Gene: SATB1

6304
-
SATB homeobox 1
protein-coding
3p24.3
Ensembl:ENSG00000182568 MIM:602075 Vega:OTTHUMG00000129890 UniprotKB:Q01826
NG_027814.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.357e-1 (AD)  7.848e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK140.964
DLGAP10.962
MYO5A0.959
STAU20.956
AKT30.956
DOCK30.956
GSK3B0.956
PTPRT0.956
PRKCE0.955
KIF3C0.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.515
HEY2-0.509
CSAG1-0.499
RNF135-0.487
MYL3-0.487
SNHG18-0.482
OR4F5-0.482
COPZ2-0.477
CMTM3-0.477
ACAP1-0.475

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of SATB1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of SATB1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SATB1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SATB1 mRNA12419474
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SATB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SATB1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SATB1 mRNA26690555
D000086AcetazolamideAcetazolamide results in increased expression of SATB1 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SATB1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SATB1 gene27153756
C006632arsenic trioxideSATB1 protein results in decreased susceptibility to arsenic trioxide25317073
D001280AtrazineAtrazine results in decreased expression of SATB1 mRNA22378314
D001554BenzeneBenzene results in decreased expression of SATB1 mRNA15120971
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SATB1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SATB1 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SATB1 mRNA"20382639
D004958EstradiolEstradiol affects the expression of SATB1 mRNA23557687
D004958EstradiolEstradiol results in decreased expression of SATB1 mRNA19484750|2521013
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SATB1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of SATB1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of SATB1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of SATB1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of SATB1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SATB1 mRNA26496021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SATB1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of SATB1 mRNA26079696
D002737ChloropreneChloroprene results in decreased expression of SATB1 mRNA23125180
D003042CocaineCocaine results in decreased expression of SATB1 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SATB1 mRNA]18355967
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of SATB1 protein20931265
D003520CyclophosphamideCyclophosphamide results in decreased expression of SATB1 mRNA21041162
D016572CyclosporineCyclosporine results in decreased expression of SATB1 mRNA20106945
C014347decitabinedecitabine affects the expression of SATB1 mRNA17145863
D003907DexamethasoneDexamethasone results in decreased expression of SATB1 mRNA21041162
D002945CisplatinCisplatin results in decreased expression of SATB1 mRNA27594783
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of SATB1 mRNA21041162
C118739entinostatentinostat results in decreased expression of SATB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SATB1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SATB1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SATB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SATB1 mRNA17942748
D005839GentamicinsGentamicins results in increased expression of SATB1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of SATB1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SATB1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SATB1 mRNA21889194
D007854LeadLead affects the expression of SATB1 mRNA28903495
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SATB1 mRNA"24972896
D015122MercaptopurineMercaptopurine results in decreased expression of SATB1 mRNA23358152
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SATB1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SATB1 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SATB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SATB1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of SATB1 mRNA16780908
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SATB1 mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SATB1 mRNA22237054
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SATB1 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of SATB1 mRNA23012394
C009166retinol acetateretinol acetate results in increased expression of SATB1 mRNA16772331
D012643SeleniumSelenium results in decreased expression of SATB1 mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of SATB1 mRNA"21148743
C017947sodium arsenitesodium arsenite affects the methylation of SATB1 gene28589171
D018038Sodium SeleniteSodium Selenite results in increased expression of SATB1 mRNA18175754
D053260SootSoot results in decreased expression of SATB1 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of SATB1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SATB1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SATB1 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SATB1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SATB1 mRNA25613284
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of SATB1 protein20931265
C009495titanium dioxidetitanium dioxide results in increased expression of SATB1 mRNA23557971
D019772TopotecanSATB1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SATB1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SATB1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SATB1 mRNA"19682533
D014635Valproic AcidValproic Acid affects the expression of SATB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SATB1 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SATB1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of SATB1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA15851481  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA15851481  
GO:0003682chromatin binding-IEA-  
GO:0003690double-stranded DNA binding-TAS1505028  
GO:0005515protein binding-IPI18408014  20126258  25416956  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP15851481  
GO:0006325chromatin organization-TAS1505028  
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0008544epidermis development-IEA-  
GO:0016032viral process-IEA-  
GO:0016571histone methylation-IEA-  
GO:0043367CD4-positive, alpha-beta T cell differentiation-IEA-  
GO:0043374CD8-positive, alpha-beta T cell differentiation-IEA-  
GO:0050798activated T cell proliferation-IEA-  
GO:0060004reflex-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18408014  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005720nuclear heterochromatin-IEA-  
GO:0016363nuclear matrix-IEA-  
GO:0016604nuclear body-IDA-  
GO:0016605PML body-IDA18408014  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4551638SUMOylation of chromatin organization proteinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24714607Susceptibility to chronic mucus hypersecretion, a genome wide association study. (2014)Dijkstra AEPLoS One