Gene info: ID 6280

Gene: S100A9

GENE ID: 6280

Synonyms: 60B8AG|CAGB|CFAG|CGLB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14

Description: S100 calcium binding protein A9

Gene type: protein-coding

Location: 1q21.3

dbXrefs: Ensembl:ENSG00000163220 MIM:123886 Vega:OTTHUMG00000013125 UniprotKB:P06702

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.807e-1 (AD) 3.662e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A8	0.963
S100A12	0.872
IFITM2	0.773
VNN2	0.757
FCGR3B	0.757
S100A11	0.752
SELL	0.749
CST7	0.748
MMP9	0.747
HK3	0.743

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH4	-0.573
ABCC12	-0.561
NEUROD6	-0.553
FRMPD2	-0.542
F7	-0.537
FBLN7	-0.537
PPEF1	-0.533
DLK2	-0.531
SLC7A4	-0.526
SLC32A1	-0.524

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of S100A9 mRNA"	19114083
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of S100A9 mRNA"	15059925
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of S100A9 mRNA"	20852150
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of S100A9 mRNA	15982314
C496492	abrine	abrine results in increased expression of S100A9 mRNA	22595364
D000082	Acetaminophen	Acetaminophen affects the expression of S100A9 mRNA	17562736
D000082	Acetaminophen	Acetaminophen affects the expression of S100A9 protein	12051698
D000082	Acetaminophen	Acetaminophen results in increased expression of S100A9 mRNA	24747151
D000082	Acetaminophen	S100A9 protein inhibits the reaction [Acetaminophen results in increased expression of HSPB1 protein]	12051698
D000082	Acetaminophen	S100A9 protein inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]	12051698
D000082	Acetaminophen	S100A9 protein promotes the reaction [Acetaminophen results in increased expression of CXCL15 mRNA]	12051698
D000082	Acetaminophen	S100A9 protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA]	12051698
D000082	Acetaminophen	S100A9 protein promotes the reaction [Acetaminophen results in increased expression of IL6 mRNA]	12051698
D000082	Acetaminophen	S100A9 protein results in increased susceptibility to Acetaminophen	12051698
D000082	Acetaminophen	Acetaminophen results in increased expression of S100A9 mRNA	17522070
C096064	actein	actein affects the expression of S100A9 mRNA	19527300
C096064	actein	actein results in increased expression of S100A9 mRNA	19527300
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of S100A9 gene	27153756
C000188	alachlor	alachlor results in increased expression of S100A9 mRNA	12419858
D000447	Aldehydes	Aldehydes results in increased expression of S100A9 mRNA	25014914
D000452	Aldrin	Aldrin results in decreased expression of S100A9 mRNA	18579281
C103303	alitretinoin	alitretinoin results in increased expression of S100A9 mRNA	15982314
D000537	Aluminum Oxide	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A9 protein"	25598225
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of S100A9 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of S100A9 mRNA"	22863853
D000667	Ampicillin	Ampicillin results in increased expression of S100A9 mRNA	24747151
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of S100A9 mRNA	28713220
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of S100A9 protein	28713220
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of S100A9 mRNA	17696278\|2444957
D001151	Arsenic	Arsenic results in decreased expression of S100A9 mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in increased expression of S100A9 mRNA	15761015
C006632	arsenic trioxide	arsenic trioxide results in increased expression of S100A9 protein	25419056
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of S100A9 protein"	21135415
D001374	Azacitidine	Azacitidine results in increased expression of S100A9 mRNA	19194470
D001379	Azathioprine	Azathioprine results in increased expression of S100A9 mRNA	24184165
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of S100A9 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of S100A9 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of S100A9 mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of S100A9 mRNA	21964900\|2373587
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of S100A9 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of S100A9 mRNA	19619570\|2813897
D004958	Estradiol	bisphenol A inhibits the reaction [Estradiol results in decreased expression of S100A9 mRNA]	27312807
D004958	Estradiol	Estradiol results in decreased expression of S100A9 mRNA	27312807
D004958	Estradiol	Estradiol results in increased expression of S100A9 mRNA	19484750
D004958	Estradiol	Estradiol results in increased expression of S100A9 mRNA	26945725
D004958	Estradiol	Plant Preparations inhibits the reaction [Estradiol results in increased expression of S100A9 mRNA]	26945725
C095105	bexarotene	bexarotene results in increased expression of S100A9 mRNA	17178900
C095105	bexarotene	bexarotene results in increased expression of S100A9 mRNA	16648578
C006780	bisphenol A	bisphenol A inhibits the reaction [Estradiol results in decreased expression of S100A9 mRNA]	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of S100A9 mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of S100A9 mRNA	25181051
D019328	Buthionine Sulfoximine	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA	23986454
D019328	Buthionine Sulfoximine	[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA	28263783
D019328	Buthionine Sulfoximine	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA	29154782
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA	26177832
D019328	Buthionine Sulfoximine	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]	26177832
C018475	butyraldehyde	butyraldehyde results in increased expression of S100A9 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of S100A9 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of S100A9 mRNA	25993096
D002118	Calcium	Calcium binds to [S100A8 protein binds to S100A9 protein]	17050004
D002118	Calcium	[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]	17050004
D002122	Calcium Chloride	Calcium Chloride results in increased expression of S100A9 mRNA	17214633
D002122	Calcium Chloride	Calcium Chloride results in increased expression of S100A9 protein	17214633
D002220	Carbamazepine	Carbamazepine results in increased expression of S100A9 mRNA	22790970
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of S100A9 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of S100A9 mRNA	17522070
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of S100A9 mRNA	19395590
C026690	cerous chloride	cerous chloride results in increased expression of S100A9 mRNA	23573234
D002725	Chloroform	Chloroform results in increased expression of S100A9 mRNA	17522070
C100187	chloropicrin	chloropicrin results in increased expression of S100A9 mRNA	26352163
D002737	Chloroprene	Chloroprene results in decreased expression of S100A9 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A9 mRNA	20938992
C418118	CI 1044	CI 1044 results in increased expression of S100A9 mRNA	17569694
D003024	Clozapine	Clozapine results in decreased expression of S100A9 mRNA	18797397
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of S100A9 mRNA	19376846
D003078	Colchicine	Colchicine results in increased expression of S100A9 mRNA	20624997
D003471	Cuprizone	Cuprizone results in increased expression of S100A9 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in decreased expression of S100A9 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of S100A9 mRNA	25562108
C014347	decitabine	decitabine affects the expression of S100A9 mRNA	18460780
C014347	decitabine	decitabine results in increased expression of S100A9 mRNA	19194470
D003907	Dexamethasone	Dexamethasone results in increased expression of S100A9 mRNA	1733233
D003907	Dexamethasone	Dexamethasone results in decreased expression of S100A9 mRNA	17522070
D003907	Dexamethasone	Dexamethasone results in increased expression of S100A9 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of S100A9 mRNA]	20032058
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of S100A9 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of S100A9 mRNA	27594783
D004008	Diclofenac	Diclofenac results in increased expression of S100A9 mRNA	28138970
D004008	Diclofenac	Diclofenac results in increased expression of S100A9 mRNA	24747151\|2693455
D004009	Dicloxacillin	Dicloxacillin results in increased expression of S100A9 mRNA	24747151
D004041	Dietary Fats	Dietary Fats affects the expression of S100A9 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in decreased expression of S100A9 mRNA	18042831\|2501614
D004041	Dietary Fats	Dietary Fats results in increased expression of S100A9 mRNA	22609946
D004041	Dietary Fats	Dietary Fats results in decreased expression of S100A9 mRNA	21852083
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of S100A9 mRNA	26033743
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of S100A9 mRNA	28412506
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of S100A9 mRNA	28085963
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of S100A9 mRNA	27405655
C014476	diethyl maleate	diethyl maleate results in decreased expression of S100A9 mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of S100A9 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of S100A9 mRNA	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of S100A9 mRNA	19638242
D002117	Calcitriol	Calcitriol results in increased expression of S100A9 mRNA	1733233\|20089671
D002117	Calcitriol	Calcitriol results in increased expression of S100A9 protein	20089671
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of S100A9 mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of S100A9 mRNA	25380136
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of S100A9 mRNA	1733233
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of S100A9 mRNA	21040762
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA]	18089841
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of S100A9 mRNA"	26539117
D004918	Erythromycin Estolate	Erythromycin Estolate results in increased expression of S100A9 mRNA	17522070
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of S100A9 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol promotes the reaction [IL1B protein results in increased expression of S100A9 mRNA]	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of S100A9 mRNA	15901920
D005419	Flavonoids	Flavonoids results in increased expression of S100A9 mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of S100A9 mRNA	28138970
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A9 mRNA	20938992
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of S100A9 mRNA	21149847
C069837	fullerene C60	fullerene C60 results in increased expression of S100A9 mRNA	20471445
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]	26177832
D019833	Genistein	ESR1 promotes the reaction [Genistein results in decreased expression of S100A9 protein]	20884965
D019833	Genistein	ESR2 promotes the reaction [Genistein results in increased expression of S100A9 protein]	20884965
D019833	Genistein	Genistein results in decreased expression of S100A9 protein	20884965
D019833	Genistein	Genistein results in increased expression of S100A9 protein	20884965
D005897	Glafenine	Glafenine results in increased expression of S100A9 mRNA	24136188
D005947	Glucose	Glucose deficiency results in increased secretion of S100A9 protein	24802182
C010974	glyphosate	glyphosate results in increased expression of S100A9 protein	24073338
C010974	glyphosate	glyphosate results in increased expression of S100A9 protein	20045496
D006220	Haloperidol	Haloperidol results in decreased expression of S100A9 mRNA	18797397
D006221	Halothane	Halothane results in increased expression of S100A9 protein	12051698
D006221	Halothane	Halothane results in increased expression of S100A9 mRNA	24747151
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of S100A9 mRNA	15159207
D017313	Fenretinide	Fenretinide results in increased expression of S100A9 mRNA	28973697
D007052	Ibuprofen	Ibuprofen results in increased expression of S100A9 mRNA	24747151
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A9 mRNA	25613284
D007501	Iron	Iron deficiency results in decreased expression of S100A9 mRNA	16629162
D007530	Isoflurane	Isoflurane results in increased expression of S100A9 mRNA	24747151
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of S100A9 mRNA	18089841\|2000320
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of S100A9 mRNA	17085751
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of S100A9 mRNA	15618438
D007840	Latex	Latex analog results in increased expression of S100A9 mRNA	24768652
D007854	Lead	S100A9 protein binds to Lead	23896426
D008012	Lidocaine	Lidocaine results in increased expression of S100A9 protein	18382663
C018584	linalool	linalool results in decreased expression of S100A9 mRNA	20536181
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of S100A9 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of S100A9 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"Particulate Matter promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA]"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"Vehicle Emissions promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA]"	15522845
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A9 mRNA	24747151
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A9 mRNA	27339419
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A9 mRNA	25613284
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of S100A9 mRNA	26378955
C013099	mancozeb	mancozeb results in increased expression of S100A9 protein	21375462
C013099	mancozeb	mancozeb results in increased expression of S100A9 protein	21375462
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA	22563483
D008345	Manganese	[S100A8 protein binds to S100A9] which binds to Manganese	23276281
C025340	manganese chloride	S100A9 protein affects the susceptibility to manganese chloride	24067723
D008463	Mebendazole	Mebendazole results in increased expression of S100A9 mRNA	24747151
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of S100A9 mRNA	16507785
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA	26177832
D008713	Methimazole	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]	26177832
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of S100A9 mRNA	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of S100A9 mRNA	17400583
D008727	Methotrexate	Methotrexate results in increased expression of S100A9 mRNA	17696278
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of S100A9 mRNA"	20188158
C045621	miglitol	miglitol results in decreased expression of S100A9 mRNA	20667563
C045621	miglitol	miglitol results in decreased expression of S100A9	20667563
D009151	Mustard Gas	Mustard Gas results in increased expression of S100A9 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of S100A9 protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of S100A9 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of S100A9 mRNA"	25620056
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with Aluminum Oxide] results in increased secretion of S100A9 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of S100A9 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of S100A9 protein"	25598225
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of S100A9 mRNA"	19836432
C031721	naphthalene	naphthalene results in increased expression of S100A9 mRNA	18978301
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of S100A9 mRNA	17522070\|2538013
D009532	Nickel	Nickel results in increased expression of S100A9 mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in increased expression of S100A9 mRNA	16100012
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of S100A9 mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A9 mRNA	27935865
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A9 mRNA"	19013360
D009638	Norepinephrine	Norepinephrine results in increased expression of S100A9 mRNA	16677282
D009638	Norepinephrine	Norepinephrine results in increased expression of S100A9 protein	16677282
C076029	olanzapine	olanzapine results in decreased expression of S100A9 mRNA	18797397
D010126	Ozone	Ozone results in decreased expression of S100A9 mRNA	12763052\|1709563
D010126	Ozone	Ozone results in decreased expression of S100A9 mRNA	16716893
D000073878	Palm Oil	Palm Oil affects the expression of S100A9 mRNA	19680557
D000073878	Palm Oil	Palm Oil results in decreased expression of S100A9 mRNA	18042831
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA	22563483
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A9 mRNA	28341207
D052638	Particulate Matter	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of S100A9 mRNA"	15522845
D052638	Particulate Matter	"Particulate Matter promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA]"	15522845
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A9 protein	17520064
D010396	Penicillamine	Penicillamine results in decreased expression of S100A9 mRNA	19575532
D010396	Penicillamine	Penicillamine results in increased expression of S100A9 mRNA	19575532
C046012	pentanal	pentanal results in increased expression of S100A9 mRNA	26079696
D010476	Perfume	Perfume results in increased expression of S100A9 mRNA	24768652
D010615	Phenacetin	Phenacetin results in increased expression of S100A9 mRNA	17082564
D010634	Phenobarbital	Phenobarbital results in increased expression of S100A9 mRNA	28138970
C030299	phenylhydrazine	phenylhydrazine results in increased expression of S100A9 mRNA	17082564
D010672	Phenytoin	[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA	23986454
D010672	Phenytoin	Phenytoin results in increased expression of S100A9 mRNA	23986454
C060836	pioglitazone	pioglitazone results in increased expression of S100A9 mRNA	28138970
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of S100A9 mRNA	27935865
C060836	pioglitazone	[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA	28263783
C006253	pirinixic acid	pirinixic acid results in increased expression of S100A9 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in decreased expression of S100A9 mRNA	19162173
D028321	Plant Preparations	Plant Preparations inhibits the reaction [Estradiol results in increased expression of S100A9 mRNA]	26945725
C019536	potassium bromate	potassium bromate results in decreased expression of S100A9 mRNA	23588252
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of S100A9 protein	23718831
C009007	potassium persulfate	potassium persulfate results in increased expression of S100A9 protein	20815409
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of S100A9 mRNA	22698814
D011324	Primidone	Primidone results in increased expression of S100A9 mRNA	28138970
D011374	Progesterone	Progesterone affects the expression of S100A9 mRNA	17251523
C005556	propionaldehyde	propionaldehyde results in increased expression of S100A9 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of S100A9 mRNA	24780913
C428725	pyridaben	pyridaben results in increased expression of S100A9 mRNA	22563483
D011791	Quartz	Quartz results in increased expression of S100A9 mRNA	19836432
D011802	Quinidine	Quinidine results in increased expression of S100A9 mRNA	17522070
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of S100A9 mRNA	25905778
C059514	resveratrol	resveratrol results in decreased expression of S100A9 mRNA	19228061
C059514	resveratrol	resveratrol results in increased expression of S100A9 mRNA	25905778
D015474	Isotretinoin	Isotretinoin results in increased expression of S100A9 mRNA	15982314
C078903	seocalcitol	seocalcitol results in decreased expression of S100A9 mRNA	12040012
C009250	sevoflurane	sevoflurane results in increased expression of S100A9 mRNA	26206149
C009250	sevoflurane	sevoflurane affects the expression of S100A9 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of S100A9 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of S100A9 mRNA	21602193
D019821	Simvastatin	Simvastatin results in increased expression of S100A9 mRNA	17428261
D012906	Smoke	Smoke results in decreased expression of S100A9 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in decreased expression of S100A9 mRNA	28713220
C017947	sodium arsenite	sodium arsenite results in decreased expression of S100A9 protein	19294697\|2871322
C017947	sodium arsenite	sodium arsenite results in increased expression of S100A9 mRNA	23165982
C017947	sodium arsenite	sodium arsenite results in increased expression of S100A9 protein	20050688
C017947	sodium arsenite	sodium arsenite results in increased expression of S100A9 mRNA	21297353
C016104	sodium bichromate	sodium bichromate results in decreased expression of S100A9 mRNA	17685462
C016104	sodium bichromate	sodium bichromate results in increased expression of S100A9 mRNA	25993096
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of S100A9 mRNA	17936526
D053260	Soot	Soot affects the expression of S100A9 protein	21135415
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of S100A9 mRNA	25905778
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of S100A9 mRNA	26378955
C016766	sulforafan	sulforafan results in increased expression of S100A9 mRNA	26833863
C013698	tallow	tallow affects the expression of S100A9 mRNA	19680557
C061133	tamibarotene	tamibarotene results in increased expression of S100A9 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of S100A9 mRNA	20937368
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of S100A9 mRNA]	20032058
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of S100A9 mRNA	28300664
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of S100A9 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100A9 mRNA	19619570\|2010694
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A9 mRNA]	16891777
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of S100A9 mRNA	26377647\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of S100A9 mRNA	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100A9 mRNA	16114106\|1612074
D013749	Tetrachlorodibenzodioxin	[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A9 mRNA]	21835898
D013752	Tetracycline	Tetracycline results in increased expression of S100A9 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A9 mRNA	1733233
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A9 protein	24073338
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A9 mRNA]	22359662
D013755	Tetradecanoylphorbol Acetate	IL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A9 protein]	22359662
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A9 mRNA	20172950\|2235966
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of S100A9 protein	20045496\|2235966
D013755	Tetradecanoylphorbol Acetate	TGFB1 affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of S100A9 mRNA]	20172950
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A9 mRNA	25613284
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of S100A9 mRNA	28943392
C009495	titanium dioxide	titanium dioxide results in increased expression of S100A9 mRNA	23409001\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of S100A9 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of S100A9 mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of S100A9 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of S100A9 protein	27818348
D014212	Tretinoin	Tretinoin inhibits the reaction [IL1A protein results in increased expression of S100A9 mRNA]	17214633
D014212	Tretinoin	Tretinoin metabolite results in increased expression of S100A9 mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of S100A9 mRNA	17214633
D014212	Tretinoin	Tretinoin results in increased expression of S100A9 mRNA	15498508\|1589460
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA	17982090\|1820051
C025541	tri-o-cresyl phosphate	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA	29154782
D014520	Urethane	Urethane results in increased expression of S100A9 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of S100A9 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased methylation of S100A9 gene	29154799
D001335	Vehicle Emissions	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of S100A9 mRNA"	15522845
D001335	Vehicle Emissions	"Vehicle Emissions promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of S100A9 mRNA]"	15522845
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of S100A9 protein	17520064
D014747	Vinblastine	Vinblastine results in increased expression of S100A9 mRNA	20624997
C025643	vinclozolin	vinclozolin affects the expression of S100A9 mRNA	19015723
D014750	Vincristine	Vincristine results in increased expression of S100A9 mRNA	20624997
D014752	Vinyl Chloride	Vinyl Chloride results in decreased expression of S100A9 mRNA	18579281
C111237	vorinostat	vorinostat results in decreased expression of S100A9 protein	20543569
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A9 mRNA	27935865
D015032	Zinc	Zinc binds to [S100A8 protein binds to S100A9 protein]	17050004
D015032	Zinc	[Zinc co-treated with Calcium] binds to [S100A8 protein binds to S100A9 protein]	17050004
D015032	Zinc	[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A9 mRNA	20857495
D015032	Zinc	[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A9 protein	20857495
D015032	Zinc	Zinc deficiency results in increased expression of S100A9 mRNA	20857495
D015032	Zinc	Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A9 mRNA]	20857495
D015032	Zinc	Zinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of S100A9 protein]	20857495
D015032	Zinc	Zinc deficiency results in increased expression of S100A9 mRNA	19111725\|2268992
D015032	Zinc	Zinc deficiency results in increased expression of S100A9 protein	22689922
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of S100A9 mRNA]	19111725
D015032	Zinc	[S100A8 protein binds to S100A9] which binds to Zinc	23276281
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of S100A9 mRNA	27215404
C088658	zoledronic acid	zoledronic acid results in increased expression of S100A9 mRNA	24714768
C020549	zomepirac	[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA	29154782

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	TAS	22489132
GO:0005515	protein binding	-	IPI	9867828 17620599 20936779 25417112
GO:0008017	microtubule binding	-	TAS	22489132
GO:0008270	zinc ion binding	-	TAS	22489132
GO:0016209	antioxidant activity	-	IEA	-
GO:0035662	Toll-like receptor 4 binding	-	TAS	22489132
GO:0050544	arachidonic acid binding	-	TAS	22489132
GO:0050786	RAGE receptor binding	-	TAS	22489132

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001816	cytokine production	-	TAS	22489132
GO:0002224	toll-like receptor signaling pathway	-	TAS	-
GO:0002523	leukocyte migration involved in inflammatory response	-	IDA	12626582
GO:0002793	positive regulation of peptide secretion	-	IEA	-
GO:0006417	regulation of translation	-	IEA	-
GO:0006914	autophagy	-	IDA	19935772
GO:0006915	apoptotic process	-	IEA	-
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	19935772
GO:0006954	inflammatory response	-	TAS	3313057
GO:0007267	cell-cell signaling	-	TAS	3313057
GO:0010976	positive regulation of neuron projection development	-	ISS	-
GO:0014002	astrocyte development	-	IEA	-
GO:0019730	antimicrobial humoral response	-	TAS	-
GO:0030194	positive regulation of blood coagulation	-	IEA	-
GO:0030307	positive regulation of cell growth	-	TAS	22489132
GO:0030593	neutrophil chemotaxis	-	IDA	12626582
GO:0031532	actin cytoskeleton reorganization	-	IEA	-
GO:0032119	sequestering of zinc ion	-	TAS	22489132
GO:0032602	chemokine production	-	TAS	22489132
GO:0035606	peptidyl-cysteine S-trans-nitrosylation	-	IDA	25417112
GO:0035821	modification of morphology or physiology of other organism	-	IDA	12874352
GO:0042742	defense response to bacterium	-	TAS	22489132
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045087	innate immune response	-	IEA	-
GO:0045113	regulation of integrin biosynthetic process	-	IEA	-
GO:0050729	positive regulation of inflammatory response	-	IDA	12626582
GO:0050832	defense response to fungus	-	TAS	22489132
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	22489132
GO:0051493	regulation of cytoskeleton organization	-	TAS	22489132
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	-	IDA	12874352
GO:0070488	neutrophil aggregation	-	IDA	12626582
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	-	IDA	19935772

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	22489132
GO:0005615	extracellular space	-	HDA	16502470 22664934 23580065
GO:0005615	extracellular space	-	IDA	21805676
GO:0005634	nucleus	-	HDA	21630459
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IDA	12874352
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	22489132
GO:0005856	cytoskeleton	-	TAS	22489132
GO:0005886	plasma membrane	-	TAS	22489132
GO:0030054	cell junction	-	IDA	-
GO:0034774	secretory granule lumen	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-5686938	Regulation of TLR by endogenous ligand	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6799990	Metal sequestration by antimicrobial proteins	TAS
R-HSA-6803157	Antimicrobial peptides	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19823685	Calprotectin--a novel marker of obesity. (2009 Oct 12)	Mortensen OH	PLoS One
24453429	S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease. (2013)	Schiopu A	Mediators Inflamm
22616666	Smoke-induced signal molecules in bone marrow cells from altered low-density lipoprotein receptor-related protein 5 mice. (2012 Jul 6)	Ma D	J Proteome Res
26653550	Diagnostic importance of S100A9 and S100A12 in breast cancer. (2015 Dec)	Gunaldi M	Biomed Pharmacother
29733516	Clinical significance of calcium-binding protein S100A8 and S100A9 expression in non-small cell lung cancer. (2018 May 7)	Huang H	Thorac Cancer
24202303	Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals. (2014 Jan)	Cotoi OS	Arterioscler Thromb Vasc Biol
25716997	Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. (2015 Apr 1)	Carvallo L	J Immunol
25036363	Susceptibility to COPD: differential proteomic profiling after acute smoking. (2014)	Franciosi L	PLoS One
25298412	Identification of vinculin as a potential plasma marker for age-related macular degeneration. (2014 Oct 8)	Kim HJ	Invest Ophthalmol Vis Sci