Gene info: ID 6356

Gene: CCL11

GENE ID: 6356

Synonyms: SCYA11

Description: C-C motif chemokine ligand 11

Gene type: protein-coding

Location: 17q12

dbXrefs: Ensembl:ENSG00000172156 MIM:601156 Vega:OTTHUMG00000132884 UniprotKB:P51671

RefSeq: NG_012212.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 6

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.011e-1 (AD) 8.724e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MROH9	0.721
KRT26	0.712
TAS2R13	0.683
TAS2R41	0.669
OR4K3	0.667
CD1B	0.666
OR56A3	0.666
POU5F2	0.66
MEOX1	0.655
OR10A7	0.653

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FBXL22	-0.302
TMEM53	-0.294
HDDC3	-0.29
SPAG8	-0.281
ZNF575	-0.279
ANKRD16	-0.278
PAQR4	-0.265
AGAP5	-0.262
METTL2A	-0.262
RHCE	-0.258

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05429	CAT-213	BiotechDrug	-	Investigational	Target

ID	Drug Name	Action	PubMed
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 inhibits the reaction [RELA protein binds to CCL11 promoter]	15531761
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	15531761
C477819	15-deoxyprostaglandin J2	15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	15531761
C477819	15-deoxyprostaglandin J2	Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]	15531761
C477819	15-deoxyprostaglandin J2	Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C477819	15-deoxyprostaglandin J2	PPARA protein affects the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C477819	15-deoxyprostaglandin J2	Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]	15531761
C477819	15-deoxyprostaglandin J2	Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]	11980903
C585004	2-monochloropropanediol	2-monochloropropanediol results in increased expression of CCL11 mRNA	28522335
C524063	2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one	"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]"	25111027
C524063	2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one	"2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]"	25111027
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene results in decreased expression of CCL11 mRNA"	22254182
C041525	3,3',4,5'-tetrahydroxystilbene	"3,3',4,5'-tetrahydroxystilbene results in decreased secretion of CCL11 protein"	22254182
C030682	3-chlorophenol	3-chlorophenol results in increased expression of CCL11 mRNA	18486366
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]	11980903
C544923	4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide	4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]	25111027
C544923	4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide	4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]	25111027
C496492	abrine	abrine results in decreased expression of CCL11 mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCL11 mRNA	26690555
C056165	acetovanillone	acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	22414048
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL11 protein]	26138014
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]	12576300
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]	12576300
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]	12576300
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]	12576300
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCL11 mRNA	22129741
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCL11 mRNA	16483693
D039741	Antigens, Dermatophagoides	"Antigens, Dermatophagoides results in increased expression of CCL11 protein"	20064775\|2406027
D039741	Antigens, Dermatophagoides	"diisononyl phthalate inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	20064775
D039741	Antigens, Dermatophagoides	"Particulate Matter promotes the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	24060272
D039741	Antigens, Dermatophagoides	"Vehicle Emissions promotes the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	24060272
C118980	antileukinate	antileukinate inhibits the reaction [CCL11 protein binds to CCR3 protein]	12842759
C118980	antileukinate	antileukinate inhibits the reaction [CCL11 protein binds to CCR3 protein]	12842759
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CCL11 mRNA	24449571
D001194	Asbestos	Asbestos results in increased expression of CCL11 protein	25162674
C416282	BAY 11-7085	"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D001507	Beclomethasone	Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]	17988555
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CCL11 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CCL11 mRNA	22228805\|2373587
D004958	Estradiol	Estradiol affects the expression of CCL11 mRNA	15598610
D004958	Estradiol	Estradiol results in increased expression of CCL11 mRNA	23144751
D004958	Estradiol	Estradiol results in increased expression of CCL11 mRNA	26945725
C095105	bexarotene	bexarotene results in decreased expression of CCL11 mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of CCL11 mRNA	27685785\|2873625
C006780	bisphenol A	bisphenol A results in increased expression of CCL11 mRNA	22718145
C006780	bisphenol A	bisphenol A results in decreased expression of CCL11 mRNA	25181051
D001761	Bleomycin	Bleomycin results in increased expression of CCL11 mRNA	16314464
D001761	Bleomycin	Bleomycin results in increased expression of CCL11 protein	16314464
D001761	Bleomycin	CCL11 gene mutant form results in decreased susceptibility to Bleomycin	16314464
D001761	Bleomycin	CCL11 protein promotes the reaction [Bleomycin results in increased expression of CCL2 mRNA]	16314464
D001761	Bleomycin	CCL11 protein promotes the reaction [Bleomycin results in increased expression of TGFB1 mRNA]	16314464
C006794	brevianamide A	brevianamide A results in increased expression of CCL11 mRNA	19818335
D019819	Budesonide	Budesonide inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]	17988555
D019328	Buthionine Sulfoximine	[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL11 mRNA	22407903\|2742157
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL11 protein]	26138014
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CCL11 protein	26138014
D000001	Calcimycin	CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]	12797483
D000001	Calcimycin	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CCL11 mRNA]	21331654
D000001	Calcimycin	IL5 protein promotes the reaction [CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]]	12797483
D000001	Calcimycin	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CCL11 mRNA	21331654
