Gene: SCN1B

6324
ATFB13|BRGDA5|EIEE52|GEFSP1
sodium voltage-gated channel beta subunit 1
protein-coding
19q13.11
Ensembl:ENSG00000105711 MIM:600235 Vega:OTTHUMG00000182472 UniprotKB:Q07699
NG_013359.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.036e-1 (AD)  5.993e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CABP10.951
CPLX10.945
SNCB0.929
CEND10.926
PNKD0.924
REEP20.922
NRGN0.919
PRKAR1B0.916
CHGA0.912
KLC20.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.626
OR4F29-0.596
TFPI2-0.462
WWTR1-0.455
C9orf135-0.447
IGF2BP2-0.446
ARHGEF5-0.446
C1orf87-0.441
HAS2-0.437
KIAA0040-0.436

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00252PhenytoinSmall Molecule57-41-0ApprovedTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB05541BrivaracetamSmall Molecule357336-20-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SCN1B mRNA"26377693
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN3A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]"21983428
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]"22465659
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"SCN1B protein affects the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the activity of SCN8A protein]"26708501
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of SCN1B mRNA"20206263
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SCN1B mRNA16788091
D000082AcetaminophenAcetaminophen results in decreased expression of SCN1B mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SCN1B mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of SCN1B mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SCN1B mRNA21298039
D000638AmiodaroneAmiodarone results in decreased expression of SCN1B mRNA15520326
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCN1B mRNA16483693
D001104ArbutinArbutin results in increased expression of SCN1B mRNA17103032
D001241AspirinAspirin results in increased expression of SCN1B mRNA11906190
D001280AtrazineAtrazine results in decreased expression of SCN1B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCN1B mRNA21715664
C018465bioallethrinbioallethrin affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]22465659
C006780bisphenol Abisphenol A results in decreased expression of SCN1B mRNA25181051
D002330CarmustineCarmustine results in increased expression of SCN1B mRNA16005536
C054133casticincasticin results in increased expression of SCN1B mRNA28444820
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCN1B mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of SCN1B mRNA19376846
D003314Corn OilCorn Oil affects the expression of SCN1B mRNA16360708
D016572CyclosporineCyclosporine results in decreased expression of SCN1B mRNA20106945
C052570cyfluthrincyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017160cypermethrincypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017160cypermethrinSCN1B protein promotes the reaction [cypermethrin binds to SCN2A protein]9863771
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SCN1B mRNA23914054
C017180decamethrindecamethrin results in decreased expression of SCN1B mRNA27058123
C017180decamethrindecamethrin affects the activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]21983428
C017180decamethrindecamethrin affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]22465659
C017180decamethrinSCN1B protein affects the reaction [decamethrin affects the activity of SCN8A protein]26708501
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SCN1B mRNA20920545
D002117CalcitriolCalcitriol results in increased expression of SCN1B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SCN1B mRNA21592394
C044267fenpropathrinfenpropathrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017690fenvaleratefenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D005485FlutamideFlutamide results in decreased expression of SCN1B mRNA24136188
C039281furanfuran results in decreased expression of SCN1B mRNA25539665
C010176halofuginonehalofuginone results in decreased expression of SCN1B mRNA17180598
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SCN1B mRNA25613284
D048628KetolidesKetolides analog results in increased expression of SCN1B mRNA24967691
D008727MethotrexateMethotrexate results in increased expression of SCN1B mRNA16005536
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCN1B mRNA"20188158
D010672PhenytoinPhenytoin binds to [SCN1B protein binds to SCN3A protein]15922564
D010672PhenytoinPhenytoin results in decreased activity of [SCN1B protein binds to SCN3A protein]15922564
D010672PhenytoinSCN1B protein mutant form results in decreased susceptibility to Phenytoin15922564
C006253pirinixic acidpirinixic acid results in decreased expression of SCN1B mRNA19162173
D011374ProgesteroneProgesterone results in increased expression of SCN1B mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCN1B mRNA24780913
D015237DinoprostDinoprost results in increased expression of SCN1B mRNA11517196
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SCN1B mRNA25895662
