Gene: SERPINB3

6317
HsT1196|SCC|SCCA-1|SCCA-PD|SCCA1|SSCA1|T4-A
serpin family B member 3
protein-coding
18q21.33
Ensembl:ENSG00000057149 MIM:600517 Vega:OTTHUMG00000060403 UniprotKB:P29508
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.904e-1 (AD)  5.964e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADH70.914
SPINK50.863
MUC210.849
DAZ10.84
FGFBP10.83
SPRR2F0.818
TMPRSS11B0.804
KRT150.783
KLK130.777
CSTA0.771

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHB10-0.196
FAM91A1-0.19
ZC2HC1A-0.188
FBXL17-0.187
MAP3K6-0.185
ZDBF2-0.179
CKAP2-0.176
PAQR3-0.175
C16orf87-0.172
ACTA1-0.172

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03929D-SerineSmall Molecule312-84-5Approved|Experimental|InvestigationalTarget
DB04522DexfosfoserineSmall Molecule407-41-0ExperimentalTarget
ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of SERPINB3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SERPINB3 mRNA18560533
C107676deguelindeguelin results in decreased secretion of SERPINB3 protein26884827
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SERPINB3 mRNA26924002
D002117CalcitriolCalcitriol results in decreased expression of SERPINB3 mRNA12040012|1600243
D002117CalcitriolKetoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA]12040012
D007654KetoconazoleKetoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA]12040012
D007854LeadSERPINB3 protein binds to Lead23896426
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of SERPINB3 mRNA23876855
D009532NickelNickel results in increased expression of SERPINB3 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of SERPINB3 mRNA18651567
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of SERPINB3 mRNA17616710
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SERPINB3 mRNA19074003
C005556propionaldehydepropionaldehyde results in increased expression of SERPINB3 mRNA26079696
D011794QuercetinQuercetin results in increased expression of SERPINB3 mRNA15309432
C078903seocalcitolseocalcitol results in decreased expression of SERPINB3 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SERPINB3 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of SERPINB3 mRNA23876855
C017947sodium arsenitesodium arsenite results in increased expression of SERPINB3 mRNA28595984
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of SERPINB3 protein20332019
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of SERPINB3 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINB3 mRNA21296121
D014212TretinoinTretinoin results in increased expression of SERPINB3 mRNA16249480
D014635Valproic AcidValproic Acid results in decreased expression of SERPINB3 mRNA24935251
C025643vinclozolinvinclozolin results in decreased expression of SERPINB3 mRNA22615374
D015032ZincZinc deficiency results in increased expression of SERPINB3 mRNA19111725
D015032ZincZinc deficiency results in increased expression of SERPINB3 protein19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB3 mRNA]19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of SERPINB3 protein]19111725
C088658zoledronic acidzoledronic acid results in increased expression of SERPINB3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA12975381  
GO:0002020protease binding-IPI21383048  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-NAS7724531  
GO:0004869cysteine-type endopeptidase inhibitor activity-IMP21383048  
GO ID GO Term Qualifier Evidence PubMed
GO:0008284positive regulation of cell proliferation-IMP20527027  
GO:0010466negative regulation of peptidase activity-IDA12949073  
GO:0010718positive regulation of epithelial to mesenchymal transition-IMP20527027  
GO:0010950positive regulation of endopeptidase activity-IDA20527027  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IMP21383048  
GO:0030335positive regulation of cell migration-IMP20527027  
GO:0035425autocrine signaling-IMP20527027  
GO:0038001paracrine signaling-IMP20527027  
GO:0043086negative regulation of catalytic activity-IDA10956412  
GO:0043312neutrophil degranulation-TAS-  
GO:0043508negative regulation of JUN kinase activity-IMP21383048  
GO:0045861negative regulation of proteolysis-IDA12975381  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA20527027  21383048  
GO:0005737cytoplasm-IDA20527027  
GO:0031410cytoplasmic vesicle-IDA21383048  
GO:0031982vesicle-HDA19190083  
GO:0035578azurophil granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25036363Susceptibility to COPD: differential proteomic profiling after acute smoking. (2014)Franciosi LPLoS One