Gene: CLIP1

6249
CLIP|CLIP-170|CLIP170|CYLN1|RSN
CAP-Gly domain containing linker protein 1
protein-coding
12q24.31
Ensembl:ENSG00000130779 MIM:179838 Vega:OTTHUMG00000168922 UniprotKB:P30622
NG_030352.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.203e-1 (AD)  1.108e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TOP10.926
C18orf250.923
RNF40.922
FAF20.912
ZNF2070.91
SEC31A0.909
CLINT10.909
KPNB10.907
TMED20.905
ELAVL10.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.645
OR4F29-0.61
CTNNA3-0.254
TNFRSF13B-0.251
SH2D1A-0.249
C5orf64-0.247
MS4A1-0.236
FXYD4-0.23
SPRR2D-0.229
RERGL-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CLIP1 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLIP1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLIP1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CLIP1 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CLIP1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CLIP1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CLIP1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CLIP1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of CLIP1 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of CLIP1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLIP1 mRNA19770486
C547126AZM551248AZM551248 results in decreased expression of CLIP1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLIP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CLIP1 mRNA"19150397
D001663BilirubinBilirubin results in decreased expression of CLIP1 mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of CLIP1 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CLIP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CLIP1 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of CLIP1 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of CLIP1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLIP1 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of CLIP1 mRNA18353800
D003010ClorgylineClorgyline results in increased expression of CLIP1 mRNA19691856
C018021cobaltous chloridecobaltous chloride results in increased expression of CLIP1 mRNA24386269
D003042CocaineCocaine results in increased expression of CLIP1 mRNA18000554
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CLIP1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CLIP1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CLIP1 mRNA"19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of CLIP1 mRNA27281708
D016572CyclosporineCyclosporine results in increased expression of CLIP1 mRNA20106945|2556210
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CLIP1 mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CLIP1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of CLIP1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CLIP1 mRNA19030233|1946730
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of CLIP1 mRNA21852083
C024629dimethyl phthalatedimethyl phthalate affects the expression of CLIP1 mRNA26924002
D004237DiuronDiuron results in decreased expression of CLIP1 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of CLIP1 mRNA16404146
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of CLIP1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of CLIP1 mRNA21233418
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLIP1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of CLIP1 mRNA24136188
C082360fipronilfipronil results in increased expression of CLIP1 mRNA23962444
D005485FlutamideFlutamide results in increased expression of CLIP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLIP1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CLIP1 mRNA20655997
C001277geldanamycingeldanamycin results in increased expression of CLIP1 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of CLIP1 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of CLIP1 mRNA22634610
D007545IsoproterenolIsoproterenol results in increased expression of CLIP1 mRNA20003209
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CLIP1 mRNA16835149
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CLIP1 mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of CLIP1 mRNA26307267
D008694MethamphetamineMethamphetamine results in increased expression of CLIP1 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLIP1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLIP1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CLIP1 mRNA23179753|2800136
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the methylation of CLIP1 promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CLIP1 mRNA"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CLIP1 mRNA26924002
C051752nefazodonenefazodone results in increased expression of CLIP1 mRNA24136188
D009532NickelNickel results in decreased expression of CLIP1 mRNA19031421
C012655nimesulidenimesulide results in increased expression of CLIP1 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CLIP1 mRNA20971185
D000073878Palm OilPalm Oil results in decreased expression of CLIP1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of CLIP1 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of CLIP1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of CLIP1 mRNA23091169
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of CLIP1 mRNA21852083
D012834SilverSilver results in increased expression of CLIP1 mRNA26014281
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLIP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CLIP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CLIP1 mRNA22808131
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of CLIP1 protein20109541
D014212TretinoinSTAT1 protein promotes the reaction [Tretinoin results in increased expression of CLIP1 mRNA]16574066
D014212TretinoinTretinoin results in increased expression of CLIP1 mRNA16574066
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CLIP1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CLIP1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CLIP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CLIP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CLIP1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of CLIP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CLIP1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of CLIP1 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of CLIP1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of CLIP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11940666  16455083  17828275  19004523  20679239  21646404  
26506308  27173435  
GO:0008017microtubule binding-IDA17889670  
GO:0008270zinc ion binding-IDA17828275  
GO:0015631tubulin binding-IDA17889670  
GO:0042803protein homodimerization activity-TAS15928712  
GO:0046872metal ion binding-NAS15928712  
GO:0051010microtubule plus-end binding-IDA12433698  
GO ID GO Term Qualifier Evidence PubMed
GO:0000278mitotic cell cycle-TAS15928712  
GO:0001578microtubule bundle formation-IMP17889670  
GO:0031116positive regulation of microtubule polymerization-IMP15262990  17889670  
GO:0044861protein transport into plasma membrane raft-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-TAS15928712  
GO:0001726ruffle-IEA-  
GO:0005635nuclear envelope-IEA-  
GO:0005768endosome-TAS1356075  
GO:0005813centrosome-IDA21399614  
GO:0005829cytosol-TAS-  
GO:0005874microtubule-IMP19004523  
GO:0005874microtubule-ISS-  
GO:0005881cytoplasmic microtubule-IEA-  
GO:0005882intermediate filament-TAS1600942  
GO:0015630microtubule cytoskeleton-IMP17889670  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0035371microtubule plus-endcolocalizes_withIDA12433698  
GO:0044354macropinosomecolocalizes_withIDA12433698  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-141424Amplification of signal from the kinetochoresTAS
R-HSA-141444Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-5626467RHO GTPases activate IQGAPsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26683835Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study. (2015 Dec 18)Ahmad SBMC Med Genet