Gene: SCT

6343
-
secretin
protein-coding
11p15.5
Ensembl:ENSG00000070031 MIM:182099 Vega:OTTHUMG00000133313 UniprotKB:P09683
NC_000011.10
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.166e-1 (AD)  8.382e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXL20.476
PCOLCE0.425
PABPC4L0.417
SPINT40.409
SIX10.407
CCDC102A0.405
OXER10.404
BTN2A20.402
MTRNR2L20.402
ANKRD370.402

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP1A1-0.263
ATP12A-0.249
LEMD1-0.246
ENPP5-0.24
RIMS1-0.237
FUT9-0.236
ACADSB-0.232
MND1-0.231
KIAA0319-0.231
DYNC2LI1-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]"22194894
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester results in decreased activity of SCT protein"10880878
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SCT mRNA16788091
C0581765-nitro-2-(3-phenylpropylamino)benzoic acid5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein10880878
D000082AcetaminophenAcetaminophen results in decreased expression of SCT mRNA22230336
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SCT mRNA]18700144
D020106AcrylamideAcrylamide results in decreased expression of SCT mRNA28959563
D000242Cyclic AMPEpinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP]6312992
D000242Cyclic AMPSCT protein results in increased abundance of Cyclic AMP6312992
D005680gamma-Aminobutyric Acid"6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [SCT protein results in increased secretion of gamma-Aminobutyric Acid]"15963647
D005680gamma-Aminobutyric AcidSCT protein results in increased secretion of gamma-Aminobutyric Acid15206007|1596364
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCT mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of SCT mRNA15761015
D001285AtropineAtropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]3562434
C013407benzamilbenzamil results in decreased activity of SCT protein10880878
D018723BethanecholSCT protein results in decreased activity of Bethanechol10198350
D001639BicarbonatesAtropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]3562434
D001639Bicarbonates[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates3562434
D001639BicarbonatesSCT protein results in increased abundance of Bicarbonates3562434
C006780bisphenol Abisphenol A results in decreased methylation of SCT promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of SCT mRNA25181051
D001786Blood GlucoseSCT protein results in decreased abundance of Blood Glucose2418308
D002104CadmiumCadmium inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]15963647|1688816
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SCT promoter22457795
D002118CalciumSCT protein results in increased abundance of Calcium1220513
D002217CarbacholSCT protein results in decreased activity of Carbachol10198350
D002509CephaloridineCephaloridine results in increased expression of SCT mRNA18500788
D002108Ceruletide[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates3562434
D002712ChloridesSCT protein results in decreased transport of Chlorides4719217
D002994ClofibrateClofibrate results in decreased expression of SCT mRNA17585979
D003078ColchicineColchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
D003078ColchicineColchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
D003078ColchicineColchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D019327Copper SulfateCopper Sulfate results in increased expression of SCT mRNA19549813
D003471CuprizoneCuprizone results in increased expression of SCT mRNA27523638
D0187506-Cyano-7-nitroquinoxaline-2,3-dione"6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [SCT protein results in increased secretion of gamma-Aminobutyric Acid]"15963647
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCT mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SCT mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SCT mRNA27392435
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SCT protein"10880878
D004298DopamineSCT protein results in increased metabolism of Dopamine16168596
D004837EpinephrineEpinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP]6312992
D005419FlavonoidsFlavonoids results in increased expression of SCT mRNA18035473
D019833GenisteinGenistein results in decreased expression of SCT mRNA22553218
C081021Go 6976Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
C081021Go 6976Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
C081021Go 6976Go 6976 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D006719Homovanillic AcidSCT protein results in increased abundance of Homovanillic Acid16168596
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SCT mRNA27392435
D019344Lactic AcidSCT protein results in decreased abundance of Lactic Acid2418308
C008261lead acetatelead acetate results in decreased expression of SCT mRNA22609695
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of SCT protein10880878
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SCT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SCT mRNA"25554681
D009529NicardipineNicardipine inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D020867omega-Agatoxin IVAomega-Agatoxin IVA inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D020866omega-Conotoxin GVIAomega-Conotoxin GVIA inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D010418PentagastrinSCT protein results in decreased activity of Pentagastrin8930176
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SCT mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of SCT mRNA23557933
D011188PotassiumSCT protein results in decreased transport of Potassium4719217
D011189Potassium ChlorideCadmium inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]15963647|1688816
D011189Potassium ChlorideNicardipine inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D011189Potassium Chlorideomega-Agatoxin IVA inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D011189Potassium Chlorideomega-Conotoxin GVIA inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]16888165
D011189Potassium ChloridePotassium Chloride results in increased secretion of SCT protein15963647|1688816
D011189Potassium ChlorideTetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]15963647|1688816
D011192Potassium DichromatePotassium Dichromate results in increased expression of SCT mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SCT mRNA22698814
D011374ProgesteroneProgesterone affects the expression of SCT mRNA17251523
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCT mRNA24780913
C003402sapropterinSCT protein results in increased abundance of sapropterin16168596
D012906SmokeSmoke promotes the reaction [SCT protein results in increased secretion of PRSS1 protein]6156949
D012964SodiumSCT protein results in decreased transport of Sodium4719217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCT mRNA22298810
D013779TetrodotoxinTetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]15963647|1688816
D014212TretinoinCDK1 protein affects the reaction [Tretinoin results in increased expression of SCT mRNA]16888198
D014212TretinoinTretinoin results in increased expression of SCT mRNA16888198
C113580U 0126U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
C113580U 0126U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
C113580U 0126U 0126 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic Acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]"22194894
D014580Ursodeoxycholic AcidColchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
D014580Ursodeoxycholic AcidColchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
D014580Ursodeoxycholic AcidColchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic AcidGo 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
D014580Ursodeoxycholic AcidGo 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
D014580Ursodeoxycholic AcidGo 6976 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic AcidN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic AcidSCT results in increased susceptibility to Ursodeoxycholic Acid22194894
D014580Ursodeoxycholic AcidSCT results in increased susceptibility to Ursodeoxycholic Acid analog22194894
D014580Ursodeoxycholic AcidSLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic AcidU 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
D014580Ursodeoxycholic AcidU 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
D014580Ursodeoxycholic AcidU 0126 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid analog results in increased activity of SCT22194894
D014580Ursodeoxycholic Acidwortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
D014580Ursodeoxycholic Acidwortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
D014580Ursodeoxycholic Acidwortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894
D014635Valproic AcidValproic Acid results in increased methylation of SCT gene29154799
C009687wortmanninwortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]22194894
C009687wortmanninwortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]22194894
C009687wortmanninwortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]22194894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI7612008  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005179hormone activity-NAS11060443  
GO:0047485protein N-terminus binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007420brain development-IBA21873635  
GO:0007420brain development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030157pancreatic juice secretion-NAS11060443  
GO:0043950positive regulation of cAMP-mediated signaling-IEA-  
GO:0048566embryonic digestive tract development-IEA-  
GO:0090187positive regulation of pancreatic juice secretion-IBA21873635  
GO:0090187positive regulation of pancreatic juice secretion-IEA-  
GO:0090274positive regulation of somatostatin secretion-IBA21873635  
GO:0090274positive regulation of somatostatin secretion-IEA-  
GO:1903640negative regulation of gastrin-induced gastric acid secretion-IBA21873635  
GO:1903640negative regulation of gastrin-induced gastric acid secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373080Class B/2 (Secretin family receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-420092Glucagon-type ligand receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24188917Repair of impaired pulmonary function is possible in very-long-term allogeneic stem cell transplantation survivors. (2014 Feb)Jain NABiol Blood Marrow Transplant