Gene info: ID 6351

Gene: CCL4

GENE ID: 6351

Synonyms: ACT2|AT744.1|G-26|HC21|LAG-1|LAG1|MIP-1-beta|MIP1B|MIP1B1|SCYA2|SCYA4

Description: C-C motif chemokine ligand 4

Gene type: protein-coding

Location: 17q12

dbXrefs: Ensembl:ENSG00000275302 MIM:182284 Vega:OTTHUMG00000188414 UniprotKB:P13236

RefSeq: NG_033066.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND|AD

# Publications: 16

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.918e-1 (AD) 4.695e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CCL3	0.957
CD300LB	0.793
PLEK	0.771
OSM	0.764
TNFAIP3	0.751
CCL20	0.745
ICAM1	0.738
OLR1	0.731
C5AR1	0.73
CCL4L2	0.726

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OMG	-0.398
B3GALT2	-0.364
ASIC2	-0.358
AMER3	-0.354
PEX5L	-0.346
KCNA2	-0.342
FUT9	-0.337
C19orf73	-0.331
KNCN	-0.331
KBTBD7	-0.327

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of CCL4 mRNA	23792671
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]"	19211157
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of CCL4 mRNA	24370436
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased secretion of CCL4 protein	24370436
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA"	23681119
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] which results in increased expression of CCL4 mRNA"	10821843
C034343	4-aminobenzhydrazide	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of CCL4 mRNA]	24530881
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA	19191707
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of CCL4 mRNA	20713136
C011421	5-chloro-2-methyl-4-isothiazolin-3-one	5-chloro-2-methyl-4-isothiazolin-3-one results in increased expression of CCL4 protein	18353026
C111855	6-formylindolo(3,2-b)carbazole	"6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]"	27783115
C111855	6-formylindolo(3,2-b)carbazole	"6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]"	27783115
C003001	7-ketocholesterol	7-ketocholesterol results in increased expression of CCL4 protein	24895526
C003001	7-ketocholesterol	resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL4 protein]	24895526
C496492	abrine	abrine results in increased expression of CCL4 mRNA	22595364
D000082	Acetaminophen	Acetaminophen affects the expression of CCL4 mRNA	17562736
D020106	Acrylamide	Acrylamide analog results in decreased expression of CCL4 mRNA	18287786
D020106	Acrylamide	Acrylamide analog results in decreased expression of CCL4 protein	18287786
D000276	Adjuvants, Immunologic	"Adjuvants, Immunologic results in increased expression of CCL4"	19439372
C430898	AGN 194204	AGN 194204 results in decreased expression of CCL4 mRNA	16339527
D000393	Air Pollutants	Air Pollutants results in increased expression of CCL4 mRNA	26618301
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of CCL4 mRNA"	23195993
C021137	alclometasone dipropionate	alclometasone dipropionate results in increased expression of CCL4 protein	20116850
C001570	alexidine	alexidine results in decreased expression of CCL4 protein	20116850
D000534	Alum Compounds	Alum Compounds results in increased secretion of CCL4 protein	18390722
D000534	Alum Compounds	Alum Compounds results in increased expression of CCL4	19439372
D000536	Aluminum Hydroxide	Aluminum Hydroxide results in increased secretion of CCL4 protein	18390722
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCL4 mRNA	16483693
D000841	Anisomycin	Anisomycin results in decreased expression of CCL4 protein	20116850
D000936	Antigen-Antibody Complex	Antigen-Antibody Complex results in increased expression of CCL4 mRNA	25451590
D000936	Antigen-Antibody Complex	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]	25451590
D052179	Antigens, Plant	"Antigens, Plant results in increased expression of CCL4 mRNA"	21334316
D052179	Antigens, Plant	"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL4 mRNA]"	21334316
D000968	Antimycin A	Antimycin A results in decreased expression of CCL4 protein	20116850
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CCL4 mRNA	24449571
D018501	Antirheumatic Agents	CCL4 mRNA results in decreased susceptibility to [Methotrexate co-treated with Antirheumatic Agents]	22753658
D001151	Arsenic	Arsenic results in decreased expression of CCL4 mRNA	16835338
C006632	arsenic trioxide	[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL4 mRNA	19828696
C015001	arsenite	arsenite affects the expression of CCL4 mRNA	22959463
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of CCL4 protein"	20855422
C051597	Bandrowski's base	Bandrowski's base affects the expression of CCL4 mRNA	18202158
D001507	Beclomethasone	Beclomethasone results in increased expression of CCL4 protein	20116850
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCL4 mRNA	27858113
