Gene info: ID 6300

Gene: MAPK12

GENE ID: 6300

Description: mitogen-activated protein kinase 12

Gene type: protein-coding

Location: 22q13.33

dbXrefs: Ensembl:ENSG00000188130 MIM:602399 Vega:OTTHUMG00000030145 UniprotKB:P53778

RefSeq: NC_000022.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : 6.566e-1 (AD) 9.749e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.408e-2 (AD) 7.145e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPC1	0.885
MAPK11	0.877
PIGQ	0.87
E4F1	0.87
OBSL1	0.87
TRMT2A	0.859
RNF215	0.857
ARVCF	0.855
SPG7	0.854
PNKP	0.849

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.608
OR4F29	-0.561
MTRNR2L9	-0.399
MTRNR2L6	-0.388
MTRNR2L10	-0.349
CTNNA3	-0.329
SGMS2	-0.325
PABPC4L	-0.325
PPBP	-0.322
DTHD1	-0.314

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02482	Phosphonothreonine	Small Molecule		Experimental	Target
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule		Experimental	Target
DB05157	KC706	Small Molecule	-	Investigational	Target
DB05403	CEP-1347	Small Molecule	-	Investigational	Target

ID	Drug Name	Action	PubMed
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased activity of MAPK12 protein	18389075
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
D020106	Acrylamide	Acrylamide affects the expression of MAPK12 mRNA	28959563
C016601	afimoxifene	MAPK12 results in decreased susceptibility to afimoxifene	21233418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MAPK12 mRNA	16483693
D000677	Amsacrine	Amsacrine results in increased activity of MAPK12 protein	21878638
D000677	Amsacrine	MAPK12 protein affects the susceptibility to Amsacrine	21878638
D000677	Amsacrine	[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine	21878638
D000677	Amsacrine	[MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine	21878638
D001241	Aspirin	Aspirin results in decreased expression of MAPK12 mRNA	20514442
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MAPK12 mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [MAPK12 protein results in decreased expression of ESR1 protein]	22399296
C006780	bisphenol A	bisphenol A results in increased expression of MAPK12 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of MAPK12 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MAPK12 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of MAPK12 mRNA	26314263
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of MAPK12 mRNA	14729362
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of MAPK12 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MAPK12 protein	19757093
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MAPK12 mRNA	19757093
D019256	Cadmium Chloride	MAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]	18348256
D019256	Cadmium Chloride	MAPK12 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]	18348256
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MAPK12 mRNA	18804290
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MAPK12 mRNA	11566570
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MAPK12 mRNA	17484886
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of MAPK12 mRNA	19320972\|2631426
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MAPK12 mRNA	20971185
D003474	Curcumin	Curcumin results in increased activity of MAPK12 protein	21594647
D016572	Cyclosporine	Cyclosporine results in decreased expression of MAPK12 mRNA	27989131
D003976	Diazinon	Diazinon affects the expression of MAPK12 mRNA	22546817
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of MAPK12 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of MAPK12 mRNA	21603599
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MAPK12 mRNA	26924002
D004026	Dieldrin	Dieldrin affects the expression of MAPK12 mRNA	22546817
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MAPK12 mRNA"	22485181
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of MAPK12 mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased methylation of MAPK12 promoter	24675093
D000431	Ethanol	Ethanol results in increased expression of MAPK12 mRNA	17920746
D005047	Etoposide	Etoposide results in increased activity of MAPK12 protein	21878638
D005047	Etoposide	MAPK12 protein affects the susceptibility to Etoposide	21878638
D005047	Etoposide	[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide	21878638
D005047	Etoposide	[MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide	21878638
C071834	glycidamide	glycidamide results in increased expression of MAPK12 mRNA	17822822
C492448	ICG 001	ICG 001 results in increased expression of MAPK12 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPK12 mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of MAPK12 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of MAPK12 mRNA	27392435
C490728	lapatinib	lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]	28739874
C490728	lapatinib	lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]	28739874
C490728	lapatinib	pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]	28739874
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of MAPK12 mRNA	20353558
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of MAPK12 mRNA	20864626
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of MAPK12 mRNA	18804290
C030957	methylmercury II	methylmercury II results in decreased expression of MAPK12 mRNA	26314263
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MAPK12 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of MAPK12 mRNA	25234470
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MAPK12 mRNA	26924002
C005246	myristicin	myristicin results in decreased expression of MAPK12 mRNA	24792648
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of MAPK12 mRNA"	25554681
C022838	nickel chloride	nickel chloride affects the expression of MAPK12 mRNA	22546817
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MAPK12 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in decreased expression of MAPK12 mRNA	27939613
C025589	ochratoxin A	ochratoxin A metabolite results in decreased expression of MAPK12 mRNA	26314263
C025589	ochratoxin A	ochratoxin A results in decreased expression of MAPK12 mRNA	26314263
C000594117	ON123300	ON123300 results in increased phosphorylation of MAPK12 protein	24568969
D009930	Organic Chemicals	Organic Chemicals results in increased expression of MAPK12 mRNA	20526952
D009966	Orphenadrine	Orphenadrine affects the expression of MAPK12 mRNA	23665939
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of MAPK12 mRNA	23948077
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MAPK12 mRNA	26300304
C093844	pirfenidone	lapatinib promotes the reaction [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]]	28739874
C093844	pirfenidone	pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]	28739874
C093844	pirfenidone	[pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein	28739874
C093844	pirfenidone	[pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in increased phosphorylation of EGFR protein	28739874
C093844	pirfenidone	pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]	22399296
C093844	pirfenidone	[pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen	22399296
C093844	pirfenidone	pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]	22399296
C093844	pirfenidone	[pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen	22399296
C093844	pirfenidone	pirfenidone promotes the reaction [lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein]]	28739874
C093844	pirfenidone	pirfenidone results in decreased activity of MAPK12 protein	28739874
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAPK12 mRNA	19710929
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MAPK12 mRNA	24780913
C547185	riccardin D	riccardin D results in decreased expression of MAPK12 mRNA	24069304
C093642	SB 203580	SB 203580 results in decreased expression of MAPK12 mRNA	19757093
D012906	Smoke	Smoke results in increased expression of MAPK12 mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK12 protein	15504454
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of MAPK12 mRNA	16705456
D013012	Sorbitol	Sorbitol results in increased phosphorylation of MAPK12 protein	15362974
D013629	Tamoxifen	JUN protein inhibits the reaction [MAPK12 mutant form results in decreased susceptibility to Tamoxifen]	22399296
D013629	Tamoxifen	MAPK12 mutant form results in decreased susceptibility to Tamoxifen	22399296
D013629	Tamoxifen	[pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen	22399296
D013629	Tamoxifen	[pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen	22399296
D013629	Tamoxifen	Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]	22399296
D013629	Tamoxifen	Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]	22399296
D013629	Tamoxifen	Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein]	22399296
D013629	Tamoxifen	Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form]	22399296
D013629	Tamoxifen	Tamoxifen results in increased activity of and results in increased expression of MAPK12 protein	22399296
D013629	Tamoxifen	Tamoxifen results in increased phosphorylation of MAPK12 protein	22399296
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAPK12 mRNA	25613284
C402769	tipifarnib	tipifarnib results in increased expression of MAPK12 mRNA	16403772
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MAPK12 mRNA"	19682533
C011559	tributyltin	tributyltin results in decreased expression of MAPK12 mRNA	26314263
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of MAPK12 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid results in increased methylation of MAPK12 gene	29154799
D002762	Cholecalciferol	Cholecalciferol results in increased expression of MAPK12 mRNA	17170073
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of MAPK12 mRNA	26272509
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of MAPK12 mRNA"	20526952
D015032	Zinc	Zinc deficiency results in increased expression of MAPK12 mRNA	12888634

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IDA	10508788
GO:0004674	protein serine/threonine kinase activity	-	IDA	8633070 15850461
GO:0004674	protein serine/threonine kinase activity	-	TAS	18221368
GO:0004707	MAP kinase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	12761180 15158451 19294699 24550280 25158884 25416956
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IEA	-
GO:0006975	DNA damage induced protein phosphorylation	-	TAS	10848581
GO:0007050	cell cycle arrest	-	TAS	10848581
GO:0007165	signal transduction	-	TAS	8633070
GO:0007517	muscle organ development	-	TAS	8633070
GO:0010468	regulation of gene expression	-	IBA	21873635
GO:0010952	positive regulation of peptidase activity	-	NAS	18221368
GO:0018105	peptidyl-serine phosphorylation	-	IDA	15850461
GO:0018105	peptidyl-serine phosphorylation	-	TAS	18221368
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0045445	myoblast differentiation	-	IDA	8633070
GO:0051149	positive regulation of muscle cell differentiation	-	TAS	-
GO:0071310	cellular response to organic substance	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005739	mitochondrion	-	IEA	-
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05131	Shigellosis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-167044	Signalling to RAS	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-171007	p38MAPK events	IEA
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-187037	Signaling by NTRK1 (TRKA)	IEA
R-HSA-187687	Signalling to ERKs	IEA
R-HSA-194138	Signaling by VEGF	TAS
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	IEA
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-375170	CDO in myogenesis	IEA
R-HSA-375170	CDO in myogenesis	TAS
R-HSA-376172	DSCAM interactions	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-4420097	VEGFA-VEGFR2 Pathway	TAS
R-HSA-525793	Myogenesis	IEA
R-HSA-525793	Myogenesis	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24993294	Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study. (2014 Sep)	Slattery ML	Cancer Causes Control
23027623	MAP kinase genes and colon and rectal cancer. (2012 Dec)	Slattery ML	Carcinogenesis