Gene info: ID 6279

Gene: S100A8

GENE ID: 6279

Synonyms: 60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8

Description: S100 calcium binding protein A8

Gene type: protein-coding

Location: 1q21.3

dbXrefs: Ensembl:ENSG00000143546 MIM:123885 Vega:OTTHUMG00000013124 UniprotKB:P05109

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 12

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.664e-1 (AD) 2.820e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A9	0.963
S100A12	0.907
MMP9	0.783
IFITM2	0.757
S100P	0.756
HK3	0.742
LILRA5	0.739
VNN2	0.736
CST7	0.735
FCGR3B	0.733

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.598
MARCH4	-0.588
ABCC12	-0.585
PPEF1	-0.567
FBLN7	-0.562
EXTL1	-0.56
SLC32A1	-0.56
RCOR2	-0.557
FRMPD2	-0.553
GPR61	-0.553

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of S100A8 mRNA"	21147608
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of S100A8 mRNA"	18281256
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of S100A8 mRNA"	21354444
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"JUN mutant form promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of S100A8 mRNA]"	21354444
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of S100A8 protein	26194647
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of S100A8 mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A8 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of S100A8 mRNA"	20852150
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of S100A8 mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A8 mRNA"	27188386
C496492	abrine	abrine results in increased expression of S100A8 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of S100A8 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of S100A8 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of S100A8 mRNA	18544908\|2474715
D000181	Acrylonitrile	Acrylonitrile results in decreased expression of S100A8 mRNA	16173056
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of S100A8 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of S100A8 gene	27153756
C000188	alachlor	alachlor results in increased expression of S100A8 mRNA	12419858
C103303	alitretinoin	alitretinoin results in decreased expression of S100A8 mRNA	15982314
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of S100A8 mRNA	21298039
D000537	Aluminum Oxide	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A8 protein"	25598225
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of S100A8 mRNA	16483693
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of S100A8 mRNA	28713220
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of S100A8 protein	28713220
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of S100A8 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of S100A8 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of S100A8 mRNA	19128835
C006632	arsenic trioxide	arsenic trioxide results in increased expression of S100A8 mRNA	15070760\|1576101
C006632	arsenic trioxide	arsenic trioxide results in increased expression of S100A8 protein	25419056
C006632	arsenic trioxide	arsenic trioxide results in increased sumoylation of S100A8 protein	28318385
C006632	arsenic trioxide	S100A8 protein results in decreased susceptibility to arsenic trioxide	21971985
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of S100A8 mRNA	15894607
D016589	Astemizole	Astemizole results in increased expression of S100A8 mRNA	20221588
D001379	Azathioprine	Azathioprine results in increased expression of S100A8 mRNA	24184165
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of S100A8 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of S100A8 mRNA	18164116
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of S100A8 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of S100A8 mRNA	20106945\|2231617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of S100A8 mRNA	22610609
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100A8 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of S100A8 mRNA	19619570\|2813897
D004958	Estradiol	[bisphenol A results in increased susceptibility to Estradiol] which results in increased expression of S100A8 mRNA	27312807
D004958	Estradiol	Estradiol results in increased expression of S100A8 mRNA	19484750
D004958	Estradiol	Estradiol results in increased expression of S100A8 mRNA	26945725
D004958	Estradiol	Plant Preparations inhibits the reaction [Estradiol results in increased expression of S100A8 mRNA]	26945725
C006780	bisphenol A	bisphenol A results in decreased expression of S100A8 mRNA	25594700
C006780	bisphenol A	[bisphenol A results in increased susceptibility to Estradiol] which results in increased expression of S100A8 mRNA	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of S100A8 mRNA	25181051
D001761	Bleomycin	Bleomycin results in increased expression of S100A8 protein	25933445
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA	23986454
D019328	Buthionine Sulfoximine	[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA	28263783
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA	26177832
D019328	Buthionine Sulfoximine	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]	26177832
D002104	Cadmium	Cadmium results in increased expression of S100A8 mRNA	21120746
D019256	Cadmium Chloride	MT3 affects the reaction [Cadmium Chloride affects the expression of S100A8 mRNA]	20371981
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of S100A8 mRNA	25993096
D002118	Calcium	Calcium binds to [S100A8 protein binds to S100A9 protein]	17050004
D002118	Calcium	[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]	17050004
D002122	Calcium Chloride	Calcium Chloride results in increased expression of S100A8 mRNA	17214633
D002122	Calcium Chloride	Calcium Chloride results in increased expression of S100A8 protein	17214633
D002220	Carbamazepine	Carbamazepine results in increased expression of S100A8 mRNA	22790970
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of S100A8 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of S100A8 mRNA	17522070
C026690	cerous chloride	cerous chloride results in increased expression of S100A8 mRNA	23573234
D002725	Chloroform	Chloroform results in increased expression of S100A8 mRNA	17522070
C100187	chloropicrin	chloropicrin affects the expression of S100A8 mRNA	26352163
D002737	Chloroprene	Chloroprene results in decreased expression of S100A8 mRNA	23125180
D002784	Cholesterol	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of S100A8 mRNA	26606054
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A8 mRNA	20938992
