Gene: SRL

6345
SAR
sarcalumenin
protein-coding
16p13.3
Ensembl:ENSG00000185739 MIM:604992 Vega:OTTHUMG00000177617 UniprotKB:Q86TD4
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.393e-1 (AD)  1.389e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs879151chr16:4200914 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLHL300.724
ALX40.717
OR51E10.706
C1QTNF70.696
CASQ20.684
TRABD2B0.682
PLN0.68
CDC20B0.68
GPC30.68
DHH0.679

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROG2-0.265
UCN-0.258
NRN1L-0.251
IFNA6-0.248
CAPN9-0.245
FEZF2-0.244
FXYD4-0.241
DAPK2-0.237
NKX6-2-0.235
CMTM5-0.232

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SRL mRNA21298039
C547126AZM551248AZM551248 results in decreased expression of SRL mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRL mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRL mRNA27195522
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of SRL mRNA25566086
D004958EstradiolEstradiol results in decreased expression of SRL mRNA19484750
D002857ChromiumLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]16940432
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SRL mRNA24317228
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SRL mRNA28085963
D004317DoxorubicinDoxorubicin results in increased expression of SRL protein16144979|2125121
D004317Doxorubicinsodium nitrate inhibits the reaction [Doxorubicin results in increased expression of SRL protein]21251210
C412815GW 4064GW 4064 results in increased expression of SRL mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SRL mRNA26752646
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SRL mRNA"24972896
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SRL mRNA27544571
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SRL mRNA24810058
D009525NiacinLEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of SRL mRNA]16940432
D009532NickelNickel results in decreased expression of SRL mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SRL mRNA27935865
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SRL mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SRL mRNA17560707|1916217
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SRL mRNA27935865
C031618sodium nitratesodium nitrate inhibits the reaction [Doxorubicin results in increased expression of SRL protein]21251210
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRL mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of SRL mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of SRL mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SRL mRNA20133372
D014635Valproic AcidValproic Acid results in increased methylation of SRL gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0033018sarcoplasmic reticulum lumen-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal