Gene: BGN

633
DSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A
biglycan
protein-coding
Xq28
Ensembl:ENSG00000182492 MIM:301870 Vega:OTTHUMG00000024205 UniprotKB:P21810
NG_015961.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GFAP0.802
KANK20.775
NDUFA4L20.768
RRAS0.766
CD1510.755
TGFB1I10.751
TLN10.75
IGFBP70.75
EHD20.746
SERPINB60.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEK10-0.458
NDST3-0.446
ADAMTS3-0.44
STYK1-0.438
CDH8-0.435
CDH12-0.434
HTR3B-0.431
LINGO2-0.43
CNTN5-0.429
SLC1A6-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BGN mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of BGN mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of BGN mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of BGN mRNA17562736
D000537Aluminum OxideAluminum Oxide results in increased expression of BGN mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BGN mRNA16483693
C547126AZM551248AZM551248 results in increased expression of BGN mRNA22323515
D004958EstradiolEstradiol results in increased expression of BGN mRNA19429434|2118537
C006780bisphenol Abisphenol A results in increased expression of BGN mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of BGN mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of BGN mRNA18958704
D002065BuspironeBuspirone results in decreased expression of BGN mRNA24136188
C584509C646 compoundC646 compound results in increased expression of BGN mRNA26191083
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA19840844
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of BGN mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BGN mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of BGN mRNA15963342
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BGN mRNA16239168
D002857ChromiumChromium results in decreased expression of BGN mRNA21437242
D002994ClofibrateClofibrate results in decreased expression of BGN mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased secretion of BGN protein22079246
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA]18200517
D000069439DasatinibDasatinib results in increased expression of BGN mRNA20579391
C014347decitabinedecitabine affects the expression of BGN mRNA23300844
D003907DexamethasoneDexamethasone results in decreased expression of BGN mRNA25047013
D003975DiazepamDiazepam results in increased expression of BGN mRNA19114084
D003976DiazinonDiazinon results in increased methylation of BGN gene22964155
D002945CisplatinCisplatin affects the expression of BGN mRNA23300844
D002945CisplatinCisplatin results in decreased expression of BGN mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of BGN mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of BGN mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of BGN mRNA"22485181
D004147DioxinsDioxins affects the expression of BGN mRNA20463971
D004317DoxorubicinDoxorubicin affects the expression of BGN protein29385562
D004317DoxorubicinDMD protein affects the reaction [Doxorubicin results in decreased expression of BGN mRNA]17888722
D004317DoxorubicinDoxorubicin affects the expression of BGN mRNA15033991
D004317DoxorubicinDoxorubicin results in decreased expression of BGN mRNA17888722
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BGN mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BGN mRNA17557909
D005485FlutamideFlutamide results in decreased expression of BGN mRNA24136188
C039281furanfuran results in increased expression of BGN mRNA27387713
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of BGN mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of BGN mRNA17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine results in decreased expression of BGN mRNA]17109745
C010176halofuginonehalofuginone results in increased expression of BGN mRNA17180598
D017313FenretinideFenretinide results in decreased expression of BGN mRNA28973697
C492448ICG 001ICG 001 results in increased expression of BGN mRNA26191083
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA19840844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BGN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of BGN mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of BGN mRNA19812364
C051752nefazodonenefazodone results in decreased expression of BGN mRNA24136188
C012655nimesulidenimesulide results in decreased expression of BGN mRNA24136188
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA19840844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of BGN mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of BGN mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of BGN mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of BGN mRNA24205000
D017239PaclitaxelBGN protein affects the susceptibility to Paclitaxel16217747
D000073878Palm OilPalm Oil results in increased expression of BGN mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of BGN mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of BGN mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of BGN mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of BGN mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of BGN mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BGN mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of BGN mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of BGN mRNA24780913
D011794QuercetinQuercetin results in increased expression of BGN mRNA16455785
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of BGN mRNA19429434
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of BGN mRNA15576828
D015474IsotretinoinIsotretinoin results in increased expression of BGN mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of BGN mRNA21172411
D012999SomanSoman results in increased expression of BGN mRNA19281266
D013629TamoxifenTamoxifen affects the expression of BGN mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BGN mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BGN mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BGN mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BGN mRNA18465118
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA19840844
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of BGN mRNA25729387
D019772TopotecanTopotecan results in increased expression of BGN mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of BGN mRNA"19682533
C011559tributyltintributyltin results in increased expression of BGN mRNA21683754
D014241TrichloroethyleneTrichloroethylene results in decreased expression of BGN mRNA15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of BGN mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of BGN mRNA18200517
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BGN mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of BGN mRNA28973697
C057693troglitazonetroglitazone results in increased expression of BGN mRNA28973697
D014501UraniumUranium affects the expression of BGN mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of BGN mRNA15672453
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BGN mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of BGN mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of BGN mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of BGN gene29154799
D014640VancomycinVancomycin results in decreased expression of BGN mRNA18930951
C025643vinclozolinvinclozolin affects the expression of BGN mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-NAS1860845  
GO:0005539glycosaminoglycan binding-IEA-  
GO:0030021extracellular matrix structural constituent conferring compression resistance-HDA20551380  27559042  
GO:0030021extracellular matrix structural constituent conferring compression resistance-ISS-  
GO:0050840extracellular matrix binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001974blood vessel remodeling-IEA-  
GO:0008150biological_process-ND-  
GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030206chondroitin sulfate biosynthetic process-TAS-  
GO:0030207chondroitin sulfate catabolic process-TAS-  
GO:0030208dermatan sulfate biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0009986cell surface-IDA2212616  
GO:0030133transport vesicle-IDA-  
GO:0031012extracellular matrix-NAS1860845  
GO:0042383sarcolemma-IEA-  
GO:0043202lysosomal lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-2022870Chondroitin sulfate biosynthesisTAS
R-HSA-2022923Dermatan sulfate biosynthesisTAS
R-HSA-2024101CS/DS degradationTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-3000178ECM proteoglycansTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560783Defective B4GALT7 causes EDS, progeroid typeTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3595172Defective CHST3 causes SEDCJDTAS
R-HSA-3595174Defective CHST14 causes EDS, musculocontractural typeTAS
R-HSA-3595177Defective CHSY1 causes TPBSTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-4420332Defective B3GALT6 causes EDSP2 and SEMDJL1TAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25463076Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis. (2014 Dec)Mandraffino GAtherosclerosis
29354674Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study. (2017 Sep 5)Diaz AAChronic Obstr Pulm Dis
28131044Biglycan expression, earlier vascular damage and pro-atherogenic profile improvement after smoke cessation in young people. (2017 Feb)Mandraffino GAtherosclerosis