Gene: S100A4

6275
18A2|42A|CAPL|FSP1|MTS1|P9KA|PEL98
S100 calcium binding protein A4
protein-coding
1q21.3
Ensembl:ENSG00000196154 MIM:114210 Vega:OTTHUMG00000013546 UniprotKB:P26447
NG_027993.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.063e-1 (AD)  6.138e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23048494chr1:153517384S100A44.200e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB1I10.792
CD480.768
CAV10.761
VEGFC0.754
TNFAIP80.754
CCL190.754
COL8A10.754
MGP0.753
COL14A10.751
TBX180.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRTM2-0.487
NEUROD6-0.487
MARCH4-0.47
YBX2-0.465
SYT12-0.464
ST6GALNAC5-0.461
ABCC12-0.46
MYADML2-0.459
PPEF1-0.455
RCOR2-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00831TrifluoperazineSmall Molecule117-89-5Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]"16948116
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK1 protein]"16948116
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK3 protein]"16948116
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]"16948116
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased phosphorylation of RELA protein]"16948116
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of S100A4 mRNA28329830
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]16948116
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to S100A4 protein"16533022
C0299552-nitrotoluene2-nitrotoluene results in increased expression of S100A4 mRNA15612046
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of S100A4 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of S100A4 mRNA21167638
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of S100A4 mRNA21167638
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of S100A4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of S100A4 mRNA17562736
C056165acetovanilloneacetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]21647593
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dietary Fats results in increased expression of S100A4 mRNA]21051528
D000171AcroleinAcrolein results in increased expression of S100A4 mRNA18515264
D000393Air PollutantsAir Pollutants results in decreased expression of S100A4 mRNA25056781
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
D006710Homocysteineacetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]21647593
D006710HomocysteineCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]21647593
D006710HomocysteineCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]21647593
D006710HomocysteineCYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]21647593
D006710Homocysteine[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA21647593
D006710Homocysteine[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein21647593
D006710HomocysteineHomocysteine results in increased expression of S100A4 mRNA21647593
D006710HomocysteineHomocysteine results in increased expression of S100A4 protein21647593
D000643Ammonium ChlorideAmmonium Chloride affects the expression of S100A4 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of S100A4 mRNA"22863853
D000871AnthelminticsAnthelmintics results in decreased expression of S100A4 mRNA21685359
D000871AnthelminticsAnthelmintics results in decreased expression of S100A4 protein21685359
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D001241AspirinAspirin results in decreased expression of S100A4 mRNA20457246
D001241AspirinAspirin results in increased expression of S100A4 mRNA14976132
D001280AtrazineAtrazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A4 mRNA]24211529
D001280AtrazineAtrazine results in decreased expression of S100A4 mRNA24211529
D001280AtrazineAtrazine results in increased expression of S100A4 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of S100A4 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of S100A4 mRNA26377693
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of S100A4 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of S100A4 mRNA15034205|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of S100A4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of S100A4 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100A4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of S100A4 mRNA23019147
D004958EstradiolEstradiol results in increased expression of S100A4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of S100A4 mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of S100A4 mRNA26496021
D001663BilirubinBilirubin results in decreased expression of S100A4 mRNA20196124
D001688Biological ProductsBiological Products results in decreased expression of S100A4 protein23624380
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of S100A4 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of S100A4 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of S100A4 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of S100A4 protein15215581
C006780bisphenol Abisphenol A affects the expression of S100A4 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of S100A4 mRNA26496021
D001761BleomycinBleomycin results in increased expression of S100A4 protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of S100A4 mRNA15336504
D002211CapsaicinCapsaicin results in increased expression of S100A4 mRNA21310942
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of S100A4 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of S100A4 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of S100A4 protein16818635|2556682
D002737ChloropreneChloroprene results in decreased expression of S100A4 mRNA23125180
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A4 mRNA23439872
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A4 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of S100A4 mRNA17553155|1937684
D003300CopperAscorbic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D003300CopperCopper binds to S100A4 protein21924240
D003300CopperCopper promotes the reaction [S100A4 protein binds to S100A4 protein]21924240
D003300CopperDithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D003300CopperEdetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D003300CopperPentetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D003300CopperQuercetin inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D019327Copper SulfateCopper Sulfate results in increased expression of S100A4 mRNA19549813
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of S100A4 mRNA]11007951
C009160cyclonitecyclonite results in increased expression of S100A4 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of S100A4 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of S100A4 mRNA21354196
D016572CyclosporineCyclosporine results in increased expression of S100A4 mRNA21865292
D003561CytarabineCytarabine results in decreased expression of S100A4 mRNA21198554
C014347decitabinedecitabine affects the expression of S100A4 mRNA23300844
C014347decitabinedecitabine affects the methylation of S100A4 gene17579622
C014347decitabinedecitabine results in increased expression of S100A4 mRNA19194470
D003703DemecolcineDemecolcine results in increased expression of S100A4 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of S100A4 mRNA25047013
D002945CisplatinCisplatin affects the expression of S100A4 mRNA23300844
D002945CisplatinCisplatin results in increased expression of S100A4 mRNA27594783
D002945CisplatinCisplatin affects the expression of S100A4 mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of S100A4 mRNA18042831
D004041Dietary FatsAcetylcysteine inhibits the reaction [Dietary Fats results in increased expression of S100A4 mRNA]21051528
D004041Dietary FatsDietary Fats results in increased expression of S100A4 mRNA21051528
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of S100A4 mRNA28085963
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of S100A4 mRNA21527772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of S100A4 mRNA28943392
D002117CalcitriolCalcitriol results in decreased expression of S100A4 mRNA26485663
D004229DithiothreitolDithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D004237DiuronDiuron results in decreased expression of S100A4 mRNA21551480
D004298DopamineDopamine results in increased expression of S100A4 mRNA21983523
D004492Edetic AcidEdetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D004726EndosulfanEndosulfan results in increased expression of S100A4 mRNA22677888
C118739entinostatentinostat results in increased expression of S100A4 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
D000431EthanolEthanol results in increased expression of S100A4 mRNA15963989
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of S100A4 mRNA12655037
D018818FenoldopamFenoldopam results in increased expression of S100A4 mRNA21983523
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of S100A4 mRNA28329830
D005472FluorouracilFluorouracil results in decreased expression of S100A4 protein15352031
D005472FluorouracilS100A4 protein affects the susceptibility to Fluorouracil15352031
D005492Folic AcidFolic Acid affects the expression of S100A4 mRNA16361273
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A4 mRNA23439872
D005492Folic AcidCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]21647593
D005492Folic AcidCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]21647593
D005492Folic AcidCYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased expression of S100A4 protein]21647593
D005492Folic Acid[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA21647593
D005492Folic Acid[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein21647593
D005492Folic AcidFolic Acid deficiency results in increased expression of S100A4 protein21647593
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A4 mRNA20938992
D004397FonofosFonofos results in decreased methylation of S100A4 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of S100A4 mRNA23649840
C039281furanfuran results in increased expression of S100A4 mRNA27387713
C001277geldanamycingeldanamycin results in decreased expression of S100A4 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of S100A4 mRNA22061828
C004312glycidolglycidol results in decreased expression of S100A4 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of S100A4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of S100A4 mRNA21179406
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
C492448ICG 001[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
C016517indole-3-carbinolindole-3-carbinol affects the expression of S100A4 mRNA21396975
D007545IsoproterenolIsoproterenol results in increased expression of S100A4 protein10886724
C544151jinfukangjinfukang results in increased expression of S100A4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of S100A4 mRNA23086925|2596192
D007649KetamineKetamine results in increased expression of S100A4 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of S100A4 mRNA21461237
D008094LithiumLithium results in decreased expression of S100A4 protein18296634
D019808Losartan[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased expression of MMP13 mRNA]16948116
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]16948116
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK1 protein]16948116
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK3 protein]16948116
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]16948116
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased phosphorylation of RELA protein]16948116
D008628MercuryMercury analog results in decreased expression of S100A4 mRNA25056781
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A4 mRNA20938992
D008727MethotrexateS100A4 protein results in decreased susceptibility to Methotrexate20515499
C036868methyl carbamatemethyl carbamate results in increased expression of S100A4 mRNA15612046
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of S100A4 mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of S100A4 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of S100A4 mRNA24810058
C008493methylselenic acidmethylselenic acid results in increased expression of S100A4 mRNA18548127
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of S100A4 mRNA24128854
C045621miglitolmiglitol results in decreased expression of S100A4 mRNA20667563
C045621miglitolmiglitol results in decreased expression of S100A420667563
D016685MitomycinS100A4 protein affects the susceptibility to Mitomycin16217747
C523799MRK 003S100A4 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of S100A4 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of S100A4 mRNA"23845593|2555468
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of S100A4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of S100A4 mRNA"25554681
D009534NiclosamideNiclosamide results in decreased expression of S100A4 mRNA21685359
D009534NiclosamideNiclosamide results in decreased expression of S100A4 protein21685359
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A4 mRNA"19013360
C030110oxaliplatinoxaliplatin results in increased expression of S100A4 mRNA16510598
D010100OxygenOxygen deficiency results in increased expression of S100A4 mRNA22711276
D010100OxygenValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of S100A4 mRNA]22711276
D010100Oxygenvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of S100A4 mRNA]22711276
D010126OzoneOzone results in decreased expression of S100A4 mRNA17095637
D010126OzoneOzone results in increased expression of S100A4 mRNA16716893
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of S100A4 protein]28578904
D017239PaclitaxelPaclitaxel results in increased expression of S100A4 mRNA19682730
D000073878Palm OilPalm Oil results in increased expression of S100A4 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of S100A4 mRNA26272509
D010278ParathionParathion results in decreased methylation of S100A4 promoter22847954
D052638Particulate Matter[S100A4 gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of S100A4 mRNA21222557|2122255
D010396PenicillaminePenicillamine results in increased expression of S100A4 mRNA19575532
D004369Pentetic AcidPentetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
D010672PhenytoinPhenytoin results in increased expression of S100A4 mRNA14741686
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of S100A4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of S100A4 mRNA23811191
D017035PravastatinPravastatin results in increased expression of S100A4 mRNA27225895
D017035PravastatinPravastatin affects the expression of S100A4 mRNA27225895
D011374ProgesteroneProgesterone results in increased expression of S100A4 mRNA19690047
D011441PropylthiouracilPropylthiouracil affects the expression of S100A4 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]16948116
D011794QuercetinQuercetin inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]21924240
C059514resveratrolresveratrol results in decreased expression of S100A4 mRNA26934322
C059514resveratrolresveratrol results in decreased expression of S100A4 protein26934322
C059514resveratrolresveratrol results in increased expression of S100A4 mRNA25905778
D015474IsotretinoinIsotretinoin results in increased expression of S100A4 mRNA20436886
D012402RotenoneRotenone results in increased expression of S100A4 mRNA23186747
C093642SB 203580SB 203580 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]16948116
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of S100A4 mRNA17540011
D012822Silicon DioxideSilicon Dioxide results in increased expression of S100A4 mRNA23221170
D012834SilverSilver results in increased expression of S100A4 mRNA26014281
D020123SirolimusSirolimus results in decreased expression of S100A4 mRNA21865292
C025399sodium tungstate(VI)sodium tungstate(VI) results in increased expression of S100A4 mRNA26164860
D053260SootSoot results in increased expression of S100A4 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 affects the expression of S100A4 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of S100A4 mRNA27225895
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of S100A4 mRNA"26680231
C061133tamibarotenetamibarotene results in decreased expression of S100A4 mRNA17229644
C061133tamibarotenetamibarotene results in increased expression of S100A4 mRNA15498508
C012568terbufosterbufos results in decreased methylation of S100A4 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S100A4 mRNA12711416
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of S100A4 mRNA]11007951
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100A4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S100A4 mRNA11007951|1961957
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of S100A4 mRNA21167638
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to S100A4 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S100A4 mRNA15034205|1565276
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S100A4 mRNA17337447|2415448
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S100A4 mRNA12711416
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S100A4 mRNA22808131
D013755Tetradecanoylphorbol AcetateAtrazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A4 mRNA]24211529
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of S100A4 mRNA24211529
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased expression of S100A4 protein20164154
D019284ThapsigarginThapsigargin results in decreased expression of S100A4 mRNA22378314
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of S100A4 mRNA28943392
C009495titanium dioxidetitanium dioxide analog results in decreased expression of S100A4 mRNA25111187
C009495titanium dioxidetitanium dioxide results in increased expression of S100A4 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of S100A4 mRNA22363418
C024746tobacco tartobacco tar results in decreased expression of S100A4 mRNA19559774
D014050TolueneToluene results in decreased expression of S100A4 mRNA22967744
D014212TretinoinTretinoin results in decreased expression of S100A4 mRNA21934132
D014212TretinoinTretinoin results in increased expression of S100A4 mRNA15498508
D014212TretinoinTretinoin results in increased expression of S100A4 mRNA24977338
C012589trichostatin Atrichostatin A results in increased expression of S100A4 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of S100A4 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of S100A4 mRNA22378314
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK1 protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK3 protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK8 protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of MAPK9 protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of PTK2B protein]16948116
C406122tyrphostin A9tyrphostin A9 inhibits the reaction [S100A4 protein results in increased phosphorylation of RELA protein]16948116
D014635Valproic AcidValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of S100A4 mRNA]22711276
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of S100A4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of S100A4 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of S100A4 gene29154799
D014640VancomycinVancomycin results in decreased expression of S100A4 mRNA18930951
D001335Vehicle Emissions[S100A4 gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of S100A4 mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of S100A4 mRNA19165385
C025643vinclozolinvinclozolin affects the expression of S100A4 mRNA19015723
D014750VincristineVincristine results in increased expression of S100A4 mRNA23649840
C111237vorinostatvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of S100A4 mRNA]22711276
C111237vorinostatvorinostat results in increased expression of S100A4 mRNA27188386
C104536xanthohumolxanthohumol results in decreased expression of S100A4 protein23503627

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003779actin binding-IEA-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI14640694  15479433  16189514  19740107  20421509  20591429  
21516116  22483112  23752197  25416956  26496610  
GO:0042802identical protein binding-IPI20421509  22483112  
GO:0046914transition metal ion binding-IEA-  
GO:0048306calcium-dependent protein binding-IEA-  
GO:0050786RAGE receptor binding-IPI15033494  
GO ID GO Term Qualifier Evidence PubMed
GO:0001837epithelial to mesenchymal transition-TAS14679171  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA15033494  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005615extracellular space-HDA22664934  23580065  
GO:0005634nucleus-IDA12118070  15033494  
GO:0043005neuron projection-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA15033494  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28197929Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease. (2017 Mar)Mahmood MQMed Oncol
20630030Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. (2010 Aug)Sohal SSRespirology