Gene info: ID 629

Gene: CFB

GENE ID: 629

Synonyms: AHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2

Description: complement factor B

Gene type: protein-coding

Location: 6p21.33

dbXrefs: Ensembl:ENSG00000243649 MIM:138470 Vega:OTTHUMG00000031198 UniprotKB:P00751

RefSeq: NG_008191.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 34

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs537160	chr6:31948623 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLA1A	0.854
CASP4	0.854
CFI	0.853
TGM2	0.851
SP140L	0.842
PARP14	0.84
IFITM1	0.84
ERG	0.837
SP100	0.837
CFH	0.833

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CPLX3	-0.498
KCNIP3	-0.492
WNT7A	-0.492
CRH	-0.471
FLRT1	-0.464
ASPDH	-0.455
ATP2C2	-0.435
MARCH4	-0.432
NEUROD6	-0.431
EXTL1	-0.43

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB02459	4-Guanidinobenzoic Acid	Small Molecule		Experimental	Target
DB04491	Diisopropylphosphono Group	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of CFB mRNA"	18281256
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of CFB mRNA"	18343893
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CFB mRNA"	17547211
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CFB mRNA"	21346803
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of CFB mRNA	25088246
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CFB mRNA"	23196670
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CFB mRNA"	18648102
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CFB mRNA	19191707
C496492	abrine	abrine results in increased expression of CFB mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of CFB mRNA	26690555\|2906747
D020106	Acrylamide	Acrylamide affects the expression of CFB mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CFB protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CFB mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CFB mRNA	19770486
D000965	Antimony	Antimony results in decreased expression of CFB mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of CFB mRNA	17547211
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CFB mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CFB mRNA	17547211
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of CFB mRNA	17639512
C547126	AZM551248	AZM551248 results in increased expression of CFB mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CFB mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CFB mRNA	27858113
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of CFB mRNA	22120849
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CFB mRNA	20106945
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CFB mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CFB mRNA	22228805
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFB mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of CFB mRNA	20106945
D004958	Estradiol	Estradiol results in increased expression of CFB mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of CFB mRNA	20068009
C006780	bisphenol A	bisphenol A results in decreased expression of CFB mRNA	25912373
C006780	bisphenol A	bisphenol A results in increased expression of CFB mRNA	27104808
C006780	bisphenol A	bisphenol A affects the expression of CFB mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CFB mRNA	26088557
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CFB mRNA	15336504
D002104	Cadmium	CFB protein binds to Cadmium	23896426
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CFB mRNA	17961207
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CFB mRNA	24794047
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CFB mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of CFB promoter	22457795
D002118	Calcium	CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium co-treated with Calcium] results in increased cleavage of CFB protein]	11724962
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of CFB mRNA	17484886
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of CFB mRNA	18804290
D002857	Chromium	Chromium results in decreased expression of CFB mRNA	17547211
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CFB mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased secretion of CFB protein	22079246
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CFB mRNA	24386269
C016310	cobra venom factor	CFB protein affects the reaction [cobra venom factor results in decreased expression of C3 protein]	11724962
C016310	cobra venom factor	CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium co-treated with Calcium] results in increased cleavage of CFB protein]	11724962
D003300	Copper	CFB protein binds to Copper	23896426
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of CFB mRNA	24690739
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CFB mRNA	19549813
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CFB mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of CFB mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of CFB mRNA	19770486
D003613	Danazol	Danazol results in increased expression of CFB protein	4014294
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CFB mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of CFB mRNA	21041162
C016366	dibenzothiophene	dibenzothiophene results in increased expression of CFB mRNA	23656968
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of CFB mRNA	28962523
D004041	Dietary Fats	Dietary Fats results in decreased expression of CFB mRNA	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CFB mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CFB mRNA	17394237\|2104116
D004147	Dioxins	Dioxins affects the expression of CFB mRNA	20463971
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of CFB mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of CFB mRNA	21551480\|2515243
D004317	Doxorubicin	CFB protein affects the susceptibility to Doxorubicin	17522263
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CFB mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CFB mRNA	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CFB mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CFB mRNA	17942748\|2409603
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CFB mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CFB mRNA	17351261\|1755790
D005485	Flutamide	Flutamide results in decreased expression of CFB mRNA	24136188
D004397	Fonofos	Fonofos results in increased methylation of CFB promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of CFB mRNA	28937961
C039281	furan	furan results in decreased expression of CFB mRNA	25539665
C546771	gardiquimod	gardiquimod results in increased expression of CFB mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CFB mRNA]	28003376