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in decreased expression of CCL4 mRNA	20713136
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in decreased expression of CCL4 protein	18353026
D001554	Benzene	Benzene results in decreased expression of CCL4 mRNA	15120971\|1512265
D001558	Benzethonium	Benzethonium results in decreased expression of CCL4 protein	20116850
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCL4 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of CCL4 mRNA	26377693
D001566	Benzocaine	Benzocaine results in increased expression of CCL4 protein	18353026
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CCL4 mRNA	20064835
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCL4 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CCL4 mRNA	22228805
C020711	beryllium sulfate	beryllium sulfate results in increased secretion of CCL4 mRNA	16314022
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of CCL4 mRNA	18192240
D001623	Betamethasone	Betamethasone results in increased expression of CCL4 protein	20116850
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of CCL4 mRNA	15912405
C006780	bisphenol A	bisphenol A results in increased expression of CCL4 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of CCL4 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of CCL4 mRNA	22434021
C006794	brevianamide A	brevianamide A results in decreased expression of CCL4 mRNA	19818335
D019819	Budesonide	Budesonide results in increased expression of CCL4 protein	20116850
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CCL4 mRNA	18804290
C040048	caffeic acid	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA	16806235
D000001	Calcimycin	Calcimycin results in increased expression of CCL4 mRNA	25451590
D000001	Calcimycin	shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA]	25451590
D002166	Camptothecin	Camptothecin results in decreased expression of CCL4 protein	20116850
C005563	captax	captax results in increased secretion of CCL4 protein	16314067
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CCL4 mRNA	24639359
D002251	Carbon Tetrachloride	HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL4 mRNA]	24639359
D002392	Catechin	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA	16806235
C034221	catechol	catechol results in increased expression of CCL4 protein	17572062
C005963	cephaelin	cephaelin results in decreased expression of CCL4 protein	20116850
D002509	Cephaloridine	Cephaloridine results in decreased expression of CCL4 mRNA	18500788
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CCL4 mRNA	22515965
C011724	cholest-5-en-3 beta,7 alpha-diol	"cholest-5-en-3 beta,7 alpha-diol results in increased expression of CCL4 mRNA"	24370436
C011724	cholest-5-en-3 beta,7 alpha-diol	"cholest-5-en-3 beta,7 alpha-diol results in increased secretion of CCL4 protein"	24370436
D002784	Cholesterol	Cholesterol results in increased expression of CCL4 mRNA	26296894
D002784	Cholesterol	CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CCL4 mRNA]	26296894
D002791	Cholesterol, Dietary	"Cholesterol, Dietary results in increased expression of CCL4 mRNA"	24370436
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCL4 mRNA	20938992
C023600	chromic oxide	chromic oxide analog results in increased secretion of CCL4 protein	24885771
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of CCL4 mRNA	27858113
D002911	Chrysenes	Chrysenes results in decreased expression of CCL4 protein	20116850
C012843	cinnamic aldehyde	cinnamic aldehyde affects the expression of CCL4 mRNA	28219650
C000488	cladosporin	cladosporin results in decreased expression of CCL4 mRNA	19818335
C055162	clopidogrel	clopidogrel results in increased expression of CCL4 mRNA	16856976
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]	27568862
D003035	Cobalt	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of CCL4 mRNA	22198552
C026305	cobalt sulfate	cobalt sulfate results in increased expression of CCL4 mRNA	20713136
C026305	cobalt sulfate	cobalt sulfate results in increased secretion of CCL4 protein	16314067
C000666	coralyne	coralyne results in decreased expression of CCL4 protein	20116850
D003436	Croton Oil	Croton Oil results in increased expression of CCL4 mRNA	19647056
D003471	Cuprizone	Cuprizone results in increased expression of CCL4 mRNA	27523638
C038459	curdlan	curdlan affects the expression of CCL4 mRNA	19904525
D016572	Cyclosporine	Cyclosporine results in decreased expression of CCL4 mRNA	27989131
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein"	19467290
D000069439	Dasatinib	Dasatinib results in decreased expression of CCL4 protein	17962511
D003630	Daunorubicin	Daunorubicin results in decreased expression of CCL4 protein	20116850
