Gene: RXRG

6258
NR2B3|RXRC
retinoid X receptor gamma
protein-coding
1q23.3
Ensembl:ENSG00000143171 MIM:180247 Vega:OTTHUMG00000034626 UniprotKB:P48443
NG_029517.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.631e-1 (AD)  9.804e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNTA10.761
TNS30.759
STOX10.752
SLC25A330.741
SLC25A180.738
DIAPH30.732
CABLES10.729
MMP280.723
TMEM470.722
EYA20.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST2-0.488
DPP4-0.468
THEMIS-0.458
SMYD1-0.446
LRMP-0.427
NPFFR2-0.418
SH2D1B-0.418
RXFP1-0.416
OLFML2B-0.414
EMB-0.414

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00210AdapaleneSmall Molecule106685-40-9ApprovedTarget
DB00307BexaroteneSmall Molecule153559-49-0Approved|InvestigationalTarget
DB00412RosiglitazoneSmall Molecule122320-73-4Approved|InvestigationalTarget
DB00459AcitretinSmall Molecule55079-83-9ApprovedTarget
DB00523AlitretinoinSmall Molecule5300-03-8Approved|InvestigationalTarget
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
DB00926EtretinateSmall Molecule54350-48-0WithdrawnTarget
DB01393BezafibrateSmall Molecule41859-67-0Approved|InvestigationalTarget
DB02746Phthalic AcidSmall Molecule88-99-3ExperimentalTarget
DB03756DoconexentSmall Molecule6217-54-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]"19686701
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of RXRG mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RXRG mRNA"21346803
C0025852-hydroxyphytanic acid2-hydroxyphytanic acid binds to RXRG protein23843199
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of RXRG mRNA"18648102
C4762005-OH,11-O-hydrophenanthrene"5-OH,11-O-hydrophenanthrene results in increased expression of RXRG mRNA"12766334
C0313909-cis-retinal9-cis-retinal promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]19686701
D000082AcetaminophenAcetaminophen affects the expression of RXRG mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of RXRG mRNA28959563
C430898AGN 194204AGN 194204 binds to and results in increased activity of RXRG protein16178010
D000452AldrinAldrin results in increased expression of RXRG mRNA18579281
C103303alitretinoinalitretinoin binds to and results in increased activity of RXRG protein7565671
C103303alitretinoinalitretinoin binds to and affects the activity of RXRG protein15941851
C103303alitretinoinalitretinoin results in decreased expression of RXRG mRNA11139446
C103303alitretinoinalitretinoin affects the activity of RXRG protein9092800
C103303alitretinoinalitretinoin results in decreased expression of RXRG mRNA12114515|8892963
C103303alitretinoinalitretinoin results in increased expression of RXRG mRNA12114515
C103303alitretinoinalitretinoin binds to RXRG protein15270780
C103303alitretinoinalitretinoin binds to RXRG protein9144408
C103303alitretinoinalitretinoin promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]19686701
D000638AmiodaroneAmiodarone results in increased expression of RXRG mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RXRG mRNA16483693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RXRG mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RXRG mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RXRG mRNA21839799
C095105bexarotenebexarotene binds to RXRG protein23843199
C095105bexarotenebexarotene results in decreased expression of RXRG mRNA17849452
C095105bexarotenebexarotene binds to RXRG protein9144408
D001629BezafibrateBezafibrate binds to RXRG protein23843199
C006780bisphenol Abisphenol A binds to RXRG protein23843199
C006780bisphenol Abisphenol A results in increased expression of RXRG mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of RXRG promoter27334623
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of RXRG gene28505145
C006780bisphenol Abisphenol A results in decreased expression of RXRG mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RXRG gene28505145
C006780bisphenol Abisphenol A results in decreased expression of RXRG mRNA16905155
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of RXRG mRNA22079614
C027561butylbenzyl phthalatebutylbenzyl phthalate binds to RXRG protein23843199
C037123cadmium sulfatecadmium sulfate results in increased expression of RXRG mRNA12064557|1467641
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of RXRG mRNA]16221973
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RXRG mRNA12734012
D002509CephaloridineCephaloridine results in increased expression of RXRG mRNA18500788
D002746ChlorpromazineRXRG protein affects the susceptibility to Chlorpromazine10336693
D003024ClozapineClozapine results in decreased expression of RXRG mRNA alternative form11564422
D003471CuprizoneCuprizone results in decreased expression of RXRG mRNA27523638
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RXRG mRNA16556975
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of RXRG mRNA23428407
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of RXRG mRNA24848799
D003907DexamethasoneDexamethasone promotes the reaction [Triiodothyronine results in decreased expression of RXRG mRNA]8674831
C438269diazepinylbenzoic aciddiazepinylbenzoic acid binds to and results in decreased activity of RXRG protein19095448
D003993Dibutyl PhthalateDibutyl Phthalate binds to RXRG protein23843199
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RXRG mRNA21544203
D004041Dietary FatsDietary Fats results in increased expression of RXRG mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RXRG mRNA18164116
C007379diethyl phthalatediethyl phthalate binds to RXRG protein23843199
C089799diheptyl phthalatediheptyl phthalate binds to RXRG protein23843199
C025605diisobutyl phthalatediisobutyl phthalate results in decreased expression of RXRG mRNA22112501
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RXRG mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate binds to RXRG protein23843199
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of RXRG protein9751115
C027387di-n-hexyl phthalatedi-n-hexyl phthalate binds to RXRG protein23843199
C034171di-n-pentyl phthalatedi-n-pentyl phthalate binds to RXRG protein23843199
C106479di-n-propylphthalatedi-n-propylphthalate binds to RXRG protein23843199
D000431EthanolEthanol results in increased expression of RXRG mRNA11696672
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RXRG mRNA17161848
D004997Ethinyl EstradiolTretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RXRG mRNA]17161848
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of RXRG gene28505145
D005897GlafenineGlafenine results in decreased expression of RXRG mRNA24136188
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of RXRG mRNA16556975
D006118GriseofulvinGriseofulvin results in decreased expression of RXRG mRNA9548566
D006220HaloperidolRXRG protein affects the susceptibility to Haloperidol10336693
D006220HaloperidolHaloperidol results in increased expression of RXRG mRNA alternative form11564422
D017313FenretinideFenretinide results in decreased expression of RXRG mRNA16570282
D017313FenretinideFenretinide results in increased expression of RXRG mRNA15735044
D017313FenretinideFenretinide results in increased expression of RXRG mRNA28973697
C104181HX 600HX 600 binds to and results in increased activity of RXRG protein9144408
C422175HX 630HX 630 binds to RXRG protein9144408
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RXRG mRNA17183730
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of RXRG mRNA23428407
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of RXRG mRNA24848799
D007649KetamineKetamine results in decreased expression of RXRG mRNA20080153
D007657Ketone BodiesKetone Bodies results in decreased expression of RXRG mRNA16807920
C008261lead acetatelead acetate results in decreased expression of RXRG mRNA22641619
C423914LG 268RXRG protein promotes the reaction [LG 268 results in decreased expression of DIO2 mRNA]16306084
D001556LindaneLindane results in decreased expression of RXRG mRNA17785943
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RXRG mRNA12388159
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RXRG protein12388159
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of RXRG mRNA16507785
D008701MethapyrileneMethapyrilene results in decreased expression of RXRG mRNA16393664
D008727MethotrexateMethotrexate affects the expression of RXRG mRNA18502557
D008770MethylnitrosoureaMethylnitrosourea affects the expression of RXRG mRNA21843606
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate binds to RXRG protein23843199
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of RXRG mRNA21544203
C500085muraglitazarmuraglitazar results in increased expression of RXRG mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of RXRG mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RXRG mRNA"25620056
C028007nickel monoxidenickel monoxide results in decreased expression of RXRG mRNA19167457
C012655nimesulidenimesulide results in decreased expression of RXRG mRNA24136188
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of RXRG mRNA"12844485
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of RXRG mRNA19162173
C032279phthalic acidphthalic acid binds to RXRG protein23843199
C006253pirinixic acidpirinixic acid results in increased expression of RXRG mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of RXRG mRNA19162173|2211250
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RXRG mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of RXRG mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of RXRG mRNA24780913
