Gene: S100P

6286
MIG9
S100 calcium binding protein P
protein-coding
4p16.1
Ensembl:ENSG00000163993 MIM:600614 Vega:OTTHUMG00000090491 UniprotKB:P25815
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.237e-1 (AD)  8.885e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A120.8
S100A80.756
MMP90.743
S100A90.719
MMP80.706
KCNJ150.703
MMP250.681
LILRA50.681
CST70.68
IL18RAP0.68

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP9-0.485
EXTL1-0.482
KCNC2-0.48
SLC32A1-0.479
NEUROD6-0.473
SVOP-0.466
VWC2-0.465
HCN1-0.457
FGF9-0.45
BCL11A-0.45

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01003Cromoglicic acidSmall Molecule16110-51-3ApprovedTarget
ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"[16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione co-treated with PGR protein] results in increased expression of S100P mRNA"21130152
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of S100P mRNA"24172598
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of S100P mRNA12958071
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of S100P mRNA25716159
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA]21882252
C0297284-phenylenediamine4-phenylenediamine results in increased expression of S100P mRNA16314067
D000082AcetaminophenAcetaminophen results in decreased expression of S100P mRNA26690555
D000082AcetaminophenAcetaminophen results in decreased expression of S100P protein22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of S100P mRNA24449571
D001151ArsenicArsenic results in decreased methylation of S100P gene25922126
D001151ArsenicArsenic results in increased expression of S100P mRNA25922126
C015001arsenitearsenite results in decreased methylation of S100P promoter23974009
C015001arsenitearsenite results in increased expression of S100P mRNA23974009
D001374AzacitidineAzacitidine results in increased expression of S100P mRNA19194470
C406592azaspiracidazaspiracid results in increased expression of S100P mRNA28939011
C547126AZM551248AZM551248 results in increased expression of S100P mRNA22323515
D001564Benzo(a)pyrene[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA21882252
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of S100P mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of S100P mRNA21632981|2623829
D001564Benzo(a)pyreneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA]21882252
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100P mRNA19619570
D004958EstradiolEstradiol results in increased expression of S100P mRNA15159206|1819185
C053541bicalutamidebicalutamide results in increased expression of S100P mRNA15638997
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of S100P mRNA12414654
D002104CadmiumCadmium results in decreased methylation of S100P gene25922126
D002104CadmiumCadmium results in increased expression of S100P mRNA22626610|2592212
D002104CadmiumCadmium results in increased expression of S100P protein22626610
D000069287CapecitabineS100P protein results in increased susceptibility to Capecitabine16734730
D002392CatechinCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of S100P mRNA]21882252
C099555CD 437CD 437 results in decreased expression of S100P mRNA12958071
D048271Chitosan[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of S100P protein]28732690
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of S100P mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of S100P mRNA16197558
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of S100P mRNA18078969
C018021cobaltous chloridecobaltous chloride results in decreased expression of S100P mRNA19376846
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of S100P mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of S100P mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of S100P mRNA19549813
C423222cotylenin Acotylenin A results in increased expression of S100P mRNA16129123|1824269
C423222cotylenin Acotylenin A results in increased expression of S100P protein16129123
D004205Cromolyn Sodium[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of S100P protein]28732690
C030973cupric oxidecupric oxide results in increased expression of S100P mRNA22077320
D003520CyclophosphamideCyclophosphamide results in decreased expression of S100P mRNA17403535
D003520CyclophosphamideS100P protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in increased expression of S100P mRNA20106945|2163298
D003561CytarabineCytarabine results in increased expression of S100P mRNA19194470
C014347decitabinedecitabine affects the expression of S100P mRNA25922126
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of S100P mRNA]21095227
C014347decitabinedecitabine results in increased expression of S100P mRNA19194470
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of S100P mRNA27392435
D002945CisplatinCisplatin results in increased expression of S100P mRNA20726978|2759478
D002945CisplatinS100P protein results in increased susceptibility to Cisplatin20726978
D002117CalcitriolCalcitriol results in increased expression of S100P mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of S100P mRNA21592394
D004127Dimethylhydrazines[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of S100P protein]28732690
D004127DimethylhydrazinesDimethylhydrazines results in increased expression of S100P protein28732690
D011397Promegestonemethoxyacetic acid promotes the reaction [Promegestone results in increased expression of S100P mRNA]15103026
D011397PromegestonePromegestone results in increased expression of S100P mRNA15103026
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of S100P mRNA24690739
D004237DiuronDiuron metabolite results in increased expression of S100P mRNA24172598
C118739entinostatentinostat results in increased expression of S100P mRNA27188386
D015251EpirubicinS100P protein results in increased susceptibility to Epirubicin18636193
D004970EstroneEstrone results in increased expression of S100P mRNA15159206
D005047EtoposideS100P protein affects the susceptibility to Etoposide16217747
D005047EtoposideS100P protein results in increased susceptibility to Etoposide18636193
D005472FluorouracilFluorouracil results in decreased expression of S100P protein15352031
