Gene info: ID 634

Gene: CEACAM1

GENE ID: 634

Synonyms: BGP|BGP1|BGPI

Description: carcinoembryonic antigen related cell adhesion molecule 1

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000079385 MIM:109770 Vega:OTTHUMG00000151078 UniprotKB:P13688

RefSeq: NG_029051.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.543e-1 (AD) 6.825e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GBP5	0.834
RHOH	0.817
CARD16	0.806
IL15	0.806
SAMD9	0.804
DDX60L	0.803
SP100	0.8
TRIM5	0.792
LILRA3	0.792
NLRC5	0.792

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYADML2	-0.496
HRH3	-0.474
GABRA5	-0.467
TMEM179	-0.456
SCRT1	-0.444
EXTL1	-0.438
SVOP	-0.434
BCL11A	-0.432
CLEC2L	-0.429
KCNC4	-0.427

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00113	Technetium Tc-99m arcitumomab	BiotechDrug	154361-49-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CEACAM1 mRNA"	19114083
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of CEACAM1 mRNA"	24172598
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CEACAM1 mRNA"	18648102
C029370	4-toluidine	4-toluidine results in decreased expression of CEACAM1 mRNA	27638505
D000082	Acetaminophen	Acetaminophen results in decreased expression of CEACAM1 mRNA	21420995\|2906747
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of CEACAM1 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CEACAM1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of CEACAM1 mRNA	17522070
D020106	Acrylamide	Acrylamide results in decreased expression of CEACAM1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CEACAM1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CEACAM1 mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CEACAM1 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of CEACAM1 mRNA	21757418
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CEACAM1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CEACAM1 mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of CEACAM1 mRNA	17103032
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CEACAM1 mRNA"	25351596
C406592	azaspiracid	azaspiracid results in increased expression of CEACAM1 mRNA	21853993\|2893901
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CEACAM1 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CEACAM1 mRNA	21632981\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CEACAM1 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CEACAM1 mRNA"	26238291
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM1 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of CEACAM1 mRNA	19619570
D004958	Estradiol	Estradiol affects the expression of CEACAM1 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of CEACAM1 mRNA	15289156
C452139	BIRB 796	BIRB 796 results in decreased expression of CEACAM1 mRNA	24303162
C006780	bisphenol A	bisphenol A results in increased expression of CEACAM1 mRNA	22576693
C006780	bisphenol A	bisphenol A results in decreased expression of CEACAM1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of CEACAM1 mRNA	12075121
D002065	Buspirone	Buspirone results in decreased expression of CEACAM1 mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in decreased expression of CEACAM1 mRNA	26079696
D002166	Camptothecin	Camptothecin results in increased expression of CEACAM1 mRNA	17374387
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of CEACAM1 mRNA	17522070
D002737	Chloroprene	Chloroprene results in increased expression of CEACAM1 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of CEACAM1 mRNA	28472532
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of CEACAM1 mRNA	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of CEACAM1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CEACAM1 mRNA]	17585979
D002995	Clofibric Acid	Clofibric Acid affects the expression of CEACAM1 mRNA	17602206
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of CEACAM1 mRNA]	19924377
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased secretion of CEACAM1 protein]	19924377
D016572	Cyclosporine	Cyclosporine results in decreased expression of CEACAM1 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of CEACAM1 mRNA	19770486
D003630	Daunorubicin	Daunorubicin results in increased expression of CEACAM1 mRNA	17374387
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CEACAM1 mRNA	23914054
C014347	decitabine	decitabine affects the expression of CEACAM1 mRNA	23300844
D003703	Demecolcine	Demecolcine results in increased expression of CEACAM1 mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in increased expression of CEACAM1 mRNA	17522070
D002945	Cisplatin	Cisplatin affects the expression of CEACAM1 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CEACAM1 mRNA	27392435
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of CEACAM1 mRNA	20705681
D002945	Cisplatin	Cisplatin results in increased expression of CEACAM1 mRNA	27392435
C000944	dicrotophos	dicrotophos results in increased expression of CEACAM1 mRNA	28302478
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CEACAM1 mRNA	18164116
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CEACAM1 mRNA	15289156
D002117	Calcitriol	Calcitriol results in increased expression of CEACAM1 mRNA	26485663
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of CEACAM1 mRNA	27638505
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of CEACAM1 mRNA	21853993\|2893901
D004237	Diuron	Diuron metabolite results in increased expression of CEACAM1 mRNA	24172598
C118739	entinostat	entinostat results in increased expression of CEACAM1 mRNA	27188386
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of CEACAM1 mRNA	17522070
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CEACAM1 mRNA	12075121\|1265503
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of CEACAM1 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of CEACAM1 mRNA	17374387
D005480	Flurbiprofen	Flurbiprofen results in increased expression of CEACAM1 mRNA	16949054
D005485	Flutamide	Flutamide results in decreased expression of CEACAM1 mRNA	24793618
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of CEACAM1 mRNA	24657277
