Gene: RYR1

6261
CCO|MHS|MHS1|PPP1R137|RYDR|RYR|RYR-1|SKRR
ryanodine receptor 1
protein-coding
19q13.2
Ensembl:ENSG00000196218 MIM:180901 Vega:OTTHUMG00000182403 UniprotKB:P21817
NG_008866.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.798e-1 (AD)  1.657e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP10.792
PLEC0.773
ANKDD1A0.76
MROH70.759
ADAMTS100.733
IGDCC30.733
PLXNB20.731
LTBP30.729
MICALL20.721
ARVCF0.721

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.482
OR4F29-0.424
SGMS2-0.338
CTNNA3-0.325
ARHGAP11A-0.32
SH2D1A-0.311
TSPAN8-0.309
TMEM139-0.289
FXYD4-0.289
LACC1-0.278

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTransporter
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTransporter
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB01219DantroleneSmall Molecule7261-97-4Approved|InvestigationalTarget
DB04786SuraminSmall Molecule145-63-1Approved|InvestigationalTarget
DB09085TetracaineSmall Molecule94-24-6ApprovedTarget
ID Drug Name Action PubMed
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl analog affects the folding of and affects the stability of and affects the activity of RYR1 protein"24014653
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl analog affects the reaction [Ryanodine binds to RYR1 protein]"24014653
C0329042,2',3,5',6-pentachlorobiphenyl"2,2',3,5',6-pentachlorobiphenyl results in increased activity of RYR1 protein"16411661
C0329042,2',3,5',6-pentachlorobiphenyl"RYR1 protein results in increased susceptibility to 2,2',3,5',6-pentachlorobiphenyl"22534141
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]"21106467
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]"21106467
C0104982,3,6,2',3',6'-hexachlorobiphenyl"[RYR1 protein co-treated with 2,3,6,2',3',6'-hexachlorobiphenyl] affects the susceptibility to Calcium"18954145
C0104982,3,6,2',3',6'-hexachlorobiphenyl"2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR1 protein]"18954145
C0104982,3,6,2',3',6'-hexachlorobiphenyl"2,3,6,2',3',6'-hexachlorobiphenyl results in increased activity of RYR1 protein"16411661
C0098282,4,5,2',5'-pentachlorobiphenyl"2,4,5,2',5'-pentachlorobiphenyl results in increased activity of RYR1 protein"16411661
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased activity of RYR1 protein"16411661
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of RYR1 mRNA"23829299
C0051475'-adenylyl (beta,gamma-methylene)diphosphonate"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]"11278295
C0051475'-adenylyl (beta,gamma-methylene)diphosphonate"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Ryanodine binds to RYR1 protein]"11278295
C065380A 68930A 68930 results in increased expression of RYR1 protein22504960
C065380A 68930Baclofen inhibits the reaction [A 68930 results in increased expression of RYR1 protein]22504960
D000082AcetaminophenAcetaminophen affects the expression of RYR1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of RYR1 mRNA28606764
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RYR1 mRNA16483693
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of RYR1 mRNA28713220
D001280AtrazineAtrazine results in decreased expression of RYR1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of RYR1 mRNA22378314
D001418BaclofenBaclofen inhibits the reaction [A 68930 results in increased expression of RYR1 protein]22504960
D001418BaclofenBaclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]22504960
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RYR1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RYR1 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of RYR1 mRNA19484750
D001640BicucullineRYR1 results in increased susceptibility to Bicuculline22534176
C006780bisphenol Abisphenol A results in decreased expression of RYR1 mRNA26063408
C006780bisphenol Abisphenol A affects the reaction [Ryanodine binds to RYR1 protein]28143888
C006780bisphenol Abisphenol A results in decreased expression of RYR1 mRNA27178563
D002104CadmiumCadmium results in increased expression of RYR1 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RYR1 mRNA24982889
D002110CaffeineCaffeine results in increased activity of RYR1 protein21485675
D002110Caffeine[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
D002110CaffeineRYR1 gene mutant form results in increased susceptibility to Caffeine19191329
D002110CaffeineRYR1 protein mutant form results in increased susceptibility to Caffeine14641996|1521016
D002110CaffeineRYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]16372898
D002110CaffeineCaffeine results in increased activity of RYR1 protein16484216
D002110CaffeineTRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]16484216
D002110CaffeineRYR1 protein mutant form results in decreased susceptibility to Caffeine11695996
D002110CaffeineRYR1 protein mutant form results in increased susceptibility to Caffeine11695996
D002110CaffeineCaffeine promotes the reaction [Ryanodine binds to RYR1 protein]11278295
D002110CaffeineCaffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D002110CaffeineCaffeine results in increased activity of RYR1 protein11278295
D002110CaffeineCaffeine results in increased activity of RYR1 protein mutant form11278295
D002110CaffeineDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D002110CaffeineDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]11278295
D002110CaffeineDantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]11278295
D002110CaffeineDantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]11278295
D002118Calcium[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
D002118CalciumCalcium affects the folding of [CALM1 protein binds to RYR1 protein modified form]15381065
D002118CalciumCalcium affects the reaction [CALM1 protein binds to and affects the activity of RYR1 protein]15381065
D002118Calcium[chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
D002118Calcium[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium17707769
D002118CalciumDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]17707769
D002118Calcium[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
D002118CalciumRYR1 gene mutant form results in increased abundance of Calcium19191329
D002118Calcium"[RYR1 protein co-treated with 2,3,6,2',3',6'-hexachlorobiphenyl] affects the susceptibility to Calcium"18954145
D002118CalciumRYR1 protein mutant form results in increased secretion of Calcium18719443
D002118CalciumRYR1 protein polymorphism affects the abundance of Calcium16372898
D002118CalciumRYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]16372898
D002118CalciumRYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]16372898
D002118CalciumCalcium affects the reaction [CALM1 protein binds to and affects the activity of RYR1 protein]15628869
D002118CalciumCalcium affects the reaction [CALM1 protein modified form binds to and affects the activity of RYR1 protein]15628869
D002118CalciumCalcium results in increased activity of RYR1 protein11278295
D002118CalciumDantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]11278295
D002118Calcium[Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium11278295
D002118CalciumCalcium results in increased activity of RYR1 protein15326217
C073316carvacrolcarvacrol results in increased activity of RYR1 protein17641978
C006984chlorocresolchlorocresol results in increased activity of RYR1 protein17707769|2148567
C006984chlorocresol[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]17707769
C006984chlorocresol[chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
C006984chlorocresol[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium17707769
C006984chlorocresolDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]17707769
C006984chlorocresolDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]17707769
C006984chlorocresolRYR1 gene mutant form results in increased susceptibility to chlorocresol19191329
C006984chlorocresolRYR1 protein alternative form affects the susceptibility to chlorocresol19191333
C006984chlorocresolRYR1 protein mutant form results in increased susceptibility to chlorocresol12810058|1521016
C006984chlorocresolRYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]16372898
C006984chlorocresolRYR1 protein results in increased susceptibility to chlorocresol19191333
C006984chlorocresolRYR1 protein mutant form results in decreased susceptibility to chlorocresol11695996
C006984chlorocresolRYR1 protein mutant form results in increased susceptibility to chlorocresol11695996
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of RYR1 protein16309888|1933751
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RYR1 mRNA20938992
C031180chrysenechrysene results in increased expression of RYR1 mRNA26377693
D003471CuprizoneCuprizone results in decreased expression of RYR1 mRNA26577399
D003620DantroleneDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]17707769
D003620DantroleneDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]17707769
D003620Dantrolene"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]"11278295
D003620DantroleneDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D003620DantroleneDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]11278295
D003620DantroleneDantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]11278295
D003620DantroleneDantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]11278295
D003620DantroleneDantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]11278295
D003620Dantrolene[Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium11278295
D003620DantroleneDantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]11278295
D003620DantroleneDantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D003620DantroleneDantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D003620DantroleneDantrolene results in decreased activity of RYR1 protein11278295
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of RYR1 mRNA23640034
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of RYR1 mRNA]21095227
D013759DronabinolDronabinol results in decreased expression of RYR1 mRNA18454173
C558403dibromodiphenyl etherdibromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]21106467
C558403dibromodiphenyl etherSirolimus inhibits the reaction [dibromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]]21106467
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of RYR1 mRNA28085963
C574336excavatolide Bexcavatolide B results in increased expression of RYR1 protein26790859
C017690fenvaleratefenvalerate results in decreased expression of RYR1 mRNA19428952
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RYR1 mRNA20938992
D006108GraphiteGraphite results in increased expression of RYR1 mRNA27440207
