRM2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRM2 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RRM2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRM2 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNA19770486|2527062
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RRM2 mRNA15667827|1946511
D013752TetracyclineTetracycline affects the expression of RRM2 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRM2 mRNA25613284
D013792Thalidomide[Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA18720364
D019284ThapsigarginThapsigargin results in decreased expression of RRM2 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of RRM2 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of RRM2 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of RRM2 mRNA17656681
C009495titanium dioxidetitanium dioxide results in increased expression of RRM2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of RRM2 mRNA20133372
D024505TocopherolsTocopherols results in increased expression of RRM2 mRNA17056531
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RRM2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RRM2 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of RRM2 mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of RRM2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of RRM2 mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RRM2 mRNA19042947
C050414tripterinetripterine results in decreased expression of RRM2 mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RRM2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RRM2 mRNA19140230
C080163trovafloxacintrovafloxacin results in decreased expression of RRM2 mRNA24136188
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of RRM2 mRNA23052192
D014415TunicamycinTunicamycin results in decreased expression of RRM2 mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of RRM2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of RRM2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of RRM2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RRM2 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of RRM2 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of RRM2 mRNA21427059
D014747VinblastineRRM2 protein affects the susceptibility to Vinblastine16217747
D014750VincristineVincristine results in decreased expression of RRM2 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of RRM2 mRNA26682919
D015032ZincZinc results in decreased expression of RRM2 mRNA20932299
C088658zoledronic acidzoledronic acid results in decreased expression of RRM2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-IBA21873635  
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-ISS-  
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor-NAS1627826  
GO:0005515protein binding-IPI17726094  21336276  22632967  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0006260DNA replication-IEA-  
GO:0009263deoxyribonucleotide biosynthetic process-IBA21873635  
GO:0009263deoxyribonucleotide biosynthetic process-ISS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00240Pyrimidine metabolism
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-499943Interconversion of nucleotide di- and triphosphatesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953750Transcriptional Regulation by E2F6TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol
26001082Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. (2015)Mah VPLoS One