Gene: SCD

6319
FADS5|MSTP008|SCD1|SCDOS|hSCD1
stearoyl-CoA desaturase
protein-coding
10q24.31
Ensembl:ENSG00000099194 MIM:604031 Vega:OTTHUMG00000018906 UniprotKB:O00767
NC_000010.11
PubMed
0   ANCO-SNPs
OD|ND|AD
23   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.529e-2 (AD)  4.469e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26351966chr10:102106080SCD3.100e-8Smoking27651444
cg24503796chr10:102107676SCD9.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHB10.851
PAQR60.847
MARCKSL10.845
RASSF20.828
DAAM20.817
SEPT40.809
COL9A20.806
CNP0.802
AIF1L0.798
PTP4A20.795

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.592
OR4F5-0.543
SPATA31C1-0.32
TRIML2-0.31
EPN3-0.31
TPBG-0.309
LANCL3-0.303
GPR55-0.297
FAM160A1-0.296
KLHL38-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SCD mRNA"17690111
C0786321-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine"SCD protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]"21123845
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SCD mRNA"25614096
C5254852-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole"2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole results in increased expression of SCD mRNA"27665778
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCD mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SCD mRNA"17547211
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SCD protein]16162944
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SCD mRNA"20406850
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of SCD mRNA"12097258
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SCD mRNA"12376462
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of SCD mRNA]21123845
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of SCD mRNA"24172598
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of SCD mRNA"11397803
C1052604-tert-octylphenol4-tert-octylphenol results in decreased expression of SCD mRNA26164745
D000082AcetaminophenAcetaminophen results in decreased expression of SCD mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of SCD mRNA17202758
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SCD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SCD mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCD gene27153756
C430898AGN 194204AGN 194204 results in increased expression of SCD mRNA11397803
D000393Air PollutantsAir Pollutants analog results in decreased expression of SCD mRNA21757418
C103303alitretinoinalitretinoin results in increased expression of SCD mRNA11397803
D000638Amiodarone[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of SCD mRNA]21123845
D000638AmiodaroneAmiodarone results in increased expression of SCD mRNA21123845|2924857
D000638Amiodarone"SCD protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]"21123845
D000639AmitriptylineAmitriptyline results in increased expression of SCD mRNA16324787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCD mRNA16483693
D000965AntimonyAntimony results in decreased expression of SCD mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of SCD mRNA17547211
D016718Arachidonic AcidArachidonic Acid results in increased expression of SCD mRNA21457203
C406592azaspiracidazaspiracid results in increased expression of SCD mRNA28939011
C547126AZM551248AZM551248 results in decreased expression of SCD mRNA22323515
D001548Benzalkonium CompoundsBenzalkonium Compounds results in increased expression of SCD mRNA29155129
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SCD mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SCD mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SCD mRNA17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCD mRNA20106945|2163298
C038328BEP protocolBEP protocol results in increased expression of SCD mRNA18987330
D004958EstradiolEstradiol results in decreased expression of SCD mRNA15757668
D004958EstradiolEstradiol results in increased expression of SCD mRNA19167446
D004958EstradiolEstradiol results in decreased expression of SCD mRNA26164745
C095105bexarotenebexarotene results in increased expression of SCD mRNA17178900
D001629BezafibrateBezafibrate results in increased expression of SCD mRNA17118139
D001629BezafibrateBezafibrate results in increased activity of SCD protein7606338
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SCD mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of SCD mRNA27685785|2927551
C006780bisphenol Abisphenol A affects the expression of SCD mRNA25181051|2865753
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SCD promoter23359474
D000069286BortezomibBortezomib results in decreased expression of SCD mRNA20977926
D016642BupropionBupropion results in increased expression of SCD mRNA16324787
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SCD mRNA15336504
D002104CadmiumCadmium results in decreased expression of SCD mRNA23369406
D002104CadmiumCadmium results in increased expression of SCD mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SCD mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SCD mRNA25993096
D000074262Canola OilCanola Oil affects the expression of SCD mRNA16177195
D002220CarbamazepineCarbamazepine results in decreased expression of SCD mRNA21123845
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SCD mRNA17202758
D002273CarcinogensCarcinogens results in increased expression of SCD mRNA16316942
C100187chloropicrinchloropicrin results in decreased expression of SCD mRNA26352163
D002737ChloropreneChloroprene results in increased expression of SCD mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of SCD mRNA21356183
D004390ChlorpyrifosChlorpyrifos results in increased expression of SCD mRNA20691718
D002784CholesterolCholesterol inhibits the reaction [FGF7 protein results in increased expression of SCD mRNA]16162944
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCD mRNA27344345
C043561chrysinchrysin results in decreased expression of SCD mRNA20816778
D015283CitalopramCitalopram results in increased expression of SCD mRNA16324787
D002994ClofibrateClofibrate affects the expression of SCD mRNA27665778
D002994ClofibrateClofibrate results in increased activity of SCD protein7606338
D002994ClofibrateClofibrate results in increased expression of SCD mRNA17363680
D002997ClomipramineClomipramine results in increased expression of SCD mRNA16324787
D003024ClozapineClozapine results in increased expression of SCD mRNA16027736|1705236
C028222cobalt-ethylenediamine tetraacetic acid chelatecobalt-ethylenediamine tetraacetic acid chelate results in decreased activity of SCD protein18356325
C521309cobalt(II) acetatecobalt(II) acetate results in decreased expression of SCD mRNA25547303
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCD mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of SCD mRNA19376846|2220211
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SCD mRNA]22202117
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SCD mRNA20971185
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SCD mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SCD mRNA19167446
C029892cupric chloridecupric chloride results in increased expression of SCD mRNA19174923
D003474CurcuminCurcumin results in decreased expression of SCD mRNA20816778
D003474CurcuminCurcumin results in decreased expression of SCD mRNA27208389
D016572CyclosporineCyclosporine results in decreased expression of SCD mRNA20106945|2556210
C089595cylindrospermopsincylindrospermopsin results in decreased expression of SCD mRNA24921660
D003907DexamethasoneDexamethasone results in decreased expression of SCD mRNA14618091
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of SCD mRNA"16269432
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SCD promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCD mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SCD mRNA17379624
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SCD mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SCD mRNA27594783
D002945CisplatinCisplatin results in decreased expression of SCD mRNA22023808
D004041Dietary Fats"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of SCD mRNA"12097258
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SCD promoter23359474
D002117CalcitriolCalcitriol results in decreased expression of SCD mRNA12798352
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of SCD mRNA25825955
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SCD mRNA"12097258|1237646
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SCD mRNA17547211
D004237DiuronDiuron metabolite results in increased expression of SCD mRNA24172598
D004237DiuronDiuron results in decreased expression of SCD mRNA21551480
D004610Ellagic AcidEllagic Acid results in decreased expression of SCD mRNA20816778
C118739entinostatentinostat results in decreased expression of SCD mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SCD mRNA22079256
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of SCD mRNA16988119
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SCD mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of SCD mRNA17118139
D011345FenofibrateFenofibrate affects the expression of SCD mRNA27665778
C004999ferulic acidferulic acid results in decreased expression of SCD mRNA20816778
C082360fipronilfipronil results in increased expression of SCD mRNA23962444
D005395Fish OilsFish Oils results in decreased expression of SCD mRNA15654130
D005472FluorouracilFluorouracil results in decreased expression of SCD mRNA17982676
D005472FluorouracilFluorouracil results in increased expression of SCD mRNA17039268
D005472FluorouracilSCD protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilTP53 protein inhibits the reaction [Fluorouracil results in decreased expression of SCD mRNA]17982676
D005473FluoxetineFluoxetine results in increased expression of SCD mRNA16324787
D005557FormaldehydeFormaldehyde results in decreased expression of SCD mRNA23649840
D005632FructoseFructose results in increased expression of SCD mRNA18063403
C056507gemcitabinegemcitabine results in increased expression of SCD mRNA17039268
D015248GemfibrozilGemfibrozil results in increased activity of SCD protein7606338
D015248GemfibrozilGemfibrozil results in increased expression of SCD mRNA27665778
D019833GenisteinGenistein results in decreased expression of SCD mRNA15257099|2081677
D019833GenisteinGenistein results in increased expression of SCD mRNA15378649|1884745
C049864ginsenoside Reginsenoside Re results in decreased expression of SCD mRNA21971952
D005947GlucoseGlucose results in increased expression of SCD mRNA16790840
C010176halofuginonehalofuginone results in increased expression of SCD mRNA17180598
D006220HaloperidolHaloperidol results in increased expression of SCD mRNA16027736
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SCD mRNA26846883
D007099ImipramineImipramine results in increased expression of SCD mRNA16324787
D007213IndomethacinIndomethacin results in increased expression of SCD mRNA18299717
D007529IsoflavonesIsoflavones affects the expression of SCD mRNA16365062
D007529IsoflavonesIsoflavones results in increased expression of SCD mRNA17374662
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SCD mRNA27392435
