Gene: SCN2A

6326
BFIC3|BFIS3|BFNIS|EIEE11|HBA|HBSCI|HBSCII|NAC2|Na(v)1.2|Nav1.2|SCN2A1|SCN2A2
sodium voltage-gated channel alpha subunit 2
protein-coding
2q24.3
Ensembl:ENSG00000136531 MIM:182390 Vega:OTTHUMG00000044172 UniprotKB:Q99250
NG_008143.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.005e-1 (AD)  7.114e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2028891chr2:165211148 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB30.981
ATP2B10.976
RBFOX10.975
CNKSR20.975
GABRG20.974
NELL20.973
GLRB0.972
GABRA10.972
PAK30.971
GABRB20.971

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.568
CNN2-0.542
HEY2-0.538
RAI14-0.53
RUNX3-0.527
RAB13-0.526
RNF135-0.525
TFPI2-0.523
WWTR1-0.522
SYDE1-0.52

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00818PropofolSmall Molecule2078-54-8Approved|InvestigationalTarget
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB05232TetrodotoxinSmall Molecule4368-28-9InvestigationalTarget
DB13520MetergolineSmall Molecule17692-51-2ExperimentalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB05541BrivaracetamSmall Molecule357336-20-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]"25358543
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A mRNA"23284745
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A protein"23284745
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of SCN2A mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SCN2A mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SCN2A mRNA"19114083
C4898272,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of SCN2A mRNA"23829299
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein]"26917740
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of SCN2A mRNA]19442820
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCN2A gene27153756
C475726APETx1, Anthopleura elegantissima"APETx1, Anthopleura elegantissima analog results in decreased activity of SCN2A protein"22972919
C475726APETx1, Anthopleura elegantissima"APETx1, Anthopleura elegantissima promotes the reaction [huwentoxin IV, Selenocosmia huwena results in decreased activity of SCN2A protein]"22972919
C475726APETx1, Anthopleura elegantissima"APETx1, Anthopleura elegantissima results in decreased activity of SCN2A protein"22972919
C501880APETx2 protein, Anthopleura elegantissima"APETx2 protein, Anthopleura elegantissima promotes the reaction [huwentoxin IV, Selenocosmia huwena results in decreased activity of SCN2A protein]"22972919
C501880APETx2 protein, Anthopleura elegantissima"APETx2 protein, Anthopleura elegantissima results in decreased activity of SCN2A protein"22972919
C006632arsenic trioxidearsenic trioxide results in increased expression of SCN2A mRNA26705709
D001280AtrazineAtrazine results in decreased expression of SCN2A mRNA22378314
C044887beta-methylcholinebeta-methylcholine affects the expression of SCN2A mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SCN2A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SCN2A gene28505145
D002101Cacodylic AcidCacodylic Acid results in decreased expression of SCN2A mRNA16122865
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCN2A mRNA24763279
D020916ConotoxinsConotoxins results in decreased activity of SCN2A protein26817840
D016572CyclosporineCyclosporine results in increased methylation of SCN2A promoter27989131
C052570cyfluthrincyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017160cypermethrincypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017160cypermethrincypermethrin binds to SCN2A protein9863771
C017160cypermethrinSCN1B protein promotes the reaction [cypermethrin binds to SCN2A protein]9863771
C017180decamethrin"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]"25358543
C017180decamethrindecamethrin results in decreased expression of SCN2A mRNA25358543
C017180decamethrinPD 150606 inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]25358543
C017180decamethrinTetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]25358543
C017180decamethrindecamethrin results in decreased expression of SCN2A mRNA27058123
C017180decamethrindecamethrin affects the reaction [SCN2A protein mutant form results in increased transport of Sodium]19442819
C017180decamethrindecamethrin affects the reaction [SCN2A protein results in increased transport of Sodium]19442819
D003976DiazinonDiazinon affects the expression of SCN2A mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SCN2A mRNA27392435
D004026DieldrinDieldrin affects the expression of SCN2A mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SCN2A mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SCN2A mRNA]19850644
C044267fenpropathrinfenpropathrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
C017690fenvaleratefenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of SCN2A mRNA21782745
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCN2A mRNA24763279
C470632huwentoxin IV, Selenocosmia huwena"APETx1, Anthopleura elegantissima promotes the reaction [huwentoxin IV, Selenocosmia huwena results in decreased activity of SCN2A protein]"22972919
C470632huwentoxin IV, Selenocosmia huwena"APETx2 protein, Anthopleura elegantissima promotes the reaction [huwentoxin IV, Selenocosmia huwena results in decreased activity of SCN2A protein]"22972919
C470632huwentoxin IV, Selenocosmia huwena"huwentoxin IV, Selenocosmia huwena results in decreased activity of SCN2A protein"22972919
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SCN2A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SCN2A mRNA24796395