D011794QuercetinQuercetin results in increased expression of RXRG mRNA15309432
D015474IsotretinoinIsotretinoin promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]19686701
D012176RetinoidsRetinoids analog binds to and results in increased activity of RXRG protein16364638
C014794retinol palmitateretinol palmitate promotes the reaction [[RXRG protein co-treated with NR1I3 protein] results in increased expression of CYP3A4 mRNA]19686701
C089730rosiglitazonerosiglitazone binds to RXRG protein23843199
C089730rosiglitazonerosiglitazone results in increased expression of RXRG mRNA24848799
C089730rosiglitazonerosiglitazone results in increased expression of RXRG mRNA21515302
D053260SootSoot results in decreased expression of RXRG mRNA26551751
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of RXRG mRNA16214533
D013449SulfonamidesSulfonamides analog binds to and results in decreased activity of RXRG protein19095448
D013449SulfonamidesSulfonamides analog binds to and results in increased activity of RXRG protein19095448
D014284TriiodothyronineTriiodothyronine results in increased expression of RXRG mRNA15708448
D014284TriiodothyronineDexamethasone promotes the reaction [Triiodothyronine results in decreased expression of RXRG mRNA]8674831
D014284TriiodothyronineTriiodothyronine affects the expression of RXRG mRNA21544203
D014284TriiodothyronineTriiodothyronine results in decreased expression of RXRG mRNA16905155|8674831
C061133tamibarotenetamibarotene binds to RXRG protein9144408
C501413tesaglitazartesaglitazar results in increased expression of RXRG mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RXRG mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of RXRG mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RXRG mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RXRG mRNA16054898
D013752TetracyclineTetracycline results in increased expression of RXRG mRNA16917069
C009495titanium dioxidetitanium dioxide results in decreased expression of RXRG mRNA23557971
D014212TretinoinTretinoin binds to RXRG protein23843199
D014212TretinoinTretinoin results in decreased expression of RXRG mRNA10866818
D014212TretinoinTretinoin results in increased expression of and results in increased activity of RXRG protein16158052
D014212TretinoinTretinoin results in increased expression of RXRG mRNA20507312|2290670
D014212TretinoinTretinoin results in increased expression of RXRG protein20507312
D014212Tretinoin[Tretinoin binds to RXRG protein] which binds to NRL promoter16854989
D014212TretinoinTretinoin results in decreased expression of RXRG mRNA8838863|8892963
D014212TretinoinTretinoin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RXRG mRNA]17161848
D014212TretinoinTretinoin results in increased expression of RXRG mRNA15708448
D014212TretinoinTretinoin results in increased expression of RXRG mRNA1312717
D014212TretinoinTretinoin results in increased activity of RXRG protein18398471
C011559tributyltintributyltin results in increased expression of RXRG mRNA25802986
C011559tributyltintributyltin results in increased expression of RXRG mRNA23428407|2484879
D014241TrichloroethyleneTrichloroethylene results in decreased expression of RXRG mRNA15363585
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RXRG mRNA19042947
C007567triphenyltin hydroxidetriphenyltin hydroxide binds to and affects the activity of RXRG protein15941851
C525131UVI 3003UVI 3003 results in decreased expression of RXRG mRNA27894914
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RXRG mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RXRG gene25560391
C017963vinyl carbamatevinyl carbamate results in decreased expression of RXRG mRNA17849452
D014801Vitamin AVitamin A results in increased expression of RXRG protein17219422
D014801Vitamin AVitamin A affects the expression of RXRG mRNA14529804

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003707steroid hormone receptor activity-IEA-  
GO:00048869-cis retinoic acid receptor activity-IEA-  
GO:0005515protein binding-IPI16189514  20133701  21516116  21988832  25303530  25416956  
25910212  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0043401steroid hormone mediated signaling pathway-IEA-  
GO:0048384retinoic acid receptor signaling pathway-IEA-  
GO:0051289protein homotetramerization-IEA-  
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05200Pathways in cancer
hsa05216Thyroid cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-383280Nuclear Receptor transcription pathwayTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
20113835Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features. (2010 Feb)Lee SMCancer Genet Cytogenet