Gene: ATXN7

6314
ADCAII|OPCA3|SCA7
ataxin 7
protein-coding
3p14.1
Ensembl:ENSG00000285258 MIM:607640 Vega:OTTHUMG00000158763 UniprotKB:O15265
NG_008227.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.257e-1 (AD)  1.707e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PROSER10.912
MLLT100.899
MED230.896
CDK130.894
SETD50.888
EDEM10.888
KMT2A0.886
NUP1530.886
UBN20.885
TTC170.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.449
OR4F29-0.426
S100A1-0.323
KLRC2-0.314
SPRR2D-0.274
RBP1-0.257
NANOGNB-0.246
CNBD2-0.244
PLA2G5-0.243
APOA1-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATXN7 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ATXN7 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ATXN7 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ATXN7 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ATXN7 mRNA19770486
D001151ArsenicArsenic affects the methylation of ATXN7 gene25304211
D001151ArsenicArsenic results in decreased expression of ATXN7 mRNA16835338
C547126AZM551248AZM551248 results in decreased expression of ATXN7 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATXN7 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATXN7 mRNA"20018196
D002104CadmiumCadmium results in decreased expression of ATXN7 mRNA24376830
D002737ChloropreneChloroprene results in increased expression of ATXN7 mRNA23125180
D003033Coal TarCoal Tar results in decreased expression of ATXN7 mRNA27858113
D005485FlutamideFlutamide results in increased expression of ATXN7 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of ATXN7 mRNA20655997
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATXN7 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of ATXN7 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ATXN7 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ATXN7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ATXN7 mRNA"25554681|2562005
C030110oxaliplatinoxaliplatin results in decreased expression of ATXN7 mRNA16510598
D010634PhenobarbitalPhenobarbital affects the expression of ATXN7 mRNA23091169
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of ATXN7 mRNA19244175
D012643SeleniumSelenium results in decreased expression of ATXN7 mRNA19244175
D012834SilverSilver results in decreased expression of ATXN7 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of ATXN7 gene28589171
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ATXN7 mRNA"26680231
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATXN7 mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ATXN7 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of ATXN7 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ATXN7 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ATXN7 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATXN7 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of ATXN7 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of ATXN7 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11371513  15115762  20634802  21078624  23892081  
GO:0036459thiol-dependent ubiquitinyl hydrolase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP22100762  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006997nucleus organization-TAS10441328  
GO:0007601visual perception-TAS9288099  
GO:0016578histone deubiquitination-IDA18206972  
GO:0016579protein deubiquitination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA22100762  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0005829cytosol-IDA-  
GO:0015630microtubule cytoskeleton-IDA22100762  
GO:0016363nuclear matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4839726Chromatin organizationIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28416970DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. (2017)Sundar IKClin Epigenetics