D003703	Demecolcine	Demecolcine results in increased expression of CCL4 mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCL4 mRNA	22846391\|2775749
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCL4 mRNA	21074547\|2296869
D003868	Dequalinium	Dequalinium results in decreased expression of CCL4 protein	20116850
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]	27568862
D002945	Cisplatin	Cisplatin results in increased expression of CCL4 mRNA	27594783
D002945	Cisplatin	Cisplatin results in decreased expression of CCL4 mRNA	22023808
C027118	didecyldimethylammonium	didecyldimethylammonium results in increased expression of CCL4 protein	19762220
D004041	Dietary Fats	Dietary Fats results in increased expression of CCL4 mRNA	22609946
D004073	Digitoxigenin	Digitoxigenin results in decreased expression of CCL4 protein	20116850
D004076	Digoxigenin	Digoxigenin results in decreased expression of CCL4 protein	20116850
D004077	Digoxin	Digoxin results in decreased expression of CCL4 protein	20116850
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of CCL4 mRNA	27638505
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCL4 mRNA	15585374\|1631406
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCL4 protein	16314067\|1835302
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased secretion of CCL4 protein	16314067
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCL4 mRNA	19647056\|2821965
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of CCL4 protein	18353026
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of CCL4 mRNA	15719370
D004317	Doxorubicin	Doxorubicin results in increased expression of CCL4 mRNA	27181935
D004317	Doxorubicin	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CCL4 mRNA]	27181935
D004391	Dust	Dust results in increased expression of CCL4 mRNA	17805423
C509867	E804 bisindole	E804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	23107598
C509867	E804 bisindole	E804 bisindole results in increased expression of CCL4 mRNA	23107598
C509867	E804 bisindole	Lipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of CCL4 mRNA]	23107598
D004640	Emetine	Emetine results in decreased expression of CCL4 protein	20116850
D004731	Endotoxins	Endotoxins results in increased expression of CCL4 mRNA	12217210
C031818	enterotoxin B, staphylococcal	"enterotoxin B, staphylococcal results in increased expression of CCL4 protein"	19874226
C031818	enterotoxin B, staphylococcal	"tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL4 protein]"	19874226
C030107	enterotoxin F, Staphylococcal	"enterotoxin F, Staphylococcal results in increased expression of CCL4 protein"	19874226
C030107	enterotoxin F, Staphylococcal	"tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL4 protein]"	19874226
C046855	epostane	[Dinoprost co-treated with epostane] results in increased expression of CCL4 mRNA	21505051
D000431	Ethanol	Ethanol affects the secretion of CCL4 protein	20624996
D000431	Ethanol	Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]	19500611
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of CCL4 mRNA	23649840
D005054	Eugenol	Eugenol results in increased expression of CCL4 mRNA	15585374
D005054	Eugenol	Eugenol results in increased expression of CCL4 protein	18353026
C000499	ferric oxide	ferric oxide results in increased secretion of CCL4 protein	24885771
C000499	ferric oxide	ferric oxide analog results in decreased expression of CCL4 mRNA	24525745
C012976	flumequine	"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CCL4 mRNA"	23681119
D005438	Fludrocortisone	Fludrocortisone results in increased expression of CCL4 protein	20116850
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCL4 mRNA	20938992
C056933	fumonisin B1	fumonisin B1 results in increased expression of CCL4 mRNA	27757495
D062610	Fungal Polysaccharides	Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CCL4 mRNA]	27181935
C039281	furan	furan results in increased expression of CCL4 mRNA	20194422
C039281	furan	furan results in decreased expression of CCL4 mRNA	25539665
C064925	gadodiamide	gadodiamide results in increased expression of CCL4 protein	20938346
C043055	gallium arsenide	gallium arsenide results in increased expression of CCL4 mRNA	14560044
D019833	Genistein	Genistein results in decreased expression of CCL4 mRNA	15256057
D005839	Gentamicins	Gentamicins results in increased expression of CCL4 mRNA	22061828
D005976	Glutaral	Glutaral results in increased expression of CCL4 mRNA	20713136
D006388	Hemagglutinins	Hemagglutinins results in increased secretion of CCL4 protein	22839698
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde results in increased expression of CCL4 protein	18353026
D017313	Fenretinide	Fenretinide results in decreased expression of CCL4 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of CCL4 mRNA	28973697
