Gene info: ID 632

Gene: BGLAP

GENE ID: 632

Synonyms: BGP|OC|OCN

Description: bone gamma-carboxyglutamate protein

Gene type: protein-coding

Location: 1q22

dbXrefs: Ensembl:ENSG00000242252 MIM:112260 Vega:OTTHUMG00000014819 UniprotKB:P02818

RefSeq: NG_047015.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.552e-2 (AD) 4.485e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg12036877	chr1:156211896	BGLAP		8.130e-8	Maternal smoking in pregnancy	27040690
cg12036877	chr1:156211896	BGLAP		3.090e-11	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDK2AP2	0.735
PCBD1	0.733
DCXR	0.733
CERS1	0.731
MT3	0.73
PHPT1	0.727
SOX15	0.72
BANF1	0.718
PRADC1	0.714
ISOC2	0.714

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.489
OR4F29	-0.466
IGSF10	-0.452
FER1L6	-0.433
LY75	-0.423
HMCN1	-0.419
PZP	-0.415
GADL1	-0.414
TRIM6	-0.407
CD163L1	-0.401

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00170	Menadione	Small Molecule	58-27-5	Approved\|Nutraceutical	Target
DB01022	Phylloquinone	Small Molecule	84-80-0	Approved\|Investigational	Target
DB03847	Gamma-Carboxy-Glutamic Acid	Small Molecule		Experimental	Target
DB05260	Gallium nitrate	Small Molecule	13494-90-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C097240	15-deoxy-delta(12,14)-prostaglandin J2	"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA"	12021203
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	21910061
C119129	18alpha-glycyrrhetinic acid	18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]	21910061
C095284	1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one	"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in decreased expression of BGLAP mRNA"	22543296
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	24102669
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]	17689939
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA	17689939
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA	21741227
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]	21741227
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in decreased expression of BGLAP]	24531206
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP mRNA]	26053266
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
C019273	2,2-bis(4-glycidyloxyphenyl)propane	"2,2-bis(4-glycidyloxyphenyl)propane results in decreased expression of BGLAP mRNA"	16972249
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BGLAP mRNA"	19114083
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of BGLAP mRNA"	25795401
C040488	26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3	"26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 results in increased expression of BGLAP mRNA"	12016462
C025160	3-aminobenzamide	3-aminobenzamide results in increased expression of BGLAP mRNA	15670817
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of BGLAP mRNA]	26053266
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BGLAP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BGLAP mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of BGLAP mRNA	29067470
C056165	acetovanillone	acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
D020106	Acrylamide	Acrylamide results in decreased expression of BGLAP mRNA	22197712
C103303	alitretinoin	alitretinoin promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]	12898515
C103303	alitretinoin	alitretinoin promotes the reaction [Calcitriol results in increased secretion of BGLAP protein]	12898515
C103303	alitretinoin	alitretinoin promotes the reaction [KH 1060 results in increased expression of BGLAP mRNA]	12898515
C103303	alitretinoin	alitretinoin promotes the reaction [KH 1060 results in increased secretion of BGLAP protein]	12898515
C103303	alitretinoin	alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]	12898515
C103303	alitretinoin	alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]	12898515
C103303	alitretinoin	alitretinoin results in decreased expression of BGLAP mRNA	12898515
C103303	alitretinoin	[Calcitriol co-treated with alitretinoin] results in increased expression of BGLAP mRNA	12898515
C103303	alitretinoin	[Calcitriol co-treated with alitretinoin] results in increased secretion of BGLAP protein	12898515
C103303	alitretinoin	[KH 1060 co-treated with alitretinoin] results in increased expression of BGLAP mRNA	12898515
C103303	alitretinoin	[KH 1060 co-treated with alitretinoin] results in increased secretion of BGLAP protein	12898515
C103303	alitretinoin	alitretinoin results in decreased expression of BGLAP mRNA	16392701
D000493	Allopurinol	Allopurinol results in increased expression of BGLAP mRNA	26968635
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of BGLAP mRNA	17898587
