Gene info: ID 6301

Gene: SARS

GENE ID: 6301

Synonyms: NEDMAS|SERRS|SERS

Description: seryl-tRNA synthetase

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000031698 MIM:607529 Vega:OTTHUMG00000011726 UniprotKB:P49591

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.120e-1 (AD) 1.031e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GARS	0.979
MDH2	0.976
DDX24	0.976
CIAPIN1	0.973
LRRC47	0.972
VDAC1	0.969
PRPF19	0.969
SAE1	0.968
PSMC1	0.967
PGK1	0.967

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.666
OR4F29	-0.63
CXCR2	-0.366
ASB4	-0.363
MTRNR2L6	-0.36
MTRNR2L9	-0.355
VNN3	-0.352
KLRB1	-0.352
MTRNR2L10	-0.351
P2RY14	-0.345

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00133	Serine	Small Molecule	56-45-1	Approved\|Nutraceutical	Target
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB00150	L-Tryptophan	Small Molecule	73-22-3	Approved\|Nutraceutical\|Withdrawn	Target
DB01831	Tryptophanyl-5'amp	Small Molecule		Experimental	Target
DB04537	L-Tryptophanamide	Small Molecule		Experimental	Target
DB00135	L-Tyrosine	Small Molecule	60-18-4	Approved\|Investigational\|Nutraceutical	Target
DB01766	Beta-(2-Naphthyl)-Alanine	Small Molecule	-	Experimental	Target
DB02709	Resveratrol	Small Molecule	501-36-0	Approved\|Experimental\|Investigational	Target
DB03978	Tyrosinal	Small Molecule		Experimental	Target
DB07205	N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE	Small Molecule		Experimental	Target
DB08371	PARA-(BENZOYL)-PHENYLALANINE	Small Molecule		Experimental	Target
DB08617	4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE	Small Molecule		Experimental	Target
DB00156	L-Threonine	Small Molecule	72-19-5	Approved\|Nutraceutical	Target
DB00160	L-Alanine	Small Molecule	56-41-7	Approved\|Nutraceutical	Target
DB00131	Adenosine monophosphate	Small Molecule	61-19-8	Approved\|Investigational\|Nutraceutical	Target
DB00171	ATP	Small Molecule	56-65-5	Investigational\|Nutraceutical	Target
DB00167	L-Isoleucine	Small Molecule	73-32-5	Approved\|Investigational\|Nutraceutical	Target
DB00114	Pyridoxal Phosphate	Small Molecule	54-47-7	Approved\|Investigational\|Nutraceutical	Target
DB00128	L-Aspartic Acid	Small Molecule	56-84-8	Approved\|Nutraceutical	Target
DB00142	Glutamic Acid	Small Molecule	56-86-0	Approved\|Nutraceutical	Target
DB00151	L-Cysteine	Small Molecule	52-90-4	Approved\|Nutraceutical	Target
DB04299	Maleic Acid	Small Molecule	110-16-7	Experimental	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target
DB00174	L-Asparagine	Small Molecule	70-47-3	Approved\|Investigational\|Nutraceutical	Target
DB00116	Tetrahydrofolic acid	Small Molecule	135-16-0	Nutraceutical	Target
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target
DB02358	LY374571	Small Molecule		Experimental	Target
DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small Molecule		Experimental	Target
DB04322	LY249543	Small Molecule		Experimental	Target
DB00151	L-Cysteine	Small Molecule	52-90-4	Approved\|Nutraceutical	Target
DB00128	L-Aspartic Acid	Small Molecule	56-84-8	Approved\|Nutraceutical	Target
DB00117	Histidine	Small Molecule	71-00-1	Approved\|Nutraceutical	Target
DB00149	L-Leucine	Small Molecule	61-90-5	Approved\|Nutraceutical	Target
DB01169	Arsenic trioxide	Small Molecule	1327-53-3	Approved\|Investigational	Target
DB02338	Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate	Small Molecule		Experimental	Target
DB03147	Flavin adenine dinucleotide	Small Molecule	146-14-5	Approved	Target
DB03566	Spermidine	Small Molecule	124-20-9	Experimental	Target
DB04106	Fotemustine	Small Molecule	-	Experimental\|Investigational	Target
DB05428	motexafin gadolinium	Small Molecule	-	Investigational	Target
DB05448	PX-12	Small Molecule	-	Investigational	Target
DB07740	(7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of SARS mRNA	25596134
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SARS mRNA"	19095052
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of SARS mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SARS mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SARS mRNA"	19561079
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SARS mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of SARS mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of SARS mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SARS gene	27153756
C103505	AM 251	AM 251 results in increased expression of SARS mRNA	16500647
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SARS mRNA	16483693
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of SARS mRNA	26496021
C006780	bisphenol A	bisphenol A affects the expression of SARS mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of SARS mRNA	20170705
C006780	bisphenol A	bisphenol A results in increased expression of SARS mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of SARS mRNA	25181051
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of SARS mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased methylation of SARS gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SARS protein	22941245
D019256	Cadmium Chloride	Cadmium Chloride affects the localization of SARS protein	18261755
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of SARS mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SARS mRNA	23741332
D002185	Cannabidiol	Cannabidiol results in increased expression of SARS mRNA	21542829
D002220	Carbamazepine	Carbamazepine affects the expression of SARS mRNA	24752500\|2597931
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of SARS mRNA	27339419
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SARS mRNA"	27188386
C100187	chloropicrin	chloropicrin results in decreased expression of SARS mRNA	26352163
C059262	cidofovir	cidofovir results in increased expression of SARS mRNA	25596134
D002994	Clofibrate	Clofibrate results in decreased expression of SARS mRNA	23811191
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SARS mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SARS mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of SARS mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of SARS mRNA	25596134
D013759	Dronabinol	Dronabinol results in increased expression of SARS mRNA	21542829
D003907	Dexamethasone	Dexamethasone results in decreased expression of SARS mRNA	22733784
D002945	Cisplatin	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of SARS mRNA]	21858171
D002945	Cisplatin	Cisplatin results in increased expression of SARS mRNA	25596134
D004008	Diclofenac	Diclofenac affects the expression of SARS mRNA	24752500
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in decreased expression of SARS mRNA	16623957
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SARS protein	20227414
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SARS mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SARS mRNA	20170705\|2686566
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of SARS mRNA	23649840
D011345	Fenofibrate	Fenofibrate results in increased expression of SARS mRNA	25596134
D005485	Flutamide	Flutamide results in increased expression of SARS mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in increased expression of SARS mRNA	23649840
D019833	Genistein	Genistein results in increased expression of SARS mRNA	26865667
D005839	Gentamicins	Gentamicins results in increased expression of SARS protein	22061828
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of SARS mRNA	22634610
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of SARS mRNA	22634610
D007052	Ibuprofen	Ibuprofen results in decreased expression of SARS mRNA	25596134
D007069	Ifosfamide	Ifosfamide results in increased expression of SARS mRNA	25596134
D007213	Indomethacin	Indomethacin results in increased expression of SARS mRNA	17401462
D007213	Indomethacin	Indomethacin results in increased expression of SARS mRNA	28201806
C410337	K 7174	K 7174 results in increased expression of SARS mRNA	24086573
D007657	Ketone Bodies	Ketone Bodies results in increased expression of SARS mRNA	16807920
C045463	leflunomide	leflunomide results in increased expression of SARS mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of SARS mRNA	24136188
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of SARS mRNA	16507785
D008687	Metformin	Metformin results in increased expression of SARS mRNA	25596134
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SARS mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SARS mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of SARS mRNA	24810058
C051752	nefazodone	nefazodone results in increased expression of SARS mRNA	24136188
C022838	nickel chloride	nickel chloride results in increased expression of SARS mRNA	24612858
D010100	Oxygen	Oxygen deficiency results in increased expression of SARS mRNA	25596134
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of SARS mRNA	19095052
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of SARS mRNA	26705709
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SARS mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SARS mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SARS protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of SARS mRNA	19159669
D010705	Phosgene	Phosgene affects the expression of SARS mRNA	16300373
D010894	Piroxicam	Cisplatin inhibits the reaction [Piroxicam results in decreased expression of SARS mRNA]	21858171
D010894	Piroxicam	Piroxicam results in decreased expression of SARS mRNA	21858171
D011374	Progesterone	Progesterone results in increased expression of SARS mRNA	18037150
C107773	pterostilbene	pterostilbene results in increased expression of SARS mRNA	22450950
D011748	Pyrogallol	Pyrogallol results in increased expression of SARS mRNA	20362636
C059514	resveratrol	resveratrol results in increased expression of SARS mRNA	12569576
C009277	sodium arsenate	sodium arsenate results in increased expression of SARS mRNA	16882884
C017947	sodium arsenite	sodium arsenite results in decreased expression of SARS mRNA	28595984
C016104	sodium bichromate	sodium bichromate results in increased expression of SARS mRNA	22561333
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SARS mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SARS mRNA	22298810
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of SARS mRNA	28973375
D019284	Thapsigargin	Thapsigargin results in increased expression of SARS mRNA	22378314
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of SARS protein	24685621
D014415	Tunicamycin	Tunicamycin results in increased expression of SARS mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of SARS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SARS mRNA	23179753\|2915479
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SARS gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of SARS mRNA	23034163
C111237	vorinostat	vorinostat results in decreased expression of SARS mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	24940000
GO:0003723	RNA binding	-	TAS	9431993
GO:0004828	serine-tRNA ligase activity	-	IBA	21873635
GO:0004828	serine-tRNA ligase activity	-	IDA	24095058
GO:0004828	serine-tRNA ligase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	26433229
GO:0005524	ATP binding	-	IEA	-
GO:0042803	protein homodimerization activity	-	IPI	26433229
GO:0098619	selenocysteine-tRNA ligase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	24940000
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006412	translation	-	TAS	9431993
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	-
GO:0006434	seryl-tRNA aminoacylation	-	IBA	21873635
GO:0006434	seryl-tRNA aminoacylation	-	IDA	24095058
GO:0006434	seryl-tRNA aminoacylation	-	IMP	28236339
GO:0008033	tRNA processing	-	TAS	9431993
GO:0016259	selenocysteine metabolic process	-	TAS	-
GO:0016525	negative regulation of angiogenesis	-	IMP	24940000
GO:0097056	selenocysteinyl-tRNA(Sec) biosynthetic process	-	IEA	-
GO:1904046	negative regulation of vascular endothelial growth factor production	-	IDA	24940000

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	28236339
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	20458337 23533145

KEGG ID	KEGG Term
hsa00970	Aminoacyl-tRNA biosynthesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-2408522	Selenoamino acid metabolism	TAS
R-HSA-2408557	Selenocysteine synthesis	TAS
R-HSA-379716	Cytosolic tRNA aminoacylation	TAS
R-HSA-379724	tRNA Aminoacylation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS
R-HSA-72766	Translation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
11170654	Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. (2001 Feb 15)	Newman AH	J Med Chem