Gene: SLC22A23

63027
C6orf85
solute carrier family 22 member 23
protein-coding
6p25.2
Ensembl:ENSG00000137266 MIM:611697 Vega:OTTHUMG00000014144 UniprotKB:A1A5C7
NC_000006.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.073e-1 (AD)  2.703e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9503551chr6:3340483 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIP2C0.911
NCOA60.91
NSD10.901
POLG0.897
TRAPPC100.893
DNMT10.893
PGS10.89
NFASC0.886
UGGT10.886
UBE3B0.885

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.535
OR4F29-0.503
TRDN-0.311
PON3-0.305
KLRC2-0.293
OR4F16-0.286
IL20RA-0.282
PON1-0.28
MTRNR2L6-0.27
ENDOU-0.267

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC22A23 mRNA28329830
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC22A23 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC22A23 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC22A23 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC22A23 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of SLC22A23 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of SLC22A23 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC22A23 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC22A23 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A23 mRNA16483693
D001151ArsenicArsenic affects the methylation of SLC22A23 gene25304211
C547126AZM551248AZM551248 results in decreased expression of SLC22A23 mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SLC22A23 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC22A23 mRNA20064835|2231617
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC22A23 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of SLC22A23 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SLC22A23 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SLC22A23 promoter22457795
D002509CephaloridineCephaloridine results in decreased expression of SLC22A23 mRNA18500788
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC22A23 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SLC22A23 mRNA19167446
D003471CuprizoneCuprizone results in decreased expression of SLC22A23 mRNA27523638
D016572CyclosporineCyclosporine results in increased methylation of SLC22A23 promoter27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC22A23 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SLC22A23 mRNA27392435
D004026DieldrinDieldrin results in decreased expression of SLC22A23 mRNA23153324
D002117CalcitriolCalcitriol results in increased expression of SLC22A23 mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC22A23 mRNA25380136
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SLC22A23 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of SLC22A23 mRNA24136188
C010974glyphosateglyphosate affects the expression of SLC22A23 mRNA26302742
D017313FenretinideFenretinide results in decreased expression of SLC22A23 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC22A23 mRNA25613284
C018091maduramicinmaduramicin results in increased expression of SLC22A23 mRNA29128925
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to SLC22A23 promoter]20348232
D0156551-Methyl-4-phenylpyridiniumpseudoisocyanine inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]28597291
D0156551-Methyl-4-phenylpyridiniumSLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog28597291
D0156551-Methyl-4-phenylpyridiniumSulpiride inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]28597291
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC22A23 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC22A23 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC22A23 mRNA25380136
C029938nickel sulfatenickel sulfate results in increased expression of SLC22A23 mRNA22714537
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of SLC22A23 mRNA19176365
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC22A23 mRNA25729387
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of SLC22A23 mRNA19176365
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC22A23 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC22A23 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of SLC22A23 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of SLC22A23 mRNA23370395
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC22A23 mRNA24780913
C100254pseudoisocyaninepseudoisocyanine inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]28597291
D012834SilverSilver results in increased expression of SLC22A23 mRNA27131904
C016104sodium bichromatesodium bichromate affects the expression of SLC22A23 mRNA22110744
D013469SulpirideSulpiride inhibits the reaction [SLC22A23 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]28597291
C501413tesaglitazartesaglitazar results in increased expression of SLC22A23 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A23 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A23 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A23 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC22A23 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SLC22A23 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC22A23 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SLC22A23 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of SLC22A23 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of SLC22A23 mRNA21515302
D014635Valproic AcidValproic Acid results in decreased methylation of SLC22A23 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC22A23 mRNA24935251|2718838
D014750VincristineVincristine results in increased expression of SLC22A23 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A23 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of SLC22A23 mRNA20044591
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA20370541
C088658zoledronic acidzoledronic acid results in increased expression of SLC22A23 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0015711organic anion transport-IEA-  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal