Gene: CCL13

6357
CKb10|MCP-4|NCC-1|NCC1|SCYA13|SCYL1
C-C motif chemokine ligand 13
protein-coding
17q12
Ensembl:ENSG00000181374 MIM:601391 Vega:OTTHUMG00000132890 UniprotKB:Q99616
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.886e-1 (AD)  6.625e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg21042139chr17:32683478CCL13Promoter1.958e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR5D180.638
FCER20.603
COL6A30.579
SPTA10.559
HOXC90.544
KRT730.527
SLC4A10.523
FGF70.522
COL3A10.509
IL1F100.508

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG8-0.335
TMEM53-0.332
TTLL1-0.325
MYH7B-0.325
KLHDC9-0.313
ACRV1-0.311
HHATL-0.31
CCDC24-0.309
HDDC3-0.309
LRRC45-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0453052,4-dinitrofluorobenzene sulfonic acid"2,4-dinitrofluorobenzene sulfonic acid results in increased expression of CCL13 mRNA"17936526
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCL13 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCL13 mRNA22316170
D004958EstradiolEstradiol affects the expression of CCL13 mRNA25878060
D004958EstradiolEstradiol results in increased expression of CCL13 mRNA25878060
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CCL13 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CCL13 mRNA25878060
C006780bisphenol Abisphenol A affects the expression of CCL13 mRNA25181051
D002118CalciumCCL13 protein results in increased uptake of Calcium10984371
D003300CopperCopper results in decreased expression of CCL13 mRNA24403277
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CCL13 mRNA28628672
D002945CisplatinCisplatin results in increased expression of CCL13 mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of CCL13 mRNA24465016
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of CCL13 mRNA]24465016
D005054EugenolEugenol results in increased expression of CCL13 mRNA17936526
D011345FenofibrateFenofibrate results in increased expression of CCL13 mRNA25572481
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CCL13 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CCL13 mRNA28628672
D007840LatexLatex analog results in increased expression of CCL13 mRNA24768652
D008727MethotrexateMethotrexate results in decreased expression of CCL13 mRNA17400583
D015735MifepristoneMifepristone results in decreased expression of CCL13 mRNA17584828
D009532NickelNickel results in increased expression of CCL13 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of CCL13 mRNA16780908
C030110oxaliplatinoxaliplatin results in increased expression of CCL13 mRNA25729387
C030110oxaliplatin[Topotecan co-treated with oxaliplatin] results in increased expression of CCL13 mRNA25729387
D010476PerfumePerfume results in increased expression of CCL13 mRNA24768652
D011241PrednisonePrednisone results in decreased expression of CCL13 protein15523430
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of CCL13 mRNA]24465016
D012969Sodium FluorideSodium Fluoride results in decreased expression of CCL13 mRNA27257137
D019772Topotecan[Topotecan co-treated with oxaliplatin] results in increased expression of CCL13 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CCL13 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of CCL13 mRNA28934090

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS9195948  9558100  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA10072545  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006874cellular calcium ion homeostasis-TAS9195948  
GO:0006935chemotaxis-TAS9195948  
GO:0006954inflammatory response-IBA21873635  
GO:0007010cytoskeleton organization-IDA10072545  
GO:0007165signal transduction-TAS9195948  9558100  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS9195948  
GO:0008360regulation of cell shape-IDA10072545  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0031640killing of cells of other organism-IDA12949249  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048245eosinophil chemotaxis-IDA10072545  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12949249  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25249326Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance. (2014 Dec)Kitahara CMCancer Epidemiol Biomarkers Prev