D005472FluorouracilS100P protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilS100P protein results in increased susceptibility to Fluorouracil18636193
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of S100P mRNA20664735
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of S100P mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of S100P mRNA12414654
D058085Iron CompoundsIron Compounds results in decreased expression of S100P mRNA28483490
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of S100P mRNA27392435
C544151jinfukangjinfukang results in increased expression of S100P mRNA27392435
C410337K 7174K 7174 results in increased expression of S100P mRNA24086573
C045463leflunomideleflunomide results in increased expression of S100P mRNA28988120
C533894LG 100815LG 100815 results in increased expression of S100P mRNA16951191
D008466MechlorethamineMechlorethamine results in increased expression of S100P mRNA15936073
D008466MechlorethamineMechlorethamine results in increased expression of S100P protein15936073
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of S100P mRNA18497975|1914686
D008727MethotrexateS100P protein affects the susceptibility to Methotrexate16217747
C013598methoxyacetic acidmethoxyacetic acid promotes the reaction [Promegestone results in increased expression of S100P mRNA]15103026
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to S100P promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of S100P mRNA28001369
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of S100P mRNA25922126
D008942MitoxantroneS100P protein affects the susceptibility to Mitoxantrone16217747
D009151Mustard GasMustard Gas results in increased expression of S100P mRNA25102026
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of S100P mRNA16129123
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of S100P protein16129123
C029938nickel sulfatenickel sulfate results in increased expression of S100P mRNA16314067
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of S100P mRNA"19013360
C025256nonylphenolnonylphenol results in increased expression of S100P mRNA15159206
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of S100P mRNA20971185
C025589ochratoxin Aochratoxin A metabolite results in increased expression of S100P mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of S100P mRNA26314263
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of S100P mRNA"16951191
C030110oxaliplatinoxaliplatin results in decreased expression of S100P mRNA17762391
C030110oxaliplatinS100P protein results in increased susceptibility to oxaliplatin18636193
D017239PaclitaxelPaclitaxel results in decreased expression of S100P mRNA19682730
D017239PaclitaxelS100P mRNA results in increased susceptibility to Paclitaxel16322897
D017239PaclitaxelS100P protein results in increased susceptibility to Paclitaxel18636193
D052638Particulate MatterParticulate Matter results in decreased expression of S100P mRNA22178795
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of S100P mRNA26705709
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of S100P protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of S100P mRNA19159669
D011374ProgesteroneProgesterone results in increased expression of S100P mRNA18497975
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of S100P mRNA19194470
D011794QuercetinQuercetin results in decreased expression of S100P mRNA15309432
C059514resveratrolresveratrol results in increased expression of S100P mRNA25888808
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of S100P mRNA25895662
D012834SilverSilver results in increased expression of S100P mRNA28959546
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of S100P mRNA]21095227
D012906SmokeSmoke results in decreased expression of S100P mRNA21095227
C025462sulindac sulfidesulindac sulfide results in increased expression of S100P mRNA16184548
D013629TamoxifenS100P protein results in decreased susceptibility to Tamoxifen27580430
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of S100P mRNA21592394
D013739TestosteroneTestosterone results in increased expression of S100P mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of S100P mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of S100P mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of S100P mRNA19619570
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of S100P mRNA16979875
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of S100P mRNA28065790
D014212TretinoinTretinoin results in increased expression of S100P mRNA16249480
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of S100P mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of S100P mRNA29024780
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of S100P mRNA18078969
D014635Valproic AcidValproic Acid results in increased expression of S100P mRNA27188386|2915479
D014635Valproic AcidValproic Acid results in increased methylation of S100P gene29154799
D024483Vitamin K 3Vitamin K 3 results in increased expression of S100P mRNA12414654
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of S100P mRNA16979875
D019287Zinc SulfateZinc Sulfate results in increased expression of S100P mRNA19013360
C088658zoledronic acidzoledronic acid results in decreased expression of S100P protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-TAS15632002  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI11747429  12042313  15171681  16061848  16189514  21044950  
25416956  25554515  26496610  26551460  27107012  
GO:0042803protein homodimerization activity-IDA11747429  
GO:0045296cadherin binding-HDA25468996  
GO:0046914transition metal ion binding-IEA-  
GO:0048306calcium-dependent protein binding-IPI15632002  
GO:0050786RAGE receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010033response to organic substance-IEP17486081  
GO:0043312neutrophil degranulation-TAS-  
GO:0043542endothelial cell migration-IMP15313892  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IDA15632002  
GO:0005737cytoplasm-IDA25468996  
GO:0005737cytoplasm-TAS15632002  
GO:0016604nuclear body-IDA-  
GO:0031528microvillus membrane-IEA-  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15623624Salivary transcriptome diagnostics for oral cancer detection. (2004 Dec 15)Li YClin Cancer Res