Gene: BHMT

635
BHMT1|HEL-S-61p
betaine--homocysteine S-methyltransferase
protein-coding
5q14.1
Ensembl:ENSG00000145692 MIM:602888 Vega:OTTHUMG00000108157 UniprotKB:Q93088
NG_029156.1
PubMed
0   ANCO-SNPs
ND|AD
6   
6.126e-1 (AD)  7.517e-1 (ND)   (Frontal_Cortex)
1.350e-1 (AD)  4.871e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CENPF0.656
FOXP20.643
TLL10.64
TRABD2A0.631
RSPO30.625
CLSTN20.623
IL1RAPL20.619
KCNK20.618
CHRM20.616
TSHZ20.614

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOX2-0.424
DBX2-0.417
EYA2-0.414
LYPD1-0.411
S100A1-0.406
PDLIM3-0.391
PDE9A-0.39
ACSF2-0.386
PIPOX-0.384
MYOM1-0.381

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00134MethionineSmall Molecule63-68-3Approved|NutraceuticalTarget
DB02337S-(D-Carboxybutyl)-L-HomocysteineSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of BHMT mRNA"15302862
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine results in decreased expression of BHMT mRNA26821219
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BHMT mRNA"22698814|2890350
C0364231-aminomethylphosphonic acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of BHMT mRNA"20566314
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of BHMT mRNA20566314
C0780921-piperonylpiperazine1-piperonylpiperazine results in decreased expression of BHMT mRNA26821219
C4838392,2',3,4,4',5',6-heptabromodiphenyl ether"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of BHMT protein"18258299
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BHMT mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BHMT mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of BHMT mRNA14600272
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of BHMT mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHMT mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of BHMT mRNA14600272
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHMT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of BHMT mRNA17202762
C043377acetochlor"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of BHMT mRNA"20566314
D020106AcrylamideAcrylamide results in decreased expression of BHMT mRNA28959563
C560978aegeline[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BHMT mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of BHMT mRNA14600272
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of BHMT protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of BHMT protein26597043
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of BHMT mRNA21298039
D006710Homocysteine[[BHMT protein results in increased metabolism of Betaine] co-treated with [BHMT protein results in increased metabolism of Homocysteine]] results in increased chemical synthesis of Methionine23665415
D006710HomocysteineBHMT protein results in increased metabolism of Homocysteine23665415
D000638AmiodaroneAmiodarone affects the expression of BHMT mRNA18355885
D000639AmitriptylineAmitriptyline affects the expression of BHMT mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BHMT mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA19737545
D001151ArsenicArsenic results in decreased expression of BHMT mRNA18487201
C015001arsenitearsenite results in increased methylation of BHMT promoter23974009
D001507BeclomethasoneBeclomethasone results in increased expression of BHMT mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of BHMT mRNA26377693
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BHMT mRNA21632981|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BHMT mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BHMT mRNA20440473
D001622BetaineBHMT protein results in increased metabolism of Betaine18230605
D001622BetaineBHMT protein results in increased metabolism of Betaine23665415
D001622Betaine[[BHMT protein results in increased metabolism of Betaine] co-treated with [BHMT protein results in increased metabolism of Homocysteine]] results in increased chemical synthesis of Methionine23665415
C006780bisphenol Abisphenol A results in increased expression of BHMT mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of BHMT mRNA25181051
C053342brevetoxinbrevetoxin analog results in decreased expression of BHMT mRNA14529743
C032036bromobenzenebromobenzene results in decreased expression of BHMT mRNA12628495
C032036bromobenzenebromobenzene results in increased expression of BHMT mRNA15056800
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of BHMT mRNA27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased methylation of BHMT gene27509014
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of BHMT mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BHMT mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BHMT mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BHMT mRNA21667247
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BHMT mRNA25993096
D002110Caffeine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of BHMT mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of BHMT mRNA18804290
D002794Choline[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of BHMT mRNA23439872
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of BHMT mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of BHMT mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of BHMT mRNA12851107
D002997ClomipramineClomipramine affects the expression of BHMT mRNA18355885
C004690coclaurine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D003300CopperCopper results in decreased expression of BHMT mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of BHMT mRNA19549813
D003314Corn OilCorn Oil affects the expression of BHMT mRNA16360708
C030123coumarincoumarin affects the expression of BHMT mRNA16963487
C030123coumarincoumarin results in decreased expression of BHMT mRNA18480146
D003471CuprizoneCuprizone results in decreased expression of BHMT mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of BHMT mRNA20106945|2163298
D0150842,4-Dichlorophenoxyacetic Acid"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of BHMT mRNA"20566314
D002945CisplatinCisplatin results in increased expression of BHMT protein22023808
D004041Dietary FatsDietary Fats results in increased expression of BHMT mRNA18042831
C014476diethyl maleatediethyl maleate results in decreased expression of BHMT mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of BHMT mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of BHMT mRNA19665456
D004054Diethylstilbestrolsodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of BHMT mRNA]19665456
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of BHMT mRNA14600272
D000431EthanolEthanol results in increased expression of BHMT mRNA16098508|1792074
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of BHMT mRNA20227414
D005411Flame RetardantsFlame Retardants results in increased expression of BHMT protein18258299
D005492Folic Acid[Choline deficiency co-treated with Folic Acid deficiency] affects the expression of BHMT mRNA23439872
C056933fumonisin B1fumonisin B1 results in decreased expression of BHMT mRNA16221962
C039281furanfuran binds to BHMT protein22240984
C039281furanfuran results in increased methylation of BHMT gene22079235
D005897GlafenineGlafenine results in decreased expression of BHMT mRNA24136188
C010974glyphosateglyphosate results in increased expression of BHMT mRNA16532367
D006540Herbicides"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of BHMT mRNA"20566314
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of BHMT mRNA20566314
C017363hexabromobenzene"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of BHMT protein"18258299
C089796hexabromocyclododecane"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of BHMT protein"18258299
C012348higenamine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D047348Hydrolyzable Tannins[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D007099ImipramineImipramine affects the expression of BHMT mRNA18355885
D007654KetoconazoleKetoconazole affects the expression of BHMT mRNA18355885
C008261lead acetatelead acetate results in decreased expression of BHMT mRNA22641619
D001556LindaneLindane results in increased expression of BHMT mRNA18804290
C008340mecoprop"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of BHMT mRNA"20566314
D008627Mercuric Chloride[Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of BHMT mRNA21084432
D008701MethapyrileneMethapyrilene results in decreased expression of BHMT mRNA16393664
D008715MethionineMethionine inhibits the reaction [BHMT protein results in increased metabolism of Vitamin U]18230605
D008715Methionine[[BHMT protein results in increased metabolism of Betaine] co-treated with [BHMT protein results in increased metabolism of Homocysteine]] results in increased chemical synthesis of Methionine23665415
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of BHMT mRNA27544571
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of BHMT mRNA24128854
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of BHMT mRNA22401849
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of BHMT mRNA"29244179
C461488N-benzylpiperazineN-benzylpiperazine results in decreased expression of BHMT mRNA26821219
C051752nefazodonenefazodone results in decreased expression of BHMT mRNA24136188
D009532NickelNickel results in increased expression of BHMT mRNA24084258
C012655nimesulidenimesulide results in decreased expression of BHMT mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of BHMT protein19716841
C025589ochratoxin Aochratoxin A results in decreased expression of BHMT mRNA12700408
D000073878Palm OilPalm Oil results in increased expression of BHMT mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of BHMT mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of BHMT mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BHMT mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BHMT mRNA26794494
D010634PhenobarbitalPhenobarbital results in decreased expression of BHMT protein19952500
D010795Phthalic AcidsPhthalic Acids results in decreased expression of BHMT mRNA15728792
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of BHMT mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BHMT mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of BHMT mRNA16221962
C006253pirinixic acidpirinixic acid results in decreased expression of BHMT mRNA19162173|2248451
D010936Plant ExtractsPlant Extracts results in increased expression of BHMT mRNA28533734
D059808PolyphenolsPolyphenols results in decreased expression of BHMT mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of BHMT mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of BHMT mRNA28903501
D011441PropylthiouracilPropylthiouracil results in increased expression of BHMT mRNA24780913
D011794QuercetinQuercetin results in decreased expression of BHMT mRNA21632981
D011794QuercetinQuercetin results in increased expression of BHMT mRNA16455785
D011794QuercetinQuercetin results in decreased expression of BHMT mRNA21565894
C017947sodium arsenitesodium arsenite affects the expression of BHMT mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BHMT mRNA16368122
C017947sodium arsenitesodium arsenite promotes the reaction [Diethylstilbestrol results in increased expression of BHMT mRNA]19665456
C017947sodium arsenitesodium arsenite results in decreased expression of BHMT mRNA15276417|1735006
C016104sodium bichromatesodium bichromate results in decreased expression of BHMT mRNA25993096
D053260SootSoot results in increased expression of BHMT mRNA26551751
D013311StreptozocinStreptozocin results in increased activity of BHMT protein16835399
D013311StreptozocinStreptozocin results in increased expression of BHMT mRNA16835399
C020806tetrabromobisphenol A"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of BHMT protein"18258299
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of BHMT mRNA18976794
C555802tetrabromobisphenol-S-bis(2,3-dibromopropyl ether)"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of BHMT protein"18258299
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHMT mRNA16443690|1849575
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BHMT mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to BHMT gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHMT mRNA28213091|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BHMT mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BHMT mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BHMT mRNA16054898|1846511
D013755Tetradecanoylphorbol Acetate[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BHMT mRNA16368122
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of BHMT mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BHMT protein27319396
D014112ToxapheneToxaphene results in increased expression of BHMT mRNA21220043
D014212TretinoinTretinoin results in decreased expression of BHMT mRNA18230668
D014212TretinoinTretinoin results in decreased expression of BHMT mRNA19960509
D014212TretinoinTretinoin results in decreased expression of BHMT protein19960509
D014241Trichloroethylene[Trichloroethylene co-treated with Mercuric Chloride] results in increased expression of BHMT mRNA21084432
D014241TrichloroethyleneTrichloroethylene results in increased expression of BHMT mRNA19254012
C012589trichostatin Atrichostatin A results in increased expression of BHMT mRNA24935251
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of BHMT mRNA29024780
D014520UrethaneUrethane results in increased expression of BHMT mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of BHMT mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BHMT mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BHMT mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BHMT mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of BHMT mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BHMT gene25560391
C025643vinclozolinvinclozolin results in increased expression of BHMT mRNA22570695
D014814Vitamin UBHMT protein results in increased metabolism of Vitamin U18230605
D014814Vitamin UMethionine inhibits the reaction [BHMT protein results in increased metabolism of Vitamin U]18230605
D015016Yohimbine[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA28843594
D015032ZincZinc deficiency results in increased expression of BHMT mRNA12672911

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IDA18230605  
GO:0047150betaine-homocysteine S-methyltransferase activity-IBA21873635  
GO:0047150betaine-homocysteine S-methyltransferase activity-IDA18230605  
GO:0047150betaine-homocysteine S-methyltransferase activity-NAS10075673  
GO:0047150betaine-homocysteine S-methyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000096sulfur amino acid metabolic process-TAS-  
GO:0006479protein methylation-NAS10075673  
GO:0006577amino-acid betaine metabolic process-IDA18230605  
GO:0006579amino-acid betaine catabolic process-IEA-  
GO:0042426choline catabolic process-TAS-  
GO:0046500S-adenosylmethionine metabolic processNOTIDA18230605  
GO:0050666regulation of homocysteine metabolic process-NAS10075673  
GO:0071267L-methionine salvage-IDA18230605  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0070062extracellular exosome-IDA21082674  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-6798163Choline catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24658151Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. (2014)Wang YPLoS One
25701738Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice. (2015 May)Tsuchiya HGastroenterology
22649255Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males. (2012 Jul)Wernimont SMJ Nutr
28369960Chronic Alcohol Exposure Differentially Alters One-Carbon Metabolism in Rat Liver and Brain. (2017 Jun)Auta JAlcohol Clin Exp Res
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
23083309Combined proteomic analysis of liver tissue and serum in chronically alcohol-fed rats. (2013 Jan)Yamada MAlcohol Clin Exp Res