Gene info: ID 6285

Gene: S100B

GENE ID: 6285

Synonyms: NEF|S100|S100-B|S100beta

Description: S100 calcium binding protein B

Gene type: protein-coding

Location: 21q22.3

dbXrefs: Ensembl:ENSG00000160307 MIM:176990 Vega:OTTHUMG00000090715 UniprotKB:P04271

RefSeq: NC_000021.9

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 9

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.636e-2 (AD) 5.305e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLEKHB1	0.91
TSC22D4	0.903
NDRG2	0.887
MARCKSL1	0.883
GCSH	0.866
CRYL1	0.865
CSRP1	0.862
HADHB	0.858
ACAA2	0.849
PTGDS	0.846

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.595
OR4F5	-0.561
KCNH5	-0.458
HRH2	-0.448
KLHL38	-0.443
KCNH1	-0.439
OPRD1	-0.43
GDF7	-0.429
LRRK1	-0.429
PROKR2	-0.428

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00768	Olopatadine	Small Molecule	113806-05-6	Approved	Target
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target
DB04464	N-Formylmethionine	Small Molecule		Experimental	Target
DB05343	Arundic acid	Small Molecule	185517-21-9	Investigational	Target
DB06941	(Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide	Small Molecule	-	Experimental	Target
DB07004	2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide	Small Molecule		Experimental	Target
DB11093	Calcium Citrate	Small Molecule	813-94-5	Approved	Target
DB11348	Calcium Phosphate	Small Molecule	10103-46-5	Approved	Target

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of S100B protein"	21673325
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
C507130	2-(8-quinolinoxy)propionic acid	2-(8-quinolinoxy)propionic acid inhibits the reaction [S100B protein results in increased expression of NOX2 mRNA]	17327432
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [S100B protein results in increased degradation of NFKBIA protein]	17327432
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C549066	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [S100B protein results in increased expression of AGER protein]"	23541064
C549066	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]"	23541064
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of S100B mRNA	26690555
D000157	Aconitine	ABCB1A gene mutant form promotes the reaction [Aconitine results in increased expression of S100B protein]	28193520
D000157	Aconitine	Aconitine results in increased expression of S100B protein	28193520
D000535	Aluminum	Aluminum results in increased expression of S100B protein	16545059
D000535	Aluminum	Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein]	16545059
D000641	Ammonia	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
D000641	Ammonia	Ammonia results in increased secretion of S100B protein	23284918\|2388015
D000641	Ammonia	[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]	23880158
D000641	Ammonia	[Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23880158
D000641	Ammonia	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
D000641	Ammonia	resveratrol inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
D000641	Ammonia	Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23880158
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of S100B mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of S100B protein	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased expression of S100B mRNA	20458559
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [cupric chloride promotes the reaction [S100B protein binds to S100B protein]]	10666291
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of S100B mRNA	15372504
D016589	Astemizole	Astemizole results in decreased expression of S100B mRNA	20221588
D001280	Atrazine	Atrazine results in decreased expression of S100B mRNA	25929836
C547126	AZM551248	AZM551248 results in decreased expression of S100B mRNA	22323515
C480180	beta-1,3-D-glucan	"beta-1,3-D-glucan results in increased expression of S100B protein"	28117141
D004958	Estradiol	Estradiol results in increased expression of S100B mRNA	19484750
C095105	bexarotene	bexarotene results in decreased expression of S100B mRNA	16648578
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of S100B mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of S100B mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of S100B mRNA	28628672
D002065	Buspirone	S100B results in decreased susceptibility to Buspirone	12888777
D002065	Buspirone	Buspirone results in increased expression of S100B mRNA	12480124
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of S100B promoter	22457795
C055494	caffeic acid phenethyl ester	caffeic acid phenethyl ester results in increased expression of S100B protein	20836997
C055494	caffeic acid phenethyl ester	NGFR protein affects the susceptibility to [caffeic acid phenethyl ester results in increased expression of S100B protein]	20836997
D002211	Capsaicin	Capsaicin results in increased expression of S100B protein	17635592
D002235	Carbofuran	Carbofuran results in increased expression of S100B mRNA	28982980
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of NCF1 protein]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of PECAM1 mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA]	17103373
D002392	Catechin	Catechin inhibits the reaction [S100B protein results in increased expression of TNF mRNA]	17103373
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of S100B mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in increased expression of S100B mRNA	21356183
C043561	chrysin	chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein]	29054324
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA	18078969
D003042	Cocaine	Cocaine affects the expression of S100B protein	8041492
D003042	Cocaine	ipsapirone inhibits the reaction [Cocaine affects the expression of S100B protein]	8041492
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in increased expression of S100B mRNA	21356183
D003300	Copper	Copper results in increased expression of S100B mRNA	21356183
C029892	cupric chloride	Ascorbic Acid inhibits the reaction [cupric chloride promotes the reaction [S100B protein binds to S100B protein]]	10666291
C029892	cupric chloride	cupric chloride promotes the reaction [S100B protein binds to S100B protein]	10666291
D003513	Cycloheximide	Cycloheximide results in decreased expression of S100B mRNA	19146868
D016572	Cyclosporine	Cyclosporine promotes the reaction [S100B protein results in increased activity of RELA protein]	10463953
D016572	Cyclosporine	Cyclosporine results in increased activity of S100B protein	10463953
C017160	cypermethrin	cypermethrin promotes the reaction [S100B protein results in increased activity of RELA protein]	10463953
C017160	cypermethrin	cypermethrin results in increased activity of S100B protein	10463953
D013759	Dronabinol	Dronabinol results in increased expression of S100B mRNA	21955143
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of S100B mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of S100B mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of S100B mRNA	28628672
D003976	Diazinon	Diazinon affects the expression of S100B mRNA	22546817
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of S100B mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of S100B mRNA	21266533
D002117	Calcitriol	Calcitriol results in increased expression of S100B mRNA	26485663
D004117	Dimethoate	Dimethoate results in increased expression of S100B mRNA	21941777
D004117	Dimethoate	Dimethoate results in increased expression of S100B protein	21941777
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of S100B mRNA"	27840820
D019813	1,2-Dimethylhydrazine	"APC protein affects the reaction [1,2-Dimethylhydrazine results in decreased expression of S100B mRNA]"	27840820
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of S100B mRNA"	27840820
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of S100B mRNA	17374397
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [S100B protein results in increased expression of NOX2 mRNA]	17327432
D004237	Diuron	Diuron results in decreased expression of S100B mRNA	25152437
C118739	entinostat	entinostat results in increased expression of S100B mRNA	27188386