D000535	Aluminum	Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]	9626627
D000535	Aluminum	Aluminum results in decreased secretion of BGLAP protein	9626627
D000535	Aluminum	Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]	9626627
D000535	Aluminum	[[TF protein binds to Aluminum] which co-treated with Calcitriol] results in decreased secretion of BGLAP protein	1476184
D000535	Aluminum	[[TF protein binds to Aluminum] which co-treated with Calcitriol] results in increased secretion of BGLAP protein	1476184
C010845	aluminum chloride	aluminum chloride results in decreased expression of BGLAP protein	23065425
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of BGLAP mRNA	19464052
D005680	gamma-Aminobutyric Acid	gamma-Aminobutyric Acid affects the expression of BGLAP protein	24098073
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of BGLAP mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of BGLAP protein	23624148
D000968	Antimycin A	sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]	23624148
C006632	arsenic trioxide	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in decreased expression of BGLAP]	24531206
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BGLAP	24531206
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of BGLAP mRNA	22465848
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA	25932594
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with Dexamethasone] results in increased expression of BGLAP mRNA	12510807
D001205	Ascorbic Acid	bexarotene inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D001205	Ascorbic Acid	[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of BGLAP protein	17692823
D001205	Ascorbic Acid	rosiglitazone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D001205	Ascorbic Acid	tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D001205	Ascorbic Acid	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA	27028516
D001205	Ascorbic Acid	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]	27028516
D001205	Ascorbic Acid	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]	27028516
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with IL11 protein] results in increased expression of BGLAP mRNA	17956465
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of BGLAP mRNA	17274723
C040896	AST 120	AST 120 results in increased expression of BGLAP mRNA	16820376
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of BGLAP mRNA	17252541
D001374	Azacitidine	Azacitidine results in decreased expression of BGLAP protein	18037191
C060988	baohuoside I	baohuoside I results in increased expression of BGLAP mRNA	17764702
D001507	Beclomethasone	Beclomethasone results in decreased expression of BGLAP protein	7746775\|9232087\|
D001599	Berberine	Berberine results in increased expression of BGLAP mRNA	26478571
D001599	Berberine	Berberine results in increased expression of BGLAP protein	26478571
D001599	Berberine	CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]	26478571
D001599	Berberine	DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]	26478571
D004958	Estradiol	[Estradiol co-treated with ESR1 protein] results in increased expression of BGLAP mRNA	19347870
D004958	Estradiol	[Estradiol co-treated with ESR2 protein] results in increased expression of BGLAP mRNA	19347870
D004958	Estradiol	Estradiol results in increased expression of BGLAP mRNA	17689939
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]	17689939
D004958	Estradiol	Estradiol results in decreased expression of BGLAP protein	15917159\|1597966
D004958	Estradiol	Estradiol results in increased expression of BGLAP mRNA	16964405
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA	25932594
C031463	beta-glycerophosphoric acid	bexarotene inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C031463	beta-glycerophosphoric acid	[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of BGLAP protein	17692823
C031463	beta-glycerophosphoric acid	rosiglitazone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C031463	beta-glycerophosphoric acid	tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C031463	beta-glycerophosphoric acid	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA	27028516
C031463	beta-glycerophosphoric acid	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]	27028516
C031463	beta-glycerophosphoric acid	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]	27028516
C095105	bexarotene	bexarotene inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C006780	bisphenol A	bisphenol A results in decreased expression of BGLAP mRNA	27257137
D001895	Boron	Boron results in increased expression of BGLAP mRNA	21625915
