Gene info: ID 6283

Gene: S100A12

GENE ID: 6283

Synonyms: CAAF1|CAGC|CGRP|ENRAGE|MRP-6|MRP6|p6

Description: S100 calcium binding protein A12

Gene type: protein-coding

Location: 1q21.3

dbXrefs: Ensembl:ENSG00000163221 MIM:603112 Vega:OTTHUMG00000013127 UniprotKB:P80511

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.206e-1 (AD) 3.205e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
S100A8	0.907
MMP9	0.875
S100A9	0.872
S100P	0.8
MMP25	0.773
CST7	0.766
VNN2	0.765
LILRA5	0.751
NFE2	0.747
CD177	0.742

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC32A1	-0.575
MARCH4	-0.56
NEUROD6	-0.56
LRRC73	-0.554
EXTL1	-0.547
GRIP2	-0.544
SVOP	-0.544
VWC2	-0.543
KCNC2	-0.536
RELL2	-0.534

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00768	Olopatadine	Small Molecule	113806-05-6	Approved	Target
DB01025	Amlexanox	Small Molecule	68302-57-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in decreased expression of S100A12 mRNA	26690555
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of S100A12 mRNA	28713220
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of S100A12 mRNA	17696278\|2444957
D001115	Arecoline	Arecoline results in decreased expression of S100A12 mRNA	17682004
D001151	Arsenic	Arsenic affects the expression of S100A12 protein	24675094
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of S100A12 mRNA"	25351596
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of S100A12 mRNA]	11007951
D005947	Glucose	GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A12 promoter]]	19833897
D005947	Glucose	GLO1 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]	19833897
D005947	Glucose	Glucose promotes the reaction [JUN protein binds to S100A12 promoter]	19833897
D005947	Glucose	Glucose results in increased expression of S100A12 mRNA	19833897
D005947	Glucose	JUN promotes the reaction [Glucose results in increased expression of S100A12 mRNA]	19833897
D005947	Glucose	SOD2 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]	19833897
D005947	Glucose	UCP1 inhibits the reaction [Glucose results in increased expression of S100A12 mRNA]	19833897
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A12 mRNA	25613284
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of S100A12 mRNA	25613284
D008727	Methotrexate	Methotrexate results in increased expression of S100A12 mRNA	17696278
C045621	miglitol	miglitol results in decreased expression of S100A12 mRNA	20667563
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A12 mRNA"	19013360
D052638	Particulate Matter	Particulate Matter results in increased expression of S100A12 mRNA	28341207
C017947	sodium arsenite	sodium arsenite affects the expression of S100A12 mRNA	29319823
C017947	sodium arsenite	sodium arsenite results in decreased expression of S100A12 mRNA	28713220
D018038	Sodium Selenite	Sodium Selenite results in increased expression of S100A12 mRNA	18175754
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of S100A12 mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of S100A12 mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100A12 mRNA	21835898\|2315218
D013749	Tetrachlorodibenzodioxin	[EGF protein results in increased activity of EGFR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of S100A12 mRNA]	21835898
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S100A12 mRNA	25613284
D015032	Zinc	Zinc binds to S100A12 protein	17050004

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005507	copper ion binding	-	TAS	18443896
GO:0005509	calcium ion binding	-	TAS	18443896
GO:0005515	protein binding	-	IPI	19386136
GO:0008270	zinc ion binding	-	TAS	11522286 18443896
GO:0050786	RAGE receptor binding	-	IDA	19386136
GO:0050786	RAGE receptor binding	-	IPI	15033494
GO:0050786	RAGE receptor binding	-	TAS	18443896

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002548	monocyte chemotaxis	-	TAS	18443896
GO:0006805	xenobiotic metabolic process	-	IDA	11522286
GO:0006954	inflammatory response	-	IEA	-
GO:0030593	neutrophil chemotaxis	-	TAS	18443896
GO:0031640	killing of cells of other organism	-	IDA	11522286
GO:0042742	defense response to bacterium	-	TAS	18443896
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	15033494
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043406	positive regulation of MAP kinase activity	-	TAS	18443896
GO:0045087	innate immune response	-	TAS	18443896
GO:0045576	mast cell activation	-	TAS	18443896
GO:0050663	cytokine secretion	-	TAS	18443896
GO:0050729	positive regulation of inflammatory response	-	TAS	18443896
GO:0050832	defense response to fungus	-	IDA	11522286
GO:0050832	defense response to fungus	-	TAS	18443896
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	18443896
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	-	IDA	11522286

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	18443896
GO:0005634	nucleus	-	IDA	15033494
GO:0005737	cytoplasm	-	IDA	15033494
GO:0005829	cytosol	-	TAS	18443896
GO:0005856	cytoskeleton	-	TAS	18443896
GO:0005886	plasma membrane	-	TAS	18443896
GO:0034774	secretory granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	TAS
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	IEA
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26653550	Diagnostic importance of S100A9 and S100A12 in breast cancer. (2015 Dec)	Gunaldi M	Biomed Pharmacother
21450080	Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study. (2011 Mar 30)	Miniati M	Respir Res