Gene: CCL8

6355
HC14|MCP-2|MCP2|SCYA10|SCYA8
C-C motif chemokine ligand 8
protein-coding
17q12
Ensembl:ENSG00000108700 MIM:602283 Vega:OTTHUMG00000132883 UniprotKB:P80075
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.024e-1 (AD)  8.664e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IDO10.943
ZBP10.942
CYP19A10.94
CCL70.938
KRTAP20-10.933
RUFY40.915
IL270.904
SIGLEC120.899
LGALS140.896
ETV70.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.276
ATP6V1E2-0.249
NME5-0.245
MYBPC1-0.233
HCN2-0.23
OLIG1-0.228
GNG7-0.225
FOXRED2-0.222
HPR-0.219
BTBD2-0.212

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03088Pidolic AcidSmall Molecule98-79-3Approved|Experimental|InvestigationalTarget
ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CCL8 mRNA"20713471
C496492abrineabrine results in increased expression of CCL8 mRNA22595364
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL8 protein]26138014
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCL8 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCL8 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CCL8 mRNA"23917077
D001280AtrazineAtrazine results in increased expression of CCL8 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CCL8 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCL8 mRNA20713471|2373587
D004958EstradiolEstradiol results in increased expression of CCL8 mRNA19484750|2314475
D000069286BortezomibBortezomib affects the expression of CCL8 protein19922463
C006794brevianamide Abrevianamide A results in increased expression of CCL8 mRNA19818335
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL8 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased secretion of CCL8 protein26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CCL8 mRNA24982889
D003035CobaltTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA23503329
D003436Croton OilCroton Oil results in increased expression of CCL8 mRNA19647056
C038459curdlancurdlan affects the expression of CCL8 mRNA19904525
D003520CyclophosphamideCyclophosphamide results in increased expression of CCL8 mRNA21041162
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]22185406
D003907DexamethasoneDexamethasone results in increased expression of CCL8 mRNA21041162|2218540
D003907DexamethasoneTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA23503329
D016264Dextran SulfateDextran Sulfate results in increased expression of CCL8 mRNA19645018|2389436
D004041Dietary FatsDietary Fats results in decreased expression of CCL8 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of CCL8 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CCL8 mRNA28085963
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CCL8 mRNA21041162
D002117CalcitriolCalcitriol results in increased expression of CCL8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CCL8 mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCL8 mRNA19647056
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of CCL8 mRNA24534155
C046855epostane[Dinoprost co-treated with epostane] results in increased expression of CCL8 mRNA21505051
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL8 mRNA17942748
C064925gadodiamidegadodiamide results in increased expression of CCL8 mRNA20959327
C064925gadodiamidegadodiamide results in increased secretion of CCL8 protein20959327
D017313FenretinideFenretinide results in decreased expression of CCL8 mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of CCL8 mRNA"26377693
D0150561-Methyl-3-isobutylxanthineTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA23503329
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL8 mRNA"23090859
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL8 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]"22185406
D008727MethotrexateMethotrexate results in decreased expression of CCL8 mRNA17400583
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL8 mRNA23519560
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CCL8 mRNA20713471
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CCL8 mRNA18804290
D015735MifepristoneMifepristone results in decreased expression of CCL8 mRNA17584828
D009020MorphineMorphine results in increased secretion of CCL8 protein20564181
D009183MycotoxinsMycotoxins results in increased expression of CCL8 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CCL8 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCL8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL8 mRNA"25554681|2710602
C031721naphthalenenaphthalene results in increased expression of CCL8 mRNA18978301
C015380neoechinulinneoechinulin results in increased expression of CCL8 mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of CCL8 mRNA19818335
D009532NickelNickel results in increased expression of CCL8 mRNA24768652|2558310
D009532NickelTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA23503329
D010081OxazoloneOxazolone results in increased expression of CCL8 mRNA19647056
D000073878Palm OilPalm Oil results in decreased expression of CCL8 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CCL8 mRNA23948077
C006253pirinixic acidpirinixic acid results in increased expression of CCL8 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of CCL8 mRNA23608068
D015237Dinoprost[Dinoprost co-treated with epostane] results in increased expression of CCL8 mRNA21505051
D015237DinoprostDinoprost results in increased expression of CCL8 mRNA21505051
C432165pyrazolanthronepyrazolanthrone promotes the reaction [IL1A protein results in increased expression of CCL8 mRNA]12832416
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]22185406
D011794QuercetinQuercetin results in increased expression of CCL8 mRNA22185406
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of CCL8 mRNA21852083
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CCL8 mRNA"23917077
C017947sodium arsenitesodium arsenite results in increased expression of CCL8 mRNA21911445
D053260SootSoot results in increased expression of CCL8 mRNA22461453|2655175
D013241SterigmatocystinSterigmatocystin results in increased expression of CCL8 mRNA19818335
C061133tamibarotenetamibarotene results in decreased expression of CCL8 mRNA20861477
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CCL8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CCL8 mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL8 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL8 mRNA23519560
C009495titanium dioxidetitanium dioxide results in increased expression of CCL8 mRNA21259345|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCL8 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCL8 mRNA18087596
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCL8 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of CCL8 mRNA"22185406
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CCL8 mRNA"19647056
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCL8 mRNA16141432
C057693troglitazonetroglitazone results in increased expression of CCL8 mRNA28973697
C066075vanadium pentoxidevanadium pentoxide results in increased expression of CCL8 mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CCL8 gene25560391
D015032ZincTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL8 mRNA23503329
C088658zoledronic acidzoledronic acid results in increased expression of CCL8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA10734056  
GO:0008009chemokine activity-IBA21873635  
GO:0008201heparin binding-IEA-  
GO:0016004phospholipase activator activity-IDA10734056  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0002687positive regulation of leukocyte migration-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0006816calcium ion transport-IDA10734056  
GO:0006874cellular calcium ion homeostasis-IDA10734056  
GO:0006887exocytosis-IDA10734056  
GO:0006935chemotaxis-TAS9468473  
GO:0006954inflammatory response-IBA21873635  
GO:0007165signal transduction-TAS9119400  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-IDA10734056  
GO:0009615response to virus-TAS9468473  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070664negative regulation of leukocyte proliferation-IEA-  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23438328Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. (2013 Apr)Fu JJOMICS
20970515Similar gene expression profiles in smokers and patients with moderate COPD. (2011 Feb)Llinas LPulm Pharmacol Ther