C544151jinfukangjinfukang results in increased expression of SCD mRNA27392435
C410337K 7174K 7174 results in decreased expression of SCD mRNA24086573
C095104LG 100268LG 100268 results in increased expression of SCD mRNA17178900
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of SCD mRNA"17322064
D008070Lipopolysaccharides[TNF protein co-treated with IL1B protein co-treated with IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of SCD mRNA20816778
D008727MethotrexateMethotrexate results in increased expression of SCD mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SCD mRNA23179753
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCD mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCD mRNA23649840
C008493methylselenic acidmethylselenic acid affects the expression of SCD mRNA14617803
C035133mirtazapinemirtazapine results in increased expression of SCD mRNA16324787
D008942MitoxantroneSCD protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of SCD mRNA23118965
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of SCD mRNA16052530
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SCD mRNA"24389112
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCD mRNA27344345
D009532NickelNickel results in increased expression of SCD mRNA24084258
C028007nickel monoxidenickel monoxide results in decreased expression of SCD mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of SCD mRNA22714537
D009538NicotineNicotine results in increased expression of SCD mRNA23825647
C570896NSC305787NSC305787 results in increased expression of SCD mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SCD mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of SCD mRNA19287073
D019787Linoleic Acid[Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA21457203
D019787Linoleic AcidLinoleic Acid results in increased expression of SCD mRNA21457203
D019787Linoleic AcidLinoleic Acid results in increased expression of SCD protein21457203
D017830OctoxynolOctoxynol results in increased expression of SCD mRNA29155129
D010100OxygenEPAS1 gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SCD mRNA]24503013
D010100OxygenHIF1A gene mutant form inhibits the reaction [Oxygen deficiency results in decreased expression of SCD mRNA]24503013
D010100OxygenOxygen deficiency results in decreased expression of SCD mRNA24503013
C053370paclobutrazolpaclobutrazol results in increased expression of SCD mRNA23202249
D052638Particulate MatterParticulate Matter results in increased expression of SCD mRNA23085030
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of SCD mRNA23567314
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of SCD mRNA23567314
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of SCD mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of SCD mRNA23567314
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SCD mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SCD protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SCD mRNA17097637
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of SCD mRNA26678675
D010634PhenobarbitalPhenobarbital results in increased expression of SCD mRNA27180240
C006253pirinixic acidpirinixic acid results in increased expression of SCD mRNA15654130|2248451
D010894PiroxicamPiroxicam results in decreased expression of SCD mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SCD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SCD mRNA22079256|2271453
D017035PravastatinPravastatin results in increased expression of SCD mRNA27225895
D011374ProgesteroneProgesterone results in increased expression of SCD mRNA18070364
D011374ProgesteroneProgesterone results in decreased expression of SCD mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCD mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of SCD protein]16162944
D011794QuercetinQuercetin affects the expression of SCD mRNA21632981
C502851quinocetonequinocetone results in increased expression of SCD mRNA27046791
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SCD mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [TO-901317 results in increased expression of SCD mRNA]23651738
C116926rofecoxibrofecoxib results in increased expression of SCD mRNA17070997
C089730rosiglitazonerosiglitazone results in increased activity of SCD protein15855323
C089730rosiglitazonerosiglitazone results in increased expression of SCD mRNA15855323|1714856
C089730rosiglitazonerosiglitazone results in increased expression of SCD17614770
D012524SarinSarin results in decreased expression of SCD mRNA19522546
D012524SarinSarin results in increased expression of SCD mRNA19522546
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in decreased expression of SCD mRNA]21245298
D012906SmokeSmoke results in decreased expression of SCD mRNA21095227
C016104sodium bichromatesodium bichromate results in increased expression of SCD mRNA22561333
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in increased expression of SCD mRNA29155129
C075117squalestatin 1squalestatin 1 results in increased expression of SCD mRNA27225895
C061133tamibarotenetamibarotene affects the expression of SCD mRNA15498508
D013739Testosterone[Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA21457203
C004648testosterone enanthatetestosterone enanthate affects the expression of SCD mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCD mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCD mRNA16704738
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCD mRNA15644576
D013752TetracyclineTetracycline results in decreased expression of SCD mRNA17202758
D013849ThimerosalThimerosal results in decreased expression of SCD mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of SCD mRNA23411599
C423915TO-901317resveratrol inhibits the reaction [TO-901317 results in increased expression of SCD mRNA]23651738
C423915TO-901317TO-901317 results in increased expression of SCD mRNA15548517
D014028Tobacco Smoke PollutionTobacco Smoke Pollution analog results in decreased expression of SCD mRNA20920546
C066340tolcaponetolcapone binds to SCD protein19783845
D019772TopotecanSCD protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of SCD mRNA20530235
D014212TretinoinTretinoin results in decreased expression of SCD mRNA15498508
D014212TretinoinTretinoin results in increased expression of SCD mRNA11397803|2193413
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SCD mRNA26745549
C012589trichostatin Atrichostatin A results in decreased expression of SCD mRNA27188386
C030665triphenyltintriphenyltin results in decreased expression of SCD mRNA24177218
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCD mRNA"25242413
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SCD mRNA"25242413
C057693troglitazonetroglitazone results in increased expression of SCD mRNA28973697
C057693troglitazonetroglitazone results in increased expression of SCD mRNA12372423
D014415TunicamycinTunicamycin results in decreased expression of SCD mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of SCD mRNA22414386
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of SCD mRNA24312631
D014635Valproic AcidValproic Acid affects the expression of SCD mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SCD mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of SCD mRNA25716160
C025643vinclozolinvinclozolin results in increased expression of SCD mRNA22570695|2303416
C111237vorinostatvorinostat results in decreased expression of SCD mRNA27188386
D015032ZincZinc deficiency results in increased expression of SCD mRNA19111725
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of SCD mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004768stearoyl-CoA 9-desaturase activity-IBA21873635  
GO:0004768stearoyl-CoA 9-desaturase activity-IDA15907797  18765284  
GO:0004768stearoyl-CoA 9-desaturase activity-TAS-  
GO:0005506iron ion binding-IBA21873635  
GO:0005506iron ion binding-IDA18765284  
GO:0016491oxidoreductase activity-IDA15907797  18765284  
GO ID GO Term Qualifier Evidence PubMed
GO:0006636unsaturated fatty acid biosynthetic process-IDA15907797  18765284  
GO:0045540regulation of cholesterol biosynthetic process-TAS-  
GO:0046949fatty-acyl-CoA biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:1903966monounsaturated fatty acid biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA15907797  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IDA18765284  
KEGG ID KEGG Term
hsa01040Biosynthesis of unsaturated fatty acids
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)TAS
R-HSA-2426168Activation of gene expression by SREBF (SREBP)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26721667Altered Saturated and Monounsaturated Plasma Phospholipid Fatty Acid Profiles in Adult Males with Colon Adenomas. (2016 Mar)Pickens CACancer Epidemiol Biomarkers Prev
16132958Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. (2005 Oct)Warensjo EDiabetologia
29118949Cardiovascular disease events and its predictors in women: Isfahan Cohort Study (ICS). (2017)Sadeghi MJ Cardiovasc Thorac Res
12045163Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. (2002 Jun 4)Albert CMCirculation
17803012Do insomnia complaints cause hypertension or cardiovascular disease? (2007 Aug 15)Phillips BJ Clin Sleep Med
28826898Relation of Chronic Obstructive Pulmonary Disease to Cardiovascular Disease in the General Population. (2017 Oct 15)Song SAm J Cardiol
29091778Risk factors for amyloid positivity in older people reporting significant memory concern. (2018 Jan)Zhang JCompr Psychiatry
18062827Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men. (2008 Jun)Petersson HBr J Nutr
11156875Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography. (2001 Feb 6)Christensen JHCirculation
18687433Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population. (2009 Mar)Petersson HAtherosclerosis
22615341Duration of QRS complex in resting electrocardiogram is a predictor of sudden cardiac death in men. (2012 May 29)Kurl SCirculation
20102864Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation. (2010 Jan)Adabag ASAm Heart J
29036813Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. (2017)Reijs BLRJ Alzheimers Dis
27784848Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study. (2017 Jun 1)Kunutsor SKJ Atheroscler Thromb
24780075Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. (2014 Jul)Planck TThyroid
22819528Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study. (2013 Jan)Chow LSMetabolism
22157513Survivors of ventricular fibrillation have persistent cardiovascular risk factors late in follow-up. (2013 Feb)Smith TEur J Prev Cardiol
22844511Common genetic variants associated with sudden cardiac death: the FinSCDgen study. (2012)Lahtinen AMPLoS One
19643915Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study. (2009 Nov 1)Eijgelsheim MHum Mol Genet
27483394Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure. (2016 Oct)Claria JHepatology
16793047Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study. (2007 Jun)Fan YMAtherosclerosis
19237854Subacute combined degeneration mimicking traumatic spinal cord injury. (2009 Mar)Paul IAm J Forensic Med Pathol
21106914Plasma and dietary magnesium and risk of sudden cardiac death in women. (2011 Feb)Chiuve SEAm J Clin Nutr