C047781lamotriginelamotrigine results in decreased activity of SCN2A protein11212204
D007854LeadLead affects the expression of SCN2A mRNA28903495
C105338makatoxin Imakatoxin I affects the activity of SCN2A protein19162162
C042720mercuric bromidemercuric bromide results in increased expression of SCN2A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of SCN2A mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SCN2A protein25809596
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SCN2A mRNA26924002
C502265mu-conotoxin KIIIA, Conus kinoshitai"mu-conotoxin KIIIA, Conus kinoshitai results in decreased activity of SCN2A protein"22972919
C502265mu-conotoxin KIIIA, Conus kinoshitai"mu-conotoxin KIIIA, Conus kinoshitai results in decreased activity of SCN2A protein"21962108
C022838nickel chloridenickel chloride affects the expression of SCN2A mRNA22546817
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SCN2A mRNA27935865
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN2A mRNA"25510870
C100442PD 150606PD 150606 inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]25358543
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A mRNA"23284745
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A protein"23284745
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN2A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SCN2A mRNA26272509
D010672PhenytoinPhenytoin results in decreased activity of SCN2A protein11212204
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SCN2A mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of SCN2A mRNA12832660
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCN2A mRNA24780913
D012604Scorpion VenomsScorpion Venoms affects the activity of SCN2A protein21887265
D012964Sodium"2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate inhibits the reaction [[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium]"19026681
D012964Sodiumcyfluthrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumcypermethrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumdecamethrin affects the reaction [SCN2A protein mutant form results in increased transport of Sodium]19442819
D012964Sodiumdecamethrin affects the reaction [SCN2A protein results in increased transport of Sodium]19442819
D012964Sodiumfenpropathrin affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodiumfenvalerate affects the reaction [[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium]18538810
D012964Sodium[SCN2A protein binds to SCN1B protein] which affects the transport of Sodium9236205
D012964Sodium[SCN2A protein binds to SCN1B protein] which results in increased transport of Sodium18538810
D012964Sodium[SCN2A protein co-treated with SCN2B protein co-treated with SCN1B protein] results in increased transport of Sodium19026681
D012964SodiumSCN2A protein mutant form results in increased transport of Sodium19442819
D012964SodiumSCN2A protein results in increased transport of Sodium19442819
C017947sodium arsenitesodium arsenite affects the methylation of SCN2A gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCN2A mRNA21354282
D013779TetrodotoxinTetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]25358543
D013779TetrodotoxinTetrodotoxin results in decreased activity of SCN2A protein22972919
D013779TetrodotoxinTetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]9236205
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of SCN2A mRNA]19442820
D019284ThapsigarginThapsigargin results in increased expression of SCN2A mRNA19442820
C028800toxin II (Anemonia sulcata)toxin II (Anemonia sulcata) binds to and affects the activity of [SCN2A protein binds to SCN1B protein]9236205
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A mRNA"23284745
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN2A protein"23284745
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SCN2A gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to SCN2A promoter]26655721
D014212TretinoinTretinoin results in increased expression of SCN2A mRNA26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of SCN2A mRNA]26655721
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SCN2A mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of SCN2A mRNA19101580|2670570

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005248voltage-gated sodium channel activity-IBA21873635  
GO:0005248voltage-gated sodium channel activity-IMP28256214  
GO:0005248voltage-gated sodium channel activity-ISS-  
GO:0005261cation channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-TAS1325650  
GO:0008627intrinsic apoptotic signaling pathway in response to osmotic stress-IEA-  
GO:0019228neuronal action potential-IBA21873635  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0035725sodium ion transmembrane transport-ISS-  
GO:0042552myelination-ISS-  
GO:0051402neuron apoptotic process-IEA-  
GO:0086010membrane depolarization during action potential-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001518voltage-gated sodium channel complex-IEA-  
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1325650  
GO:0014704intercalated disc-IEA-  
GO:0030315T-tubule-IEA-  
GO:0030424axon-TAS16652168  
GO:0031226intrinsic component of plasma membrane-ISS-  
GO:0033268node of Ranvier-ISS-  
GO:0033270paranode region of axon-IEA-  
GO:0034706sodium channel complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-397014Muscle contractionTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal