Gene: ACSM3

6296
SA|SAH
acyl-CoA synthetase medium chain family member 3
protein-coding
16p12.3
Ensembl:ENSG00000005187 MIM:145505 Vega:OTTHUMG00000131552 UniprotKB:Q53FZ2
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.996e-1 (AD)  4.599e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06478823chr16:20774873ACSM32.300e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAME0.841
IGF2BP10.829
RHAG0.828
HOXB90.807
SSX10.798
CTCFL0.796
HBG10.78
PAGE50.778
MAGEB20.773
MAGEC20.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES6-0.263
ABHD16B-0.244
C4orf48-0.232
AIFM3-0.231
ARSF-0.227
HPR-0.221
PYGM-0.216
BTBD17-0.211
ENHO-0.205
HOMER3-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ACSM3 mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of ACSM3 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACSM3 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACSM3 mRNA"28433925
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ACSM3 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACSM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ACSM3 mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of ACSM3 mRNA17562736
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of ACSM3 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ACSM3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACSM3 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ACSM3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACSM3 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ACSM3 mRNA21757418
D000393Air PollutantsAir Pollutants results in decreased expression of ACSM3 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ACSM3 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACSM3 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of ACSM3 mRNA22323515
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSM3 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSM3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACSM3 mRNA21569818|2222880
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ACSM3 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ACSM3 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of ACSM3 mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of ACSM3 promoter27334623
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACSM3 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of ACSM3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ACSM3 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of ACSM3 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACSM3 mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ACSM3 mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of ACSM3 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACSM3 mRNA22941251
D003471CuprizoneCuprizone results in decreased expression of ACSM3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ACSM3 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of ACSM3 mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ACSM3 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ACSM3 mRNA28302478
D004026DieldrinDieldrin results in decreased expression of ACSM3 mRNA23153324
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ACSM3 mRNA]"19467301
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACSM3 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of ACSM3 mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of ACSM3 mRNA19467301
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACSM3 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACSM3 mRNA"28433925
C118739entinostatentinostat results in increased expression of ACSM3 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C039281furanfuran results in increased methylation of ACSM3 gene22079235
D019833GenisteinGenistein results in increased methylation of ACSM3 gene28505145
D005839GentamicinsGentamicins results in decreased expression of ACSM3 protein21081137|2206182
C010178heliotrineheliotrine results in decreased expression of ACSM3 mRNA26100227
D017313FenretinideFenretinide results in increased expression of ACSM3 mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of ACSM3 mRNA"26377693
C016517indole-3-carbinolindole-3-carbinol affects the expression of ACSM3 mRNA21396975
C544151jinfukangjinfukang results in decreased expression of ACSM3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ACSM3 mRNA21889194
C008261lead acetatelead acetate affects the expression of ACSM3 mRNA21864555
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ACSM3 mRNA26667767
D008713MethimazoleMethimazole results in increased expression of ACSM3 mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ACSM3 mRNA28001369
C500085muraglitazarmuraglitazar results in increased expression of ACSM3 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ACSM3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ACSM3 mRNA"25620056
D009532NickelNickel results in decreased expression of ACSM3 mRNA24768652
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ACSM3 mRNA19716841
D009966OrphenadrineOrphenadrine affects the expression of ACSM3 mRNA23665939
D000073878Palm OilPalm Oil results in decreased expression of ACSM3 mRNA18042831
C496932panobinostatpanobinostat results in increased expression of ACSM3 mRNA26272509
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of ACSM3 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ACSM3 mRNA21705711
D010634PhenobarbitalPhenobarbital results in increased expression of ACSM3 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ACSM3 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSM3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ACSM3 mRNA18301758|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ACSM3 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ACSM3 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of ACSM3 mRNA22504374|2478091
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of ACSM3 mRNA26100227
D011794QuercetinQuercetin results in decreased expression of ACSM3 mRNA21632981
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of ACSM3 mRNA26667767
C009237senecioninesenecionine results in decreased expression of ACSM3 mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of ACSM3 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ACSM3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ACSM3 mRNA25351596
C017947sodium arsenitesodium arsenite affects the methylation of ACSM3 gene28589171
C016766sulforafansulforafan results in decreased expression of ACSM3 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSM3 mRNA21998131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACSM3 mRNA26377647
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACSM3 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSM3 mRNA19770486|2253962
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSM3 mRNA21215274|2172422
D013752TetracyclineTetracycline results in decreased expression of ACSM3 mRNA24489787
D013853ThioacetamideThioacetamide results in decreased expression of ACSM3 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ACSM3 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ACSM3 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ACSM3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ACSM3 mRNA24383497|2627250
D014640VancomycinVancomycin results in increased expression of ACSM3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACSM3 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ACSM3 mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSM3 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ACSM3 mRNA26272509
D015034Zinc OxideZinc Oxide analog results in increased expression of ACSM3 mRNA27215404
C088658zoledronic acidzoledronic acid results in decreased expression of ACSM3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0003996acyl-CoA ligase activity-IBA21873635  
GO:0004321fatty-acyl-CoA synthase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0015645fatty acid ligase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0047760butyrate-CoA ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006633fatty acid biosynthetic process-IBA21873635  
GO:0006637acyl-CoA metabolic process-IBA21873635  
GO:0008217regulation of blood pressure-NAS7907320  
GO:0042632cholesterol homeostasis-NAS15361761  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005759mitochondrial matrix-IBA21873635  
KEGG ID KEGG Term
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-556833Metabolism of lipidsIEA
R-HSA-77286mitochondrial fatty acid beta-oxidation of saturated fatty acidsIEA
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationIEA
R-HSA-77352Beta oxidation of butanoyl-CoA to acetyl-CoAIEA
R-HSA-8978868Fatty acid metabolismIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29618728Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health. (2018 Apr 4)Miyake KSci Rep