C418118	CI 1044	CI 1044 results in increased expression of S100A8 mRNA	17569694
C052387	cocoa butter	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of S100A8 mRNA	26606054
D003078	Colchicine	Colchicine results in increased expression of S100A8 mRNA	20624997
D003300	Copper	S100A8 protein binds to Copper	14534351
D003471	Cuprizone	Cuprizone results in increased expression of S100A8 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in decreased expression of S100A8 mRNA	20106945
C093628	cyproconazole	cyproconazole results in increased expression of S100A8 mRNA	22334560
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of S100A8 mRNA	23914054
C014347	decitabine	decitabine affects the expression of S100A8 mRNA	18460780
D003907	Dexamethasone	Dexamethasone results in increased expression of S100A8 mRNA	1733233
D003907	Dexamethasone	Dexamethasone results in increased expression of S100A8 mRNA	22733784
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of S100A8 mRNA	20824662
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of S100A8 mRNA	24893172
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of S100A8 mRNA	28962523
D004008	Diclofenac	Diclofenac results in increased expression of S100A8 mRNA	28138970
D004008	Diclofenac	Diclofenac results in increased expression of S100A8 mRNA	24747151\|2693455
D004009	Dicloxacillin	Dicloxacillin results in increased expression of S100A8 mRNA	28138970
D004009	Dicloxacillin	Dicloxacillin results in increased expression of S100A8 mRNA	24747151
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA	16931933
D004041	Dietary Fats	Dietary Fats affects the expression of S100A8 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of S100A8 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of S100A8 mRNA	18503570\|2260994
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of S100A8 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of S100A8 mRNA	28412506
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of S100A8 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of S100A8 mRNA]	19850644
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of S100A8 mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of S100A8 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of S100A8 mRNA	15171707
D002117	Calcitriol	Calcitriol results in decreased expression of S100A8 mRNA	16002434\|2648566
D002117	Calcitriol	Calcitriol results in increased expression of S100A8 mRNA	1733233\|20089671
D002117	Calcitriol	Calcitriol results in increased expression of S100A8 protein	20089671
C472511	dimethylarsinous acid	dimethylarsinous acid results in decreased expression of S100A8 mRNA	23876855
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of S100A8 mRNA"	22485181
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene affects the expression of S100A8 mRNA"	21785161
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of S100A8 protein"	22248470
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of S100A8 mRNA"	27840820
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of S100A8 mRNA	1733233
D004237	Diuron	Diuron metabolite results in increased expression of S100A8 mRNA	24172598
D004317	Doxorubicin	Doxorubicin results in increased expression of S100A8 mRNA	21971985
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of S100A8 mRNA	21040762
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA]	18089841
D004726	Endosulfan	Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A8 mRNA]	26159488
C109476	epoxiconazole	epoxiconazole results in increased expression of S100A8 mRNA	22334560\|2397080
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of S100A8 mRNA	17522070
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of S100A8 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of S100A8 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of S100A8 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of S100A8 mRNA	15901920
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of S100A8 mRNA	17347304
D005485	Flutamide	Flutamide results in increased expression of S100A8 mRNA	28138970
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A8 mRNA	20938992
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]	26177832
C419708	gefitinib	[gefitinib co-treated with naphthalene] affects the expression of S100A8 mRNA	20935109
C419708	gefitinib	[gefitinib co-treated with naphthalene] affects the expression of S100A8 protein	20935109
D019833	Genistein	ESR1 promotes the reaction [Genistein results in decreased expression of S100A8 protein]	20884965
D019833	Genistein	ESR2 promotes the reaction [Genistein results in decreased expression of S100A8 protein]	20884965
D019833	Genistein	Genistein results in decreased expression of S100A8 protein	20884965
D005897	Glafenine	Glafenine results in increased expression of S100A8 mRNA	24136188
D005947	Glucose	GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A8 promoter]]	19833897
D005947	Glucose	GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]	19833897
D005947	Glucose	GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]	19833897
D005947	Glucose	Glucose promotes the reaction [JUN protein binds to S100A8 promoter]	19833897
D005947	Glucose	Glucose results in increased expression of S100A8 mRNA	19833897
D005947	Glucose	Glucose results in increased expression of S100A8 protein	19833897
D005947	Glucose	JUN promotes the reaction [Glucose results in increased expression of S100A8 mRNA]	19833897
D005947	Glucose	SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]	19833897
D005947	Glucose	SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 protein]	19833897
D005947	Glucose	UCP1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]	19833897
D005947	Glucose	UCP1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]	19833897
D006221	Halothane	Halothane results in increased expression of S100A8 mRNA	28138970
D006221	Halothane	Halothane results in increased expression of S100A8 mRNA	24747151
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of S100A8 mRNA	15159207
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in decreased expression of S100A8 mRNA	17183730
D019469	Indinavir	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA	16931933
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A8 mRNA	25613284
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of S100A8 protein"	22248470
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of S100A8 mRNA	18089841\|2000320
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of S100A8 mRNA	26582142
D007840	Latex	Latex analog results in increased expression of S100A8 mRNA	24768652
C052901	lemongrass oil	lemongrass oil affects the expression of S100A8 mRNA	25976427
D008012	Lidocaine	Lidocaine results in increased expression of S100A8 protein	18382663
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of S100A8 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of S100A8 mRNA"	15522845
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A8 mRNA	22235868
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A8 mRNA	24747151
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A8 mRNA	21461237\|2733941
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A8 mRNA	25613284
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of S100A8 mRNA	26378955
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA	22563483
D008345	Manganese	[S100A8 protein binds to S100A9] which binds to Manganese	23276281
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of S100A8 mRNA]	19833897
D008463	Mebendazole	Mebendazole results in increased expression of S100A8 mRNA	24747151
D008701	Methapyrilene	Methapyrilene results in decreased expression of S100A8 mRNA	28935588
D008701	Methapyrilene	Methapyrilene results in increased expression of S100A8 mRNA	28935588
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA	26177832
D008713	Methimazole	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]	26177832
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A8 mRNA	20938992
D008767	Methylmercury Compounds	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of S100A8 mRNA	20020106
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of S100A8 mRNA"	20188158
C045621	miglitol	miglitol results in decreased expression of S100A8	20667563
C406082	monomethylarsonous acid	monomethylarsonous acid affects the expression of S100A8 mRNA	25177542
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of S100A8 mRNA	22108045
C523799	MRK 003	S100A8 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of S100A8 protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of S100A8 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A8 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of S100A8 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of S100A8 protein"	25598225
C031721	naphthalene	[gefitinib co-treated with naphthalene] affects the expression of S100A8 mRNA	20935109
C031721	naphthalene	[gefitinib co-treated with naphthalene] affects the expression of S100A8 protein	20935109
C031721	naphthalene	naphthalene results in increased expression of S100A8 mRNA	18978301\|2139966
C031721	naphthalene	naphthalene results in increased expression of S100A8 protein	21399660
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of S100A8 mRNA	17522070
D009532	Nickel	Nickel results in increased expression of S100A8 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in increased expression of S100A8 mRNA	12540486
C028007	nickel monoxide	nickel monoxide results in decreased expression of S100A8 mRNA	19167457
C029938	nickel sulfate	nickel sulfate affects the expression of S100A8 mRNA	12718980
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of S100A8 mRNA	17616710
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A8 mRNA	27935865
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A8 mRNA"	19013360
D009638	Norepinephrine	Norepinephrine results in increased expression of S100A8 mRNA	16677282
D009638	Norepinephrine	Norepinephrine results in increased expression of S100A8 protein	16677282
D010126	Ozone	Ozone results in decreased expression of S100A8 mRNA	17095637
D000073878	Palm Oil	Palm Oil affects the expression of S100A8 mRNA	19680557
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA	22563483
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A8 mRNA	28341207
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A8 protein	28341207
D052638	Particulate Matter	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of S100A8 mRNA"	15522845
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A8 protein	17520064
D010396	Penicillamine	Penicillamine results in decreased expression of S100A8 mRNA	19575532
D010396	Penicillamine	Penicillamine results in increased expression of S100A8 mRNA	19575532
C046012	pentanal	pentanal results in increased expression of S100A8 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of S100A8 mRNA	18281256
C023036	perfluorooctanoic acid	PPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of S100A8 mRNA]	18281256
D010476	Perfume	Perfume results in increased expression of S100A8 mRNA	24768652
D010615	Phenacetin	Phenacetin results in increased expression of S100A8 mRNA	17082564
D010634	Phenobarbital	Phenobarbital affects the expression of S100A8 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of S100A8 mRNA	28138970
C030299	phenylhydrazine	phenylhydrazine results in increased expression of S100A8 mRNA	17082564
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA	23986454
C060836	pioglitazone	pioglitazone results in increased expression of S100A8 mRNA	28138970
C060836	pioglitazone	[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA	28263783
C006253	pirinixic acid	pirinixic acid results in increased expression of S100A8 mRNA	18445702
D010936	Plant Extracts	Plant Extracts results in increased expression of S100A8 mRNA	28533734
D028321	Plant Preparations	Plant Preparations inhibits the reaction [Estradiol results in increased expression of S100A8 mRNA]	26945725
D011078	Polychlorinated Biphenyls	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of S100A8 mRNA	20020106
C019536	potassium bromate	potassium bromate results in increased expression of S100A8 mRNA	23588252
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of S100A8 mRNA	22698814
D011324	Primidone	Primidone results in increased expression of S100A8 mRNA	28138970
D011374	Progesterone	Progesterone affects the expression of S100A8 mRNA	17251523
C045950	propiconazole	propiconazole results in increased expression of S100A8 mRNA	16730040\|2127805
C005556	propionaldehyde	propionaldehyde results in increased expression of S100A8 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of S100A8 mRNA	24780913
C428725	pyridaben	pyridaben results in increased expression of S100A8 mRNA	22563483
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in decreased localization of S100A8 protein	21971985
C052785	rebamipide	rebamipide results in increased expression of S100A8 mRNA	15104358
C059514	resveratrol	resveratrol results in decreased expression of S100A8 mRNA	19228061