D002118	Calcium	CCL11 protein results in increased uptake of Calcium	10984371
C034221	catechol	catechol results in increased expression of CCL11 protein	17572062
D002713	Chlorine	Chlorine results in increased expression of CCL11 protein	23146759
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of CCL11 mRNA	28472532
C433247	Cilomilast	Cilomilast results in decreased expression of CCL11 mRNA	16956605
C055162	clopidogrel	clopidogrel results in increased expression of CCL11 mRNA	19155974
C000593591	coagulin-L	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	27568862
D003033	Coal Tar	Coal Tar results in increased expression of CCL11 mRNA	27858113
D003471	Cuprizone	Cuprizone results in increased expression of CCL11 mRNA	26577399\|2752363
C038459	curdlan	curdlan affects the expression of CCL11 mRNA	19904525
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein"	19467290
D003609	Dactinomycin	Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	15531761
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCL11 mRNA	22968694
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	27568862
D003907	Dexamethasone	Dexamethasone results in increased expression of CCL11 mRNA	21041162
D016264	Dextran Sulfate	Dextran Sulfate results in increased secretion of CCL11 protein	21858153
D016264	Dextran Sulfate	Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]	21858153
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCL11 mRNA	22129741
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CCL11 mRNA	21041162
C012125	diisononyl phthalate	"diisononyl phthalate inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	20064775
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CCL11 mRNA	23133493
D004137	Dinitrochlorobenzene	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]	23133493
D004137	Dinitrochlorobenzene	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]	23133493
D004237	Diuron	Diuron results in decreased expression of CCL11 mRNA	21551480
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]"	25111027
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [IL4 protein results in increased expression of CCL11 protein]"	25111027
D004391	Dust	Dust affects the expression of CCL11 protein	17805423
D004391	Dust	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004391	Dust	[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein	26882889
D004391	Dust	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004391	Dust	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004391	Dust	TLR4 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D004731	Endotoxins	Endotoxins results in increased expression of CCL11 mRNA	12217210
C031818	enterotoxin B, staphylococcal	"enterotoxin B, staphylococcal results in increased expression of and results in increased secretion of CCL11 protein"	25556216
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of CCL11 mRNA	19118595
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CCL11 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CCL11 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CCL11 mRNA	12655037\|1583489
C093230	fexofenadine	fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 mRNA]	15460210
C093230	fexofenadine	fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	15460210
C093230	fexofenadine	fexofenadine inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	15460210
D000068298	Fluticasone	Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]	15531761
D000068298	Fluticasone	Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	15531761
D000068298	Fluticasone	Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	15531761
D000068298	Fluticasone	Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]	15531761
D000068298	Fluticasone	Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C005023	fulvic acid	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CCL11 mRNA]	21331654
C032005	fumaric acid	fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	23707484
C032005	fumaric acid	fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	23707484
C039281	furan	furan results in increased expression of CCL11 mRNA	27387713
C579046	GDC-0152	GDC-0152 results in increased expression of CCL11 protein	22956632
D005839	Gentamicins	Gentamicins results in decreased expression of CCL11 protein	25051504
D006388	Hemagglutinins	Hemagglutinins results in increased secretion of CCL11 protein	22839698
D006493	Heparin	Heparin binds to CCL11 protein	17384413
D006493	Heparin	Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]	17384413
C031927	hydroquinone	hydroquinone results in increased expression of CCL11 protein	17572062
C013038	hydroxyhydroquinone	hydroxyhydroquinone affects the expression of CCL11 protein	17572062
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCL11 mRNA	22129741
D015759	Ionomycin	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL11 protein	17685462
D015759	Ionomycin	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL11 protein]	17685462
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL11 protein	17572062
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CCL11 mRNA	15251112
D007854	Lead	Lead results in increased expression of and results in increased secretion of CCL11 protein	28973681
D008070	Lipopolysaccharides	coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	27568862
D008070	Lipopolysaccharides	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	27568862
D008070	Lipopolysaccharides	fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 mRNA]	15460210
D008070	Lipopolysaccharides	fexofenadine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL11 protein]	15460210
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL11 mRNA	15460210
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL11 protein	15460210\|2756886
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein	26918785
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL11 mRNA	10027076
D008070	Lipopolysaccharides	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein]"	26918785
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of CCL11 protein	21984480
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CCL11 protein	21984480
D008713	Methimazole	[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL11 mRNA	22407903\|2742157
D008713	Methimazole	Methimazole results in increased expression of CCL11 mRNA	26177832
D008727	Methotrexate	Methotrexate results in decreased expression of CCL11 mRNA	17400583\|2444957
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein]"	26918785
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein]	24056979
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CCL11 mRNA	24213012
D009151	Mustard Gas	Mustard Gas results in increased expression of CCL11 protein	17620002
D009183	Mycotoxins	Mycotoxins results in increased expression of CCL11 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CCL11 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCL11 mRNA"	25554681\|2710602
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CCL11 protein"	27106021
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased secretion of CCL11 protein"	19371758
C015380	neoechinulin	neoechinulin results in decreased expression of CCL11 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in increased expression of CCL11 mRNA	19818335
D009532	Nickel	Nickel affects the expression of CCL11 mRNA	14575637
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of CCL11 mRNA]	14575637
C028007	nickel monoxide	nickel monoxide results in decreased expression of CCL11 mRNA	19167457
C029938	nickel sulfate	nickel sulfate affects the expression of CCL11 mRNA	18202158
C029938	nickel sulfate	nickel sulfate results in decreased expression of CCL11 mRNA	18832182
C029938	nickel sulfate	nickel sulfate results in increased expression of CCL11 mRNA	16166746
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of CCL11 mRNA	10715624
D010047	Ovalbumin	MYD88 gene mutant form inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein	26882889
D010047	Ovalbumin	Ovalbumin results in increased expression of CCL11 mRNA	12794006
D010047	Ovalbumin	PH 163 inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
D010047	Ovalbumin	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	TLR2 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	TLR4 gene mutant form promotes the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
D010047	Ovalbumin	verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
D010047	Ovalbumin	zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
D010100	Oxygen	Oxygen results in decreased expression of CCL11 mRNA	9555576
D010100	Oxygen	Oxygen results in increased expression of CCL11 mRNA	10027076
D010100	Oxygen	SCGB1A1 protein affects the reaction [Oxygen results in increased expression of CCL11 mRNA]	10027076
D010126	Ozone	Ozone results in increased expression of CCL11 protein	21945493
D010126	Ozone	IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of CCL11 protein]	17575079
D010126	Ozone	LEP gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]	12794034
D010126	Ozone	[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein	27472835
D010126	Ozone	LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]	16373670
D010126	Ozone	Ozone results in increased expression of CCL11 mRNA	10027076\|1002708
D010126	Ozone	Ozone results in increased expression of CCL11 protein	12794034\|1551649
D010126	Ozone	SCGB1A1 protein affects the reaction [Ozone results in increased expression of CCL11 mRNA]	10027076
D010126	Ozone	Ozone results in increased expression of CCL11 mRNA	9458816
D010126	Ozone	Ozone results in increased expression of CCL11 protein	9458816
D052638	Particulate Matter	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]	12576300
D052638	Particulate Matter	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]	12576300
D052638	Particulate Matter	[Particulate Matter co-treated with IL13 protein] results in increased expression of CCL11 protein	12576300
D052638	Particulate Matter	Particulate Matter results in decreased expression of CCL11 protein	28189646
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL11 mRNA	12576300
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL11 protein	12576300
D052638	Particulate Matter	prolinedithiocarbamate inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]	12576300
D052638	Particulate Matter	prolinedithiocarbamate inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]	12576300
D052638	Particulate Matter	[Particulate Matter co-treated with OVAL protein] affects the expression of CCL11 protein	23896513
D052638	Particulate Matter	"Particulate Matter promotes the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	24060272
D052638	Particulate Matter	Particulate Matter promotes the reaction [OVAL protein results in increased expression of CCL11 mRNA]	20562226
D052638	Particulate Matter	Particulate Matter results in decreased expression of CCL11 protein	18307122
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL11 mRNA	21708214\|2734150
C104857	PH 163	PH 163 inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
C043103	phthalic anhydride	phthalic anhydride results in increased expression of CCL11 protein	20219652
C060836	pioglitazone	"pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
C006253	pirinixic acid	pirinixic acid results in decreased expression of CCL11 mRNA	18249437
D010936	Plant Extracts	Plant Extracts results in decreased expression of CCL11 mRNA	23557933
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]	23133493
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in decreased expression of CCL11 protein	29175452
D011070	Poly I-C	methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein]	24056979
D011070	Poly I-C	Poly I-C results in increased secretion of CCL11 protein	24056979
D011112	Polymyxin B	Polymyxin B inhibits the reaction [[Ovalbumin co-treated with Dust] results in increased expression of CCL11 protein]	26882889
C068291	poractant alfa	poractant alfa results in increased expression of CCL11 protein	14644929
D011239	Prednisolone	Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA]	23133493
D011241	Prednisone	Prednisone results in decreased expression of CCL11 protein	15523430
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]	12576300
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]	12576300
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]	12576300
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]	12576300
C066229	prolinedithiocarbamate	prolinedithiocarbamate inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	23707484
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CCL11 mRNA	24780913
C004532	quinone	quinone results in increased expression of CCL11 protein	17572062
D017382	Reactive Oxygen Species	CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]	12797483
D017382	Reactive Oxygen Species	IL5 protein promotes the reaction [CCL11 protein promotes the reaction [Calcimycin affects the abundance of and affects the chemical synthesis of Reactive Oxygen Species]]	12797483
