Gene: RXRB

6257
DAUDI6|H-2RIIBP|NR2B2|RCoR-1
retinoid X receptor beta
protein-coding
6p21.32
Ensembl:ENSG00000204231 MIM:180246 Vega:OTTHUMG00000031298 UniprotKB:P28702
NG_023374.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14362925chr6:33165707RXRB8.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MICU10.966
NDUFA100.958
WIPI20.958
CCAR20.958
ACTR1A0.957
IDH3B0.957
ZFYVE270.956
ATG9A0.955
DEF80.954
SCYL10.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.715
OR4F29-0.67
TFPI2-0.384
MTRNR2L6-0.349
MTRNR2L9-0.343
KLRB1-0.339
RAI14-0.335
C9orf153-0.33
KCNJ15-0.326
IL18RAP-0.323

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00210AdapaleneSmall Molecule106685-40-9ApprovedTarget
DB00307BexaroteneSmall Molecule153559-49-0Approved|InvestigationalTarget
DB00412RosiglitazoneSmall Molecule122320-73-4Approved|InvestigationalTarget
DB00459AcitretinSmall Molecule55079-83-9ApprovedTarget
DB00523AlitretinoinSmall Molecule5300-03-8Approved|InvestigationalTarget
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
DB00799TazaroteneSmall Molecule118292-40-3Approved|InvestigationalTarget
DB00926EtretinateSmall Molecule54350-48-0WithdrawnTarget
DB01393BezafibrateSmall Molecule41859-67-0Approved|InvestigationalTarget
DB019416-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidSmall MoleculeExperimentalTarget
DB02746Phthalic AcidSmall Molecule88-99-3ExperimentalTarget
DB03756DoconexentSmall Molecule6217-54-5Approved|InvestigationalTarget
DB07080N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDESmall MoleculeExperimentalTarget
DB07929N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDESmall MoleculeExperimentalTarget
DB08175(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of RXRB mRNA"19162173
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRB mRNA"26563996
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased expression of RXRB protein"26563996
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"RXRB mRNA promotes the reaction [2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene results in increased activity of CASP3 protein]"26563996
C0245642,4,6-trichlorophenol"2,4,6-trichlorophenol inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]"27565853
C0047622,4-dichlorophenol"2,4-dichlorophenol results in increased activity of RXRB protein"18207673
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RXRB mRNA"21346803
C0025852-hydroxyphytanic acid2-hydroxyphytanic acid binds to RXRB protein23843199
C0912382-isopropylphenol2-isopropylphenol results in increased activity of RXRB protein18207673
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RXRB mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RXRB mRNA]28655636
C0354062-tert-butylphenol2-tert-butylphenol results in increased activity of RXRB protein18207673
C0433743,4-dichlorophenol"3,4-dichlorophenol results in increased activity of RXRB protein"18207673
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RXRB mRNA12419474
C1052604-tert-octylphenol4-tert-octylphenol results in increased activity of RXRB protein18207673
C430898AGN 194204AGN 194204 binds to and results in increased activity of RXRB protein16178010
C103303alitretinoinalitretinoin binds to and results in increased activity of RXRB protein7565671
C103303alitretinoin"2,4,6-trichlorophenol inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]"27565853
C103303alitretinoinalitretinoin binds to and affects the activity of RXRB protein15941851
C103303alitretinoinalitretinoin binds to RXRB protein11939783
C103303alitretinoin[alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein22227104
C103303alitretinoinalitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]12898515
C103303alitretinoinalitretinoin results in increased activity of RXRB protein18207673
C103303alitretinoinalitretinoin results in increased degradation of RXRB protein12898515
C103303alitretinoinbisphenol A analog inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
C103303alitretinoinbisphenol A inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
C103303alitretinointetrachlorodian inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
C103303alitretinoinalitretinoin results in increased expression of RXRB protein16043492
C103303alitretinoinalitretinoin binds to RXRB protein16258897|9144408
C103303alitretinoinalitretinoin promotes the reaction [[RXRB protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]19686701
C103303alitretinoinalitretinoin results in increased activity of RXRB protein22227104
C103303alitretinoinLithocholic Acid inhibits the reaction [alitretinoin binds to RXRB protein]16258897
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RXRB mRNA24449571
D001151ArsenicArsenic affects the methylation of RXRB gene25304211
C095105bexarotenebexarotene binds to RXRB protein23843199
C095105bexarotenebexarotene binds to RXRB protein9144408
D001629BezafibrateBezafibrate binds to RXRB protein23843199
C053541bicalutamidebicalutamide results in decreased expression of RXRB11845989