D015474	Isotretinoin	Isotretinoin results in increased expression of S100A8 mRNA	15982314
D019258	Saquinavir	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA	16931933
C078903	seocalcitol	seocalcitol results in decreased expression of S100A8 mRNA	12040012
C009250	sevoflurane	sevoflurane results in increased expression of S100A8 mRNA	26206149
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of S100A8 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of S100A8 mRNA	21602193\|2243100
D019821	Simvastatin	Simvastatin results in increased expression of S100A8 mRNA	17428261
C017947	sodium arsenite	sodium arsenite results in decreased expression of S100A8 mRNA	23876855\|2871322
C017947	sodium arsenite	sodium arsenite results in decreased expression of S100A8 protein	28713220
C017947	sodium arsenite	sodium arsenite results in increased expression of S100A8 mRNA	23165982\|2859598
C017947	sodium arsenite	sodium arsenite results in increased expression of S100A8 mRNA	21297353
C016104	sodium bichromate	sodium bichromate results in increased expression of S100A8 mRNA	25993096
D020358	Sodium Cholate	[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of S100A8 mRNA	26606054
D018038	Sodium Selenite	Sodium Selenite results in increased expression of S100A8 mRNA	18175754
D053260	Soot	Soot results in increased expression of S100A8 mRNA	26551751
D013311	Streptozocin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of S100A8 mRNA]	19833897
D013311	Streptozocin	Streptozocin results in increased expression of S100A8 mRNA	19833897
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of S100A8 mRNA	26378955
C016766	sulforafan	sulforafan results in increased expression of S100A8 mRNA	26833863
C446685	systhane	systhane results in increased expression of S100A8 mRNA	23970803
C013698	tallow	tallow affects the expression of S100A8 mRNA	19680557
C061133	tamibarotene	tamibarotene results in increased expression of S100A8 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of S100A8 mRNA	20937368
D013739	Testosterone	Testosterone results in decreased expression of S100A8 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Endosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A8 mRNA]	26159488
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100A8 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100A8 mRNA	19619570\|1968428
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A8 mRNA]	16891777
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of S100A8 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of S100A8 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of S100A8 mRNA	19684285\|2821309
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100A8 mRNA	16114106\|1612074
D013752	Tetracycline	Tetracycline results in increased expression of S100A8 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A8 mRNA	1733233
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A8 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A8 mRNA	20172950\|2235966
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A8 protein	22359662
D013755	Tetradecanoylphorbol Acetate	TGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A8 mRNA]	20172950
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A8 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of S100A8 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of S100A8 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of S100A8 mRNA	27865774
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of S100A8 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of S100A8 protein	27818348
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of S100A8 mRNA	15894607
D014212	Tretinoin	Tretinoin inhibits the reaction [IL1A protein results in increased expression of S100A8 mRNA]	17214633
D014212	Tretinoin	Tretinoin metabolite results in increased expression of S100A8 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of S100A8 mRNA	15982314\|1721463
D014212	Tretinoin	Tretinoin results in increased expression of S100A8 mRNA	15498508\|1589460
C032910	triadimefon	triadimefon results in increased expression of S100A8 mRNA	23970803
D014241	Trichloroethylene	Trichloroethylene results in increased expression of S100A8 mRNA	25549359
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA	17982090\|1820051
C057693	troglitazone	troglitazone results in increased expression of S100A8 mRNA	28138970
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of S100A8 mRNA	19654044
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in decreased expression of S100A8 mRNA	17183730
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100A8 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of S100A8 mRNA	26272509
D001335	Vehicle Emissions	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of S100A8 mRNA"	15522845
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of S100A8 mRNA	23940539
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of S100A8 protein	17520064
D014747	Vinblastine	Vinblastine results in increased expression of S100A8 mRNA	20624997
C025643	vinclozolin	vinclozolin affects the expression of S100A8 mRNA	19015723
D014750	Vincristine	Vincristine results in increased expression of S100A8 mRNA	21971985
D014750	Vincristine	Vincristine results in increased expression of S100A8 mRNA	20624997
D014800	Vitallium	Vitallium analog results in increased expression of S100A8 mRNA	23825117
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A8 mRNA	27935865
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA	16931933
D015032	Zinc	Zinc binds to [S100A8 protein binds to S100A9 protein]	17050004
D015032	Zinc	[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]	17050004
D015032	Zinc	[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A8 mRNA	20857495
D015032	Zinc	[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A8 protein	20857495
D015032	Zinc	Zinc deficiency results in increased expression of S100A8 mRNA	20857495
D015032	Zinc	Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A8 mRNA]	20857495
D015032	Zinc	Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A8 protein]	20857495
D015032	Zinc	Zinc deficiency results in increased expression of S100A8 mRNA	19111725\|2268992
D015032	Zinc	Zinc deficiency results in increased expression of S100A8 protein	19111725\|2268992
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A8 mRNA]	19111725
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A8 protein]	19111725
D015032	Zinc	[S100A8 protein binds to S100A9] which binds to Zinc	23276281