D000431	Ethanol	Ethanol results in increased expression of S100B mRNA	21955143
D005473	Fluoxetine	Fluoxetine results in increased expression of S100B mRNA	20857517
D005473	Fluoxetine	Fluoxetine results in increased expression of S100B protein	12960766
D005473	Fluoxetine	S100B protein results in increased susceptibility to Fluoxetine	22113448
D005473	Fluoxetine	Fluoxetine results in increased expression of S100B protein	12960766
D005485	Flutamide	Flutamide results in decreased expression of S100B mRNA	21126777
D005492	Folic Acid	Folic Acid results in decreased expression of S100B mRNA	25006883
C069837	fullerene C60	fullerene C60 results in decreased expression of S100B mRNA	19167457
D005665	Furosemide	[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]	23880158
D005665	Furosemide	[Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23880158
C010974	glyphosate	glyphosate affects the expression of S100B protein	28627408
D006493	Heparin	Heparin affects the expression of S100B protein	12186470
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased secretion of S100B protein	18835240
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of S100B mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of S100B mRNA	28628672
C043077	ipsapirone	ipsapirone inhibits the reaction [Cocaine affects the expression of S100B protein]	8041492
C043077	ipsapirone	ipsapirone results in increased secretion of S100B protein	12480124
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of S100B mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of S100B mRNA	28628672
D007649	Ketamine	Ketamine results in increased expression of S100B mRNA	20080153
C008261	lead acetate	lead acetate results in increased expression of S100B protein	17047031
C485003	LR-90	LR-90 inhibits the reaction [S100B protein affects the localization of RELA protein]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased degradation of NFKBIA protein]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of AGER mRNA]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of CCL2 protein]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of NOX2 mRNA]	17327432
C485003	LR-90	LR-90 inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA]	17327432
C025340	manganese chloride	manganese chloride results in increased expression of S100B mRNA	15295902
C025340	manganese chloride	manganese chloride results in increased expression of S100B protein	15295902
D015122	Mercaptopurine	Mercaptopurine results in increased expression of S100B mRNA	23358152
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of S100B protein	21783483
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of S100B mRNA	26558463
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of S100B mRNA	16966085
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of S100B protein	15288508
C060893	MK-886	MK-886 inhibits the reaction [pirinixic acid affects the expression of S100B protein]	16863991
C517880	monascin	monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in increased expression of and affects the localization of NCF1 protein]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]	23331247
C517880	monascin	monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]	23331247
C517880	monascin	monascin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]	23331247
C517880	monascin	NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]	23331247
C517880	monascin	NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]	23331247
C517880	monascin	NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of IL1B protein]]	23331247
C517880	monascin	NFE2L2 mutant form inhibits the reaction [monascin inhibits the reaction [S100B protein results in increased expression of TNF protein]]	23331247
D009020	Morphine	Morphine results in decreased expression of S100B mRNA	21955143
C523799	MRK 003	MRK 003 results in decreased expression of S100B mRNA	21169257
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of S100B mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in decreased expression of S100B mRNA	17374397
D009538	Nicotine	Nicotine results in decreased expression of S100B mRNA	21955143
D009569	Nitric Oxide	[S100B protein binds to S100B protein] which results in increased abundance of Nitric Oxide	10666291
D009569	Nitric Oxide	[S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide	16376947
D009569	Nitric Oxide	[S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide	16376947
D009599	Nitroprusside	Nitroprusside results in increased secretion of S100B protein	23284918
D009599	Nitroprusside	resveratrol inhibits the reaction [Nitroprusside results in increased secretion of S100B protein]	23284918
D009638	Norepinephrine	Norepinephrine results in increased expression of S100B mRNA	9788975
D009638	Norepinephrine	Norepinephrine results in increased expression of S100B protein	9788975
D009638	Norepinephrine	S100B protein affects the susceptibility to Norepinephrine	9788975
D016627	Oxidopamine	chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein]	29054324
D016627	Oxidopamine	Oxidopamine results in increased expression of S100B protein	29054324
D010081	Oxazolone	Oxazolone results in decreased expression of S100B mRNA	17374397
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of S100B mRNA	26272509
D010269	Paraquat	Paraquat results in increased expression of S100B mRNA	25314302
D010269	Paraquat	Paraquat affects the expression of S100B mRNA	16854511
D010269	Paraquat	Paraquat results in increased expression of S100B protein	24521700
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of S100B mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of S100B protein	20937303
D010656	Phenylephrine	Phenylephrine results in increased expression of S100B mRNA	15652358
D010656	Phenylephrine	S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of S100B mRNA]	15652358
D010656	Phenylephrine	S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]	15652358
D010656	Phenylephrine	S100B protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]	15652358
D010862	Pilocarpine	Pilocarpine results in increased expression of S100B protein	18226170
C004479	pimagedine	pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]	19494442
C004479	pimagedine	pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]	19494442
C006253	pirinixic acid	MK-886 inhibits the reaction [pirinixic acid affects the expression of S100B protein]	16863991
C006253	pirinixic acid	pirinixic acid affects the expression of S100B protein	16863991
D028321	Plant Preparations	Plant Preparations results in increased expression of S100B mRNA	26945725
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of S100B mRNA	24780913
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]	17597607
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]	17597607
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]	17597607
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]	17597607
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]	17597607
C005581	protocatechualdehyde	protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein]	17597607
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of CCL2 mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of IL1B mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of MAPK1 protein]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of MAPK3 protein]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of NCF1 protein]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of PECAM1 mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of PTGS2 mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased expression of TNF mRNA]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased phosphorylation of MAPK1 protein]	17103373
D011794	Quercetin	Quercetin inhibits the reaction [S100B protein results in increased phosphorylation of MAPK3 protein]	17103373
D017382	Reactive Oxygen Species	Catechin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]	17103373
D017382	Reactive Oxygen Species	Quercetin inhibits the reaction [S100B protein results in increased abundance of Reactive Oxygen Species]	17103373
D017382	Reactive Oxygen Species	S100B protein results in increased abundance of Reactive Oxygen Species	17103373
D017382	Reactive Oxygen Species	S100B protein results in increased abundance of Reactive Oxygen Species	16376947
D017382	Reactive Oxygen Species	S100B protein results in increased abundance of Reactive Oxygen Species	16376947
C059514	resveratrol	resveratrol inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23284918
C059514	resveratrol	resveratrol inhibits the reaction [Nitroprusside results in increased secretion of S100B protein]	23284918
C059514	resveratrol	resveratrol results in increased expression of S100B protein	16904623
C059514	resveratrol	resveratrol results in increased secretion of S100B protein	17554623
D018967	Risperidone	Risperidone results in increased secretion of S100B protein	18421423
D012524	Sarin	Sarin results in decreased expression of S100B protein	25842371
C093642	SB 203580	SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 mRNA]	16376947
C093642	SB 203580	SB 203580 inhibits the reaction [S100B protein results in increased expression of NOS2 protein]	16376947
D012715	Sesame Oil	Sesame Oil results in increased expression of S100B mRNA	29191790
D012838	Silymarin	NFE2L2 mutant form inhibits the reaction [Silymarin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]]	23331247
D012838	Silymarin	NFE2L2 mutant form inhibits the reaction [Silymarin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in decreased expression of GCLM mRNA]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in decreased expression of HMOX1 mRNA]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in decreased expression of NFE2L2 protein]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in increased expression of and affects the localization of NCF1 protein]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in increased expression of IL1B protein]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]	23331247
D012838	Silymarin	Silymarin inhibits the reaction [S100B protein results in increased expression of TNF protein]	23331247
D012838	Silymarin	Silymarin promotes the reaction [S100B protein affects the localization of NFE2L2 protein]	23331247
D012999	Soman	Soman results in decreased expression of S100B mRNA	19281266
D013311	Streptozocin	pimagedine inhibits the reaction [Streptozocin results in decreased expression of S100B protein]	19494442
D013311	Streptozocin	pimagedine inhibits the reaction [Streptozocin results in increased expression of S100B protein]	19494442
D013311	Streptozocin	Streptozocin results in decreased expression of S100B protein	19494442\|2095364
D013311	Streptozocin	Streptozocin results in increased expression of S100B protein	19494442
D010042	Ouabain	Ouabain results in increased expression of S100B protein	15581912
D016559	Tacrolimus	Tacrolimus promotes the reaction [S100B protein results in increased activity of RELA protein]	10463953
D016559	Tacrolimus	Tacrolimus results in increased activity of S100B protein	10463953
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of S100B mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of S100B mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100B mRNA	21296121
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of S100B mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to S100B promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of S100B mRNA	22808131
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of S100B mRNA	26232522
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]	23541064
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]	23541064
D008063	Thioctic Acid	[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]	23880158
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]	23880158
C009495	titanium dioxide	titanium dioxide affects the expression of S100B mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in decreased expression of S100B mRNA	23557971
D014107	Tosyllysine Chloromethyl Ketone	Tosyllysine Chloromethyl Ketone inhibits the reaction [S100B protein results in increased expression of NOS2 mRNA]	16376947
D014107	Tosyllysine Chloromethyl Ketone	Tosyllysine Chloromethyl Ketone inhibits the reaction [S100B protein results in increased expression of NOS2 protein]	16376947
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of S100B mRNA	24935251\|2627250
D014266	Trientine	Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]	23541064
D014266	Trientine	Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]	23541064
D014266	Trientine	Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]	23541064
D014266	Trientine	Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]	23541064
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in decreased expression of S100B mRNA	18078969
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of S100B mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of S100B gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of S100B mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of S100B mRNA	17292431
C025643	vinclozolin	vinclozolin results in decreased expression of S100B mRNA	23034163
D014810	Vitamin E	Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein]	16545059
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of S100B mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of S100B mRNA	27188386
D015032	Zinc	Zinc binds to S100B protein	17050004