D019819	Budesonide	Budesonide results in decreased expression of BGLAP protein	9232087
C038091	butylparaben	butylparaben results in decreased expression of BGLAP mRNA	28527915
D002104	Cadmium	Cadmium results in decreased expression of BGLAP mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of BGLAP mRNA	20570719
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with Plant Extracts] results in increased expression of BGLAP protein	25656917
D019256	Cadmium Chloride	[Cadmium Chloride co-treated with Polyphenols] results in increased expression of BGLAP protein	25656917
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BGLAP mRNA	22209727
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of BGLAP protein	22708652
D002119	Calcium Carbonate	Calcium Carbonate results in decreased expression of BGLAP protein	2027271
D002122	Calcium Chloride	Calcium Chloride results in increased expression of BGLAP mRNA	25824407
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of BGLAP protein	12631673
D002586	Cesium	Cesium results in decreased secretion of BGLAP protein	18797846
C450419	CHF 4056	CHF 4056 affects the expression of BGLAP protein	11861784
D048271	Chitosan	Chitosan results in increased expression of BGLAP mRNA	25246786
D002716	Chlormequat	Chlormequat results in decreased expression of BGLAP protein	28214531
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of BGLAP mRNA	25795401
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin co-treated with IL1B protein] results in increased expression of BGLAP mRNA	22155307
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in decreased secretion of BGLAP protein]	21954917
C018021	cobaltous chloride	cobaltous chloride affects the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	26054564
C018021	cobaltous chloride	[cobaltous chloride co-treated with BMP2 protein] results in increased expression of BGLAP protein	26054564
C018021	cobaltous chloride	cobaltous chloride results in increased expression of BGLAP mRNA	26054564
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of BGLAP mRNA	19549813
D003513	Cycloheximide	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]	17203194
D003513	Cycloheximide	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA]	17203194
C004742	daidzein	[daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA	19347870
C004742	daidzein	[daidzein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA	19347870
D003907	Dexamethasone	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA	25932594
D003907	Dexamethasone	[Ascorbic Acid co-treated with Dexamethasone] results in increased expression of BGLAP mRNA	12510807
D003907	Dexamethasone	bexarotene inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D003907	Dexamethasone	rosiglitazone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D003907	Dexamethasone	tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
D003907	Dexamethasone	[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA	27028516
D003907	Dexamethasone	Dexamethasone results in decreased expression of BGLAP protein	27387537
D003907	Dexamethasone	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein]	27387537
D003907	Dexamethasone	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]	27028516
D003907	Dexamethasone	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]	27028516
D003907	Dexamethasone	[Simvastatin co-treated with Dexamethasone] results in increased expression of BGLAP	19216230
D004075	Diglycerides	Diglycerides results in increased expression of BGLAP mRNA	22286232
D002117	Calcitriol	alitretinoin promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]	12898515
D002117	Calcitriol	alitretinoin promotes the reaction [Calcitriol results in increased secretion of BGLAP protein]	12898515
D002117	Calcitriol	[Calcitriol co-treated with alitretinoin] results in increased expression of BGLAP mRNA	12898515
D002117	Calcitriol	[Calcitriol co-treated with alitretinoin] results in increased secretion of BGLAP protein	12898515
D002117	Calcitriol	[Calcitriol co-treated with resveratrol] results in increased expression of BGLAP mRNA	16267019
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to BGLAP enhancer]	17293108
D002117	Calcitriol	Calcitriol results in increased expression of BGLAP mRNA	10470102\|1201646
D002117	Calcitriol	Calcitriol results in increased secretion of BGLAP protein	12898515
D002117	Calcitriol	FST protein promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]	23589129
D002117	Calcitriol	INHBA protein inhibits the reaction [Calcitriol results in increased expression of BGLAP mRNA]	23589129
D002117	Calcitriol	Calcitriol results in decreased expression of BGLAP mRNA	17293108