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of CCL4 mRNA	17183730
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of CCL4 mRNA	16129981
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of CCL4 protein	16129981
D006851	Hydrochloric Acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]	16129981
D006851	Hydrochloric Acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein]	16129981
D006854	Hydrocortisone	Hydrocortisone results in increased expression of CCL4 protein	20116850
C031927	hydroquinone	hydroquinone results in increased expression of CCL4 protein	17572062\|1835302
C013038	hydroxyhydroquinone	4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in increased expression of CCL4 mRNA]	24530881
C013038	hydroxyhydroquinone	hydroxyhydroquinone affects the expression of CCL4 protein	17572062
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of CCL4 mRNA	24530881
C490483	icilin	icilin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL4 protein]	23596210
C474021	indirubin-3'-monoxime	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA	18958680
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of CCL4 mRNA	21396975
D007213	Indomethacin	Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]	21913898
D007213	Indomethacin	Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D015759	Ionomycin	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein	17685462
D015759	Ionomycin	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein]	17685462
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL4 protein	17572062
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL4 mRNA	25613284
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of CCL4 mRNA	17085751
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CCL4 mRNA	15251112
C561695	(+)-JQ1 compound	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL4 mRNA]"	24799421
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	25890327
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 enhancer]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 promoter]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein] results in increased expression of CCL4 mRNA]	25982114
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCL4 mRNA	25982114
D019344	Lactic Acid	Lactic Acid results in decreased expression of CCL4 protein	18353026
C018548	lanatoside C	lanatoside C results in decreased expression of CCL4 protein	20116850
D007854	Lead	Lead results in increased expression of and results in increased secretion of CCL4 protein	28973681
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL4 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 mRNA"	24972896
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of CCL4 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of CCL4 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 mRNA"	15522845
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 protein"	23306164\|2360453
C482199	lipopolysaccharide, E coli O55-B5	"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 protein]"	23604539
C440499	lipopolysaccharide, Escherichia coli O111 B4	"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL4 mRNA]"	24799421
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL4 mRNA"	24799421
D008070	Lipopolysaccharides	"2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]"	19211157
D008070	Lipopolysaccharides	"6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]"	27783115
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]	27568862
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]	27568862
D008070	Lipopolysaccharides	Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]	21913898
D008070	Lipopolysaccharides	Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D008070	Lipopolysaccharides	Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D008070	Lipopolysaccharides	Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CCL4 mRNA	9122163
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCL4 mRNA	22777745
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL4 mRNA	14966191\|1752990
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL4 protein	15788441\|1902077
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased secretion of CCL4 protein	15289356\|1839072
D008070	Lipopolysaccharides	Particulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	14966191
D008070	Lipopolysaccharides	Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]	21913898
D008070	Lipopolysaccharides	roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]	21913898
D008070	Lipopolysaccharides	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	27783115
D008070	Lipopolysaccharides	[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA	22777745
D008070	Lipopolysaccharides	Vehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	14966191