D005557	Formaldehyde	Formaldehyde results in decreased expression of CEACAM1 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of CEACAM1 mRNA	23649840
C056933	fumonisin B1	fumonisin B1 results in decreased expression of CEACAM1 mRNA	16221962
D019833	Genistein	Genistein results in increased expression of CEACAM1 mRNA	15289156
D019833	Genistein	Genistein results in increased expression of CEACAM1 mRNA	12075121
D005897	Glafenine	Glafenine results in decreased expression of CEACAM1 mRNA	24136188
D005947	Glucose	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased expression of CEACAM1 mRNA]	19924377
D005947	Glucose	cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased secretion of CEACAM1 protein]	19924377
D005947	Glucose	Glucose results in decreased expression of CEACAM1 mRNA	19924377
D005947	Glucose	Glucose results in decreased secretion of CEACAM1 protein	19924377
D017313	Fenretinide	Fenretinide results in increased expression of CEACAM1 mRNA	28973697
D006834	Hydrazines	Hydrazines results in decreased expression of CEACAM1 mRNA	21647536
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CEACAM1 mRNA	20044591
D007052	Ibuprofen	Ibuprofen affects the expression of CEACAM1 mRNA	17070997
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CEACAM1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CEACAM1 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CEACAM1 mRNA	26752646
C410337	K 7174	K 7174 results in decreased expression of CEACAM1 mRNA	24086573
D007608	Kainic Acid	Kainic Acid results in increased expression of CEACAM1 mRNA	17997037
C011890	kojic acid	kojic acid results in decreased expression of CEACAM1 mRNA	16595896
C008261	lead acetate	lead acetate results in increased expression of CEACAM1 mRNA	22609695
C008261	lead acetate	lead acetate results in decreased expression of CEACAM1 mRNA	22641619
C045463	leflunomide	leflunomide results in increased expression of CEACAM1 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of CEACAM1 mRNA	24136188
C533894	LG 100815	LG 100815 results in increased expression of CEACAM1 mRNA	16951191
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of CEACAM1 mRNA	24657277
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CEACAM1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CEACAM1 mRNA"	26251327
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of CEACAM1 mRNA	22108045
D009151	Mustard Gas	Mustard Gas results in increased expression of CEACAM1 mRNA	25102026
C051752	nefazodone	nefazodone results in decreased expression of CEACAM1 mRNA	24136188
D009538	Nicotine	Nicotine results in increased expression of CEACAM1 mRNA	17997037
C012655	nimesulide	nimesulide results in decreased expression of CEACAM1 mRNA	24136188
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of CEACAM1 mRNA"	16951191
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CEACAM1 mRNA	25729387
D010126	Ozone	Ozone results in increased expression of CEACAM1 mRNA	19555225
D010126	Ozone	Ozone results in increased expression of CEACAM1 mRNA	16330353
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of CEACAM1 mRNA	20705681
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CEACAM1 mRNA	26705709
D010634	Phenobarbital	Phenobarbital results in decreased expression of CEACAM1 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of CEACAM1 mRNA	19270015\|2527062
C006253	pirinixic acid	pirinixic acid results in decreased expression of CEACAM1 mRNA	16221962\|1742611
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of CEACAM1 mRNA]	20059764
D011374	Progesterone	Progesterone results in decreased expression of CEACAM1 mRNA	19553605
D011374	Progesterone	Progesterone results in increased expression of CEACAM1 mRNA	18692832
C045950	propiconazole	propiconazole results in decreased expression of CEACAM1 mRNA	21278054
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of CEACAM1 mRNA"	21152443
D011802	Quinidine	Quinidine results in increased expression of CEACAM1 mRNA	17522070
C059514	resveratrol	resveratrol results in increased expression of CEACAM1 mRNA	15280659\|2588880
D015474	Isotretinoin	Isotretinoin results in decreased expression of CEACAM1 mRNA	20436886
C116926	rofecoxib	rofecoxib affects the expression of CEACAM1 mRNA	17070997
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CEACAM1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CEACAM1 mRNA	22300531
C009277	sodium arsenate	sodium arsenate results in increased expression of CEACAM1 mRNA	21795629
D013739	Testosterone	Testosterone results in decreased expression of CEACAM1 mRNA	20600201\|2166921
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CEACAM1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CEACAM1 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CEACAM1 mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CEACAM1 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CEACAM1 mRNA	23238561
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CEACAM1 mRNA	20959002\|2323856
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CEACAM1 mRNA	16054898\|1879615
D013806	Theophylline	Theophylline results in decreased expression of CEACAM1 mRNA	17522070
C009495	titanium dioxide	titanium dioxide results in decreased expression of CEACAM1 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CEACAM1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CEACAM1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of CEACAM1 mRNA	23830798
C012589	trichostatin A	trichostatin A results in increased expression of CEACAM1 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of CEACAM1 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CEACAM1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CEACAM1 mRNA	23527032
D014635	Valproic Acid	Valproic Acid affects the expression of CEACAM1 mRNA	17292431
D014640	Vancomycin	Vancomycin results in increased expression of CEACAM1 mRNA	18930951
D014750	Vincristine	Vincristine results in increased expression of CEACAM1 mRNA	23649840
D002762	Cholecalciferol	Cholecalciferol results in increased expression of CEACAM1 mRNA	17170073
D015032	Zinc	Zinc deficiency results in increased expression of CEACAM1 mRNA	11717422

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003674	molecular_function	-	ND	-
GO:0003779	actin binding	-	IPI	17192268
GO:0005515	protein binding	-	IPI	11035932 11994468 16246332 18424730 18497748 21982860 23696226 25363763
GO:0005516	calmodulin binding	-	ISS	-
GO:0015125	bile acid transmembrane transporter activity	-	ISS	-
GO:0019900	kinase binding	-	IPI	7478590
GO:0019903	protein phosphatase binding	-	IPI	18424730
GO:0031005	filamin binding	-	IPI	16291724
GO:0042802	identical protein binding	-	IDA	26483485
GO:0042803	protein homodimerization activity	-	IMP	19948502
GO:0042803	protein homodimerization activity	-	ISS	-
GO:0046983	protein dimerization activity	-	ISS	-
GO:1990782	protein tyrosine kinase binding	-	IPI	18424730

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	NAS	15687237
GO:0001558	regulation of cell growth	-	ISS	-
GO:0001568	blood vessel development	-	ISS	-
GO:0001915	negative regulation of T cell mediated cytotoxicity	-	IDA	18424730
GO:0002859	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	-	IMP	23696226
GO:0006469	negative regulation of protein kinase activity	-	ISS	-
GO:0007155	cell adhesion	-	ISS	-
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	ISS	-
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	-	NAS	15687237
GO:0007229	integrin-mediated signaling pathway	-	NAS	15687237
GO:0010594	regulation of endothelial cell migration	-	ISS	-
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	-	ISS	-
GO:0015721	bile acid and bile salt transport	-	ISS	-
GO:0016477	cell migration	-	NAS	15687237
GO:0030334	regulation of cell migration	-	IDA	16291724
GO:0030853	negative regulation of granulocyte differentiation	-	ISS	-
GO:0032692	negative regulation of interleukin-1 production	-	ISS	-
GO:0032869	cellular response to insulin stimulus	-	ISS	-
GO:0035726	common myeloid progenitor cell proliferation	-	ISS	-
GO:0038016	insulin receptor internalization	-	ISS	-
GO:0038158	granulocyte colony-stimulating factor signaling pathway	-	ISS	-
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	-	ISS	-
GO:0043116	negative regulation of vascular permeability	-	ISS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043318	negative regulation of cytotoxic T cell degranulation	-	IDA	18424730
GO:0044319	wound healing, spreading of cells	-	IDA	16291724
GO:0045601	regulation of endothelial cell differentiation	-	ISS	-
GO:0045717	negative regulation of fatty acid biosynthetic process	-	ISS	-
GO:0050860	negative regulation of T cell receptor signaling pathway	-	IDA	18424730
GO:0050900	leukocyte migration	-	TAS	-
GO:0051055	negative regulation of lipid biosynthetic process	-	ISS	-
GO:0060312	regulation of blood vessel remodeling	-	ISS	-
GO:0070372	regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0090331	negative regulation of platelet aggregation	-	ISS	-
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	-	ISS	-
GO:1901143	insulin catabolic process	-	ISS	-
GO:1903385	regulation of homophilic cell adhesion	-	ISS	-
GO:1903670	regulation of sprouting angiogenesis	-	ISS	-
GO:2000346	negative regulation of hepatocyte proliferation	-	ISS	-
GO:2001214	positive regulation of vasculogenesis	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	17192268
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	NAS	15687237
GO:0005911	cell-cell junction	-	IDA	16291724
GO:0005912	adherens junction	-	ISS	-
GO:0009925	basal plasma membrane	-	ISS	-
GO:0009986	cell surface	-	IDA	25363763
GO:0009986	cell surface	-	ISS	-
GO:0016020	membrane	-	TAS	2457922
GO:0016021	integral component of membrane	-	IDA	11994468
GO:0016324	apical plasma membrane	-	IDA	10436421
GO:0016324	apical plasma membrane	-	ISS	-
GO:0016328	lateral plasma membrane	-	ISS	-
GO:0030054	cell junction	-	IDA	8018919
GO:0030054	cell junction	-	ISS	-
GO:0030658	transport vesicle membrane	-	IEA	-
GO:0031528	microvillus membrane	-	IEA	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0042101	T cell receptor complex	colocalizes_with	IDA	18424730
GO:0070062	extracellular exosome	-	HDA	19199708 23533145
GO:0070821	tertiary granule membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1566977	Fibronectin matrix formation	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23941132	Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. (2013 Aug 14)	Klaile E	Respir Res