D002117	Calcitriol	Calcitriol results in increased expression of BGLAP mRNA	16889531
D002117	Calcitriol	Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]	9626627
D002117	Calcitriol	Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]	9626627
D002117	Calcitriol	Calcitriol results in increased expression of BGLAP mRNA	16813520
D002117	Calcitriol	[[TF protein binds to Aluminum] which co-treated with Calcitriol] results in decreased secretion of BGLAP protein	1476184
D002117	Calcitriol	[[TF protein binds to Aluminum] which co-treated with Calcitriol] results in increased secretion of BGLAP protein	1476184
D019794	2,3-Diphosphoglycerate	"2,3-Diphosphoglycerate results in decreased activity of BGLAP protein"	16857255
D004164	Diphosphonates	Diphosphonates results in decreased expression of BGLAP mRNA	19597852
D004221	Disulfiram	Disulfiram results in increased expression of BGLAP mRNA	24496638
C070609	EMD 53998	EMD 53998 analog results in decreased expression of BGLAP mRNA	24977338
C038939	enzacamene	enzacamene results in increased expression of BGLAP protein	15979666
D004967	Estrogens	Estrogens affects the expression of BGLAP protein	24098073
D000431	Ethanol	Ethanol results in decreased expression of BGLAP mRNA	22892342
D000431	Ethanol	Ethanol results in decreased expression of BGLAP protein	22892342
D000431	Ethanol	[Genistein co-treated with Ethanol] results in increased expression of BGLAP mRNA	24872432
D000431	Ethanol	Vitamin D affects the reaction [Ethanol results in decreased expression of BGLAP mRNA]	22892342
D000431	Ethanol	Ethanol promotes the reaction [lead acetate results in decreased expression of BGLAP protein]	23376407
D000431	Ethanol	Ethanol results in decreased expression of BGLAP protein	23376407
D004997	Ethinyl Estradiol	VDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of BGLAP protein]	12521655
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of BGLAP protein	17240242
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of BGLAP protein	11861784\|1526130
C074031	exenatide	exenatide results in increased expression of BGLAP mRNA	19586609
D005419	Flavonoids	Flavonoids results in increased expression of BGLAP mRNA	23238999
D005459	Fluorides	Fluorides analog results in increased expression of BGLAP mRNA	20634111
D005472	Fluorouracil	Fluorouracil results in increased expression of BGLAP mRNA	16888818
D000068298	Fluticasone	Fluticasone results in increased expression of BGLAP protein	11555383
D002955	Leucovorin	[Methotrexate co-treated with Leucovorin] results in increased expression of BGLAP mRNA	25187349
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]	17689939
C070081	fulvestrant	fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]	26362186
C070081	fulvestrant	fulvestrant inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]	17689939
C070081	fulvestrant	fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]	23596885
C013172	gamma-oryzanol	gamma-oryzanol affects the expression of BGLAP protein	24098073
D019833	Genistein	[Genistein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA	19347870
D019833	Genistein	[Genistein co-treated with ESR2 protein] results in increased expression of BGLAP mRNA	19347870
D019833	Genistein	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]	17203194
D019833	Genistein	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA]	17203194
D019833	Genistein	[Genistein co-treated with Ethanol] results in increased expression of BGLAP mRNA	24872432
D019833	Genistein	[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA	17203194
D019833	Genistein	[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA	17203194
D019833	Genistein	Genistein results in increased expression of BGLAP mRNA	24872432
C097367	ginsenoside Rg3	ginsenoside Rg3 inhibits the reaction [Dexamethasone results in decreased expression of BGLAP protein]	27387537
D005944	Glucosamine	Glucosamine analog results in increased expression of BGLAP mRNA	20458730
D017273	Goserelin	[Goserelin co-treated with kuntai capsule] affects the expression of BGLAP protein	25566615
C119543	GW0072	GW0072 results in decreased expression of BGLAP mRNA	12021203
C089796	hexabromocyclododecane	hexabromocyclododecane affects the expression of BGLAP mRNA	24680724
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of BGLAP	17183249
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BGLAP mRNA	25130202
D006861	Hydrogen Peroxide	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]	25130202
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of BGLAP mRNA	25130202
D006861	Hydrogen Peroxide	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]	25130202
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]	27028516
D006861	Hydrogen Peroxide	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]	27028516
C056599	icariin	icariin results in increased expression of BGLAP mRNA	18295595
C056599	icariin	NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]	18295595
C056599	icariin	SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]	18295595
C056599	icariin	icariin results in increased expression of BGLAP mRNA	18236786
C499403	icaritin	icaritin results in increased expression of BGLAP mRNA	17764702
D007069	Ifosfamide	Ifosfamide results in decreased expression of BGLAP protein	1525342
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BGLAP mRNA	25613284
D007505	Iron-Dextran Complex	Iron-Dextran Complex results in decreased expression of BGLAP mRNA	29122540
C027681	isonicotinamide	isonicotinamide results in increased expression of BGLAP mRNA	21745208
C027681	isonicotinamide	isonicotinamide results in increased expression of BGLAP mRNA	16813520
C074279	KH 1060	alitretinoin promotes the reaction [KH 1060 results in increased expression of BGLAP mRNA]	12898515
C074279	KH 1060	alitretinoin promotes the reaction [KH 1060 results in increased secretion of BGLAP protein]	12898515
C074279	KH 1060	[KH 1060 co-treated with alitretinoin] results in increased expression of BGLAP mRNA	12898515
C074279	KH 1060	[KH 1060 co-treated with alitretinoin] results in increased secretion of BGLAP protein	12898515
C074279	KH 1060	KH 1060 results in increased expression of BGLAP mRNA	12898515
C074279	KH 1060	KH 1060 results in increased secretion of BGLAP protein	12898515
C000620717	kuntai capsule	[Goserelin co-treated with kuntai capsule] affects the expression of BGLAP protein	25566615
D007854	Lead	Lead results in decreased expression of BGLAP mRNA	23086611
D007854	Lead	Lead results in decreased expression of BGLAP mRNA	23086611
C008261	lead acetate	Ethanol promotes the reaction [lead acetate results in decreased expression of BGLAP protein]	23376407
C008261	lead acetate	lead acetate results in decreased expression of BGLAP protein	23376407
C108255	levormeloxifene	levormeloxifene affects the expression of BGLAP protein	11861784
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of BGLAP protein]"	26961602
C482199	lipopolysaccharide, E coli O55-B5	"MIR23B mRNA inhibits the reaction [lipopolysaccharide, E coli O55-B5 inhibits the reaction [BMP2 protein results in increased expression of BGLAP protein]]"	26961602
D008095	Lithocholic Acid	Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of BGLAP mRNA]	20055894
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of BGLAP mRNA	20055894
D008274	Magnesium	Magnesium results in increased expression of BGLAP protein	10397942
D008550	Melatonin	Melatonin results in increased expression of BGLAP mRNA	20738756
C030814	menatetrenone	menatetrenone results in increased expression of BGLAP mRNA	11113387
D008727	Methotrexate	[Methotrexate co-treated with Leucovorin] results in increased expression of BGLAP mRNA	25187349
C015358	methylparaben	methylparaben results in decreased expression of BGLAP mRNA	28527915
C015358	methylparaben	NR3C1 protein promotes the reaction [methylparaben results in decreased expression of BGLAP mRNA]	28527915
C015358	methylparaben	PPARG protein promotes the reaction [methylparaben results in decreased expression of BGLAP mRNA]	28527915
D015741	Metribolone	Metribolone results in increased expression of BGLAP mRNA	19759027
C093875	montelukast	montelukast results in increased expression of BGLAP mRNA	19544365
C008577	myricitrin	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]	25130202
C008577	myricitrin	myricitrin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP mRNA]	25130202
C558527	N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide	"N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide affects the expression of BGLAP protein"	21306167
C005274	naringin	naringin results in increased expression of BGLAP mRNA	18495116
C005274	naringin	naringin results in increased expression of BGLAP protein	18495116
C005274	naringin	naringin results in increased expression of BGLAP mRNA	18495116\|2174122
C005274	naringin	naringin results in increased expression of BGLAP protein	18495116
C005274	naringin	fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]	23596885
C005274	naringin	naringin results in increased secretion of BGLAP protein	23596885
C553460	neoeriocitrin	neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]	21741227
C553460	neoeriocitrin	neoeriocitrin results in increased expression of BGLAP mRNA	21741227
D009538	Nicotine	Nicotine results in decreased expression of BGLAP	19436947
D009538	Nicotine	Nicotine results in increased expression of BGLAP	19436947
D009538	Nicotine	Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]	19436947
D017942	Nitric Acid	Nitric Acid results in increased expression of BGLAP protein	16436523
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BGLAP protein"	22228435
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA"	19913120
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA"	19913120
D009640	Norethindrone	Norethindrone results in increased secretion of BGLAP protein	8053399
D016912	Levonorgestrel	VDR gene polymorphism affects the reaction [[Ethinyl Estradiol co-treated with Levonorgestrel] affects the expression of BGLAP protein]	12521655
C072936	notoginsenoside R1	fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]	26362186
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of BGLAP mRNA	26362186
C508548	ormeloxifene	ormeloxifene affects the expression of BGLAP protein	15261309
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of BGLAP mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of BGLAP mRNA	25729387
D010117	Oxypurinol	Oxypurinol results in increased expression of BGLAP mRNA	26968635
D019308	Palmitic Acid	acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
D019308	Palmitic Acid	CYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
D019308	Palmitic Acid	Palmitic Acid results in increased expression of BGLAP mRNA	24080574
D019308	Palmitic Acid	U 0126 inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
C019248	pamidronate	pamidronate results in increased expression of BGLAP protein	11683535
C047088	phenylamil	phenylamil results in increased expression of BGLAP mRNA	24102669
D010712	Phosphatidic Acids	Phosphatidic Acids results in increased activity of BGLAP protein	16857255
D010936	Plant Extracts	[Cadmium Chloride co-treated with Plant Extracts] results in increased expression of BGLAP protein	25656917
D010936	Plant Extracts	Plant Extracts affects the expression of BGLAP protein	24098073
D020959	Polyethylene	Polyethylene results in decreased expression of BGLAP protein	10225790
D059808	Polyphenols	[Cadmium Chloride co-treated with Polyphenols] results in increased expression of BGLAP protein	25656917
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of BGLAP mRNA	24780913
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of BGLAP protein	9154658
C432165	pyrazolanthrone	[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
D011794	Quercetin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	24102669
D011794	Quercetin	Quercetin results in decreased expression of BGLAP mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of BGLAP mRNA	24102669
D011794	Quercetin	Quercetin results in increased expression of BGLAP protein	24102669
D011794	Quercetin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP mRNA]	26053266
D011794	Quercetin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
D011794	Quercetin	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of BGLAP mRNA]	26053266
D011794	Quercetin	[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
D011794	Quercetin	pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
D011794	Quercetin	Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of BGLAP mRNA]]	27028516
D011794	Quercetin	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]	23117658
D011794	Quercetin	Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]	23223575
D011794	Quercetin	Quercetin results in decreased expression of BGLAP mRNA	14757127
D011794	Quercetin	Quercetin results in increased expression of BGLAP mRNA	26053266
D011794	Quercetin	Quercetin results in increased expression of BGLAP protein	26136938
D011794	Quercetin	SB 203580 inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of BGLAP protein	17823083
C073419	Remifemin	Remifemin affects the expression of BGLAP protein	24098073
C059514	resveratrol	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]	17689939
C059514	resveratrol	[Calcitriol co-treated with resveratrol] results in increased expression of BGLAP mRNA	16267019
C059514	resveratrol	fulvestrant inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]	17689939
C059514	resveratrol	resveratrol results in increased expression of BGLAP mRNA	16267019\|1768993
C059514	resveratrol	resveratrol results in increased expression of BGLAP mRNA	16813520\|1696440
C059514	resveratrol	resveratrol results in increased expression of BGLAP protein	21715682
C089730	rosiglitazone	rosiglitazone inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C089730	rosiglitazone	rosiglitazone affects the expression of BGLAP protein	18948404
C089730	rosiglitazone	rosiglitazone results in decreased expression of BGLAP mRNA	12021203