D017313	Fenretinide	Fenretinide results in decreased expression of CFB mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CFB mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CFB mRNA	28628672
D007854	Lead	Lead affects the expression of CFB mRNA	28903495
D001556	Lindane	Lindane results in decreased expression of CFB mRNA	18804290
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of CFB mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CFB mRNA"	23306164
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CFB mRNA	22235868
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CFB mRNA	24056979
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of CFB mRNA]	24056979
D008274	Magnesium	CFD protein affects the reaction [[cobra venom factor co-treated with Magnesium co-treated with Calcium] results in increased cleavage of CFB protein]	11724962
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CFB mRNA	20353558
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CFB mRNA	22136142
D008628	Mercury	Mercury affects the expression of CFB protein	22030286
D008628	Mercury	Mercury results in decreased expression of CFB mRNA	17547211
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of CFB mRNA	18804290
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of CFB mRNA]	24056979
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CFB mRNA	17961207\|2345815
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of CFB mRNA	24694518
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CFB mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CFB promoter"	26251327
D015735	Mifepristone	Mifepristone results in decreased expression of CFB mRNA	25972201
D009151	Mustard Gas	Mustard Gas results in increased expression of CFB mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CFB mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CFB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CFB mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of CFB mRNA	18978301
C051752	nefazodone	nefazodone results in decreased expression of CFB mRNA	24136188
D009532	Nickel	CFB protein binds to Nickel	23896426
D009532	Nickel	Nickel results in increased expression of CFB mRNA	25583101
C076029	olanzapine	olanzapine affects the phosphorylation of CFB protein	25821032
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CFB mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of CFB mRNA"	24096037
D017239	Paclitaxel	Paclitaxel results in increased expression of CFB mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of CFB mRNA	18042831
D010278	Parathion	Parathion results in increased methylation of CFB promoter	22847954
C002669	parthenolide	parthenolide results in decreased expression of CFB mRNA	16921510
C036567	perfluorodecanoic acid	perfluorodecanoic acid results in decreased expression of CFB mRNA	21984479
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of CFB mRNA	21984479
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of CFB mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of CFB mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CFB mRNA	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CFB mRNA]	18467677
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CFB mRNA	21984479
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of CFB mRNA	18804290
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of CFB mRNA	19162173
D010578	Petroleum	Petroleum affects the expression of CFB mRNA	25208076
C006253	pirinixic acid	[pirinixic acid co-treated with PPARA] results in decreased expression of CFB mRNA	20813756
C006253	pirinixic acid	pirinixic acid results in decreased expression of CFB mRNA	18467677\|2005976
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CFB mRNA]	18467677\|2005976
D028321	Plant Preparations	Plant Preparations results in decreased expression of CFB protein	28284660
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CFB mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of CFB mRNA	22079256
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of CFB mRNA	17547211
D011374	Progesterone	Progesterone results in decreased expression of CFB mRNA	22238285
C005556	propionaldehyde	propionaldehyde results in decreased expression of CFB mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CFB mRNA	24780913
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CFB mRNA]	28003376
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of CFB mRNA	17639512
D011794	Quercetin	Quercetin results in decreased expression of CFB mRNA	21632981
C089730	rosiglitazone	rosiglitazone results in decreased expression of CFB mRNA	25572481
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CFB mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CFB mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CFB mRNA	22431001
D053260	Soot	Soot results in increased expression of CFB mRNA	22461453\|2655175
D013629	Tamoxifen	Tamoxifen affects the expression of CFB mRNA	17555576
C012568	terbufos	terbufos results in increased methylation of CFB promoter	22847954
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CFB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CFB mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CFB mRNA	18343893\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CFB mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CFB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CFB mRNA	15328365\|1696003
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CFB mRNA	16267337
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CFB mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CFB mRNA	15644576
C009495	titanium dioxide	titanium dioxide results in increased expression of CFB mRNA	19464567\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CFB mRNA	28065790
D014028	Tobacco Smoke Pollution	CFB gene mutant form results in decreased susceptibility to Tobacco Smoke Pollution	23825688
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CFB mRNA	20133372
C066340	tolcapone	tolcapone results in increased expression of CFB mRNA	24136188
D014212	Tretinoin	Tretinoin results in increased expression of CFB mRNA	16249480
C057693	troglitazone	troglitazone results in increased expression of CFB mRNA	19140230
D014635	Valproic Acid	Valproic Acid results in decreased expression of CFB mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CFB protein	3124010
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of CFB mRNA"	22326570
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of CFB mRNA"	25208076
D015032	Zinc	CFB protein binds to Zinc	23896426
D015032	Zinc	Zinc results in increased expression of CFB mRNA	15984569
C088658	zoledronic acid	zoledronic acid results in increased expression of CFB mRNA	24714768
D015054	Zymosan	CFB gene mutant form inhibits the reaction [Zymosan results in increased expression of C3 protein]	17916747

