Gene: SCN4B

6330
ATFB17|LQT10|Navbeta4
sodium voltage-gated channel beta subunit 4
protein-coding
11q23.3
Ensembl:ENSG00000177098 MIM:608256 Vega:OTTHUMG00000166994 UniprotKB:Q8IWT1
NG_011710.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.226e-1 (AD)  9.954e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21858113chr11:118015340SCN4BPromoter5.590e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM230.952
SCN2B0.945
NEFM0.94
RBFOX10.94
ATP2B30.94
CAMKK10.938
KCNQ50.936
SLC12A50.935
NSF0.934
NEFL0.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.544
MYL3-0.54
WWTR1-0.537
YES1-0.534
TFPI2-0.529
CNN2-0.522
HEY2-0.516
REST-0.515
SGMS2-0.512
KIAA0040-0.5

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00909ZonisamideSmall Molecule68291-97-4Approved|InvestigationalTarget
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTarget
DB05541BrivaracetamSmall Molecule357336-20-0Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in increased expression of SCN4B mRNA"24046277
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in increased expression of SCN4B mRNA"24046277
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C1079462,7-dihydroxynaphthalene"2,7-dihydroxynaphthalene results in decreased expression of SCN4B mRNA"28940058
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SCN4B mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCN4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCN4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SCN4B mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SCN4B gene27153756
D000447AldehydesAldehydes results in increased expression of SCN4B mRNA25014914
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SCN4B mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of SCN4B mRNA26705709
D001280AtrazineAtrazine results in decreased expression of SCN4B mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of SCN4B mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SCN4B mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCN4B mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCN4B mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SCN4B mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of SCN4B mRNA25594700
C006780bisphenol Abisphenol A affects the expression of SCN4B mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SCN4B mRNA26079696
D003300CopperCopper deficiency results in increased expression of SCN4B mRNA26033743
D003471CuprizoneCuprizone results in increased expression of SCN4B mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SCN4B mRNA23914054
C017180decamethrindecamethrin results in decreased expression of SCN4B mRNA27058123
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCN4B mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SCN4B mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SCN4B mRNA22129741
D004317DoxorubicinDoxorubicin results in increased expression of SCN4B mRNA28940058
C118739entinostatentinostat results in increased expression of SCN4B mRNA26272509
C016517indole-3-carbinolindole-3-carbinol affects the expression of SCN4B mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SCN4B mRNA22129741
D007545IsoproterenolIsoproterenol results in decreased expression of SCN4B mRNA20003209
D007649KetamineKetamine results in increased expression of SCN4B mRNA20080153
D009532NickelNickel results in decreased expression of SCN4B mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SCN4B mRNA27935865
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SCN4B mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SCN4B mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of SCN4B mRNA26705709
C046012pentanalpentanal results in increased expression of SCN4B mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SCN4B mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SCN4B mRNA16221955
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCN4B mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SCN4B mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of SCN4B mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of SCN4B mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of SCN4B mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCN4B mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SCN4B mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of SCN4B mRNA27862939
D053260SootSoot results in increased expression of SCN4B mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCN4B mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCN4B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCN4B mRNA20558275|2121527
D014212TretinoinTretinoin results in increased expression of SCN4B mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SCN4B mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SCN4B mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of SCN4B mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCN4B gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SCN4B mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCN4B mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SCN4B mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005248voltage-gated sodium channel activity-IDA12930796  
GO:0017080sodium channel regulator activity-IDA17592081  24297919  
GO:0044325ion channel binding-IPI17592081  
GO:0086006voltage-gated sodium channel activity involved in cardiac muscle cell action potential-IMP17592081  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IDA12930796  
GO:0010765positive regulation of sodium ion transport-IDA17592081  
GO:0035725sodium ion transmembrane transport-IDA20226894  
GO:0060048cardiac muscle contraction-IMP17592081  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IMP17592081  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP17592081  
GO:0086012membrane depolarization during cardiac muscle cell action potential-IMP17592081  
GO:0086016AV node cell action potential-IMP17592081  
GO:0086091regulation of heart rate by cardiac conduction-IMP17592081  
GO:2000649regulation of sodium ion transmembrane transporter activity-IDA17592081  24297919  
GO ID GO Term Qualifier Evidence PubMed
GO:0001518voltage-gated sodium channel complex-IDA12930796  17592081  
GO:0001518voltage-gated sodium channel complex-IMP24297919  
GO:0014704intercalated disc-ISS-  
GO:0031226intrinsic component of plasma membrane-IDA24297919  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-397014Muscle contractionTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25450227Transcriptome organization for chronic alcohol abuse in human brain. (2015 Nov)Farris SPMol Psychiatry