C093642	SB 203580	[pyrazolanthrone co-treated with SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
C093642	SB 203580	SB 203580 inhibits the reaction [Quercetin results in increased expression of BGLAP protein]	26136938
C086243	sciadopitysin	sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]	23624148
C086243	sciadopitysin	sciadopitysin results in increased expression of BGLAP protein	23624148
D020845	Selective Estrogen Receptor Modulators	Selective Estrogen Receptor Modulators results in decreased expression of BGLAP protein	17240242
D064588	Selenium Oxides	[Selenium Oxides co-treated with silica-calcium phosphate nanocomposite] results in increased expression of BGLAP mRNA	17019725\|1703400
C499768	silica-calcium phosphate nanocomposite	[Selenium Oxides co-treated with silica-calcium phosphate nanocomposite] results in increased expression of BGLAP mRNA	17019725\|1703400
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP	20381859
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP mRNA	15953866\|1725254
D019821	Simvastatin	Simvastatin results in increased secretion of BGLAP protein	20381859
D019821	Simvastatin	CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]	22058016
D019821	Simvastatin	DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]	22058016
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP	20564244
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP mRNA	12914771\|1460131
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP protein	12914771\|1460131
D019821	Simvastatin	[Simvastatin co-treated with Dexamethasone] results in increased expression of BGLAP	19216230
D019821	Simvastatin	Simvastatin results in increased expression of BGLAP protein	19292885
C017947	sodium arsenite	sodium arsenite results in decreased expression of BGLAP mRNA	28206643
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of BGLAP mRNA	26339601
D012969	Sodium Fluoride	Sodium Fluoride affects the expression of BGLAP mRNA	25132241
D013311	Streptozocin	Streptozocin results in decreased expression of BGLAP mRNA	25617479
D013311	Streptozocin	Streptozocin results in decreased expression of BGLAP protein	25617479
D013629	Tamoxifen	[Tamoxifen co-treated with ESR1 protein] results in increased expression of BGLAP mRNA	19347870
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]	19264158
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of BGLAP mRNA	24680724
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BGLAP	19367694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA	19264158\|2274996
D013749	Tetrachlorodibenzodioxin	tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]	22749964
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA	28077779
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA	19201780\|1926415
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BGLAP mRNA	25613284
D014025	Titanium	Titanium results in increased expression of BGLAP mRNA	15914587
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of BGLAP mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of BGLAP mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP	17170073
D014212	Tretinoin	Tretinoin results in decreased expression of BGLAP mRNA	16350840\|1639270
D014212	Tretinoin	Tretinoin results in increased expression of BGLAP mRNA	16889531
C011559	tributyltin	tributyltin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of BGLAP mRNA]	25932594
C011559	tributyltin	tributyltin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of BGLAP mRNA]	22749964
C011559	tributyltin	tributyltin results in increased expression of BGLAP mRNA	22749964
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of BGLAP protein	23747339
C057693	troglitazone	troglitazone results in decreased expression of BGLAP mRNA	16813520
D014403	Tubocurarine	Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]	19436947
D014414	Tungsten	Tungsten results in decreased expression of BGLAP mRNA	26865663
C113580	U 0126	U 0126 inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA]	24080574
D014501	Uranium	Uranium results in increased expression of BGLAP protein	16436523
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BGLAP mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BGLAP mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BGLAP mRNA	24383497
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of BGLAP mRNA	23940539
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of BGLAP gene	25560391
D014807	Vitamin D	Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of BGLAP mRNA]	20055894
D014807	Vitamin D	Vitamin D results in increased expression of BGLAP mRNA	20055894
D014807	Vitamin D	Vitamin D affects the reaction [Ethanol results in decreased expression of BGLAP mRNA]	22892342
D002762	Cholecalciferol	[Cholecalciferol co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid] results in increased expression of BGLAP protein	17692823
D002762	Cholecalciferol	Cholecalciferol results in increased secretion of BGLAP protein	17996099
D002762	Cholecalciferol	[Tretinoin co-treated with Cholecalciferol] results in increased expression of BGLAP	17170073
D002762	Cholecalciferol	Cholecalciferol results in increased expression of BGLAP mRNA	19759027
D014812	Vitamin K	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]	23117658
D014812	Vitamin K	[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA	23117658
D024482	Vitamin K 2	Vitamin K 2 inhibits the reaction [IL1B protein results in decreased expression of BGLAP protein modified form]	20460758
D024482	Vitamin K 2	Vitamin K 2 results in decreased expression of BGLAP mRNA	19675304
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of BGLAP mRNA	19675304
C111237	vorinostat	vorinostat results in decreased expression of BGLAP mRNA	27188386
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]	21910061
D014859	Warfarin	Warfarin inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]	21910061
D014859	Warfarin	Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA]	23117658
D014859	Warfarin	Quercetin inhibits the reaction [Warfarin results in increased expression of BGLAP mRNA]	23223575
D014859	Warfarin	[Warfarin co-treated with Vitamin K] results in increased expression of BGLAP mRNA	23117658
D014859	Warfarin	Warfarin results in increased expression of BGLAP mRNA	23223575
D015032	Zinc	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]	17203194
D015032	Zinc	[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA	17203194
D015032	Zinc	Zinc results in decreased expression of BGLAP protein	22228435
D015032	Zinc	Zinc deficiency results in decreased expression of BGLAP mRNA	21893222
D015032	Zinc	Zinc deficiency results in decreased expression of BGLAP protein	21893222
C016837	zinc chloride	"[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA"	19913120
C016837	zinc chloride	"[zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA"	19913120
D019287	Zinc Sulfate	Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA]	17203194
D019287	Zinc Sulfate	[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA	17203194
C088658	zoledronic acid	zoledronic acid results in increased expression of BGLAP mRNA	14751568

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005198	structural molecule activity	-	NAS	10486212
GO:0005509	calcium ion binding	-	IEA	-
GO:0008147	structural constituent of bone	-	NAS	12467198
GO:0046848	hydroxyapatite binding	-	NAS	10486212

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001501	skeletal system development	-	TAS	10865224
GO:0001649	osteoblast differentiation	-	IEP	17023519
GO:0002076	osteoblast development	-	IEA	-
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0007155	cell adhesion	-	NAS	12202187
GO:0007569	cell aging	-	IEA	-
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0009629	response to gravity	-	IEA	-
GO:0010043	response to zinc ion	-	IEA	-
GO:0014823	response to activity	-	IEA	-
GO:0030282	bone mineralization	-	NAS	10486212
GO:0030500	regulation of bone mineralization	-	IEA	-
GO:0032571	response to vitamin K	-	IEA	-
GO:0033280	response to vitamin D	-	IEP	17023519
GO:0033574	response to testosterone	-	IEA	-
GO:0033594	response to hydroxyisoflavone	-	IEA	-
GO:0042476	odontogenesis	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0045124	regulation of bone resorption	-	NAS	10486212
GO:0045471	response to ethanol	-	IEA	-
GO:0045670	regulation of osteoclast differentiation	-	NAS	10486212
GO:0051384	response to glucocorticoid	-	IEA	-
GO:0060348	bone development	-	IEA	-
GO:0071305	cellular response to vitamin D	-	IEA	-
GO:0071363	cellular response to growth factor stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IEA	-
GO:0005737	cytoplasm	-	IDA	11856645
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005791	rough endoplasmic reticulum	-	IEA	-
GO:0005796	Golgi lumen	-	TAS	-
GO:0030425	dendrite	-	IEA	-
GO:0031982	vesicle	-	IEA	-
GO:0043204	perikaryon	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-159740	Gamma-carboxylation of protein precursors	TAS
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	TAS
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	TAS
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	TAS
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23030247	Nicotine alters MicroRNA expression and hinders human adult stem cell regenerative potential. (2013 Mar 1)	Ng TK	Stem Cells Dev