D006221HalothaneHalothane results in increased activity of RYR1 protein21485675
D006221Halothane[Halothane results in increased activity of RYR1 protein] which affects the localization of Calcium21485675
D006221HalothaneRYR1 protein mutant form results in increased susceptibility to Halothane14641996|1521016
C492448ICG 001ICG 001 results in increased expression of RYR1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RYR1 mRNA25613284
C045463leflunomideleflunomide results in decreased expression of RYR1 mRNA19751817
D008070Lipopolysaccharides[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]17707769
D008070LipopolysaccharidesDantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]17707769
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RYR1 mRNA20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of RYR1 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RYR1 mRNA22401849
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of RYR1 mRNA27935865
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of RYR1 mRNA16221955
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of RYR1 mRNA27935865
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of RYR1 mRNA14699072
D012430Ruthenium RedRuthenium Red results in decreased activity of RYR1 protein15326217
D012433RyanodineTriclosan promotes the reaction [Ryanodine binds to RYR1 protein]18795164
D012433Ryanodine"2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR1 protein]"18954145
D012433Ryanodine"2,2',3,5',6-pentachlorobiphenyl analog affects the reaction [Ryanodine binds to RYR1 protein]"24014653
D012433Ryanodine"2,2',4,4'-tetrabromodiphenyl ether affects the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]"21106467
D012433Ryanodine"2,2',4,4'-tetrabromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]"21106467
D012433Ryanodinebisphenol A affects the reaction [Ryanodine binds to RYR1 protein]28143888
D012433Ryanodinedibromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]21106467
D012433RyanodineRyanodine binds to and results in increased activity of RYR1 protein21106467
D012433RyanodineRyanodine binds to RYR1 protein24014653|2814388
D012433RyanodineSirolimus inhibits the reaction [dibromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]]21106467
D012433Ryanodinetetrabromobisphenol A promotes the reaction [Ryanodine binds to RYR1 protein]28143888
D012433Ryanodinetribromodiphenyl ether 28 promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]21106467
D012433RyanodineTriclosan inhibits the reaction [tetrabromobisphenol A promotes the reaction [Ryanodine binds to RYR1 protein]]28143888
D012433Ryanodine"5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Ryanodine binds to RYR1 protein]"11278295
D012433RyanodineCaffeine promotes the reaction [Ryanodine binds to RYR1 protein]11278295
D012433RyanodineCaffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D012433RyanodineDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D012433RyanodineDantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]11278295
D012433RyanodineDantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]11278295
D012433RyanodineDantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D012433RyanodineDantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D012433RyanodineRyanodine binds to RYR1 protein11278295
D012433RyanodineRyanodine binds to RYR1 protein mutant form11278295
D012433RyanodineStrontium promotes the reaction [Ryanodine binds to RYR1 protein]11278295
D012433RyanodineStrontium promotes the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D012433RyanodineRyanodine results in decreased activity of RYR1 protein15326217
D012433RyanodineRyanodine results in increased activity of RYR1 protein15326217
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of RYR1 mRNA21427059
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]22504960
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RYR1 mRNA25895662
D020123SirolimusSirolimus inhibits the reaction [dibromodiphenyl ether analog promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]]21106467
D020123SirolimusSirolimus inhibits the reaction [FKBP1A protein binds to RYR1 protein]16411661
D020123SirolimusSirolimus inhibits the reaction [RYR1 protein binds to FKBP1A protein]21106467
C071262SK&F 82958Baclofen inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]22504960
C071262SK&F 82958SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein]22504960
C071262SK&F 82958SK&F 82958 results in increased expression of RYR1 protein22504960
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of RYR1 mRNA]21095227
C017947sodium arsenitesodium arsenite results in decreased expression of RYR1 mRNA28713220
D012999SomanSoman results in decreased expression of RYR1 mRNA19281266
D053260SootSoot results in increased expression of RYR1 mRNA26551751
D013096SpermineSpermine results in increased expression of RYR1 mRNA18673383
D013324StrontiumDantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]11278295
D013324StrontiumStrontium promotes the reaction [Ryanodine binds to RYR1 protein]11278295
D013324StrontiumStrontium promotes the reaction [Ryanodine binds to RYR1 protein mutant form]11278295
D013324StrontiumStrontium results in increased activity of RYR1 protein11278295
D016559TacrolimusTacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RYR1 protein]18172213|1817288
D016559TacrolimusTacrolimus inhibits the reaction [FKBP1A protein binds to RYR1 protein]16411661
D013629TamoxifenTamoxifen affects the expression of RYR1 mRNA14699072
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased activity of RYR1 protein18329244
C020806tetrabromobisphenol ATetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein]18329244
C020806tetrabromobisphenol Atetrabromobisphenol A promotes the reaction [Ryanodine binds to RYR1 protein]28143888
C020806tetrabromobisphenol ATriclosan inhibits the reaction [tetrabromobisphenol A promotes the reaction [Ryanodine binds to RYR1 protein]]28143888
D013748TetracaineTetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein]18329244
D013749TetrachlorodibenzodioxinTacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RYR1 protein]18172213|1817288
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RYR1 mRNA18172213
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RYR1 protein18172213|1817288
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RYR1 mRNA25613284
D013943ThymolThymol results in increased activity of RYR1 protein17641978
C533760tribromodiphenyl ether 28tribromodiphenyl ether 28 promotes the reaction [Ryanodine binds to and results in increased activity of RYR1 protein]21106467
D014260TriclosanTriclosan promotes the reaction [Ryanodine binds to RYR1 protein]18795164
D014260TriclosanTriclosan inhibits the reaction [tetrabromobisphenol A promotes the reaction [Ryanodine binds to RYR1 protein]]28143888
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of RYR1 mRNA23537331
D014635Valproic AcidValproic Acid results in increased expression of RYR1 mRNA21427059
D024483Vitamin K 3Vitamin K 3 affects the expression of RYR1 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of RYR1 mRNA18769122
D015032ZincZinc deficiency results in decreased expression of RYR1 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO:0005219ryanodine-sensitive calcium-release channel activity-IBA21873635  
GO:0005219ryanodine-sensitive calcium-release channel activity-IDA22480578  
GO:0005219ryanodine-sensitive calcium-release channel activity-IMP11741831  16163667  26115329  
GO:0005219ryanodine-sensitive calcium-release channel activity-ISS-  
GO:0005219ryanodine-sensitive calcium-release channel activity-TAS19095005  
GO:0005245voltage-gated calcium channel activity-ISS-  
GO:0005262calcium channel activity-ISS-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI23414517  
GO:0005516calmodulin binding-ISS-  
GO:0005524ATP binding-ISS-  
GO:0015278calcium-release channel activity-TAS9030597  
GO:0048763calcium-induced calcium release activity-IBA21873635  
GO:0048763calcium-induced calcium release activity-IMP26115329  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IDA19120137  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0006816calcium ion transport-ISS-  
GO:0006936muscle contraction-ISS-  
GO:0014808release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-ISS-  
GO:0031000response to caffeine-ISS-  
GO:0034220ion transmembrane transport-TAS-  
GO:0043588skin development-ISS-  
GO:0043931ossification involved in bone maturation-ISS-  
GO:0048741skeletal muscle fiber development-ISS-  
GO:0051209release of sequestered calcium ion into cytosol-IBA21873635  
GO:0051209release of sequestered calcium ion into cytosol-IMP11741831  16163667  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0051289protein homotetramerization-ISS-  
GO:0051480regulation of cytosolic calcium ion concentration-ISS-  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071313cellular response to caffeine-IMP16163667  26115329  
GO:0071313cellular response to caffeine-ISS-  
GO:1903779regulation of cardiac conduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA11206130  
GO:0005790smooth endoplasmic reticulum-IBA21873635  
GO:0005790smooth endoplasmic reticulum-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11206130  
GO:0005887integral component of plasma membrane-TAS2298749  
GO:0005938cell cortex-IDA11206130  
GO:0014701junctional sarcoplasmic reticulum membrane-TAS19095005  
GO:0014802terminal cisterna-ISS1374404  
GO:0016529sarcoplasmic reticulum-ISS-  
GO:0030018Z disc-IBA21873635  
GO:0030314junctional membrane complex-IEA-  
GO:0030315T-tubule-IEA-  
GO:0030659cytoplasmic vesicle membrane-IBA21873635  
GO:0031301integral component of organelle membrane-ISS-  
GO:0031674I band-IDA11206130  
GO:0033017sarcoplasmic reticulum membrane-IBA21873635  
GO:0033017sarcoplasmic reticulum membrane-IDA7556644  
GO:0033017sarcoplasmic reticulum membrane-ISS-  
GO:0033017sarcoplasmic reticulum membrane-TAS-  
GO:0034704calcium channel complex-IBA21873635  
GO:0042383sarcolemma-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
GO:1990425ryanodine receptor complex-ISS-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04730Long-term depression
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5578775Ion homeostasisTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22063434The interaction between calpastatin and RYR1 genes for some pork quality traits. (2003 Oct)Kocwin-Podsiadla MMeat Sci
29459480Occupational exposure to pesticides is associated with differential DNA methylation. (2018 Jun)van der Plaat DAOccup Environ Med