D008070	Lipopolysaccharides	E804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	23107598
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of CCL4 mRNA]	23107598
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein	26918785
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL4 mRNA	10027076\|1097585
D008070	Lipopolysaccharides	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein]"	26918785
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL4 mRNA	25613284
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL4 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCL4 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL4 mRNA	26378955
C551151	manganese ferrite	manganese ferrite results in increased secretion of CCL4 protein	24885771
C100122	meclocycline	meclocycline results in decreased expression of CCL4 protein	20116850
D008694	Methamphetamine	Methamphetamine results in increased expression of CCL4 mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCL4 mRNA	20938992
D008717	Methionine Sulfoximine	Methionine Sulfoximine results in decreased expression of CCL4 protein	20116850
D008727	Methotrexate	CCL4 mRNA results in decreased susceptibility to Methotrexate	22753658
D008727	Methotrexate	CCL4 mRNA results in decreased susceptibility to [Methotrexate co-treated with Antirheumatic Agents]	22753658
D008727	Methotrexate	Methotrexate results in decreased expression of CCL4 mRNA	17400583
D008727	Methotrexate	Methotrexate results in decreased expression of CCL4 protein	19100307
D008727	Methotrexate	SB 203580 affects the reaction [Methotrexate results in decreased expression of CCL4 protein]	19100307
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein]"	26918785
C005106	methylbenzethonium chloride	methylbenzethonium chloride results in decreased expression of CCL4 protein	20116850
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]	24056979
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CCL4 mRNA	24213012
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of CCL4 mRNA	21628967\|2320844
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CCL4 mRNA	23649840
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of CCL4 mRNA	17412507
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]	16321392
D008798	Mevalonic Acid	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]	16321392
C089950	MF59 oil emulsion	MF59 oil emulsion results in increased secretion of CCL4 protein	18390722
D008911	Minocycline	Minocycline results in decreased expression of CCL4 protein	20116850
C500085	muraglitazar	muraglitazar results in decreased expression of CCL4 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of CCL4 protein	17720292
D009151	Mustard Gas	Mustard Gas results in increased expression of CCL4 mRNA	15674843
D009173	Mycophenolic Acid	Mycophenolic Acid results in decreased expression of CCL4 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in decreased expression of CCL4 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of CCL4 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CCL4 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CCL4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCL4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCL4 mRNA"	24911292
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CCL4 mRNA	26921287
C002701	neocuproine	"neocuproine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL4 protein]"	23604539
C015380	neoechinulin	neoechinulin results in decreased expression of CCL4 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in decreased expression of CCL4 mRNA	19818335
D009532	Nickel	Nickel results in increased expression of CCL4 mRNA	23195993\|2558310
D009532	Nickel	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of CCL4 mRNA	22198552
C029938	nickel sulfate	nickel sulfate results in increased expression of CCL4 mRNA	12060402\|1558537
C029938	nickel sulfate	nickel sulfate results in increased expression of CCL4 protein	16314067\|1835302
C029938	nickel sulfate	nickel sulfate results in increased secretion of CCL4 protein	16314067
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in increased expression of CCL4 mRNA	22561872
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CCL4 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of CCL4 mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of CCL4 mRNA	15585374
D010081	Oxazolone	Oxazolone results in increased expression of CCL4 mRNA	19647056
D010100	Oxygen	AHR mutant form promotes the reaction [Oxygen results in increased expression of CCL4 protein]	25831079
D010100	Oxygen	Oxygen results in increased expression of CCL4 protein	25831079
D010100	Oxygen	Oxygen results in increased expression of CCL4 mRNA	10027076\|2236362