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001848	complement binding	-	TAS	11367526
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	19255449

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IEA	-
GO:0006956	complement activation	-	TAS	-
GO:0006957	complement activation, alternative pathway	-	NAS	8225386
GO:0006957	complement activation, alternative pathway	-	TAS	-
GO:0030449	regulation of complement activation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	16502470
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-166658	Complement cascade	TAS
R-HSA-166663	Initial triggering of complement	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-173736	Alternative complement activation	TAS
R-HSA-174577	Activation of C3 and C5	TAS
R-HSA-977606	Regulation of Complement cascade	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22232432	Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population. (2012 Feb 16)	Nakata I	Invest Ophthalmol Vis Sci
22247473	Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)	Yu Y	Invest Ophthalmol Vis Sci
21541267	Complement factor B polymorphism 32W protects against age-related macular degeneration. (2011 Apr 20)	Hughes AE	Mol Vis
27170480	Genetic factors associated with the development of age-related macular degeneration. (2016)	Sergejeva O	Medicina (Kaunas)
29801032	Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)	Lin LY	JAMA Ophthalmol
21807600	Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration. (2011 Jul)	Hageman GS	Hum Genomics
18502988	ATM gene variants in patients with idiopathic perifoveal telangiectasia. (2008 Sep)	Barbazetto IA	Invest Ophthalmol Vis Sci
18325906	C3 R102G polymorphism increases risk of age-related macular degeneration. (2008 Jun 15)	Spencer KL	Hum Mol Genet
23825688	Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury. (2013)	Woodell A	PLoS One
21169531	Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. (2011 Mar)	Spencer KL	Invest Ophthalmol Vis Sci
20157618	Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort. (2010 Feb 10)	McKay GJ	Mol Vis
24557084	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration. (2014 May)	Caire J	JAMA Ophthalmol
28735646	Hyperhomocysteinemia and Age-related Macular Degeneration: Role of Inflammatory Mediators and Pyroptosis; A Proposal. (2017 Aug)	Singh M	Med Hypotheses
22273503	Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. (2012 Mar)	Kim SJ	Exp Eye Res
22933840	Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration. (2012)	van de Ven JP	Mol Vis
21959373	Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)	Seddon JM	Ophthalmology
21402993	Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. (2011 Mar)	Chen Y	Arch Ophthalmol
28926193	Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration. (2018 Mar)	Cobos E	Acta Ophthalmol
18806297	Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration. (2009 Feb)	McKay GJ	Invest Ophthalmol Vis Sci
25893111	Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)	Chavali VR	J Clin Med
17576744	Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. (2007 Aug 15)	Spencer KL	Hum Mol Genet
19899988	Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population. (2009 Aug)	Pei XT	Curr Eye Res
20090206	The molecular genetic basis of age-related macular degeneration: an overview. (2009 Dec)	Katta S	J Genet
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