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	TAS	22489132
GO:0005515	protein binding	-	IPI	9867828 20936779 25417112
GO:0008017	microtubule binding	-	TAS	22489132
GO:0008270	zinc ion binding	-	TAS	22489132
GO:0035662	Toll-like receptor 4 binding	-	TAS	22489132
GO:0050544	arachidonic acid binding	-	TAS	22489132
GO:0050786	RAGE receptor binding	-	TAS	22489132

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001816	cytokine production	-	TAS	22489132
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002523	leukocyte migration involved in inflammatory response	-	IDA	12626582
GO:0002526	acute inflammatory response	-	IEA	-
GO:0002544	chronic inflammatory response	-	IEA	-
GO:0002793	positive regulation of peptide secretion	-	IEA	-
GO:0006914	autophagy	-	IDA	19935772
GO:0006915	apoptotic process	-	IEA	-
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	19935772
GO:0006954	inflammatory response	-	TAS	3313057
GO:0010043	response to zinc ion	-	IEA	-
GO:0014002	astrocyte development	-	IEA	-
GO:0018119	peptidyl-cysteine S-nitrosylation	-	IMP	25417112
GO:0019730	antimicrobial humoral response	-	TAS	-
GO:0030307	positive regulation of cell growth	-	TAS	22489132
GO:0030593	neutrophil chemotaxis	-	IDA	12626582
GO:0032119	sequestering of zinc ion	-	TAS	22489132
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032602	chemokine production	-	TAS	22489132
GO:0042060	wound healing	-	IEA	-
GO:0042742	defense response to bacterium	-	TAS	22489132
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IDA	12626582
GO:0050832	defense response to fungus	-	TAS	22489132
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	22489132
GO:0051493	regulation of cytoskeleton organization	-	TAS	22489132
GO:0070488	neutrophil aggregation	-	IDA	12626582
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	-	IDA	19935772

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	22489132
GO:0005615	extracellular space	-	HDA	16502470 22664934
GO:0005615	extracellular space	-	IDA	21805676
GO:0005634	nucleus	-	HDA	21630459
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	22489132
GO:0005856	cytoskeleton	-	TAS	22489132
GO:0005886	plasma membrane	-	TAS	22489132
GO:0034774	secretory granule lumen	-	TAS	-
GO:0045111	intermediate filament cytoskeleton	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6799990	Metal sequestration by antimicrobial proteins	TAS
R-HSA-6803157	Antimicrobial peptides	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res
26946461	Platelet-Derived S100A8/A9 and Cardiovascular Disease in Systemic Lupus Erythematosus. (2016 Aug)	Lood C	Arthritis Rheumatol
24453429	S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease. (2013)	Schiopu A	Mediators Inflamm
22616666	Smoke-induced signal molecules in bone marrow cells from altered low-density lipoprotein receptor-related protein 5 mice. (2012 Jul 6)	Ma D	J Proteome Res
19823685	Calprotectin--a novel marker of obesity. (2009 Oct 12)	Mortensen OH	PLoS One
19222993	Effects of cigarette smoking on the human urinary proteome. (2009 Apr 10)	Airoldi L	Biochem Biophys Res Commun
29733516	Clinical significance of calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer. (2018 May 7)	Huang H	Thorac Cancer
24202303	Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals. (2014 Jan)	Cotoi OS	Arterioscler Thromb Vasc Biol
20935109	EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. (2011 Mar 15)	Harada C	Am J Respir Crit Care Med
25036363	Susceptibility to COPD: differential proteomic profiling after acute smoking. (2014)	Franciosi L	PLoS One
25298412	Identification of vinculin as a potential plasma marker for age-related macular degeneration. (2014 Oct 8)	Kim HJ	Invest Ophthalmol Vis Sci
17451265	S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining. (2007 Jun)	Lo WY	J Proteome Res