D010100	Oxygen	POSTN gene mutant form inhibits the reaction [Oxygen results in increased expression of CCL4 mRNA]	22363622
D010100	Oxygen	[POSTN gene mutant form results in decreased susceptibility to Oxygen] which results in decreased expression of CCL4 mRNA	22363622
D010100	Oxygen	SCGB1A1 protein affects the reaction [Oxygen results in increased expression of CCL4 mRNA]	10027076
D010118	Oxytetracycline	Oxytetracycline results in decreased expression of CCL4 protein	20116850
D010126	Ozone	IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein]	27472835
D010126	Ozone	[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein	27472835
D010126	Ozone	Ozone results in increased expression of CCL4 protein	27679563
C005413	palmatine	palmatine results in decreased expression of CCL4 protein	20116850
D052638	Particulate Matter	Particulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	14966191
D052638	Particulate Matter	Particulate Matter results in decreased expression of CCL4 protein	28189646
D052638	Particulate Matter	"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of CCL4 mRNA"	15522845
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL4 mRNA	21708214
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL4 mRNA	26618301
D010396	Penicillamine	Penicillamine results in increased expression of CCL4 mRNA	22843330
D010396	Penicillamine	Penicillamine results in increased expression of CCL4 mRNA	19575532
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of CCL4 mRNA	23602845
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CCL4 mRNA	23626681
D015232	Dinoprostone	Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]	21913898
D015232	Dinoprostone	Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D015232	Dinoprostone	Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
D015232	Dinoprostone	Dinoprostone results in decreased expression of CCL4 mRNA	16303787
D015232	Dinoprostone	Dinoprostone results in decreased expression of CCL4 protein	17667525
D010743	Phospholipids	CCL2 protein promotes the reaction [Phospholipids results in increased expression of CCL4 mRNA]	11937571
D010743	Phospholipids	Phospholipids results in increased expression of CCL4 mRNA	11937571
C043103	phthalic anhydride	phthalic anhydride results in increased expression of CCL4 protein	20219652
D010844	Picibanil	Picibanil results in increased secretion of CCL4 protein	15289356
D011070	Poly I-C	"6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]"	27783115
D011070	Poly I-C	Poly I-C results in increased expression of CCL4 mRNA	27783115
D011070	Poly I-C	Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]	27783115
D011070	Poly I-C	Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]	19500611
D011070	Poly I-C	methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]	24056979
D011070	Poly I-C	Poly I-C results in increased expression of CCL4 protein	19500611
D011070	Poly I-C	Poly I-C results in increased secretion of CCL4 protein	24056979
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CCL4 protein	18353026
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CCL4 mRNA	23608068
D011239	Prednisolone	Prednisolone results in increased expression of CCL4 protein	20116850
D011419	Propidium	Propidium results in decreased expression of CCL4 protein	20116850
D011442	Proscillaridin	Proscillaridin results in decreased expression of CCL4 protein	20116850
D015237	Dinoprost	[Dinoprost co-treated with epostane] results in increased expression of CCL4 mRNA	21505051
D015237	Dinoprost	Dinoprost results in increased expression of CCL4 mRNA	21505051
D011691	Puromycin	Puromycin results in decreased expression of CCL4 protein	20116850
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of CCL4 mRNA	27029645
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]	16129981
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein]	16129981
C004532	quinone	quinone results in increased expression of CCL4 protein	17572062
C059514	resveratrol	resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL4 protein]	24895526
C059514	resveratrol	[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA	16806235
D019438	Ritonavir	Ritonavir results in decreased expression of CCL4	26626330
C424423	Roflumilast	Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]	21913898
C424423	Roflumilast	Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
C424423	Roflumilast	Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
C424423	Roflumilast	Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]	21913898
C517734	roflumilast N-oxide	Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]	21913898
C517734	roflumilast N-oxide	roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]	21913898
C089730	rosiglitazone	rosiglitazone results in decreased expression of CCL4 mRNA	21515302