D012964Sodium"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN3A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
D012964Sodium[SCN3A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium19026681
D012964Sodium"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]"22465659
D012964Sodium"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
D012964Sodiumbioallethrin affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]22465659
D012964Sodiumcyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumcypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumdecamethrin affects the reaction [[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium]22465659
D012964Sodiumfenpropathrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumfenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodium[SCN2A protein binds to SCN1B protein] which affects the transport of Sodium9236205
D012964Sodium[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium18538810
D012964Sodium[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium19026681
D012964Sodium[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein mutant form] results in increased transport of Sodium22465659
D012964Sodium[SCN2B protein co-treated with SCN1B protein co-treated with SCN8A protein] results in increased transport of Sodium22465659
C017947sodium arsenitesodium arsenite affects the methylation of SCN1B gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of SCN1B mRNA27862939
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SCN1B mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SCN1B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCN1B mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCN1B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCN1B mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SCN1B mRNA25613284
D013779TetrodotoxinTetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]9236205
D013779TetrodotoxinTetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]21983428
D013866ThioguanineThioguanine results in increased expression of SCN1B mRNA16005536
C028800toxin II (Anemonia sulcata)toxin II (Anemonia sulcata) binds to and affects the activity of [SCN2A protein binds to SCN1B protein]9236205
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCN1B mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SCN1B mRNA29024780
D014520UrethaneUrethane results in decreased expression of SCN1B mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of SCN1B mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of SCN1B mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005248voltage-gated sodium channel activity-IDA19808477  
GO:0005515protein binding-IPI26900580  
GO:0017080sodium channel regulator activity-IDA18464934  19808477  
GO:0019871sodium channel inhibitor activity-IBA21873635  
GO:0019871sodium channel inhibitor activity-ISS17884088  
GO:0044325ion channel binding-IBA21873635  
GO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potential-IMP19808477  
GO:0086062voltage-gated sodium channel activity involved in Purkinje myocyte action potential-IMP18464934  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007268chemical synaptic transmission-TAS9697698  
GO:0007411axon guidance-ISS-  
GO:0010765positive regulation of sodium ion transport-IDA19808477  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0019227neuronal action potential propagation-ISS-  
GO:0021966corticospinal neuron axon guidance-ISS-  
GO:0035725sodium ion transmembrane transport-IDA18464934  19808477  21051419  
GO:0040011locomotion-ISS-  
GO:0046684response to pyrethroid-IEA-  
GO:0051899membrane depolarization-IDA21051419  
GO:0060048cardiac muscle contraction-IMP19808477  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-ISS17884088  
GO:0060371regulation of atrial cardiac muscle cell membrane depolarization-IMP19808477  22247482  
GO:0061337cardiac conduction-ISS-  
GO:0086002cardiac muscle cell action potential involved in contraction-IBA21873635  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP19808477  
GO:0086012membrane depolarization during cardiac muscle cell action potential-ISS17884088  
GO:0086047membrane depolarization during Purkinje myocyte cell action potential-IMP18464934  
GO:0086091regulation of heart rate by cardiac conduction-IBA21873635  
GO:0086091regulation of heart rate by cardiac conduction-IMP19808477  
GO:2000649regulation of sodium ion transmembrane transporter activity-IBA21873635  
GO:2000649regulation of sodium ion transmembrane transporter activity-IDA19808477  
GO ID GO Term Qualifier Evidence PubMed
GO:0001518voltage-gated sodium channel complex-IBA21873635  
GO:0001518voltage-gated sodium channel complex-IDA19808477  21051419  
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0014704intercalated disc-ISS-  
GO:0030315T-tubule-ISS-  
GO:0033268node of Ranvier-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-397014Muscle contractionTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22511924Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. (2012)Wolen ARPLoS One