C006780bisphenol Abisphenol A analog inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
C006780bisphenol Abisphenol A binds to RXRB protein23843199
C006780bisphenol Abisphenol A inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
C006780bisphenol Abisphenol A results in increased activity of RXRB protein18207673
C006780bisphenol Abisphenol A results in decreased expression of RXRB mRNA24534842
C006780bisphenol Abisphenol A results in increased methylation of RXRB gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RXRB mRNA22079614
C027561butylbenzyl phthalatebutylbenzyl phthalate binds to RXRB protein23843199
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RXRB mRNA12419474
C018475butyraldehydebutyraldehyde results in decreased expression of RXRB mRNA26079696
C584509C646 compoundC646 compound results in increased expression of RXRB mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of RXRB promoter22457795
D002211CapsaicinCapsaicin results in decreased expression of RXRB mRNA18769453
D002784Cholesterol[RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol14993927
D002994ClofibrateClofibrate results in decreased expression of RXRB mRNA17585979
D016572CyclosporineCyclosporine results in decreased expression of RXRB mRNA25270620
D003634DDTDDT analog results in increased activity of RXRB protein18207673
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of RXRB mRNA]21095227
C014347decitabinedecitabine results in increased expression of RXRB mRNA17908484
C438269diazepinylbenzoic aciddiazepinylbenzoic acid binds to and results in decreased activity of RXRB protein19095448
D003976DiazinonDiazinon results in increased methylation of RXRB gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate binds to RXRB protein23843199
D002945CisplatinRXRB protein affects the susceptibility to Cisplatin16217747
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of RXRB mRNA26563996
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of RXRB protein26563996
D003633Dichlorodiphenyl DichloroethyleneRXRB mRNA promotes the reaction [Dichlorodiphenyl Dichloroethylene results in increased activity of CASP3 protein]26563996
C027718didecyl phthalatedidecyl phthalate binds to RXRB protein23843199
D004041Dietary FatsDietary Fats results in decreased expression of RXRB mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of RXRB mRNA]19030233
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate binds to RXRB protein23843199
C007379diethyl phthalatediethyl phthalate binds to RXRB protein23843199
C089799diheptyl phthalatediheptyl phthalate binds to RXRB protein23843199
C042080diisodecyl phthalatediisodecyl phthalate binds to RXRB protein23843199
C012125diisononyl phthalatediisononyl phthalate binds to RXRB protein23843199
C024629dimethyl phthalatedimethyl phthalate binds to RXRB protein23843199
C027387di-n-hexyl phthalatedi-n-hexyl phthalate binds to RXRB protein23843199
C019174dinonylphthalatedinonylphthalate binds to RXRB protein23843199
C034171di-n-pentyl phthalatedi-n-pentyl phthalate binds to RXRB protein23843199
C106479di-n-propylphthalatedi-n-propylphthalate binds to RXRB protein23843199
D004281Docosahexaenoic AcidsDocosahexaenoic Acids binds to RXRB protein11939783
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RXRB protein23301498
D000431EthanolEthanol results in increased expression of RXRB mRNA11696672
C108339fludioxonilfludioxonil results in increased activity of RXRB protein20143881
C069837fullerene C60fullerene C60 results in increased expression of RXRB mRNA19167457
D006581HexachlorobenzeneHexachlorobenzene results in increased activity of RXRB protein18207673
D017313FenretinideFenretinide results in increased expression of RXRB mRNA16570282
C104181HX 600HX 600 binds to and results in increased activity of RXRB protein9144408
C422175HX 630HX 630 binds to RXRB protein9144408
C410337K 7174K 7174 results in increased expression of RXRB mRNA24086573
C045463leflunomideleflunomide results in decreased expression of RXRB mRNA28988120
D001556LindaneLindane results in increased activity of RXRB protein18207673
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RXRB mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased activity of RXRB protein12388159
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RXRB mRNA12388159|1684731
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RXRB protein12388159
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RXRB mRNA12057914
D008095Lithocholic AcidLithocholic Acid binds to RXRB protein11939783
D008095Lithocholic AcidLithocholic Acid inhibits the reaction [alitretinoin binds to RXRB protein]16258897
D008726MethopreneMethoprene binds to and results in increased activity of RXRB protein12970175
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate binds to RXRB protein23843199
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RXRB mRNA"25554681
C498045NCX 4040NCX 4040 results in decreased expression of RXRB mRNA20188076
C028007nickel monoxidenickel monoxide results in increased expression of RXRB mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of RXRB mRNA22714537
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of RXRB mRNA17725831
D010269ParaquatParaquat results in increased expression of RXRB mRNA18198484
D010278ParathionRXRB gene SNP affects the susceptibility to Parathion23833127
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RXRB mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of RXRB mRNA28655636
C046012pentanalpentanal results in decreased expression of RXRB mRNA26079696
C032279phthalic acidphthalic acid binds to RXRB protein23843199
D010831Phytanic AcidPhytanic Acid binds to RXRB protein11939783
C006253pirinixic acidpirinixic acid results in increased expression of RXRB mRNA22112501
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RXRB mRNA11678601
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of RXRB mRNA16497877
D015474IsotretinoinIsotretinoin results in decreased expression of RXRB mRNA19041696
D012176RetinoidsRetinoids analog binds to and results in increased activity of RXRB protein16364638
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of RXRB mRNA]19030233
C089730rosiglitazonerosiglitazone binds to RXRB protein23843199
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of RXRB mRNA]21095227
D013449SulfonamidesSulfonamides analog binds to and results in decreased activity of RXRB protein19095448
D013449SulfonamidesSulfonamides analog binds to and results in increased activity of RXRB protein19095448
D014284TriiodothyronineTriiodothyronine results in increased expression of RXRB mRNA15708448
C061133tamibarotenetamibarotene binds to RXRB protein9144408
C004648testosterone enanthatetestosterone enanthate affects the expression of RXRB mRNA17440010
C041181tetrachlorodiantetrachlorodian inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein]27565853
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RXRB mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RXRB mRNA17586704
D014212TretinoinTretinoin binds to RXRB protein15958702|2384319
D014212TretinoinTretinoin results in increased expression of and results in increased activity of RXRB protein16158052
D014212TretinoinTretinoin results in increased expression of RXRB mRNA20507312
D014212Tretinoin[Tretinoin binds to RXRB protein] which binds to COL11A2 enhancer15206905
D014212TretinoinTretinoin results in increased expression of RXRB mRNA16392701
D014212TretinoinIL1B protein promotes the reaction [Tretinoin affects the localization of RXRB protein]17078027
D014212TretinoinIL1B protein promotes the reaction [Tretinoin results in increased expression of RXRB protein]11171635
D014212TretinoinTretinoin affects the localization of RXRB protein17078027
D014212TretinoinTretinoin results in increased expression of RXRB mRNA15708448
D014212TretinoinTretinoin results in increased expression of RXRB protein11171635
D014212TretinoinTretinoin results in increased activity of RXRB protein18398471
C007567triphenyltin hydroxidetriphenyltin hydroxide binds to and affects the activity of RXRB protein15941851
D014520UrethaneUrethane results in increased expression of RXRB mRNA28818685
C525131UVI 3003UVI 3003 results in decreased expression of RXRB mRNA27894914
D014635Valproic AcidValproic Acid affects the expression of RXRB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RXRB mRNA23179753
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RXRB mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of RXRB mRNA28655636
D014800VitalliumVitallium analog results in increased expression of RXRB mRNA23825117
D014801Vitamin AVitamin A affects the expression of RXRB mRNA14529804
D002762CholecalciferolCholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]17008384
D015054ZymosanZymosan results in decreased expression of RXRB mRNA16847310

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA12767074  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA12767074  
GO:0003700DNA-binding transcription factor activity-NAS1662118  
GO:0003707steroid hormone receptor activity-IEA-  
GO:0003713transcription coactivator activity-TAS1662118  
GO:0004879nuclear receptor activity-IDA7990953  
GO:00048869-cis retinoic acid receptor activity-TAS1662118  
GO:0005515protein binding-IPI16189514  20195357  21988832  25303530  25416956  26871637  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12767074  
GO:0048384retinoic acid receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA7990953  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1368082RORA activates gene expressionTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-400253Circadian ClockTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11840500Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. (2002 Jan 8)Ishiguro HAm J Med Genet
20113835Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features. (2010 Feb)Lee SMCancer Genet Cytogenet