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005509	calcium ion binding	-	NAS	9519411
GO:0005515	protein binding	-	IPI	3111527 10913138 16189514 17660747 17726019 20591429 21516116 25416956 26496610 26871637 27107012 27107014
GO:0008270	zinc ion binding	-	ISS	-
GO:0042802	identical protein binding	-	IPI	10913138 17660747 25416956 26871637 27107012
GO:0042803	protein homodimerization activity	-	IDA	10913138
GO:0042803	protein homodimerization activity	-	IPI	9519411
GO:0044548	S100 protein binding	-	IPI	9519411 10913138
GO:0048156	tau protein binding	-	ISS	-
GO:0048306	calcium-dependent protein binding	-	IDA	10913138
GO:0050786	RAGE receptor binding	-	IPI	15033494

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007409	axonogenesis	-	TAS	8202493
GO:0007417	central nervous system development	-	TAS	8202493
GO:0007611	learning or memory	-	ISS	-
GO:0007613	memory	-	IEA	-
GO:0008283	cell proliferation	-	TAS	8202493
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008360	regulation of cell shape	-	IEA	-
GO:0031643	positive regulation of myelination	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	15033494
GO:0045087	innate immune response	-	TAS	-
GO:0048168	regulation of neuronal synaptic plasticity	-	IEA	-
GO:0048708	astrocyte differentiation	-	IEA	-
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0051597	response to methylmercury	-	IEA	-
GO:0060291	long-term synaptic potentiation	-	IEA	-
GO:0071456	cellular response to hypoxia	-	IEA	-
GO:2001015	negative regulation of skeletal muscle cell differentiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001726	ruffle	-	IDA	10913138
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IEA	-
GO:0005634	nucleus	-	IDA	10913138
GO:0005737	cytoplasm	-	IDA	10913138
GO:0005737	cytoplasm	-	ISS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	12118070 15033494

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1236394	Signaling by ERBB4	TAS
R-HSA-1251985	Nuclear signaling by ERBB4	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	TAS
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	TAS
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-933542	TRAF6 mediated NF-kB activation	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28117141	Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study. (2017 Apr)	Liu L	Environ Int
21785943	An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD). (2011 Dec)	Oades RD	Atten Defic Hyperact Disord
20510426	Increased serum S100B in never-medicated and medicated schizophrenic patients. (2010 Dec)	Zhang XY	J Psychiatr Res
16687214	Specific changes in levels of autoantibodies to glutamate and opiate receptors induced by morphine administration in rats. (2006 Jul 31)	Granstrem O	Neurosci Lett
29607329	Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer. (2018)	Liu Y	Biomed Res Int
28499411	Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade. (2017 May 12)	Gambichler T	BMC Cancer
16631170	A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. (2006 Aug)	Evrard SG	Exp Neurol
20593192	S100B and homocysteine in the acute alcohol withdrawal syndrome. (2011 Mar)	Wedekind D	Eur Arch Psychiatry Clin Neurosci
28418321	S100A10 identified in a genome-wide gene x cannabis dependence interaction analysis of risky sexual behaviours. (2017 Jun)	Polimanti R	J Psychiatry Neurosci