Gene: SORT1

6272
Gp95|LDLCQ6|NT3|NTR3
sortilin 1
protein-coding
1p13.3|1p21.3-p13.1
Ensembl:ENSG00000134243 MIM:602458 Vega:OTTHUMG00000011999 UniprotKB:Q99523
NG_028280.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.945e-1 (AD)  3.615e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE4B0.936
TRAPPC100.927
EZH10.924
COPA0.921
MPHOSPH80.917
SENP20.913
RPS6KC10.913
PLEKHA10.911
EXOC6B0.911
NFASC0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.632
KLRB1-0.341
MTRNR2L6-0.325
TIGIT-0.323
LRAT-0.31
MTRNR2L10-0.31
MTRNR2L9-0.307
TFPI2-0.305
KLRF1-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of SORT1 mRNA"21920950
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SORT1 mRNA"18648102
C0293704-toluidine4-toluidine results in increased expression of SORT1 mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of SORT1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SORT1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SORT1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SORT1 mRNA23630614
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SORT1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SORT1 mRNA16483693
D001205Ascorbic AcidAscorbic Acid results in increased expression of SORT1 mRNA15305145
C547126AZM551248AZM551248 results in decreased expression of SORT1 mRNA22323515
C040929bafilomycin A1bafilomycin A1 results in decreased expression of SORT1 protein25805502
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SORT1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SORT1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrabromocinnamic acid results in increased degradation of SORT1 protein]25805502
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]25805502
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SORT1 protein25805502
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in increased expression of SORT1 mRNA]28476547
D004958EstradiolEstradiol results in decreased expression of SORT1 mRNA19484750
D004958EstradiolEstradiol results in increased expression of SORT1 mRNA28476547
D004958EstradiolEstradiol results in increased expression of SORT1 protein28476547
C044887beta-methylcholinebeta-methylcholine affects the expression of SORT1 mRNA21179406
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in increased expression of SORT1 mRNA]28476547
C006780bisphenol Abisphenol A results in increased expression of SORT1 mRNA28476547
C006780bisphenol Abisphenol A results in increased expression of SORT1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SORT1 mRNA26079696
D002738ChloroquineChloroquine results in decreased expression of SORT1 protein25805502
D002784CholesterolSORT1 protein results in decreased abundance of Cholesterol25805502
D008078Cholesterol, LDL"SORT1 protein affects the abundance of Cholesterol, LDL"24986865
C018021cobaltous chloridecobaltous chloride results in decreased expression of SORT1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of SORT1 mRNA24386269
D003513CycloheximideCycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]24986865
D003513CycloheximideDocosahexaenoic Acids inhibits the reaction [Cycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]]24986865
D003513CycloheximideCycloheximide results in increased degradation of SORT1 protein mutant form25805502
D003513CycloheximideSORT1 mutant form inhibits the reaction [Pentanoic Acids results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]22555848
D003513CycloheximideSORT1 mutant form inhibits the reaction [sodium arsenite results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]22555848
D016572CyclosporineCyclosporine results in decreased expression of SORT1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of SORT1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SORT1 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SORT1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of SORT1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of SORT1 mRNA25016146
D004041Dietary FatsDietary Fats results in decreased expression of SORT1 mRNA22715380
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SORT1 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SORT1 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of SORT1 mRNA26924002
D004281Docosahexaenoic AcidsDocosahexaenoic Acids inhibits the reaction [Cycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]]24986865
D004281Docosahexaenoic AcidsDocosahexaenoic Acids inhibits the reaction [Palmitic Acid results in decreased expression of SORT1 protein]24986865
D004317DoxorubicinSORT1 protein affects the susceptibility to Doxorubicin16217747
D015118Eicosapentaenoic AcidEicosapentaenoic Acid inhibits the reaction [Palmitic Acid results in decreased expression of SORT1 protein]24986865
D005047EtoposideSORT1 protein affects the susceptibility to Etoposide16217747
D011345FenofibrateFenofibrate results in increased expression of SORT1 mRNA24986865
D005395Fish OilsFish Oils results in increased expression of SORT1 mRNA24986865
C039281furanfuran results in increased expression of SORT1 mRNA25539665|2619464
C546771gardiquimodgardiquimod results in increased expression of SORT1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SORT1 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of SORT1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of SORT1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA28628672
D007501IronIron deficiency results in increased expression of SORT1 mRNA20368581
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SORT1 mRNA28628672
D048628KetolidesKetolides analog results in increased expression of SORT1 mRNA24967691
D008345ManganeseManganese results in decreased expression of SORT1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of SORT1 mRNA17175027
D008727MethotrexateMethotrexate affects the expression of SORT1 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SORT1 mRNA"20188158
D016685MitomycinSORT1 protein affects the susceptibility to Mitomycin16217747
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SORT1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SORT1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SORT1 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of SORT1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of SORT1 mRNA19167457
D009569Nitric OxideSORT1 protein affects the reaction [FASL protein results in decreased abundance of Nitric Oxide]19761405
D009966OrphenadrineOrphenadrine affects the expression of SORT1 mRNA23665939
D010100OxygenSORT1 protein affects the reaction [FASL protein results in increased chemical synthesis of Oxygen]19761405
D019308Palmitic AcidCycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]24986865
D019308Palmitic AcidDocosahexaenoic Acids inhibits the reaction [Cycloheximide promotes the reaction [Palmitic Acid results in increased degradation of SORT1 protein]]24986865
D019308Palmitic AcidDocosahexaenoic Acids inhibits the reaction [Palmitic Acid results in decreased expression of SORT1 protein]24986865
D019308Palmitic AcidEicosapentaenoic Acid inhibits the reaction [Palmitic Acid results in decreased expression of SORT1 protein]24986865
D019308Palmitic AcidPalmitic Acid results in increased degradation of SORT1 protein24986865
D019308Palmitic AcidPalmitic Acid results in increased phosphorylation of SORT1 protein24986865
D019308Palmitic AcidPalmitic Acid results in increased ubiquitination of SORT1 protein24986865
D000073878Palm OilPalm Oil results in decreased expression of SORT1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of SORT1 mRNA23892564
D010421Pentanoic AcidsSORT1 mutant form inhibits the reaction [Pentanoic Acids results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]22555848
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SORT1 protein26879310
D010705PhosgenePhosgene affects the expression of SORT1 mRNA16300373
C006253pirinixic acidpirinixic acid results in decreased expression of SORT1 mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of SORT1 mRNA20864642
D011441PropylthiouracilPropylthiouracil results in increased expression of SORT1 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of SORT1 mRNA]28003376
C496788PX-866[PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA25805502
C496788PX-866[PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA25805502
C496788PX-866PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]25805502
C496788PX-866PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]25805502
C496788PX-866PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]25805502
C496788PX-866PX-866 results in decreased expression of SORT1 protein25805502
C496788PX-866SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]25805502
D015474IsotretinoinIsotretinoin results in decreased expression of SORT1 mRNA20436886
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of SORT1 mRNA18514395
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SORT1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of SORT1 mRNA19590694
C017947sodium arseniteSORT1 mutant form inhibits the reaction [sodium arsenite results in decreased susceptibility to [TNF protein co-treated with Cycloheximide]]22555848
D018038Sodium SeleniteSodium Selenite results in increased expression of SORT1 mRNA18514395
D013311StreptozocinStreptozocin results in decreased expression of SORT1 protein25805502
D013739TestosteroneTestosterone results in increased expression of SORT1 mRNA21475673
C518786tetrabromocinnamic acidbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [tetrabromocinnamic acid results in increased degradation of SORT1 protein]25805502
C518786tetrabromocinnamic acidtetrabromocinnamic acid inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]25805502
C518786tetrabromocinnamic acidtetrabromocinnamic acid results in decreased expression of and results in increased degradation of SORT1 protein25805502
C518786tetrabromocinnamic acidtetrabromocinnamic acid results in increased ubiquitination of SORT1 protein25805502
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SORT1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SORT1 mRNA26290441
D013853ThioacetamideThioacetamide results in increased expression of SORT1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SORT1 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of SORT1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of SORT1 mRNA24935251
D014280TriglyceridesSORT1 protein affects the abundance of Triglycerides24986865
D014280TriglyceridesSORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]25805502
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SORT1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SORT1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of SORT1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SORT1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of SORT1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SORT1 mRNA17292431|1796380
D014747VinblastineSORT1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of SORT1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of SORT1 mRNA19244175
C009687wortmanninbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]25805502
C009687wortmanninwortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]25805502
C009687wortmanninwortmannin results in decreased expression of and results in increased degradation of SORT1 protein25805502
C009687wortmanninwortmannin results in increased ubiquitination of SORT1 protein25805502
D015032ZincZinc deficiency results in increased expression of SORT1 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10085125  11331584  11390366  14985763  17353931  19122660  
20676133  21102451  22431521  23236149  24070898  26496610  
GO:0010465nerve growth factor receptor activity-IDA14985763  
GO:0019899enzyme binding-IPI10085125  
GO:0030379neurotensin receptor activity, non-G-protein coupled-IDA9756851  
GO:0048406nerve growth factor binding-IPI14985763  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0006895Golgi to endosome transport-IDA11331584  
GO:0006897endocytosis-IDA11331584  
GO:0007186G-protein coupled receptor signaling pathway-IMP18258592  
GO:0007218neuropeptide signaling pathway-IDA9756851  
GO:0007275multicellular organism development-IEA-  
GO:0008333endosome to lysosome transport-IDA11331584  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IDA14985763  
GO:0010468regulation of gene expression-IMP18258592  
GO:0014902myotube differentiation-IMP18258592  
GO:0016050vesicle organization-IDA15992544  
GO:0032509endosome transport via multivesicular body sorting pathway-IDA11331584  
GO:0032868response to insulin-IMP15992544  
GO:0038180nerve growth factor signaling pathway-IEA-  
GO:0045599negative regulation of fat cell differentiation-IEA-  
GO:0046323glucose import-IMP15992544  
GO:0048011neurotrophin TRK receptor signaling pathway-IMP14985763  
GO:0048227plasma membrane to endosome transport-IDA11331584  
GO:0051005negative regulation of lipoprotein lipase activity-IDA10085125  
GO:1904037positive regulation of epithelial cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0005769early endosome-IDA11331584  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA11331584  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA11331584  
GO:0005886plasma membrane-NAS14985763  
GO:0005905clathrin-coated pit-IDA11331584  
GO:0009986cell surface-IDA10085125  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IDA15992544  
GO:0030136clathrin-coated vesicle-IDA11331584  
GO:0030140trans-Golgi network transport vesicle-IEA-  
GO:0030425dendrite-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031410cytoplasmic vesicle-IDA9756851  
GO:0031965nuclear membrane-IEA-  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA11331584  
KEGG ID KEGG Term
hsa04142Lysosome
hsa04722Neurotrophin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432722Golgi Associated Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27846466Increased sortilin and its independent effect on circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) in statin-naive patients with coronary artery disease. (2017 Jan 15)Hu DInt J Cardiol
28167353Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)Shahid SUAtherosclerosis
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One
28128572[Genetic determination of dyslipidemia - What tell us the results of genome-wide association studies?] (Fall 2016)Hubacek JAVnitr Lek