C059514	resveratrol	resveratrol inhibits the reaction [IL13 protein results in increased expression of CCL11 mRNA]	22254182
C059514	resveratrol	resveratrol inhibits the reaction [IL13 protein results in increased secretion of CCL11 protein]	22254182
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	22254182
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased secretion of CCL11 protein]	22254182
C059514	resveratrol	resveratrol results in decreased expression of CCL11 mRNA	22254182
C059514	resveratrol	resveratrol results in decreased secretion of CCL11 protein	22254182
C059514	resveratrol	resveratrol results in decreased expression of CCL11 protein	17872969
C089730	rosiglitazone	"rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D012402	Rotenone	NLRP3 gene mutant form inhibits the reaction [Rotenone results in decreased secretion of CCL11 protein]	28903492
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate inhibits the reaction [RELA protein binds to CCL11 promoter]	15531761
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	15531761
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	15531761
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]	15531761
D000068299	Salmeterol Xinafoate	Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C093642	SB 203580	SB 203580 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	23707484
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased secretion of CCL11 protein"	23017228
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of CCL11 protein"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form promotes the reaction [Asbestos, Serpentine results in decreased expression of CCL11 protein]"	21514415
C017947	sodium arsenite	sodium arsenite results in increased expression of CCL11 mRNA	21911445
C016104	sodium bichromate	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL11 protein]	17685462
C016104	sodium bichromate	sodium bichromate results in increased secretion of CCL11 protein	17685462
D053260	Soot	Soot results in decreased expression of CCL11 mRNA	22461453
D053260	Soot	Soot results in increased expression of CCL11 mRNA	22461453\|2655175
D013578	Synephrine	Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]	25111027
D013578	Synephrine	Synephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]	25111027
D013578	Synephrine	Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA]	25111027
D016559	Tacrolimus	Tacrolimus results in decreased expression of CCL11 mRNA	15948978
D013629	Tamoxifen	Tamoxifen affects the expression of CCL11 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL11 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Dextran Sulfate results in increased secretion of CCL11 protein]	21858153
D013755	Tetradecanoylphorbol Acetate	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CCL11 mRNA]	21331654
D013755	Tetradecanoylphorbol Acetate	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL11 protein	17685462
D013755	Tetradecanoylphorbol Acetate	sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL11 protein]	17685462
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CCL11 mRNA	21331654
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL11 protein	17572062
C009495	titanium dioxide	titanium dioxide results in increased expression of CCL11 mRNA	21259345
C402696	TMC 120A	TMC 120A results in decreased expression of CCL11 mRNA	19818335
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL11 protein	24096154
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CCL11 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CCL11 mRNA	18087596
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of CCL11 protein	26609137
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CCL11 mRNA	28111298
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of CCL11 protein	27818348
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CCL11 protein	27793746
D014051	Toluene 2,4-Diisocyanate	"BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein]"	17015710
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CCL11 protein"	17015710\|2021965
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CCL11 mRNA"	15823807
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CCL11 mRNA"	19682533
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of CCL11 mRNA]	14575637
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of CCL11 mRNA	19042947
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CCL11 protein	20219652
C001899	triptolide	IL17A protein promotes the reaction [triptolide results in increased expression of CCL11 mRNA]	24949944
C001899	triptolide	triptolide results in increased expression of CCL11 mRNA	24949944
C057693	troglitazone	PPARA protein affects the reaction [troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]	15531761
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]	15531761
C057693	troglitazone	troglitazone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]	15531761
C057693	troglitazone	troglitazone results in decreased activity of CCL11 protein	12644321
C113580	U 0126	U 0126 inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]	11980903
D001335	Vehicle Emissions	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]	12576300
D001335	Vehicle Emissions	Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]	12576300
D001335	Vehicle Emissions	prolinedithiocarbamate inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]	12576300
D001335	Vehicle Emissions	prolinedithiocarbamate inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]	12576300
D001335	Vehicle Emissions	[Vehicle Emissions co-treated with IL13 protein] results in increased expression of CCL11 protein	12576300
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CCL11 protein	28189646
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CCL11 mRNA	12576300
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CCL11 protein	12576300
D001335	Vehicle Emissions	"Vehicle Emissions promotes the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 protein]"	24060272
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CCL11 protein	18307122
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CCL11 gene	25560391
C059141	verlukast	verlukast inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
C063449	zileuton	zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]	12794006
C016837	zinc chloride	zinc chloride results in increased expression of CCL11 mRNA	19428942