C093642	SB 203580	SB 203580 affects the reaction [Methotrexate results in decreased expression of CCL4 protein]	19100307
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of CCL4 mRNA"	21148743
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of CCL4 protein"	17200189\|2151441
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of CCL4 protein]"	21514415
C016101	shikonin	shikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of CCL4 mRNA]	25451590
C016101	shikonin	shikonin inhibits the reaction [Calcimycin results in increased expression of CCL4 mRNA]	25451590
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CCL4 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CCL4 mRNA	19073995\|2322117
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]	16321392
D019821	Simvastatin	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]	16321392
D019821	Simvastatin	Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]	16321392
D019821	Simvastatin	Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA]	16321392
C017947	sodium arsenite	sodium arsenite affects the expression of CCL4 mRNA	20451245
C017947	sodium arsenite	sodium arsenite results in increased expression of CCL4 mRNA	21911445
C016104	sodium bichromate	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein]	17685462
C016104	sodium bichromate	sodium bichromate results in decreased secretion of CCL4 protein	17685462
D015086	2,6-Dichloroindophenol	"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of CCL4 mRNA"	21034357
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of CCL4 mRNA	20713136
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CCL4 mRNA	27257137
D012999	Soman	Soman results in increased expression of CCL4 mRNA	19281266
D053260	Soot	Soot results in increased expression of CCL4 mRNA	22461453\|2655175
D013328	Strophanthins	Strophanthins results in decreased expression of CCL4 protein	20116850
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL4 mRNA	26378955
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCL4 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL4 mRNA	26378955
C061133	tamibarotene	tamibarotene results in increased expression of CCL4 mRNA	15498508
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of CCL4 mRNA	21224055
C501413	tesaglitazar	tesaglitazar results in decreased expression of CCL4 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	27783115
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]	27783115
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCL4 mRNA	27562557
D013755	Tetradecanoylphorbol Acetate	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA	18958680
D013755	Tetradecanoylphorbol Acetate	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein	17685462
D013755	Tetradecanoylphorbol Acetate	[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CCL4 mRNA	9122163
D013755	Tetradecanoylphorbol Acetate	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein]	17685462
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL4 protein	17572062
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL4 mRNA	25613284
D013883	Thiostrepton	Thiostrepton results in decreased expression of CCL4 mRNA	22321511
C119092	tigecycline	"tigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL4 protein]"	19874226
C119092	tigecycline	"tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL4 protein]"	19874226
C009495	titanium dioxide	titanium dioxide results in increased expression of CCL4 mRNA	19695317
C009495	titanium dioxide	titanium dioxide results in increased secretion of CCL4 protein	20005940
C009495	titanium dioxide	titanium dioxide results in increased expression of CCL4 mRNA	19464567\|2355797
C009495	titanium dioxide	titanium dioxide results in increased expression of CCL4 protein	23557971
C402696	TMC 120A	TMC 120A results in decreased expression of CCL4 mRNA	19818335
C402696	TMC 120A	TMC 120A results in increased expression of CCL4 mRNA	19818335
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL4 protein	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CCL4 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL4 protein]	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of CCL4 protein	27818348
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CCL4 protein	27793746
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CCL4 mRNA"	19647056
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CCL4 protein"	20219652
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CCL4 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CCL4 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CCL4 mRNA"	19682533
D014212	Tretinoin	[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL4 mRNA	19828696
D014212	Tretinoin	Tretinoin results in increased expression of CCL4 mRNA	15498508\|1982869
D014212	Tretinoin	Tretinoin results in increased expression of CCL4 protein	19828696
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CCL4 protein	20219652
C046488	trimethyltin	trimethyltin results in increased expression of CCL4 mRNA	24002884
D014302	Trinitrobenzenesulfonic Acid	icilin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL4 protein]	23596210
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of CCL4 protein	23596210
C057693	troglitazone	troglitazone results in decreased expression of CCL4 mRNA	19631733\|2084649
C057693	troglitazone	troglitazone results in increased expression of CCL4 mRNA	19631733
D014414	Tungsten	[Nickel co-treated with Cobalt co-treated with Tungsten] results in increased expression of CCL4 mRNA	22198552
C073339	usnic acid	[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA	22777745
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of CCL4 mRNA	17183730
D014635	Valproic Acid	Valproic Acid results in decreased expression of CCL4 mRNA	29154799
D001335	Vehicle Emissions	Vehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]	14966191
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CCL4 protein	28189646
D001335	Vehicle Emissions	"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of CCL4 mRNA"	15522845
D014750	Vincristine	Vincristine results in increased expression of CCL4 mRNA	23649840
C067172	zopolrestat	"zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL4 mRNA]"	21334316

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005125	cytokine activity	-	TAS	2462251
GO:0005515	protein binding	-	IPI	25416956
GO:0008009	chemokine activity	-	IBA	21873635
GO:0031726	CCR1 chemokine receptor binding	-	IPI	7545673
GO:0031730	CCR5 chemokine receptor binding	-	IPI	10383387 10679098
GO:0042802	identical protein binding	-	IPI	20959807
GO:0048020	CCR chemokine receptor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002548	monocyte chemotaxis	-	IBA	21873635
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006955	immune response	-	TAS	10929056
GO:0007155	cell adhesion	-	TAS	10929056
GO:0007163	establishment or maintenance of cell polarity	-	TAS	9759849
GO:0007165	signal transduction	-	TAS	9558100 10929056
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007267	cell-cell signaling	-	TAS	2521882
GO:0009615	response to virus	-	TAS	9743377
GO:0009636	response to toxic substance	-	IDA	10841574
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030593	neutrophil chemotaxis	-	IBA	21873635
GO:0043547	positive regulation of GTPase activity	-	IBA	21873635
GO:0043922	negative regulation by host of viral transcription	-	IDA	10841574
GO:0048245	eosinophil chemotaxis	-	IBA	21873635
GO:0048247	lymphocyte chemotaxis	-	IBA	21873635
GO:0050729	positive regulation of inflammatory response	-	IBA	21873635
GO:0050850	positive regulation of calcium-mediated signaling	-	IMP	10679098
GO:0051928	positive regulation of calcium ion transport	-	IDA	8699119
GO:0070098	chemokine-mediated signaling pathway	-	IBA	21873635
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0071346	cellular response to interferon-gamma	-	IBA	21873635
GO:0071347	cellular response to interleukin-1	-	IBA	21873635
GO:0071356	cellular response to tumor necrosis factor	-	IBA	21873635
GO:2000503	positive regulation of natural killer cell chemotaxis	-	IDA	7545673

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa04623	Cytosolic DNA-sensing pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
2641831	Effect of cyanamide on transaminases and other serum proteins in the rat. (1989)	Llor J	Rev Esp Fisiol
27650194	Abnormalities in chemokine levels in schizophrenia and their clinical correlates. (2017 Mar)	Hong S	Schizophr Res
26424214	Plasma Chemokine signature correlates with lung goblet cell hyperplasia in smokers with and without chronic obstructive pulmonary disease. (2015 Sep 30)	Kim V	BMC Pulm Med
23951170	Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study. (2013)	Spears M	PLoS One
26781212	Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. (2016 Feb)	O'Halloran EB	Alcohol
25092442	Is serum Interleukin-17 associated with early atherosclerosis in obese patients? (2014 Aug 6)	Tarantino G	J Transl Med
18230951	Decreased cytokine and chemokine mRNA expression in bronchoalveolar lavage in asymptomatic smoking subjects. (2008)	Meuronen A	Respiration
28810615	Detecting serum and urine metabolic profile changes of CCl4-liver fibrosis in rats at 12 weeks based on gas chromatography-mass spectrometry. (2017 Aug)	Gao J	Exp Ther Med
27129864	Concomitants of alcoholism: differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo. (2016 Jul)	Zahr NM	Psychopharmacology (Berl)
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