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	18275857 21314817 23597562
GO:0008009	chemokine activity	-	IBA	21873635
GO:0008009	chemokine activity	-	IDA	10072545
GO:0031728	CCR3 chemokine receptor binding	-	IDA	11425309
GO:0046983	protein dimerization activity	-	IDA	9712872
GO:0048018	receptor ligand activity	-	IDA	11425309
GO:0048020	CCR chemokine receptor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001938	positive regulation of endothelial cell proliferation	-	IDA	19525930
GO:0002544	chronic inflammatory response	-	IEA	-
GO:0002548	monocyte chemotaxis	-	IBA	21873635
GO:0002551	mast cell chemotaxis	-	IEA	-
GO:0006468	protein phosphorylation	-	TAS	10706854
GO:0006874	cellular calcium ion homeostasis	-	TAS	10415069
GO:0006935	chemotaxis	-	TAS	10706854
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006954	inflammatory response	-	TAS	10708591
GO:0007010	cytoskeleton organization	-	IDA	10072545
GO:0007015	actin filament organization	-	IEA	-
GO:0007155	cell adhesion	-	TAS	10201960
GO:0007165	signal transduction	-	TAS	10706854
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0008360	regulation of cell shape	-	IDA	10072545
GO:0009314	response to radiation	-	TAS	10708591
GO:0009615	response to virus	-	TAS	9558100
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030335	positive regulation of cell migration	-	IDA	19525930
GO:0030593	neutrophil chemotaxis	-	IBA	21873635
GO:0030838	positive regulation of actin filament polymerization	-	IDA	19525930
GO:0035962	response to interleukin-13	-	IEA	-
GO:0043547	positive regulation of GTPase activity	-	IBA	21873635
GO:0043547	positive regulation of GTPase activity	-	IDA	19525930
GO:0045766	positive regulation of angiogenesis	-	IEA	-
GO:0048245	eosinophil chemotaxis	-	IBA	21873635
GO:0048245	eosinophil chemotaxis	-	IDA	10072545
GO:0048247	lymphocyte chemotaxis	-	IBA	21873635
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0060763	mammary duct terminal end bud growth	-	IEA	-
GO:0070098	chemokine-mediated signaling pathway	-	IBA	21873635
GO:0070371	ERK1 and ERK2 cascade	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070670	response to interleukin-4	-	IEA	-
GO:0071346	cellular response to interferon-gamma	-	IBA	21873635
GO:0071347	cellular response to interleukin-1	-	IBA	21873635
GO:0071356	cellular response to tumor necrosis factor	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IDA	20041150
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005622	intracellular	-	IEA	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa05310	Asthma

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27650194	Abnormalities in chemokine levels in schizophrenia and their clinical correlates. (2017 Mar)	Hong S	Schizophr Res
23999066	Pre- and perinatal characteristics and breast milk immune markers. (2013 Nov)	Burch J	Pediatr Res
17868461	Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study. (2007 Sep 14)	Lee JS	Respir Res
25274579	Cigarette smoking and variations in systemic immune and inflammation markers. (2014 Nov)	Shiels MS	J Natl Cancer Inst
18727632	CD8 chemokine receptors in chronic obstructive pulmonary disease. (2008 Oct)	Smyth LJ	Clin Exp Immunol
15186951	Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. (2004 Jul)	Zee RY	Atherosclerosis